Immunophenotypic characterization of acute leukemia at a public oncology reference center in Maranhão, northeastern Brazil
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | São Paulo medical journal (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802011000600005 |
Resumo: | CONTEXT AND OBJECTIVES: The incidence of acute leukemia (AL) subtypes varies according to geographical distribution. The aim here was to determine the incidence of morphological and immunophenotypic AL subtypes in the state of Maranhão, Brazil, and to correlate the expression of aberrant phenotypes in children with acute lymphoblastic leukemia (ALL) with prognostic factors. DESIGN AND SETTING: Single prospective cohort study at a public oncology reference center in Maranhão. METHODS: Seventy AL cases were diagnosed between September 2008 and January 2010. For the diagnosis, complete blood cell counts, myelograms (at diagnosis and at the end of the induction phase), cytochemical analysis and immunophenotyping were performed. RESULTS: Among adult patients (n = 22), the incidence of AL types was: ALL (22.7%) and acute myeloid leukemia (AML) (77.3%). The subtype AML M0 occurred most frequently (29.4%). In children (n = 48), the types were: AML (18.7%), most frequently subtype AML M4 (33.4%); biphenotypic acute leukemia (BAL) (4.2%); and ALL (77.1%), including the subtypes B-ALL (72.9%) and T-ALL (27.1%). Among the children with ALL, there were no statistically significant differences between patients with and without aberrant phenotypes, in relation to hematological parameters and treatment response. CONCLUSION: This work demonstrates that the frequencies of AML M0 cases among adults and T-ALL cases among children in Maranhão were high. This suggests that there may be differences in AML subtype incidence, as seen with ALL subtypes, in different regions of Brazil. No association was found between the expression of aberrant phenotypes and prognostic factors, in children with ALL. |
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Immunophenotypic characterization of acute leukemia at a public oncology reference center in Maranhão, northeastern BrazilPrecursor cell lymphoblastic leukemia-lymphomaLeukemia, myeloid, acutePrevalenceImmunophenotypingPrognosisCONTEXT AND OBJECTIVES: The incidence of acute leukemia (AL) subtypes varies according to geographical distribution. The aim here was to determine the incidence of morphological and immunophenotypic AL subtypes in the state of Maranhão, Brazil, and to correlate the expression of aberrant phenotypes in children with acute lymphoblastic leukemia (ALL) with prognostic factors. DESIGN AND SETTING: Single prospective cohort study at a public oncology reference center in Maranhão. METHODS: Seventy AL cases were diagnosed between September 2008 and January 2010. For the diagnosis, complete blood cell counts, myelograms (at diagnosis and at the end of the induction phase), cytochemical analysis and immunophenotyping were performed. RESULTS: Among adult patients (n = 22), the incidence of AL types was: ALL (22.7%) and acute myeloid leukemia (AML) (77.3%). The subtype AML M0 occurred most frequently (29.4%). In children (n = 48), the types were: AML (18.7%), most frequently subtype AML M4 (33.4%); biphenotypic acute leukemia (BAL) (4.2%); and ALL (77.1%), including the subtypes B-ALL (72.9%) and T-ALL (27.1%). Among the children with ALL, there were no statistically significant differences between patients with and without aberrant phenotypes, in relation to hematological parameters and treatment response. CONCLUSION: This work demonstrates that the frequencies of AML M0 cases among adults and T-ALL cases among children in Maranhão were high. This suggests that there may be differences in AML subtype incidence, as seen with ALL subtypes, in different regions of Brazil. No association was found between the expression of aberrant phenotypes and prognostic factors, in children with ALL.Associação Paulista de Medicina - APM2011-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802011000600005Sao Paulo Medical Journal v.129 n.6 2011reponame:São Paulo medical journal (Online)instname:Associação Paulista de Medicinainstacron:APM10.1590/S1516-31802011000600005info:eu-repo/semantics/openAccessNoronha,Elda PereiraMarinho,Heliana TrindadeThomaz,Erika Bárbara Abreu FonsecaSilva,Cintia AssunçãoVeras,Geni Lourdes RamosOliveira,Raimundo Antônio Gomeseng2012-01-11T00:00:00Zoai:scielo:S1516-31802011000600005Revistahttp://www.scielo.br/spmjhttps://old.scielo.br/oai/scielo-oai.phprevistas@apm.org.br1806-94601516-3180opendoar:2012-01-11T00:00São Paulo medical journal (Online) - Associação Paulista de Medicinafalse |
dc.title.none.fl_str_mv |
Immunophenotypic characterization of acute leukemia at a public oncology reference center in Maranhão, northeastern Brazil |
title |
Immunophenotypic characterization of acute leukemia at a public oncology reference center in Maranhão, northeastern Brazil |
spellingShingle |
Immunophenotypic characterization of acute leukemia at a public oncology reference center in Maranhão, northeastern Brazil Noronha,Elda Pereira Precursor cell lymphoblastic leukemia-lymphoma Leukemia, myeloid, acute Prevalence Immunophenotyping Prognosis |
title_short |
Immunophenotypic characterization of acute leukemia at a public oncology reference center in Maranhão, northeastern Brazil |
title_full |
Immunophenotypic characterization of acute leukemia at a public oncology reference center in Maranhão, northeastern Brazil |
title_fullStr |
Immunophenotypic characterization of acute leukemia at a public oncology reference center in Maranhão, northeastern Brazil |
title_full_unstemmed |
Immunophenotypic characterization of acute leukemia at a public oncology reference center in Maranhão, northeastern Brazil |
title_sort |
Immunophenotypic characterization of acute leukemia at a public oncology reference center in Maranhão, northeastern Brazil |
author |
Noronha,Elda Pereira |
author_facet |
Noronha,Elda Pereira Marinho,Heliana Trindade Thomaz,Erika Bárbara Abreu Fonseca Silva,Cintia Assunção Veras,Geni Lourdes Ramos Oliveira,Raimundo Antônio Gomes |
author_role |
author |
author2 |
Marinho,Heliana Trindade Thomaz,Erika Bárbara Abreu Fonseca Silva,Cintia Assunção Veras,Geni Lourdes Ramos Oliveira,Raimundo Antônio Gomes |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Noronha,Elda Pereira Marinho,Heliana Trindade Thomaz,Erika Bárbara Abreu Fonseca Silva,Cintia Assunção Veras,Geni Lourdes Ramos Oliveira,Raimundo Antônio Gomes |
dc.subject.por.fl_str_mv |
Precursor cell lymphoblastic leukemia-lymphoma Leukemia, myeloid, acute Prevalence Immunophenotyping Prognosis |
topic |
Precursor cell lymphoblastic leukemia-lymphoma Leukemia, myeloid, acute Prevalence Immunophenotyping Prognosis |
description |
CONTEXT AND OBJECTIVES: The incidence of acute leukemia (AL) subtypes varies according to geographical distribution. The aim here was to determine the incidence of morphological and immunophenotypic AL subtypes in the state of Maranhão, Brazil, and to correlate the expression of aberrant phenotypes in children with acute lymphoblastic leukemia (ALL) with prognostic factors. DESIGN AND SETTING: Single prospective cohort study at a public oncology reference center in Maranhão. METHODS: Seventy AL cases were diagnosed between September 2008 and January 2010. For the diagnosis, complete blood cell counts, myelograms (at diagnosis and at the end of the induction phase), cytochemical analysis and immunophenotyping were performed. RESULTS: Among adult patients (n = 22), the incidence of AL types was: ALL (22.7%) and acute myeloid leukemia (AML) (77.3%). The subtype AML M0 occurred most frequently (29.4%). In children (n = 48), the types were: AML (18.7%), most frequently subtype AML M4 (33.4%); biphenotypic acute leukemia (BAL) (4.2%); and ALL (77.1%), including the subtypes B-ALL (72.9%) and T-ALL (27.1%). Among the children with ALL, there were no statistically significant differences between patients with and without aberrant phenotypes, in relation to hematological parameters and treatment response. CONCLUSION: This work demonstrates that the frequencies of AML M0 cases among adults and T-ALL cases among children in Maranhão were high. This suggests that there may be differences in AML subtype incidence, as seen with ALL subtypes, in different regions of Brazil. No association was found between the expression of aberrant phenotypes and prognostic factors, in children with ALL. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802011000600005 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802011000600005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1516-31802011000600005 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Paulista de Medicina - APM |
publisher.none.fl_str_mv |
Associação Paulista de Medicina - APM |
dc.source.none.fl_str_mv |
Sao Paulo Medical Journal v.129 n.6 2011 reponame:São Paulo medical journal (Online) instname:Associação Paulista de Medicina instacron:APM |
instname_str |
Associação Paulista de Medicina |
instacron_str |
APM |
institution |
APM |
reponame_str |
São Paulo medical journal (Online) |
collection |
São Paulo medical journal (Online) |
repository.name.fl_str_mv |
São Paulo medical journal (Online) - Associação Paulista de Medicina |
repository.mail.fl_str_mv |
revistas@apm.org.br |
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1754209263061827584 |