Ethiological treatment of acute and chronic Chagas' heart disease
Autor(a) principal: | |
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Data de Publicação: | 1995 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | São Paulo medical journal (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801995000200020 |
Resumo: | The uncertaintties in the ethiological treatment of Chagas' Disease are consequence of the lack of entire knowledge of its pathogeny and the no existence of a healing criterium. There is a consensus that antiparasite drugs should be used in the acute phase of the infection, regardless of the infection route, in new crisis, in patients under immunossuppression and in organs transplantation. There is still controversy regarding subacute, chronic or indetermined phase or cases with mild cardiac/digestive forms, not included in the situations listed above neither in a research protocol. The treatment includes oral benzonidazol 5 mg/kg/day, bid or tid for 60 days. In 71 patients monitored in this fashion, the authors have found 60% of negative xenodiagnostic at the end of treatment. It is still necessary, however, to continue to investigate and accomplishing more randomized trials to confirm the efficacy of such method, and also to try to obtain effective and less toxic agents. It is also fundamental to standardize a more reliable healing criterium. |
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São Paulo medical journal (Online) |
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Ethiological treatment of acute and chronic Chagas' heart diseaseChagas's diseaseBenzonidazolCardiomyopathiesThe uncertaintties in the ethiological treatment of Chagas' Disease are consequence of the lack of entire knowledge of its pathogeny and the no existence of a healing criterium. There is a consensus that antiparasite drugs should be used in the acute phase of the infection, regardless of the infection route, in new crisis, in patients under immunossuppression and in organs transplantation. There is still controversy regarding subacute, chronic or indetermined phase or cases with mild cardiac/digestive forms, not included in the situations listed above neither in a research protocol. The treatment includes oral benzonidazol 5 mg/kg/day, bid or tid for 60 days. In 71 patients monitored in this fashion, the authors have found 60% of negative xenodiagnostic at the end of treatment. It is still necessary, however, to continue to investigate and accomplishing more randomized trials to confirm the efficacy of such method, and also to try to obtain effective and less toxic agents. It is also fundamental to standardize a more reliable healing criterium.Associação Paulista de Medicina - APM1995-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801995000200020Sao Paulo Medical Journal v.113 n.2 1995reponame:São Paulo medical journal (Online)instname:Associação Paulista de Medicinainstacron:APM10.1590/S1516-31801995000200020info:eu-repo/semantics/openAccessFragata Filho,Abílio AugustoSilva,Marco Aurélio Dias daBoainain,Eliaseng2009-05-28T00:00:00Zoai:scielo:S1516-31801995000200020Revistahttp://www.scielo.br/spmjhttps://old.scielo.br/oai/scielo-oai.phprevistas@apm.org.br1806-94601516-3180opendoar:2009-05-28T00:00São Paulo medical journal (Online) - Associação Paulista de Medicinafalse |
dc.title.none.fl_str_mv |
Ethiological treatment of acute and chronic Chagas' heart disease |
title |
Ethiological treatment of acute and chronic Chagas' heart disease |
spellingShingle |
Ethiological treatment of acute and chronic Chagas' heart disease Fragata Filho,Abílio Augusto Chagas's disease Benzonidazol Cardiomyopathies |
title_short |
Ethiological treatment of acute and chronic Chagas' heart disease |
title_full |
Ethiological treatment of acute and chronic Chagas' heart disease |
title_fullStr |
Ethiological treatment of acute and chronic Chagas' heart disease |
title_full_unstemmed |
Ethiological treatment of acute and chronic Chagas' heart disease |
title_sort |
Ethiological treatment of acute and chronic Chagas' heart disease |
author |
Fragata Filho,Abílio Augusto |
author_facet |
Fragata Filho,Abílio Augusto Silva,Marco Aurélio Dias da Boainain,Elias |
author_role |
author |
author2 |
Silva,Marco Aurélio Dias da Boainain,Elias |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Fragata Filho,Abílio Augusto Silva,Marco Aurélio Dias da Boainain,Elias |
dc.subject.por.fl_str_mv |
Chagas's disease Benzonidazol Cardiomyopathies |
topic |
Chagas's disease Benzonidazol Cardiomyopathies |
description |
The uncertaintties in the ethiological treatment of Chagas' Disease are consequence of the lack of entire knowledge of its pathogeny and the no existence of a healing criterium. There is a consensus that antiparasite drugs should be used in the acute phase of the infection, regardless of the infection route, in new crisis, in patients under immunossuppression and in organs transplantation. There is still controversy regarding subacute, chronic or indetermined phase or cases with mild cardiac/digestive forms, not included in the situations listed above neither in a research protocol. The treatment includes oral benzonidazol 5 mg/kg/day, bid or tid for 60 days. In 71 patients monitored in this fashion, the authors have found 60% of negative xenodiagnostic at the end of treatment. It is still necessary, however, to continue to investigate and accomplishing more randomized trials to confirm the efficacy of such method, and also to try to obtain effective and less toxic agents. It is also fundamental to standardize a more reliable healing criterium. |
publishDate |
1995 |
dc.date.none.fl_str_mv |
1995-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801995000200020 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801995000200020 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1516-31801995000200020 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Paulista de Medicina - APM |
publisher.none.fl_str_mv |
Associação Paulista de Medicina - APM |
dc.source.none.fl_str_mv |
Sao Paulo Medical Journal v.113 n.2 1995 reponame:São Paulo medical journal (Online) instname:Associação Paulista de Medicina instacron:APM |
instname_str |
Associação Paulista de Medicina |
instacron_str |
APM |
institution |
APM |
reponame_str |
São Paulo medical journal (Online) |
collection |
São Paulo medical journal (Online) |
repository.name.fl_str_mv |
São Paulo medical journal (Online) - Associação Paulista de Medicina |
repository.mail.fl_str_mv |
revistas@apm.org.br |
_version_ |
1754209259212505088 |