The perimenopause, depressive disorders, and hormonal variability

Detalhes bibliográficos
Autor(a) principal: Soares,Cláudio de Novaes
Data de Publicação: 2001
Outros Autores: Cohen,Lee Stuart
Tipo de documento: Artigo
Idioma: eng
Título da fonte: São Paulo medical journal (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802001000200008
Resumo: CONTEXT: Several investigations have postulated that the perimenopause may represent a period of increased psychiatric vulnerability, particularly for mood disorders. This review characterizes the perimenopause, including biological changes, the influence of psychosocial factors and the most common clinical manifestations. Clinic-based studies and community-based surveys addressing the prevalence of depressive symptoms in perimenopausal women are critically reviewed. We also discuss the potential greater vulnerability to mood disturbance during the perimenopause in response to hormonal variability. A therapeutic algorithm for management of depressive symptoms in middle-aged perimenopausal women is also presented. The role of estrogen in the treatment of perimenopausal depressive symptoms is particularly discussed. In addition, we review the existing data regarding the potential efficacy of estrogen as an antidepressant agent (monotherapy, augmentation strategy or prophylaxis). DESIGN: Narrative review.
id APM-1_8019d5732befe9da155de805d8742a2e
oai_identifier_str oai:scielo:S1516-31802001000200008
network_acronym_str APM-1
network_name_str São Paulo medical journal (Online)
repository_id_str
spelling The perimenopause, depressive disorders, and hormonal variabilityPerimenopauseDepressionReviewEstrogenTreatmentCONTEXT: Several investigations have postulated that the perimenopause may represent a period of increased psychiatric vulnerability, particularly for mood disorders. This review characterizes the perimenopause, including biological changes, the influence of psychosocial factors and the most common clinical manifestations. Clinic-based studies and community-based surveys addressing the prevalence of depressive symptoms in perimenopausal women are critically reviewed. We also discuss the potential greater vulnerability to mood disturbance during the perimenopause in response to hormonal variability. A therapeutic algorithm for management of depressive symptoms in middle-aged perimenopausal women is also presented. The role of estrogen in the treatment of perimenopausal depressive symptoms is particularly discussed. In addition, we review the existing data regarding the potential efficacy of estrogen as an antidepressant agent (monotherapy, augmentation strategy or prophylaxis). DESIGN: Narrative review.Associação Paulista de Medicina - APM2001-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802001000200008Sao Paulo Medical Journal v.119 n.2 2001reponame:São Paulo medical journal (Online)instname:Associação Paulista de Medicinainstacron:APM10.1590/S1516-31802001000200008info:eu-repo/semantics/openAccessSoares,Cláudio de NovaesCohen,Lee Stuarteng2001-03-19T00:00:00Zoai:scielo:S1516-31802001000200008Revistahttp://www.scielo.br/spmjhttps://old.scielo.br/oai/scielo-oai.phprevistas@apm.org.br1806-94601516-3180opendoar:2001-03-19T00:00São Paulo medical journal (Online) - Associação Paulista de Medicinafalse
dc.title.none.fl_str_mv The perimenopause, depressive disorders, and hormonal variability
title The perimenopause, depressive disorders, and hormonal variability
spellingShingle The perimenopause, depressive disorders, and hormonal variability
Soares,Cláudio de Novaes
Perimenopause
Depression
Review
Estrogen
Treatment
title_short The perimenopause, depressive disorders, and hormonal variability
title_full The perimenopause, depressive disorders, and hormonal variability
title_fullStr The perimenopause, depressive disorders, and hormonal variability
title_full_unstemmed The perimenopause, depressive disorders, and hormonal variability
title_sort The perimenopause, depressive disorders, and hormonal variability
author Soares,Cláudio de Novaes
author_facet Soares,Cláudio de Novaes
Cohen,Lee Stuart
author_role author
author2 Cohen,Lee Stuart
author2_role author
dc.contributor.author.fl_str_mv Soares,Cláudio de Novaes
Cohen,Lee Stuart
dc.subject.por.fl_str_mv Perimenopause
Depression
Review
Estrogen
Treatment
topic Perimenopause
Depression
Review
Estrogen
Treatment
description CONTEXT: Several investigations have postulated that the perimenopause may represent a period of increased psychiatric vulnerability, particularly for mood disorders. This review characterizes the perimenopause, including biological changes, the influence of psychosocial factors and the most common clinical manifestations. Clinic-based studies and community-based surveys addressing the prevalence of depressive symptoms in perimenopausal women are critically reviewed. We also discuss the potential greater vulnerability to mood disturbance during the perimenopause in response to hormonal variability. A therapeutic algorithm for management of depressive symptoms in middle-aged perimenopausal women is also presented. The role of estrogen in the treatment of perimenopausal depressive symptoms is particularly discussed. In addition, we review the existing data regarding the potential efficacy of estrogen as an antidepressant agent (monotherapy, augmentation strategy or prophylaxis). DESIGN: Narrative review.
publishDate 2001
dc.date.none.fl_str_mv 2001-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802001000200008
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802001000200008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-31802001000200008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Paulista de Medicina - APM
publisher.none.fl_str_mv Associação Paulista de Medicina - APM
dc.source.none.fl_str_mv Sao Paulo Medical Journal v.119 n.2 2001
reponame:São Paulo medical journal (Online)
instname:Associação Paulista de Medicina
instacron:APM
instname_str Associação Paulista de Medicina
instacron_str APM
institution APM
reponame_str São Paulo medical journal (Online)
collection São Paulo medical journal (Online)
repository.name.fl_str_mv São Paulo medical journal (Online) - Associação Paulista de Medicina
repository.mail.fl_str_mv revistas@apm.org.br
_version_ 1754209260362792960

Registros relacionados