Inhibitory serum factor of lymphoproliferative response to allogeneic cells in pregnancy
Autor(a) principal: | |
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Data de Publicação: | 1997 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | São Paulo medical journal (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801997000400006 |
Resumo: | INTRODUCTION: An inhibitory serum factor of mixed lymphocyte culture (MLC) has been associated with successful pregnancy after lymphocyte transfusion in women with unexplained recurrent spontaneous abortions (RSA). OBJECTIVE: Investigate whether the inhibitory serum factor of MLC is essential for a successful pregnancy. METHOD: Sera from 33 healthy pregnant women and from 40 women with RSA were assessed by a one-way MLC in which the woman's lymphocytes were stimulated with her partner's lymphocytes or with third party lymphocytes. RESULTS: An inhibitory serum effect (inhibition > 50% as compared to normal serum) was detected in 45% of the pregnant women who had at least 1 previous parity, in 8% of the primigravidea, in 29% of those with one abortion and in 58% of those with more than one abortion. CONCLUSION: MLC inhibitory serum factor does not seem to be an essential factor for pregnancy development. Therefore, it should not be considered as a parameter for the assessment of RSA patients. |
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São Paulo medical journal (Online) |
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Inhibitory serum factor of lymphoproliferative response to allogeneic cells in pregnancyMixed lymphocyte culture testPregnancyHabitual abortionINTRODUCTION: An inhibitory serum factor of mixed lymphocyte culture (MLC) has been associated with successful pregnancy after lymphocyte transfusion in women with unexplained recurrent spontaneous abortions (RSA). OBJECTIVE: Investigate whether the inhibitory serum factor of MLC is essential for a successful pregnancy. METHOD: Sera from 33 healthy pregnant women and from 40 women with RSA were assessed by a one-way MLC in which the woman's lymphocytes were stimulated with her partner's lymphocytes or with third party lymphocytes. RESULTS: An inhibitory serum effect (inhibition > 50% as compared to normal serum) was detected in 45% of the pregnant women who had at least 1 previous parity, in 8% of the primigravidea, in 29% of those with one abortion and in 58% of those with more than one abortion. CONCLUSION: MLC inhibitory serum factor does not seem to be an essential factor for pregnancy development. Therefore, it should not be considered as a parameter for the assessment of RSA patients.Associação Paulista de Medicina - APM1997-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801997000400006Sao Paulo Medical Journal v.115 n.4 1997reponame:São Paulo medical journal (Online)instname:Associação Paulista de Medicinainstacron:APM10.1590/S1516-31801997000400006info:eu-repo/semantics/openAccessDaher,SilviaFonseca,FlaviaMattar,RoseaneMusatti,Chloe CambaLima,Maria Gerbase deeng2008-11-05T00:00:00Zoai:scielo:S1516-31801997000400006Revistahttp://www.scielo.br/spmjhttps://old.scielo.br/oai/scielo-oai.phprevistas@apm.org.br1806-94601516-3180opendoar:2008-11-05T00:00São Paulo medical journal (Online) - Associação Paulista de Medicinafalse |
dc.title.none.fl_str_mv |
Inhibitory serum factor of lymphoproliferative response to allogeneic cells in pregnancy |
title |
Inhibitory serum factor of lymphoproliferative response to allogeneic cells in pregnancy |
spellingShingle |
Inhibitory serum factor of lymphoproliferative response to allogeneic cells in pregnancy Daher,Silvia Mixed lymphocyte culture test Pregnancy Habitual abortion |
title_short |
Inhibitory serum factor of lymphoproliferative response to allogeneic cells in pregnancy |
title_full |
Inhibitory serum factor of lymphoproliferative response to allogeneic cells in pregnancy |
title_fullStr |
Inhibitory serum factor of lymphoproliferative response to allogeneic cells in pregnancy |
title_full_unstemmed |
Inhibitory serum factor of lymphoproliferative response to allogeneic cells in pregnancy |
title_sort |
Inhibitory serum factor of lymphoproliferative response to allogeneic cells in pregnancy |
author |
Daher,Silvia |
author_facet |
Daher,Silvia Fonseca,Flavia Mattar,Roseane Musatti,Chloe Camba Lima,Maria Gerbase de |
author_role |
author |
author2 |
Fonseca,Flavia Mattar,Roseane Musatti,Chloe Camba Lima,Maria Gerbase de |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Daher,Silvia Fonseca,Flavia Mattar,Roseane Musatti,Chloe Camba Lima,Maria Gerbase de |
dc.subject.por.fl_str_mv |
Mixed lymphocyte culture test Pregnancy Habitual abortion |
topic |
Mixed lymphocyte culture test Pregnancy Habitual abortion |
description |
INTRODUCTION: An inhibitory serum factor of mixed lymphocyte culture (MLC) has been associated with successful pregnancy after lymphocyte transfusion in women with unexplained recurrent spontaneous abortions (RSA). OBJECTIVE: Investigate whether the inhibitory serum factor of MLC is essential for a successful pregnancy. METHOD: Sera from 33 healthy pregnant women and from 40 women with RSA were assessed by a one-way MLC in which the woman's lymphocytes were stimulated with her partner's lymphocytes or with third party lymphocytes. RESULTS: An inhibitory serum effect (inhibition > 50% as compared to normal serum) was detected in 45% of the pregnant women who had at least 1 previous parity, in 8% of the primigravidea, in 29% of those with one abortion and in 58% of those with more than one abortion. CONCLUSION: MLC inhibitory serum factor does not seem to be an essential factor for pregnancy development. Therefore, it should not be considered as a parameter for the assessment of RSA patients. |
publishDate |
1997 |
dc.date.none.fl_str_mv |
1997-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801997000400006 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801997000400006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1516-31801997000400006 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Paulista de Medicina - APM |
publisher.none.fl_str_mv |
Associação Paulista de Medicina - APM |
dc.source.none.fl_str_mv |
Sao Paulo Medical Journal v.115 n.4 1997 reponame:São Paulo medical journal (Online) instname:Associação Paulista de Medicina instacron:APM |
instname_str |
Associação Paulista de Medicina |
instacron_str |
APM |
institution |
APM |
reponame_str |
São Paulo medical journal (Online) |
collection |
São Paulo medical journal (Online) |
repository.name.fl_str_mv |
São Paulo medical journal (Online) - Associação Paulista de Medicina |
repository.mail.fl_str_mv |
revistas@apm.org.br |
_version_ |
1754209259576360960 |