Evaluation of BDNF levels in patients hospitalized for physical trauma at an emergency hospital in Porto Alegre, southern Brazil
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Trends in Psychiatry and Psychotherapy |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-60892019000300237 |
Resumo: | Abstract Objective To assess the association between brain-derived neurotrophic factor (BDNF) levels and acute stress disorder (ASD) in patients who have suffered physical trauma. Methods Data were collected at an emergency hospital in Porto Alegre, state of Rio Grande do Sul, southern Brazil. Participants were over 18 years of age, victims of physical trauma, and had been hospitalized for a minimum of 48 hours. A total of 117 hospitalized patients who agreed to participate in the research were grouped according to the shift in which blood was collected (38 subjects from the morning shift and 79 from the afternoon shift), had their BDNF levels measured and responded to other questionnaires. Respondents were further grouped by age into three ranges: 18-30, 31-50 and 51-70 years. Results We found a significant difference in the distribution of BDNF between the two shifts in which blood samples were collected, with the afternoon group having higher BDNF levels (U = 1906.5, p = 0.018). A difference was observed only between the 18-30 group and the 51-70 group in the afternoon shift (Umorning = 1107, pmorning = 0.575; Uafternoon = 7175, pafternoon = 0.028). Conclusions The population whose blood samples were collected in the afternoon showed significantly higher values of BDNF compared to those of the morning shift. This same population presented lower BDNF levels when associated with ASD subtypes A1, A2, and A. We hypothesize that the lower values of BDNF measured in the morning shift were due to a response to the circadian cycle of cortisol, whose action inhibits the expression of serum neurotrophins. |
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Trends in Psychiatry and Psychotherapy |
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Evaluation of BDNF levels in patients hospitalized for physical trauma at an emergency hospital in Porto Alegre, southern BrazilAcute stress disorderBDNFphysical traumatrauma in childhoodAbstract Objective To assess the association between brain-derived neurotrophic factor (BDNF) levels and acute stress disorder (ASD) in patients who have suffered physical trauma. Methods Data were collected at an emergency hospital in Porto Alegre, state of Rio Grande do Sul, southern Brazil. Participants were over 18 years of age, victims of physical trauma, and had been hospitalized for a minimum of 48 hours. A total of 117 hospitalized patients who agreed to participate in the research were grouped according to the shift in which blood was collected (38 subjects from the morning shift and 79 from the afternoon shift), had their BDNF levels measured and responded to other questionnaires. Respondents were further grouped by age into three ranges: 18-30, 31-50 and 51-70 years. Results We found a significant difference in the distribution of BDNF between the two shifts in which blood samples were collected, with the afternoon group having higher BDNF levels (U = 1906.5, p = 0.018). A difference was observed only between the 18-30 group and the 51-70 group in the afternoon shift (Umorning = 1107, pmorning = 0.575; Uafternoon = 7175, pafternoon = 0.028). Conclusions The population whose blood samples were collected in the afternoon showed significantly higher values of BDNF compared to those of the morning shift. This same population presented lower BDNF levels when associated with ASD subtypes A1, A2, and A. We hypothesize that the lower values of BDNF measured in the morning shift were due to a response to the circadian cycle of cortisol, whose action inhibits the expression of serum neurotrophins.Associação de Psiquiatria do Rio Grande do Sul2019-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-60892019000300237Trends in Psychiatry and Psychotherapy v.41 n.3 2019reponame:Trends in Psychiatry and Psychotherapyinstname:Sociedade de Psiquiatria do Rio Grande do Sulinstacron:APRGS10.1590/2237-6089-2018-0060info:eu-repo/semantics/openAccessZatti,CleoniceGuimarães,Luciano Santos PintoSantana,Márcia Rosane MoreiraScherner,Eliana Ferreira GonçalvesSalle,EmílioPiltcher,RenatoSpader,Mariana LunardiCalegaro,Vitor CrestaniWollenhaupt-Aguiar,BiancaFreitas,Lúcia Helena Machadoeng2019-10-15T00:00:00Zoai:scielo:S2237-60892019000300237Revistahttp://www.scielo.br/scielo.php?script=sci_serial&pid=2237-6089&lng=en&nrm=isohttps://old.scielo.br/oai/scielo-oai.phprevista@aprs.org.br|| rodrigo_grassi@terra.com.br2238-00192237-6089opendoar:2019-10-15T00:00Trends in Psychiatry and Psychotherapy - Sociedade de Psiquiatria do Rio Grande do Sulfalse |
dc.title.none.fl_str_mv |
Evaluation of BDNF levels in patients hospitalized for physical trauma at an emergency hospital in Porto Alegre, southern Brazil |
title |
Evaluation of BDNF levels in patients hospitalized for physical trauma at an emergency hospital in Porto Alegre, southern Brazil |
spellingShingle |
Evaluation of BDNF levels in patients hospitalized for physical trauma at an emergency hospital in Porto Alegre, southern Brazil Zatti,Cleonice Acute stress disorder BDNF physical trauma trauma in childhood |
title_short |
Evaluation of BDNF levels in patients hospitalized for physical trauma at an emergency hospital in Porto Alegre, southern Brazil |
title_full |
Evaluation of BDNF levels in patients hospitalized for physical trauma at an emergency hospital in Porto Alegre, southern Brazil |
title_fullStr |
Evaluation of BDNF levels in patients hospitalized for physical trauma at an emergency hospital in Porto Alegre, southern Brazil |
title_full_unstemmed |
Evaluation of BDNF levels in patients hospitalized for physical trauma at an emergency hospital in Porto Alegre, southern Brazil |
title_sort |
Evaluation of BDNF levels in patients hospitalized for physical trauma at an emergency hospital in Porto Alegre, southern Brazil |
author |
Zatti,Cleonice |
author_facet |
Zatti,Cleonice Guimarães,Luciano Santos Pinto Santana,Márcia Rosane Moreira Scherner,Eliana Ferreira Gonçalves Salle,Emílio Piltcher,Renato Spader,Mariana Lunardi Calegaro,Vitor Crestani Wollenhaupt-Aguiar,Bianca Freitas,Lúcia Helena Machado |
author_role |
author |
author2 |
Guimarães,Luciano Santos Pinto Santana,Márcia Rosane Moreira Scherner,Eliana Ferreira Gonçalves Salle,Emílio Piltcher,Renato Spader,Mariana Lunardi Calegaro,Vitor Crestani Wollenhaupt-Aguiar,Bianca Freitas,Lúcia Helena Machado |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Zatti,Cleonice Guimarães,Luciano Santos Pinto Santana,Márcia Rosane Moreira Scherner,Eliana Ferreira Gonçalves Salle,Emílio Piltcher,Renato Spader,Mariana Lunardi Calegaro,Vitor Crestani Wollenhaupt-Aguiar,Bianca Freitas,Lúcia Helena Machado |
dc.subject.por.fl_str_mv |
Acute stress disorder BDNF physical trauma trauma in childhood |
topic |
Acute stress disorder BDNF physical trauma trauma in childhood |
description |
Abstract Objective To assess the association between brain-derived neurotrophic factor (BDNF) levels and acute stress disorder (ASD) in patients who have suffered physical trauma. Methods Data were collected at an emergency hospital in Porto Alegre, state of Rio Grande do Sul, southern Brazil. Participants were over 18 years of age, victims of physical trauma, and had been hospitalized for a minimum of 48 hours. A total of 117 hospitalized patients who agreed to participate in the research were grouped according to the shift in which blood was collected (38 subjects from the morning shift and 79 from the afternoon shift), had their BDNF levels measured and responded to other questionnaires. Respondents were further grouped by age into three ranges: 18-30, 31-50 and 51-70 years. Results We found a significant difference in the distribution of BDNF between the two shifts in which blood samples were collected, with the afternoon group having higher BDNF levels (U = 1906.5, p = 0.018). A difference was observed only between the 18-30 group and the 51-70 group in the afternoon shift (Umorning = 1107, pmorning = 0.575; Uafternoon = 7175, pafternoon = 0.028). Conclusions The population whose blood samples were collected in the afternoon showed significantly higher values of BDNF compared to those of the morning shift. This same population presented lower BDNF levels when associated with ASD subtypes A1, A2, and A. We hypothesize that the lower values of BDNF measured in the morning shift were due to a response to the circadian cycle of cortisol, whose action inhibits the expression of serum neurotrophins. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-60892019000300237 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-60892019000300237 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/2237-6089-2018-0060 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação de Psiquiatria do Rio Grande do Sul |
publisher.none.fl_str_mv |
Associação de Psiquiatria do Rio Grande do Sul |
dc.source.none.fl_str_mv |
Trends in Psychiatry and Psychotherapy v.41 n.3 2019 reponame:Trends in Psychiatry and Psychotherapy instname:Sociedade de Psiquiatria do Rio Grande do Sul instacron:APRGS |
instname_str |
Sociedade de Psiquiatria do Rio Grande do Sul |
instacron_str |
APRGS |
institution |
APRGS |
reponame_str |
Trends in Psychiatry and Psychotherapy |
collection |
Trends in Psychiatry and Psychotherapy |
repository.name.fl_str_mv |
Trends in Psychiatry and Psychotherapy - Sociedade de Psiquiatria do Rio Grande do Sul |
repository.mail.fl_str_mv |
revista@aprs.org.br|| rodrigo_grassi@terra.com.br |
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1754209281534590976 |