Bipolar disorder: an association between body mass index and cingulate gyrus fractional anisotropy not mediated by systemic inflammation
Main Author: | |
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Publication Date: | 2022 |
Other Authors: | , , , , , , , , , |
Format: | Article |
Language: | eng |
Source: | Trends in Psychiatry and Psychotherapy |
Download full: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-60892022000100416 |
Summary: | Abstract Objective To investigate associations between body mass index (BMI), white matter fractional anisotropy (FA), and C-reactive protein (CRP) in a group of individuals with bipolar disorder (BD) during euthymia and compare them with a control group of healthy subjects (CTR). Methods The sample consisted of 101 individuals (BD n = 35 and CTR n = 66). Regions of interest (ROI) were defined using a machine learning approach. For each ROI, a regression model tested the association between FA and BMI, controlling for covariates. Peripheral CRP levels were assayed, correlated with BMI, and included in a mediation analysis. Results BMI predicted the FA of the right cingulate gyrus in BD (AdjR2 = 0.312 F(3) = 5.537 p = 0.004; β = -0.340 p = 0.034), while there was no association in CTR. There was an interaction effect between BMI and BD diagnosis (F(5) = 3.5857 p = 0.012; Fchange = 0.227 AdjR2 = 0.093; β = -1.093, p = 0.048). Furthermore, there was a positive correlation between BMI and CRP in both groups (AdjR2 = 0.170 F(3) = 7.337 p < 0.001; β = 0.364 p = 0.001), but it did not act as a mediator of the effect on FA. Conclusion Higher BMI is associated with right cingulate microstructure in BD, but not in CTR, and this effect could not be explained by inflammatory mediation alone. |
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Trends in Psychiatry and Psychotherapy |
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Bipolar disorder: an association between body mass index and cingulate gyrus fractional anisotropy not mediated by systemic inflammationBipolar disorderobesitywhite matterdiffusion tensor imagingAbstract Objective To investigate associations between body mass index (BMI), white matter fractional anisotropy (FA), and C-reactive protein (CRP) in a group of individuals with bipolar disorder (BD) during euthymia and compare them with a control group of healthy subjects (CTR). Methods The sample consisted of 101 individuals (BD n = 35 and CTR n = 66). Regions of interest (ROI) were defined using a machine learning approach. For each ROI, a regression model tested the association between FA and BMI, controlling for covariates. Peripheral CRP levels were assayed, correlated with BMI, and included in a mediation analysis. Results BMI predicted the FA of the right cingulate gyrus in BD (AdjR2 = 0.312 F(3) = 5.537 p = 0.004; β = -0.340 p = 0.034), while there was no association in CTR. There was an interaction effect between BMI and BD diagnosis (F(5) = 3.5857 p = 0.012; Fchange = 0.227 AdjR2 = 0.093; β = -1.093, p = 0.048). Furthermore, there was a positive correlation between BMI and CRP in both groups (AdjR2 = 0.170 F(3) = 7.337 p < 0.001; β = 0.364 p = 0.001), but it did not act as a mediator of the effect on FA. Conclusion Higher BMI is associated with right cingulate microstructure in BD, but not in CTR, and this effect could not be explained by inflammatory mediation alone.Associação de Psiquiatria do Rio Grande do Sul2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-60892022000100416Trends in Psychiatry and Psychotherapy v.44 2022reponame:Trends in Psychiatry and Psychotherapyinstname:Sociedade de Psiquiatria do Rio Grande do Sulinstacron:APRGS10.47626/2237-6089-2020-0132info:eu-repo/semantics/openAccessReckziegel,RamiroRabelo-da-Ponte,Francisco DiegoFeiten,Jacson GabrielBosini Remus,IsadoraGoi,Pedro DominguesVianna-Sulzbach,Miréia FortesMassuda,RaffaelMacedo,Daniellede Lucena,DavidCzepielewski,Letícia SanguinettiGama,Clarissa Severinoeng2022-09-20T00:00:00Zoai:scielo:S2237-60892022000100416Revistahttp://www.scielo.br/scielo.php?script=sci_serial&pid=2237-6089&lng=en&nrm=isohttps://old.scielo.br/oai/scielo-oai.phprevista@aprs.org.br|| rodrigo_grassi@terra.com.br2238-00192237-6089opendoar:2022-09-20T00:00Trends in Psychiatry and Psychotherapy - Sociedade de Psiquiatria do Rio Grande do Sulfalse |
dc.title.none.fl_str_mv |
Bipolar disorder: an association between body mass index and cingulate gyrus fractional anisotropy not mediated by systemic inflammation |
title |
Bipolar disorder: an association between body mass index and cingulate gyrus fractional anisotropy not mediated by systemic inflammation |
spellingShingle |
Bipolar disorder: an association between body mass index and cingulate gyrus fractional anisotropy not mediated by systemic inflammation Reckziegel,Ramiro Bipolar disorder obesity white matter diffusion tensor imaging |
title_short |
Bipolar disorder: an association between body mass index and cingulate gyrus fractional anisotropy not mediated by systemic inflammation |
title_full |
Bipolar disorder: an association between body mass index and cingulate gyrus fractional anisotropy not mediated by systemic inflammation |
title_fullStr |
Bipolar disorder: an association between body mass index and cingulate gyrus fractional anisotropy not mediated by systemic inflammation |
title_full_unstemmed |
Bipolar disorder: an association between body mass index and cingulate gyrus fractional anisotropy not mediated by systemic inflammation |
title_sort |
Bipolar disorder: an association between body mass index and cingulate gyrus fractional anisotropy not mediated by systemic inflammation |
author |
Reckziegel,Ramiro |
author_facet |
Reckziegel,Ramiro Rabelo-da-Ponte,Francisco Diego Feiten,Jacson Gabriel Bosini Remus,Isadora Goi,Pedro Domingues Vianna-Sulzbach,Miréia Fortes Massuda,Raffael Macedo,Danielle de Lucena,David Czepielewski,Letícia Sanguinetti Gama,Clarissa Severino |
author_role |
author |
author2 |
Rabelo-da-Ponte,Francisco Diego Feiten,Jacson Gabriel Bosini Remus,Isadora Goi,Pedro Domingues Vianna-Sulzbach,Miréia Fortes Massuda,Raffael Macedo,Danielle de Lucena,David Czepielewski,Letícia Sanguinetti Gama,Clarissa Severino |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Reckziegel,Ramiro Rabelo-da-Ponte,Francisco Diego Feiten,Jacson Gabriel Bosini Remus,Isadora Goi,Pedro Domingues Vianna-Sulzbach,Miréia Fortes Massuda,Raffael Macedo,Danielle de Lucena,David Czepielewski,Letícia Sanguinetti Gama,Clarissa Severino |
dc.subject.por.fl_str_mv |
Bipolar disorder obesity white matter diffusion tensor imaging |
topic |
Bipolar disorder obesity white matter diffusion tensor imaging |
description |
Abstract Objective To investigate associations between body mass index (BMI), white matter fractional anisotropy (FA), and C-reactive protein (CRP) in a group of individuals with bipolar disorder (BD) during euthymia and compare them with a control group of healthy subjects (CTR). Methods The sample consisted of 101 individuals (BD n = 35 and CTR n = 66). Regions of interest (ROI) were defined using a machine learning approach. For each ROI, a regression model tested the association between FA and BMI, controlling for covariates. Peripheral CRP levels were assayed, correlated with BMI, and included in a mediation analysis. Results BMI predicted the FA of the right cingulate gyrus in BD (AdjR2 = 0.312 F(3) = 5.537 p = 0.004; β = -0.340 p = 0.034), while there was no association in CTR. There was an interaction effect between BMI and BD diagnosis (F(5) = 3.5857 p = 0.012; Fchange = 0.227 AdjR2 = 0.093; β = -1.093, p = 0.048). Furthermore, there was a positive correlation between BMI and CRP in both groups (AdjR2 = 0.170 F(3) = 7.337 p < 0.001; β = 0.364 p = 0.001), but it did not act as a mediator of the effect on FA. Conclusion Higher BMI is associated with right cingulate microstructure in BD, but not in CTR, and this effect could not be explained by inflammatory mediation alone. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-60892022000100416 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-60892022000100416 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.47626/2237-6089-2020-0132 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação de Psiquiatria do Rio Grande do Sul |
publisher.none.fl_str_mv |
Associação de Psiquiatria do Rio Grande do Sul |
dc.source.none.fl_str_mv |
Trends in Psychiatry and Psychotherapy v.44 2022 reponame:Trends in Psychiatry and Psychotherapy instname:Sociedade de Psiquiatria do Rio Grande do Sul instacron:APRGS |
instname_str |
Sociedade de Psiquiatria do Rio Grande do Sul |
instacron_str |
APRGS |
institution |
APRGS |
reponame_str |
Trends in Psychiatry and Psychotherapy |
collection |
Trends in Psychiatry and Psychotherapy |
repository.name.fl_str_mv |
Trends in Psychiatry and Psychotherapy - Sociedade de Psiquiatria do Rio Grande do Sul |
repository.mail.fl_str_mv |
revista@aprs.org.br|| rodrigo_grassi@terra.com.br |
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1754209282102919168 |