Virulence factors of human pathogens: an always-needed approach / Fatores de virulência de patógenos humanos: uma abordagem sempre necessária
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Health Review |
Texto Completo: | https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/44124 |
Resumo: | Hospital infections caused by resistant bacteria are a worldwide public health problem that mainly affects immunocompromised patients. These infections are mainly caused by inadequate antibiotic prescriptions, self-medication and long hospital stays. The World Health Organization mentions a list of resistant bacteria, especially Gram-negative ones considered as priorities for research, discovery and development of new drugs. These pathogens to survive and propagate use a varied set of strategies known as virulence factors. The present study corresponds to a review of the state-of-the-art related to main factors associated with pathogenicity in clinical important Gram-positive and Gram-negative bacteria. The virulence factors, alone or together, guarantee important defenses to the host organism's immune system, as well as adverse external conditions. Consequently, there is an increase in morbidity and mortality rates in hospital environments. Thus, effective microbial control measures are needed, especially in health institutions; also, the encouragement of new therapeutic approaches that target the main virulence factors. |
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Brazilian Journal of Health Review |
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Virulence factors of human pathogens: an always-needed approach / Fatores de virulência de patógenos humanos: uma abordagem sempre necessáriabacterial infectionspathogenicitypreventionpublic health .Hospital infections caused by resistant bacteria are a worldwide public health problem that mainly affects immunocompromised patients. These infections are mainly caused by inadequate antibiotic prescriptions, self-medication and long hospital stays. The World Health Organization mentions a list of resistant bacteria, especially Gram-negative ones considered as priorities for research, discovery and development of new drugs. These pathogens to survive and propagate use a varied set of strategies known as virulence factors. The present study corresponds to a review of the state-of-the-art related to main factors associated with pathogenicity in clinical important Gram-positive and Gram-negative bacteria. The virulence factors, alone or together, guarantee important defenses to the host organism's immune system, as well as adverse external conditions. Consequently, there is an increase in morbidity and mortality rates in hospital environments. Thus, effective microbial control measures are needed, especially in health institutions; also, the encouragement of new therapeutic approaches that target the main virulence factors.Brazilian Journals Publicações de Periódicos e Editora Ltda.2022-02-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/4412410.34119/bjhrv5n1-257Brazilian Journal of Health Review; Vol. 5 No. 1 (2022); 2900-2922Brazilian Journal of Health Review; v. 5 n. 1 (2022); 2900-29222595-6825reponame:Brazilian Journal of Health Reviewinstname:Federação das Indústrias do Estado do Paraná (FIEP)instacron:BJRHenghttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/44124/pdfCopyright (c) 2022 Brazilian Journal of Health Reviewinfo:eu-repo/semantics/openAccessSilva, Sivoneide Maria daSilva, Francisco Henrique Santana daSá, Rafael Artur de Queiroz Cavalcanti deBarbosa, Amanda VirgíniaLima, Ana Vitória AraújoPerez, Amanda Maria da ConceiçãoFilho, Admilson de Castro ChavesLima, Anderson Rodrigues Balbino deRamos, Bárbara de AzevedoPaiva, Patrícia Maria GuedesCorreia, Maria Tereza dos SantosOliveira, Maria Betânia Melo de2022-02-28T20:37:33Zoai:ojs2.ojs.brazilianjournals.com.br:article/44124Revistahttp://www.brazilianjournals.com/index.php/BJHR/indexPRIhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/oai|| brazilianjhr@gmail.com2595-68252595-6825opendoar:2022-02-28T20:37:33Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP)false |
dc.title.none.fl_str_mv |
Virulence factors of human pathogens: an always-needed approach / Fatores de virulência de patógenos humanos: uma abordagem sempre necessária |
title |
Virulence factors of human pathogens: an always-needed approach / Fatores de virulência de patógenos humanos: uma abordagem sempre necessária |
spellingShingle |
Virulence factors of human pathogens: an always-needed approach / Fatores de virulência de patógenos humanos: uma abordagem sempre necessária Silva, Sivoneide Maria da bacterial infections pathogenicity prevention public health . |
title_short |
Virulence factors of human pathogens: an always-needed approach / Fatores de virulência de patógenos humanos: uma abordagem sempre necessária |
title_full |
Virulence factors of human pathogens: an always-needed approach / Fatores de virulência de patógenos humanos: uma abordagem sempre necessária |
title_fullStr |
Virulence factors of human pathogens: an always-needed approach / Fatores de virulência de patógenos humanos: uma abordagem sempre necessária |
title_full_unstemmed |
Virulence factors of human pathogens: an always-needed approach / Fatores de virulência de patógenos humanos: uma abordagem sempre necessária |
title_sort |
Virulence factors of human pathogens: an always-needed approach / Fatores de virulência de patógenos humanos: uma abordagem sempre necessária |
author |
Silva, Sivoneide Maria da |
author_facet |
Silva, Sivoneide Maria da Silva, Francisco Henrique Santana da Sá, Rafael Artur de Queiroz Cavalcanti de Barbosa, Amanda Virgínia Lima, Ana Vitória Araújo Perez, Amanda Maria da Conceição Filho, Admilson de Castro Chaves Lima, Anderson Rodrigues Balbino de Ramos, Bárbara de Azevedo Paiva, Patrícia Maria Guedes Correia, Maria Tereza dos Santos Oliveira, Maria Betânia Melo de |
author_role |
author |
author2 |
Silva, Francisco Henrique Santana da Sá, Rafael Artur de Queiroz Cavalcanti de Barbosa, Amanda Virgínia Lima, Ana Vitória Araújo Perez, Amanda Maria da Conceição Filho, Admilson de Castro Chaves Lima, Anderson Rodrigues Balbino de Ramos, Bárbara de Azevedo Paiva, Patrícia Maria Guedes Correia, Maria Tereza dos Santos Oliveira, Maria Betânia Melo de |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Silva, Sivoneide Maria da Silva, Francisco Henrique Santana da Sá, Rafael Artur de Queiroz Cavalcanti de Barbosa, Amanda Virgínia Lima, Ana Vitória Araújo Perez, Amanda Maria da Conceição Filho, Admilson de Castro Chaves Lima, Anderson Rodrigues Balbino de Ramos, Bárbara de Azevedo Paiva, Patrícia Maria Guedes Correia, Maria Tereza dos Santos Oliveira, Maria Betânia Melo de |
dc.subject.por.fl_str_mv |
bacterial infections pathogenicity prevention public health . |
topic |
bacterial infections pathogenicity prevention public health . |
description |
Hospital infections caused by resistant bacteria are a worldwide public health problem that mainly affects immunocompromised patients. These infections are mainly caused by inadequate antibiotic prescriptions, self-medication and long hospital stays. The World Health Organization mentions a list of resistant bacteria, especially Gram-negative ones considered as priorities for research, discovery and development of new drugs. These pathogens to survive and propagate use a varied set of strategies known as virulence factors. The present study corresponds to a review of the state-of-the-art related to main factors associated with pathogenicity in clinical important Gram-positive and Gram-negative bacteria. The virulence factors, alone or together, guarantee important defenses to the host organism's immune system, as well as adverse external conditions. Consequently, there is an increase in morbidity and mortality rates in hospital environments. Thus, effective microbial control measures are needed, especially in health institutions; also, the encouragement of new therapeutic approaches that target the main virulence factors. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-02-15 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/44124 10.34119/bjhrv5n1-257 |
url |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/44124 |
identifier_str_mv |
10.34119/bjhrv5n1-257 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/44124/pdf |
dc.rights.driver.fl_str_mv |
Copyright (c) 2022 Brazilian Journal of Health Review info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2022 Brazilian Journal of Health Review |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
dc.source.none.fl_str_mv |
Brazilian Journal of Health Review; Vol. 5 No. 1 (2022); 2900-2922 Brazilian Journal of Health Review; v. 5 n. 1 (2022); 2900-2922 2595-6825 reponame:Brazilian Journal of Health Review instname:Federação das Indústrias do Estado do Paraná (FIEP) instacron:BJRH |
instname_str |
Federação das Indústrias do Estado do Paraná (FIEP) |
instacron_str |
BJRH |
institution |
BJRH |
reponame_str |
Brazilian Journal of Health Review |
collection |
Brazilian Journal of Health Review |
repository.name.fl_str_mv |
Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP) |
repository.mail.fl_str_mv |
|| brazilianjhr@gmail.com |
_version_ |
1797240072357019648 |