Preparation and evaluation of the pentavalent antimony-quercetin complex (SbV-QUE) / Preparação e avaliação do complexo antimonial pentavalente-quercetina (SbV-QUE)
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Health Review |
Texto Completo: | https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/2106 |
Resumo: | Leishmaniasis is a parasitic disease that has the first choice of treatment medications with antimony as active ingredient. These characteristics justify the search for new compounds with easy administration. In this context, there are quercetin, flavonoid leishmanicidal with chelation power, enabling complexation with metalloids, such as antimony. Thereby, this research aims to prepare and evaluate the complex antimony-quercetin (SbV) in solution and powder form. Precursor materials were quercetin anhydrous (methanolic solution) and potassium hexahydroxoantimonate (V) (aqueous solution), in 1: 1 ratio. After the formation of the complex SbV-QUE SOL (solution), it was dried by rotoevaporation, lyophilization or spray drying. For characterization of SbV-QUE SOL, spectrofluorimetry and UV-Vis spectrophotometry were utilized. In addition, for SbV-QUE powder, X-ray diffraction (XRD), energy dispersive X-Ray analysis (EDX), Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA) and fluorescence microscopy were made. In SbV-QUE SOL, an increase of fluorescence and the bathochromic shift in UV-Vis were observed, demonstrating the formation of the complex. In SbV-QUE powder, a difference of crystallinity between precursors and products was perceived, by XRD analysis. Analyzing DX results, a presence of antimony was observed in the samples. FT-IR indicated the binding site of the complex. Finally, the same thermal profile for the powdered complexes was observed, in addition to the micrographs elucidating the surface morphologies of quercetin and SbV-QUE powder. This confirms the characteristic of post-drying fluorescence. Therefore, the formation of the complex was evidenced, which is essential for further investigation of its use, aiming at leishmaniasis treatment. |
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Preparation and evaluation of the pentavalent antimony-quercetin complex (SbV-QUE) / Preparação e avaliação do complexo antimonial pentavalente-quercetina (SbV-QUE)leishmaniasisantimonialquercetinLeishmaniasis is a parasitic disease that has the first choice of treatment medications with antimony as active ingredient. These characteristics justify the search for new compounds with easy administration. In this context, there are quercetin, flavonoid leishmanicidal with chelation power, enabling complexation with metalloids, such as antimony. Thereby, this research aims to prepare and evaluate the complex antimony-quercetin (SbV) in solution and powder form. Precursor materials were quercetin anhydrous (methanolic solution) and potassium hexahydroxoantimonate (V) (aqueous solution), in 1: 1 ratio. After the formation of the complex SbV-QUE SOL (solution), it was dried by rotoevaporation, lyophilization or spray drying. For characterization of SbV-QUE SOL, spectrofluorimetry and UV-Vis spectrophotometry were utilized. In addition, for SbV-QUE powder, X-ray diffraction (XRD), energy dispersive X-Ray analysis (EDX), Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA) and fluorescence microscopy were made. In SbV-QUE SOL, an increase of fluorescence and the bathochromic shift in UV-Vis were observed, demonstrating the formation of the complex. In SbV-QUE powder, a difference of crystallinity between precursors and products was perceived, by XRD analysis. Analyzing DX results, a presence of antimony was observed in the samples. FT-IR indicated the binding site of the complex. Finally, the same thermal profile for the powdered complexes was observed, in addition to the micrographs elucidating the surface morphologies of quercetin and SbV-QUE powder. This confirms the characteristic of post-drying fluorescence. Therefore, the formation of the complex was evidenced, which is essential for further investigation of its use, aiming at leishmaniasis treatment.Brazilian Journals Publicações de Periódicos e Editora Ltda.2019-06-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/210610.34119/bjhrv2n4-074Brazilian Journal of Health Review; Vol. 2 No. 4 (2019); 3091-3103Brazilian Journal of Health Review; v. 2 n. 4 (2019); 3091-31032595-682510.34119/bjhrv2n4reponame:Brazilian Journal of Health Reviewinstname:Federação das Indústrias do Estado do Paraná (FIEP)instacron:BJRHenghttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/2106/2111Copyright (c) 2019 Brazilian Journal of Health Reviewinfo:eu-repo/semantics/openAccessSouza, Joyelanne Kaline ChagasBarbosa, Valcilaine TeixeiraSouza, Joyanne Cristine ChagasMenezes, Janaína Barros deGrillo, Luciano Aparecido MeirelesDornelas, Camila Braga2019-09-02T18:15:19Zoai:ojs2.ojs.brazilianjournals.com.br:article/2106Revistahttp://www.brazilianjournals.com/index.php/BJHR/indexPRIhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/oai|| brazilianjhr@gmail.com2595-68252595-6825opendoar:2019-09-02T18:15:19Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP)false |
dc.title.none.fl_str_mv |
Preparation and evaluation of the pentavalent antimony-quercetin complex (SbV-QUE) / Preparação e avaliação do complexo antimonial pentavalente-quercetina (SbV-QUE) |
title |
Preparation and evaluation of the pentavalent antimony-quercetin complex (SbV-QUE) / Preparação e avaliação do complexo antimonial pentavalente-quercetina (SbV-QUE) |
spellingShingle |
Preparation and evaluation of the pentavalent antimony-quercetin complex (SbV-QUE) / Preparação e avaliação do complexo antimonial pentavalente-quercetina (SbV-QUE) Souza, Joyelanne Kaline Chagas leishmaniasis antimonial quercetin |
title_short |
Preparation and evaluation of the pentavalent antimony-quercetin complex (SbV-QUE) / Preparação e avaliação do complexo antimonial pentavalente-quercetina (SbV-QUE) |
title_full |
Preparation and evaluation of the pentavalent antimony-quercetin complex (SbV-QUE) / Preparação e avaliação do complexo antimonial pentavalente-quercetina (SbV-QUE) |
title_fullStr |
Preparation and evaluation of the pentavalent antimony-quercetin complex (SbV-QUE) / Preparação e avaliação do complexo antimonial pentavalente-quercetina (SbV-QUE) |
title_full_unstemmed |
Preparation and evaluation of the pentavalent antimony-quercetin complex (SbV-QUE) / Preparação e avaliação do complexo antimonial pentavalente-quercetina (SbV-QUE) |
title_sort |
Preparation and evaluation of the pentavalent antimony-quercetin complex (SbV-QUE) / Preparação e avaliação do complexo antimonial pentavalente-quercetina (SbV-QUE) |
author |
Souza, Joyelanne Kaline Chagas |
author_facet |
Souza, Joyelanne Kaline Chagas Barbosa, Valcilaine Teixeira Souza, Joyanne Cristine Chagas Menezes, Janaína Barros de Grillo, Luciano Aparecido Meireles Dornelas, Camila Braga |
author_role |
author |
author2 |
Barbosa, Valcilaine Teixeira Souza, Joyanne Cristine Chagas Menezes, Janaína Barros de Grillo, Luciano Aparecido Meireles Dornelas, Camila Braga |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Souza, Joyelanne Kaline Chagas Barbosa, Valcilaine Teixeira Souza, Joyanne Cristine Chagas Menezes, Janaína Barros de Grillo, Luciano Aparecido Meireles Dornelas, Camila Braga |
dc.subject.por.fl_str_mv |
leishmaniasis antimonial quercetin |
topic |
leishmaniasis antimonial quercetin |
description |
Leishmaniasis is a parasitic disease that has the first choice of treatment medications with antimony as active ingredient. These characteristics justify the search for new compounds with easy administration. In this context, there are quercetin, flavonoid leishmanicidal with chelation power, enabling complexation with metalloids, such as antimony. Thereby, this research aims to prepare and evaluate the complex antimony-quercetin (SbV) in solution and powder form. Precursor materials were quercetin anhydrous (methanolic solution) and potassium hexahydroxoantimonate (V) (aqueous solution), in 1: 1 ratio. After the formation of the complex SbV-QUE SOL (solution), it was dried by rotoevaporation, lyophilization or spray drying. For characterization of SbV-QUE SOL, spectrofluorimetry and UV-Vis spectrophotometry were utilized. In addition, for SbV-QUE powder, X-ray diffraction (XRD), energy dispersive X-Ray analysis (EDX), Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA) and fluorescence microscopy were made. In SbV-QUE SOL, an increase of fluorescence and the bathochromic shift in UV-Vis were observed, demonstrating the formation of the complex. In SbV-QUE powder, a difference of crystallinity between precursors and products was perceived, by XRD analysis. Analyzing DX results, a presence of antimony was observed in the samples. FT-IR indicated the binding site of the complex. Finally, the same thermal profile for the powdered complexes was observed, in addition to the micrographs elucidating the surface morphologies of quercetin and SbV-QUE powder. This confirms the characteristic of post-drying fluorescence. Therefore, the formation of the complex was evidenced, which is essential for further investigation of its use, aiming at leishmaniasis treatment. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-06-04 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/2106 10.34119/bjhrv2n4-074 |
url |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/2106 |
identifier_str_mv |
10.34119/bjhrv2n4-074 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/2106/2111 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2019 Brazilian Journal of Health Review info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2019 Brazilian Journal of Health Review |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
dc.source.none.fl_str_mv |
Brazilian Journal of Health Review; Vol. 2 No. 4 (2019); 3091-3103 Brazilian Journal of Health Review; v. 2 n. 4 (2019); 3091-3103 2595-6825 10.34119/bjhrv2n4 reponame:Brazilian Journal of Health Review instname:Federação das Indústrias do Estado do Paraná (FIEP) instacron:BJRH |
instname_str |
Federação das Indústrias do Estado do Paraná (FIEP) |
instacron_str |
BJRH |
institution |
BJRH |
reponame_str |
Brazilian Journal of Health Review |
collection |
Brazilian Journal of Health Review |
repository.name.fl_str_mv |
Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP) |
repository.mail.fl_str_mv |
|| brazilianjhr@gmail.com |
_version_ |
1797240048059416576 |