A pediatric case of tubulointerstitial nephritis and uveitis syndrome
Main Author: | |
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Publication Date: | 2024 |
Other Authors: | , , , |
Format: | Article |
Language: | por |
Source: | Brazilian Journal of Health Review |
Download full: | https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/66511 |
Summary: | Tubulointerstitial Nephritis and Uveitis Syndrome (TINU Syndrome) is a rare entity of unknown origin. Most cases described affect adolescents and women. It often implies a renal biopsy and is established upon the presence of uveitis and tubulointerstitial nephritis in the same patient, after all possible causes are excluded. The authors report the case of a 12-year-old teenage boy with nausea, vomiting, and weight loss lasting two weeks, taken to his local hospital with acute kidney injury, oliguria, and high blood pressure. After transfer to a specialized centre and exclusion of infectious, toxic, and autoimmune causes, intravenous and oral corticosteroid therapy was started. Renal biopsy confirmed interstitial nephritis of undetermined aetiology and the patient was discharged after favourable restauration of renal function, with a course of 4 weeks of steroids and progressive decrements over 10 weeks. Four months after the onset of the condition, the teenager was taken to the hospital with eye redness and tenderness. Bilateral anterior uveitis was described, which established the diagnosis of TINU Syndrome. After two years of joint follow-up by Paediatric Nephrology and Ophthalmology, the patient remains stable, without relapses, or ocular or renal sequelae. |
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A pediatric case of tubulointerstitial nephritis and uveitis syndromeTINU syndromenephritisuveitispaediatricsTubulointerstitial Nephritis and Uveitis Syndrome (TINU Syndrome) is a rare entity of unknown origin. Most cases described affect adolescents and women. It often implies a renal biopsy and is established upon the presence of uveitis and tubulointerstitial nephritis in the same patient, after all possible causes are excluded. The authors report the case of a 12-year-old teenage boy with nausea, vomiting, and weight loss lasting two weeks, taken to his local hospital with acute kidney injury, oliguria, and high blood pressure. After transfer to a specialized centre and exclusion of infectious, toxic, and autoimmune causes, intravenous and oral corticosteroid therapy was started. Renal biopsy confirmed interstitial nephritis of undetermined aetiology and the patient was discharged after favourable restauration of renal function, with a course of 4 weeks of steroids and progressive decrements over 10 weeks. Four months after the onset of the condition, the teenager was taken to the hospital with eye redness and tenderness. Bilateral anterior uveitis was described, which established the diagnosis of TINU Syndrome. After two years of joint follow-up by Paediatric Nephrology and Ophthalmology, the patient remains stable, without relapses, or ocular or renal sequelae.Brazilian Journals Publicações de Periódicos e Editora Ltda.2024-01-23info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/6651110.34119/bjhrv7n1-149Brazilian Journal of Health Review; Vol. 7 No. 1 (2024); 1923-1930Brazilian Journal of Health Review; Vol. 7 Núm. 1 (2024); 1923-1930Brazilian Journal of Health Review; v. 7 n. 1 (2024); 1923-19302595-6825reponame:Brazilian Journal of Health Reviewinstname:Federação das Indústrias do Estado do Paraná (FIEP)instacron:BJRHporhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/66511/47439Santos, Mariana FlóridoMachado, Marta Sofia da Cunha AlvesCordinhã, Ana Carolina GonçalvesFerreira, Carmen do Carmo CarapauFerreira, Clara Maria da Silva Gomesinfo:eu-repo/semantics/openAccess2024-01-23T13:09:56Zoai:ojs2.ojs.brazilianjournals.com.br:article/66511Revistahttp://www.brazilianjournals.com/index.php/BJHR/indexPRIhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/oai|| brazilianjhr@gmail.com2595-68252595-6825opendoar:2024-01-23T13:09:56Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP)false |
dc.title.none.fl_str_mv |
A pediatric case of tubulointerstitial nephritis and uveitis syndrome |
title |
A pediatric case of tubulointerstitial nephritis and uveitis syndrome |
spellingShingle |
A pediatric case of tubulointerstitial nephritis and uveitis syndrome Santos, Mariana Flórido TINU syndrome nephritis uveitis paediatrics |
title_short |
A pediatric case of tubulointerstitial nephritis and uveitis syndrome |
title_full |
A pediatric case of tubulointerstitial nephritis and uveitis syndrome |
title_fullStr |
A pediatric case of tubulointerstitial nephritis and uveitis syndrome |
title_full_unstemmed |
A pediatric case of tubulointerstitial nephritis and uveitis syndrome |
title_sort |
A pediatric case of tubulointerstitial nephritis and uveitis syndrome |
author |
Santos, Mariana Flórido |
author_facet |
Santos, Mariana Flórido Machado, Marta Sofia da Cunha Alves Cordinhã, Ana Carolina Gonçalves Ferreira, Carmen do Carmo Carapau Ferreira, Clara Maria da Silva Gomes |
author_role |
author |
author2 |
Machado, Marta Sofia da Cunha Alves Cordinhã, Ana Carolina Gonçalves Ferreira, Carmen do Carmo Carapau Ferreira, Clara Maria da Silva Gomes |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Santos, Mariana Flórido Machado, Marta Sofia da Cunha Alves Cordinhã, Ana Carolina Gonçalves Ferreira, Carmen do Carmo Carapau Ferreira, Clara Maria da Silva Gomes |
dc.subject.por.fl_str_mv |
TINU syndrome nephritis uveitis paediatrics |
topic |
TINU syndrome nephritis uveitis paediatrics |
description |
Tubulointerstitial Nephritis and Uveitis Syndrome (TINU Syndrome) is a rare entity of unknown origin. Most cases described affect adolescents and women. It often implies a renal biopsy and is established upon the presence of uveitis and tubulointerstitial nephritis in the same patient, after all possible causes are excluded. The authors report the case of a 12-year-old teenage boy with nausea, vomiting, and weight loss lasting two weeks, taken to his local hospital with acute kidney injury, oliguria, and high blood pressure. After transfer to a specialized centre and exclusion of infectious, toxic, and autoimmune causes, intravenous and oral corticosteroid therapy was started. Renal biopsy confirmed interstitial nephritis of undetermined aetiology and the patient was discharged after favourable restauration of renal function, with a course of 4 weeks of steroids and progressive decrements over 10 weeks. Four months after the onset of the condition, the teenager was taken to the hospital with eye redness and tenderness. Bilateral anterior uveitis was described, which established the diagnosis of TINU Syndrome. After two years of joint follow-up by Paediatric Nephrology and Ophthalmology, the patient remains stable, without relapses, or ocular or renal sequelae. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-01-23 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/66511 10.34119/bjhrv7n1-149 |
url |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/66511 |
identifier_str_mv |
10.34119/bjhrv7n1-149 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/66511/47439 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
dc.source.none.fl_str_mv |
Brazilian Journal of Health Review; Vol. 7 No. 1 (2024); 1923-1930 Brazilian Journal of Health Review; Vol. 7 Núm. 1 (2024); 1923-1930 Brazilian Journal of Health Review; v. 7 n. 1 (2024); 1923-1930 2595-6825 reponame:Brazilian Journal of Health Review instname:Federação das Indústrias do Estado do Paraná (FIEP) instacron:BJRH |
instname_str |
Federação das Indústrias do Estado do Paraná (FIEP) |
instacron_str |
BJRH |
institution |
BJRH |
reponame_str |
Brazilian Journal of Health Review |
collection |
Brazilian Journal of Health Review |
repository.name.fl_str_mv |
Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP) |
repository.mail.fl_str_mv |
|| brazilianjhr@gmail.com |
_version_ |
1797240041026617344 |