Maternofetal exposure to glicocorticoids and attention deficit hyperactivity disorder
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Brazilian Journal of Health Review |
Texto Completo: | https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/60349 |
Resumo: | Pregnancy is a critical development period, in a way that small alterations can be crucial in shaping an individual's health for the rest of his life. Depending on wich adversive conditions the fetus is exposed to, like metabolic, hormonal and nutricional alterations by the mother, there is a higher susceptibility in developing certain diseases, syndromes and disturbs. Among the aforementioned adversities, we can mention the excessive use of synthetic glucocorticoids during pregnancy. It is known that glucocorticoids act at various levels within the fetal brain, physiologically modulating the individual's neurological function, and, by that, exposing him to cognitive decline and behavioral changes. This review aimed to explore some evidence of the impact of excessive glucocorticoid signaling on HPA axis modulation and consequent fetal adaptive changes, related to the vulnerability of the development of Attention Deficit Hyperactivity Disorder (ADHD). In view of the growing number of diagnoses of this disease, it is necessary to review medical recommendations, the use of these drugs by pregnant women and infants, and public health policies. |
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Brazilian Journal of Health Review |
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Maternofetal exposure to glicocorticoids and attention deficit hyperactivity disordergestationHPA axisfetal programmingPregnancy is a critical development period, in a way that small alterations can be crucial in shaping an individual's health for the rest of his life. Depending on wich adversive conditions the fetus is exposed to, like metabolic, hormonal and nutricional alterations by the mother, there is a higher susceptibility in developing certain diseases, syndromes and disturbs. Among the aforementioned adversities, we can mention the excessive use of synthetic glucocorticoids during pregnancy. It is known that glucocorticoids act at various levels within the fetal brain, physiologically modulating the individual's neurological function, and, by that, exposing him to cognitive decline and behavioral changes. This review aimed to explore some evidence of the impact of excessive glucocorticoid signaling on HPA axis modulation and consequent fetal adaptive changes, related to the vulnerability of the development of Attention Deficit Hyperactivity Disorder (ADHD). In view of the growing number of diagnoses of this disease, it is necessary to review medical recommendations, the use of these drugs by pregnant women and infants, and public health policies.Brazilian Journals Publicações de Periódicos e Editora Ltda.2023-06-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/6034910.34119/bjhrv6n3-235Brazilian Journal of Health Review; Vol. 6 No. 3 (2023); 11358-11378Brazilian Journal of Health Review; Vol. 6 Núm. 3 (2023); 11358-11378Brazilian Journal of Health Review; v. 6 n. 3 (2023); 11358-113782595-6825reponame:Brazilian Journal of Health Reviewinstname:Federação das Indústrias do Estado do Paraná (FIEP)instacron:BJRHporhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/60349/43612Vecchia , André Henrique Ascêncio DallaSobh, Karyme SaruatVargas, Rodrigoinfo:eu-repo/semantics/openAccess2023-06-21T14:57:33Zoai:ojs2.ojs.brazilianjournals.com.br:article/60349Revistahttp://www.brazilianjournals.com/index.php/BJHR/indexPRIhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/oai|| brazilianjhr@gmail.com2595-68252595-6825opendoar:2023-06-21T14:57:33Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP)false |
dc.title.none.fl_str_mv |
Maternofetal exposure to glicocorticoids and attention deficit hyperactivity disorder |
title |
Maternofetal exposure to glicocorticoids and attention deficit hyperactivity disorder |
spellingShingle |
Maternofetal exposure to glicocorticoids and attention deficit hyperactivity disorder Vecchia , André Henrique Ascêncio Dalla gestation HPA axis fetal programming |
title_short |
Maternofetal exposure to glicocorticoids and attention deficit hyperactivity disorder |
title_full |
Maternofetal exposure to glicocorticoids and attention deficit hyperactivity disorder |
title_fullStr |
Maternofetal exposure to glicocorticoids and attention deficit hyperactivity disorder |
title_full_unstemmed |
Maternofetal exposure to glicocorticoids and attention deficit hyperactivity disorder |
title_sort |
Maternofetal exposure to glicocorticoids and attention deficit hyperactivity disorder |
author |
Vecchia , André Henrique Ascêncio Dalla |
author_facet |
Vecchia , André Henrique Ascêncio Dalla Sobh, Karyme Saruat Vargas, Rodrigo |
author_role |
author |
author2 |
Sobh, Karyme Saruat Vargas, Rodrigo |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Vecchia , André Henrique Ascêncio Dalla Sobh, Karyme Saruat Vargas, Rodrigo |
dc.subject.por.fl_str_mv |
gestation HPA axis fetal programming |
topic |
gestation HPA axis fetal programming |
description |
Pregnancy is a critical development period, in a way that small alterations can be crucial in shaping an individual's health for the rest of his life. Depending on wich adversive conditions the fetus is exposed to, like metabolic, hormonal and nutricional alterations by the mother, there is a higher susceptibility in developing certain diseases, syndromes and disturbs. Among the aforementioned adversities, we can mention the excessive use of synthetic glucocorticoids during pregnancy. It is known that glucocorticoids act at various levels within the fetal brain, physiologically modulating the individual's neurological function, and, by that, exposing him to cognitive decline and behavioral changes. This review aimed to explore some evidence of the impact of excessive glucocorticoid signaling on HPA axis modulation and consequent fetal adaptive changes, related to the vulnerability of the development of Attention Deficit Hyperactivity Disorder (ADHD). In view of the growing number of diagnoses of this disease, it is necessary to review medical recommendations, the use of these drugs by pregnant women and infants, and public health policies. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-06-02 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/60349 10.34119/bjhrv6n3-235 |
url |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/60349 |
identifier_str_mv |
10.34119/bjhrv6n3-235 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/60349/43612 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
dc.source.none.fl_str_mv |
Brazilian Journal of Health Review; Vol. 6 No. 3 (2023); 11358-11378 Brazilian Journal of Health Review; Vol. 6 Núm. 3 (2023); 11358-11378 Brazilian Journal of Health Review; v. 6 n. 3 (2023); 11358-11378 2595-6825 reponame:Brazilian Journal of Health Review instname:Federação das Indústrias do Estado do Paraná (FIEP) instacron:BJRH |
instname_str |
Federação das Indústrias do Estado do Paraná (FIEP) |
instacron_str |
BJRH |
institution |
BJRH |
reponame_str |
Brazilian Journal of Health Review |
collection |
Brazilian Journal of Health Review |
repository.name.fl_str_mv |
Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP) |
repository.mail.fl_str_mv |
|| brazilianjhr@gmail.com |
_version_ |
1797240030597480448 |