Impaired bone mineral accrual in prepubertal HIV-infected children: a cohort study

Detalhes bibliográficos
Autor(a) principal: Palchetti,Cecília Zanin
Data de Publicação: 2015
Outros Autores: Szejnfeld,Vera Lúcia, Succi,Regina Célia de Menezes, Patin,Rose Vega, Teixeira,Patrícia Fonseca, Machado,Daisy Maria, Oliveira,Fernanda Luisa Ceragioli
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Infectious Diseases
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000600623
Resumo: ABSTRACT OBJECTIVE: To evaluate bone mass accrual and determine the influence of clinical, anthropometric, dietary and biochemical parameters on bone mass. METHODS: A cohort study including 35 prepubertal HIV-infected children, between 7 and 12 years, attended at a referral center. At time 1 (T1) and time 2 (T2), patients were assessed according to clinical, anthropometric, dietary, biochemical parameters and bone mineral density (BMD). At T2, patients were divided into prepubertal and pubertal. RESULTS: Despite the increase in bone mass absolute values, there was no improvement in lumbar spine BMD (LSBMD) Z-score (p = 0.512) and worsening in total body BMD (TBMD) Z-score (p = 0.040). Pubertal patients (n = 19) showed higher bone mineral content (BMC) (p = 0.001), TBMD (p = 0.006) and LSBMD (p = 0.002) compared to prepubertal patients. After multivariate linear regression analysis, the predictors of bone mass in T1 were age, BMI and HAZ-scores for BMC; BMI Z-score, adequate serum magnesium concentration and dietary calcium intake for TBMD; adequate serum concentration of magnesium, BMI and HAZ-scores for LSBMD. In T2, age, total body fat and lean body mass (kg) for BMC; BMI Z-score and puberty for TBMD; dietary fat intake, BMI Z-score for BMD and puberty for LSBMD. CONCLUSION: HIV-infected children have compromised bone mass and the presence of puberty seems to provide suitability of these parameters. Adequate intake of calcium and fat appears to be protective for proper bone mass accumulation factor, as well as monitoring nutritional status and serum magnesium concentration.
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spelling Impaired bone mineral accrual in prepubertal HIV-infected children: a cohort studyHIVChildBody compositionBone mineral densityABSTRACT OBJECTIVE: To evaluate bone mass accrual and determine the influence of clinical, anthropometric, dietary and biochemical parameters on bone mass. METHODS: A cohort study including 35 prepubertal HIV-infected children, between 7 and 12 years, attended at a referral center. At time 1 (T1) and time 2 (T2), patients were assessed according to clinical, anthropometric, dietary, biochemical parameters and bone mineral density (BMD). At T2, patients were divided into prepubertal and pubertal. RESULTS: Despite the increase in bone mass absolute values, there was no improvement in lumbar spine BMD (LSBMD) Z-score (p = 0.512) and worsening in total body BMD (TBMD) Z-score (p = 0.040). Pubertal patients (n = 19) showed higher bone mineral content (BMC) (p = 0.001), TBMD (p = 0.006) and LSBMD (p = 0.002) compared to prepubertal patients. After multivariate linear regression analysis, the predictors of bone mass in T1 were age, BMI and HAZ-scores for BMC; BMI Z-score, adequate serum magnesium concentration and dietary calcium intake for TBMD; adequate serum concentration of magnesium, BMI and HAZ-scores for LSBMD. In T2, age, total body fat and lean body mass (kg) for BMC; BMI Z-score and puberty for TBMD; dietary fat intake, BMI Z-score for BMD and puberty for LSBMD. CONCLUSION: HIV-infected children have compromised bone mass and the presence of puberty seems to provide suitability of these parameters. Adequate intake of calcium and fat appears to be protective for proper bone mass accumulation factor, as well as monitoring nutritional status and serum magnesium concentration.Brazilian Society of Infectious Diseases2015-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000600623Brazilian Journal of Infectious Diseases v.19 n.6 2015reponame:Brazilian Journal of Infectious Diseasesinstname:Brazilian Society of Infectious Diseases (BSID)instacron:BSID10.1016/j.bjid.2015.08.010info:eu-repo/semantics/openAccessPalchetti,Cecília ZaninSzejnfeld,Vera LúciaSucci,Regina Célia de MenezesPatin,Rose VegaTeixeira,Patrícia FonsecaMachado,Daisy MariaOliveira,Fernanda Luisa Ceragiolieng2016-01-12T00:00:00Zoai:scielo:S1413-86702015000600623Revistahttps://www.bjid.org.br/https://old.scielo.br/oai/scielo-oai.phpbjid@bjid.org.br||lgoldani@ufrgs.br1678-43911413-8670opendoar:2016-01-12T00:00Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)false
dc.title.none.fl_str_mv Impaired bone mineral accrual in prepubertal HIV-infected children: a cohort study
title Impaired bone mineral accrual in prepubertal HIV-infected children: a cohort study
spellingShingle Impaired bone mineral accrual in prepubertal HIV-infected children: a cohort study
Palchetti,Cecília Zanin
HIV
Child
Body composition
Bone mineral density
title_short Impaired bone mineral accrual in prepubertal HIV-infected children: a cohort study
title_full Impaired bone mineral accrual in prepubertal HIV-infected children: a cohort study
title_fullStr Impaired bone mineral accrual in prepubertal HIV-infected children: a cohort study
title_full_unstemmed Impaired bone mineral accrual in prepubertal HIV-infected children: a cohort study
title_sort Impaired bone mineral accrual in prepubertal HIV-infected children: a cohort study
author Palchetti,Cecília Zanin
author_facet Palchetti,Cecília Zanin
Szejnfeld,Vera Lúcia
Succi,Regina Célia de Menezes
Patin,Rose Vega
Teixeira,Patrícia Fonseca
Machado,Daisy Maria
Oliveira,Fernanda Luisa Ceragioli
author_role author
author2 Szejnfeld,Vera Lúcia
Succi,Regina Célia de Menezes
Patin,Rose Vega
Teixeira,Patrícia Fonseca
Machado,Daisy Maria
Oliveira,Fernanda Luisa Ceragioli
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Palchetti,Cecília Zanin
Szejnfeld,Vera Lúcia
Succi,Regina Célia de Menezes
Patin,Rose Vega
Teixeira,Patrícia Fonseca
Machado,Daisy Maria
Oliveira,Fernanda Luisa Ceragioli
dc.subject.por.fl_str_mv HIV
Child
Body composition
Bone mineral density
topic HIV
Child
Body composition
Bone mineral density
description ABSTRACT OBJECTIVE: To evaluate bone mass accrual and determine the influence of clinical, anthropometric, dietary and biochemical parameters on bone mass. METHODS: A cohort study including 35 prepubertal HIV-infected children, between 7 and 12 years, attended at a referral center. At time 1 (T1) and time 2 (T2), patients were assessed according to clinical, anthropometric, dietary, biochemical parameters and bone mineral density (BMD). At T2, patients were divided into prepubertal and pubertal. RESULTS: Despite the increase in bone mass absolute values, there was no improvement in lumbar spine BMD (LSBMD) Z-score (p = 0.512) and worsening in total body BMD (TBMD) Z-score (p = 0.040). Pubertal patients (n = 19) showed higher bone mineral content (BMC) (p = 0.001), TBMD (p = 0.006) and LSBMD (p = 0.002) compared to prepubertal patients. After multivariate linear regression analysis, the predictors of bone mass in T1 were age, BMI and HAZ-scores for BMC; BMI Z-score, adequate serum magnesium concentration and dietary calcium intake for TBMD; adequate serum concentration of magnesium, BMI and HAZ-scores for LSBMD. In T2, age, total body fat and lean body mass (kg) for BMC; BMI Z-score and puberty for TBMD; dietary fat intake, BMI Z-score for BMD and puberty for LSBMD. CONCLUSION: HIV-infected children have compromised bone mass and the presence of puberty seems to provide suitability of these parameters. Adequate intake of calcium and fat appears to be protective for proper bone mass accumulation factor, as well as monitoring nutritional status and serum magnesium concentration.
publishDate 2015
dc.date.none.fl_str_mv 2015-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000600623
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000600623
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.bjid.2015.08.010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
dc.source.none.fl_str_mv Brazilian Journal of Infectious Diseases v.19 n.6 2015
reponame:Brazilian Journal of Infectious Diseases
instname:Brazilian Society of Infectious Diseases (BSID)
instacron:BSID
instname_str Brazilian Society of Infectious Diseases (BSID)
instacron_str BSID
institution BSID
reponame_str Brazilian Journal of Infectious Diseases
collection Brazilian Journal of Infectious Diseases
repository.name.fl_str_mv Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)
repository.mail.fl_str_mv bjid@bjid.org.br||lgoldani@ufrgs.br
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