The incidence of cytomegalovirus infection in lung transplant recipients under universal prophylaxis with intravenous ganciclovir
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Infectious Diseases |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200008 |
Resumo: | The best strategy for control of cytomegalovirus (CMV) infection in lung transplant patients is still not determined. The aim of this study was to document the incidence of CMV infection in a cohort of lung transplant recipients under universal prophylaxis with intravenous ganciclovir. All patients received immunosuppressive regimens consisting of cyclosporine, azathioprine, and prednisone. Regardless of CMV serostatus, intravenous ganciclovir was prescribed for every patient in the first 3 months post-transplantation. CMV infection was defined as the detection of CMV pp65 in leukocytes. Eighty-two lung transplant patients were included over a 5-year period. The incidence of CMV infection in the first year post-transplantation was 68.3%, occurring after a median length of 114 days (range, 26-343 days). This study revealed a high incidence of CMV infection in the first year following lung transplantation despite prolonged universal ganciclovir prophylaxis. |
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Brazilian Journal of Infectious Diseases |
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The incidence of cytomegalovirus infection in lung transplant recipients under universal prophylaxis with intravenous ganciclovirCytomegalovirusantigenemialung transplantationganciclovirprophylaxisThe best strategy for control of cytomegalovirus (CMV) infection in lung transplant patients is still not determined. The aim of this study was to document the incidence of CMV infection in a cohort of lung transplant recipients under universal prophylaxis with intravenous ganciclovir. All patients received immunosuppressive regimens consisting of cyclosporine, azathioprine, and prednisone. Regardless of CMV serostatus, intravenous ganciclovir was prescribed for every patient in the first 3 months post-transplantation. CMV infection was defined as the detection of CMV pp65 in leukocytes. Eighty-two lung transplant patients were included over a 5-year period. The incidence of CMV infection in the first year post-transplantation was 68.3%, occurring after a median length of 114 days (range, 26-343 days). This study revealed a high incidence of CMV infection in the first year following lung transplantation despite prolonged universal ganciclovir prophylaxis.Brazilian Society of Infectious Diseases2007-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200008Brazilian Journal of Infectious Diseases v.11 n.2 2007reponame:Brazilian Journal of Infectious Diseasesinstname:Brazilian Society of Infectious Diseases (BSID)instacron:BSID10.1590/S1413-86702007000200008info:eu-repo/semantics/openAccessSchröeder,ReginaMichelon,TatianaWurdig,JoãoFagundes,IaraSchio,SadiSanchez,LeticiaCamargo,José J.Sukkienik,Teresa C.Pasqualotto,Alessandro C.Neumann,Jorgeeng2007-06-27T00:00:00Zoai:scielo:S1413-86702007000200008Revistahttps://www.bjid.org.br/https://old.scielo.br/oai/scielo-oai.phpbjid@bjid.org.br||lgoldani@ufrgs.br1678-43911413-8670opendoar:2007-06-27T00:00Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)false |
dc.title.none.fl_str_mv |
The incidence of cytomegalovirus infection in lung transplant recipients under universal prophylaxis with intravenous ganciclovir |
title |
The incidence of cytomegalovirus infection in lung transplant recipients under universal prophylaxis with intravenous ganciclovir |
spellingShingle |
The incidence of cytomegalovirus infection in lung transplant recipients under universal prophylaxis with intravenous ganciclovir Schröeder,Regina Cytomegalovirus antigenemia lung transplantation ganciclovir prophylaxis |
title_short |
The incidence of cytomegalovirus infection in lung transplant recipients under universal prophylaxis with intravenous ganciclovir |
title_full |
The incidence of cytomegalovirus infection in lung transplant recipients under universal prophylaxis with intravenous ganciclovir |
title_fullStr |
The incidence of cytomegalovirus infection in lung transplant recipients under universal prophylaxis with intravenous ganciclovir |
title_full_unstemmed |
The incidence of cytomegalovirus infection in lung transplant recipients under universal prophylaxis with intravenous ganciclovir |
title_sort |
The incidence of cytomegalovirus infection in lung transplant recipients under universal prophylaxis with intravenous ganciclovir |
author |
Schröeder,Regina |
author_facet |
Schröeder,Regina Michelon,Tatiana Wurdig,João Fagundes,Iara Schio,Sadi Sanchez,Leticia Camargo,José J. Sukkienik,Teresa C. Pasqualotto,Alessandro C. Neumann,Jorge |
author_role |
author |
author2 |
Michelon,Tatiana Wurdig,João Fagundes,Iara Schio,Sadi Sanchez,Leticia Camargo,José J. Sukkienik,Teresa C. Pasqualotto,Alessandro C. Neumann,Jorge |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Schröeder,Regina Michelon,Tatiana Wurdig,João Fagundes,Iara Schio,Sadi Sanchez,Leticia Camargo,José J. Sukkienik,Teresa C. Pasqualotto,Alessandro C. Neumann,Jorge |
dc.subject.por.fl_str_mv |
Cytomegalovirus antigenemia lung transplantation ganciclovir prophylaxis |
topic |
Cytomegalovirus antigenemia lung transplantation ganciclovir prophylaxis |
description |
The best strategy for control of cytomegalovirus (CMV) infection in lung transplant patients is still not determined. The aim of this study was to document the incidence of CMV infection in a cohort of lung transplant recipients under universal prophylaxis with intravenous ganciclovir. All patients received immunosuppressive regimens consisting of cyclosporine, azathioprine, and prednisone. Regardless of CMV serostatus, intravenous ganciclovir was prescribed for every patient in the first 3 months post-transplantation. CMV infection was defined as the detection of CMV pp65 in leukocytes. Eighty-two lung transplant patients were included over a 5-year period. The incidence of CMV infection in the first year post-transplantation was 68.3%, occurring after a median length of 114 days (range, 26-343 days). This study revealed a high incidence of CMV infection in the first year following lung transplantation despite prolonged universal ganciclovir prophylaxis. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200008 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200008 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1413-86702007000200008 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
dc.source.none.fl_str_mv |
Brazilian Journal of Infectious Diseases v.11 n.2 2007 reponame:Brazilian Journal of Infectious Diseases instname:Brazilian Society of Infectious Diseases (BSID) instacron:BSID |
instname_str |
Brazilian Society of Infectious Diseases (BSID) |
instacron_str |
BSID |
institution |
BSID |
reponame_str |
Brazilian Journal of Infectious Diseases |
collection |
Brazilian Journal of Infectious Diseases |
repository.name.fl_str_mv |
Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID) |
repository.mail.fl_str_mv |
bjid@bjid.org.br||lgoldani@ufrgs.br |
_version_ |
1754209239815946240 |