Urine as a promising sample for Leishmania DNA extraction in the diagnosis of visceral leishmaniasis - a review
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Infectious Diseases |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000200111 |
Resumo: | ABSTRACT Visceral leishmaniasis is a serious and debilitating infection with high fatality rate in tropical and subtropical countries. As clinical symptoms of visceral leishmaniasis are not so specific, confirmatory diagnostic methods with high sensitivity and specificity are needed. Noninvasive methods have been developed using urine as a clinical sample for visceral leishmaniasis diagnosis. In fact, there is a clear correlation between kidney impairment and Leishmania DNA in urine. However, it has been proved that Leishmania nucleic acid may also be isolated from patients without any sign of renal involvement. Even though urine has become a promissing biological sample, it is still not widely used due to several issues, such as (i) incomprehension of the whole renal pathophysiology process in visceral leishmaniasis, (ii) presence of many amplification inhibitors in urine, and (iii) lack of an efficient urinary DNA extraction method. In this article, we performed a literature review to bring a new perspective for Leishmania DNA isolation in urine. |
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Brazilian Journal of Infectious Diseases |
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spelling |
Urine as a promising sample for Leishmania DNA extraction in the diagnosis of visceral leishmaniasis - a reviewVisceral leishmaniasisRenal involvementDiagnosisUrine sampleDNA extractionABSTRACT Visceral leishmaniasis is a serious and debilitating infection with high fatality rate in tropical and subtropical countries. As clinical symptoms of visceral leishmaniasis are not so specific, confirmatory diagnostic methods with high sensitivity and specificity are needed. Noninvasive methods have been developed using urine as a clinical sample for visceral leishmaniasis diagnosis. In fact, there is a clear correlation between kidney impairment and Leishmania DNA in urine. However, it has been proved that Leishmania nucleic acid may also be isolated from patients without any sign of renal involvement. Even though urine has become a promissing biological sample, it is still not widely used due to several issues, such as (i) incomprehension of the whole renal pathophysiology process in visceral leishmaniasis, (ii) presence of many amplification inhibitors in urine, and (iii) lack of an efficient urinary DNA extraction method. In this article, we performed a literature review to bring a new perspective for Leishmania DNA isolation in urine.Brazilian Society of Infectious Diseases2019-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000200111Brazilian Journal of Infectious Diseases v.23 n.2 2019reponame:Brazilian Journal of Infectious Diseasesinstname:Brazilian Society of Infectious Diseases (BSID)instacron:BSID10.1016/j.bjid.2019.04.001info:eu-repo/semantics/openAccessBezerra,Gilberto Silva NunesBarbosa Júnior,Walter LinsSilva,Elis Dionísio daLeal,Nilma CintraMedeiros,Zulma Maria deeng2019-07-16T00:00:00Zoai:scielo:S1413-86702019000200111Revistahttps://www.bjid.org.br/https://old.scielo.br/oai/scielo-oai.phpbjid@bjid.org.br||lgoldani@ufrgs.br1678-43911413-8670opendoar:2019-07-16T00:00Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)false |
dc.title.none.fl_str_mv |
Urine as a promising sample for Leishmania DNA extraction in the diagnosis of visceral leishmaniasis - a review |
title |
Urine as a promising sample for Leishmania DNA extraction in the diagnosis of visceral leishmaniasis - a review |
spellingShingle |
Urine as a promising sample for Leishmania DNA extraction in the diagnosis of visceral leishmaniasis - a review Bezerra,Gilberto Silva Nunes Visceral leishmaniasis Renal involvement Diagnosis Urine sample DNA extraction |
title_short |
Urine as a promising sample for Leishmania DNA extraction in the diagnosis of visceral leishmaniasis - a review |
title_full |
Urine as a promising sample for Leishmania DNA extraction in the diagnosis of visceral leishmaniasis - a review |
title_fullStr |
Urine as a promising sample for Leishmania DNA extraction in the diagnosis of visceral leishmaniasis - a review |
title_full_unstemmed |
Urine as a promising sample for Leishmania DNA extraction in the diagnosis of visceral leishmaniasis - a review |
title_sort |
Urine as a promising sample for Leishmania DNA extraction in the diagnosis of visceral leishmaniasis - a review |
author |
Bezerra,Gilberto Silva Nunes |
author_facet |
Bezerra,Gilberto Silva Nunes Barbosa Júnior,Walter Lins Silva,Elis Dionísio da Leal,Nilma Cintra Medeiros,Zulma Maria de |
author_role |
author |
author2 |
Barbosa Júnior,Walter Lins Silva,Elis Dionísio da Leal,Nilma Cintra Medeiros,Zulma Maria de |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Bezerra,Gilberto Silva Nunes Barbosa Júnior,Walter Lins Silva,Elis Dionísio da Leal,Nilma Cintra Medeiros,Zulma Maria de |
dc.subject.por.fl_str_mv |
Visceral leishmaniasis Renal involvement Diagnosis Urine sample DNA extraction |
topic |
Visceral leishmaniasis Renal involvement Diagnosis Urine sample DNA extraction |
description |
ABSTRACT Visceral leishmaniasis is a serious and debilitating infection with high fatality rate in tropical and subtropical countries. As clinical symptoms of visceral leishmaniasis are not so specific, confirmatory diagnostic methods with high sensitivity and specificity are needed. Noninvasive methods have been developed using urine as a clinical sample for visceral leishmaniasis diagnosis. In fact, there is a clear correlation between kidney impairment and Leishmania DNA in urine. However, it has been proved that Leishmania nucleic acid may also be isolated from patients without any sign of renal involvement. Even though urine has become a promissing biological sample, it is still not widely used due to several issues, such as (i) incomprehension of the whole renal pathophysiology process in visceral leishmaniasis, (ii) presence of many amplification inhibitors in urine, and (iii) lack of an efficient urinary DNA extraction method. In this article, we performed a literature review to bring a new perspective for Leishmania DNA isolation in urine. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000200111 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000200111 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjid.2019.04.001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
dc.source.none.fl_str_mv |
Brazilian Journal of Infectious Diseases v.23 n.2 2019 reponame:Brazilian Journal of Infectious Diseases instname:Brazilian Society of Infectious Diseases (BSID) instacron:BSID |
instname_str |
Brazilian Society of Infectious Diseases (BSID) |
instacron_str |
BSID |
institution |
BSID |
reponame_str |
Brazilian Journal of Infectious Diseases |
collection |
Brazilian Journal of Infectious Diseases |
repository.name.fl_str_mv |
Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID) |
repository.mail.fl_str_mv |
bjid@bjid.org.br||lgoldani@ufrgs.br |
_version_ |
1754209244644638720 |