Dosimetric evaluation of radionuclides for VCAM-1-targeted radionuclide therapy of early brain metastases

Detalhes bibliográficos
Autor(a) principal: Fuente Rosales, Liset de la, 1986-
Data de Publicação: 2018
Outros Autores: Bernal Rodriguez, Mario Antonio, 1972-
Tipo de documento: Artigo
Título da fonte: Repositório da Produção Científica e Intelectual da Unicamp
Texto Completo: https://hdl.handle.net/20.500.12733/1664465
Resumo: Agradecimentos: This work was supported by grants from Cancer Research UK (CRUK) (C5255/A15935), the Medical Research Council (MRC) (MC_PC_12004) and the CRUK Oxford Centre This work was also supported by the Centre National de la Recherche Scientifique (CNRS), the French National Agency for Research "Investissements d'Avenir" no ANR-11LABX0018-01 and the Conseil Regional de Normandie. M. A. Bernal and L. de la Fuente acknowledge the support received from the Conselho Nacional para o Desenvolvimento Cientifico e Tecnologico (CNPq), Brazil, for financing their research activities through the projects 306775/2015-8 and 190154/2013-6, respectively. S. Peeters acknowledges the support received the by Engineering and Physical Sciences Research Council (EPSRC) under Programme Grant EP/L024012/1 (OxCD3: Oxford Centre for Drug Delivery Devices)
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spelling Dosimetric evaluation of radionuclides for VCAM-1-targeted radionuclide therapy of early brain metastasesRadioisótoposMetástaseRadioisotopesNeoplasm metastasisBrain metastasisArtigo originalAgradecimentos: This work was supported by grants from Cancer Research UK (CRUK) (C5255/A15935), the Medical Research Council (MRC) (MC_PC_12004) and the CRUK Oxford Centre This work was also supported by the Centre National de la Recherche Scientifique (CNRS), the French National Agency for Research "Investissements d'Avenir" no ANR-11LABX0018-01 and the Conseil Regional de Normandie. M. A. Bernal and L. de la Fuente acknowledge the support received from the Conselho Nacional para o Desenvolvimento Cientifico e Tecnologico (CNPq), Brazil, for financing their research activities through the projects 306775/2015-8 and 190154/2013-6, respectively. S. Peeters acknowledges the support received the by Engineering and Physical Sciences Research Council (EPSRC) under Programme Grant EP/L024012/1 (OxCD3: Oxford Centre for Drug Delivery Devices)Abstract: Brain metastases develop frequently in patients with breast cancer, and present a pressing therapeutic challenge. Expression of vascular cell adhesion molecule 1 (VCAM-1) is upregulated on brain endothelial cells during the early stages of metastasis and provides a target for the detection and treatment of early brain metastases. The aim of this study was to use a model of early brain metastasis to evaluate the efficacy of a-emitting radionuclides, Tb-149, At-211, Pb-212, Bi-213 and Ac-225|| beta-emitting radionuclides, Y-90, Tb-161 and Lu-177|| and Auger electron (AE)-emitters Ga-67, Zr-89, In-111 and I-124, for targeted radionuclide therapy (TRT). METHODS: Histologic sections and two photon microscopy of mouse brain parenchyma were used to inform a cylindrical vessel geometry using the Geant4 general purpose Monte Carlo (MC) toolkit with the Geant4-DNA low energy physics models. Energy deposition was evaluated as a radial function and the resulting phase spaces were superimposed on a DNA model to estimate double-strand break (DSB) yields for representative beta- and alpha-emitters, Lu-177 and Pb-212. Relative biological effectiveness (RBE) values were determined by only evaluating DNA damage due to physical interactions. RESULTS: Lu-177 produced 2.69 +/- 0.08 DSB per GbpGy, without significant variation from the lumen of the vessel to a radius of 100 mu m. The DSB yield of Pb-212 included two local maxima produced by the 6.1 MeV and 8.8 MeV alpha-emissions from decay products, Bi-212 and Po-212, with yields of 7.64 +/- 0.12 and 9.15 +/- 0.24 per GbpGy, respectively. Given its higher DSB yield Pb-212 may be more effective for short range targeting of early micrometastatic lesions than Lu-177. CONCLUSION: MC simulation of a model of early brain metastases provides invaluable insight into the potential efficacy of alpha-, beta- and AE-emitting radionuclides for TRT. Pb-212, which has the attributes of a theranostic radionuclide since it can be used for SPECT imaging, showed a favorable dose profile and RBECONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQAbertoUNIVERSIDADE ESTADUAL DE CAMPINASFuente Rosales, Liset de la, 1986-Bernal Rodriguez, Mario Antonio, 1972-2018info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.12733/1664465FUENTE ROSALES, Liset de la; BERNAL RODRIGUEZ, Mario Antonio. Dosimetric evaluation of radionuclides for VCAM-1-targeted radionuclide therapy of early brain metastases. Theranostics. Sydney : Ivyspring International Publisher, 2018. Vol. 8, n. 1 (Jan., 2018), p. 292-303. Disponível em: https://hdl.handle.net/20.500.12733/1664465. Acesso em: 24 mai. 2023.Inglêshttps://repositorio.unicamp.br/acervo/detalhe/1215194reponame:Repositório da Produção Científica e Intelectual da Unicampinstname:Universidade Estadual de Campinas (UNICAMP)instacron:UNICAMPinfo:eu-repo/semantics/openAccess2022-05-09T10:04:03Zoai:https://www.repositorio.unicamp.br/:1215194Repositório InstitucionalPUBhttp://repositorio.unicamp.br/oai/requestreposip@unicamp.bropendoar:2022-05-09T10:04:03Repositório da Produção Científica e Intelectual da Unicamp - Universidade Estadual de Campinas (UNICAMP)false
dc.title.none.fl_str_mv Dosimetric evaluation of radionuclides for VCAM-1-targeted radionuclide therapy of early brain metastases
title Dosimetric evaluation of radionuclides for VCAM-1-targeted radionuclide therapy of early brain metastases
spellingShingle Dosimetric evaluation of radionuclides for VCAM-1-targeted radionuclide therapy of early brain metastases
Fuente Rosales, Liset de la, 1986-
Radioisótopos
Metástase
Radioisotopes
Neoplasm metastasis
Brain metastasis
Artigo original
title_short Dosimetric evaluation of radionuclides for VCAM-1-targeted radionuclide therapy of early brain metastases
title_full Dosimetric evaluation of radionuclides for VCAM-1-targeted radionuclide therapy of early brain metastases
title_fullStr Dosimetric evaluation of radionuclides for VCAM-1-targeted radionuclide therapy of early brain metastases
title_full_unstemmed Dosimetric evaluation of radionuclides for VCAM-1-targeted radionuclide therapy of early brain metastases
title_sort Dosimetric evaluation of radionuclides for VCAM-1-targeted radionuclide therapy of early brain metastases
author Fuente Rosales, Liset de la, 1986-
author_facet Fuente Rosales, Liset de la, 1986-
Bernal Rodriguez, Mario Antonio, 1972-
author_role author
author2 Bernal Rodriguez, Mario Antonio, 1972-
author2_role author
dc.contributor.none.fl_str_mv UNIVERSIDADE ESTADUAL DE CAMPINAS
dc.contributor.author.fl_str_mv Fuente Rosales, Liset de la, 1986-
Bernal Rodriguez, Mario Antonio, 1972-
dc.subject.por.fl_str_mv Radioisótopos
Metástase
Radioisotopes
Neoplasm metastasis
Brain metastasis
Artigo original
topic Radioisótopos
Metástase
Radioisotopes
Neoplasm metastasis
Brain metastasis
Artigo original
description Agradecimentos: This work was supported by grants from Cancer Research UK (CRUK) (C5255/A15935), the Medical Research Council (MRC) (MC_PC_12004) and the CRUK Oxford Centre This work was also supported by the Centre National de la Recherche Scientifique (CNRS), the French National Agency for Research "Investissements d'Avenir" no ANR-11LABX0018-01 and the Conseil Regional de Normandie. M. A. Bernal and L. de la Fuente acknowledge the support received from the Conselho Nacional para o Desenvolvimento Cientifico e Tecnologico (CNPq), Brazil, for financing their research activities through the projects 306775/2015-8 and 190154/2013-6, respectively. S. Peeters acknowledges the support received the by Engineering and Physical Sciences Research Council (EPSRC) under Programme Grant EP/L024012/1 (OxCD3: Oxford Centre for Drug Delivery Devices)
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/20.500.12733/1664465
FUENTE ROSALES, Liset de la; BERNAL RODRIGUEZ, Mario Antonio. Dosimetric evaluation of radionuclides for VCAM-1-targeted radionuclide therapy of early brain metastases. Theranostics. Sydney : Ivyspring International Publisher, 2018. Vol. 8, n. 1 (Jan., 2018), p. 292-303. Disponível em: https://hdl.handle.net/20.500.12733/1664465. Acesso em: 24 mai. 2023.
url https://hdl.handle.net/20.500.12733/1664465
identifier_str_mv FUENTE ROSALES, Liset de la; BERNAL RODRIGUEZ, Mario Antonio. Dosimetric evaluation of radionuclides for VCAM-1-targeted radionuclide therapy of early brain metastases. Theranostics. Sydney : Ivyspring International Publisher, 2018. Vol. 8, n. 1 (Jan., 2018), p. 292-303. Disponível em: https://hdl.handle.net/20.500.12733/1664465. Acesso em: 24 mai. 2023.
dc.language.iso.fl_str_mv Inglês
language_invalid_str_mv Inglês
dc.relation.none.fl_str_mv https://repositorio.unicamp.br/acervo/detalhe/1215194
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.source.none.fl_str_mv reponame:Repositório da Produção Científica e Intelectual da Unicamp
instname:Universidade Estadual de Campinas (UNICAMP)
instacron:UNICAMP
instname_str Universidade Estadual de Campinas (UNICAMP)
instacron_str UNICAMP
institution UNICAMP
reponame_str Repositório da Produção Científica e Intelectual da Unicamp
collection Repositório da Produção Científica e Intelectual da Unicamp
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repository.mail.fl_str_mv reposip@unicamp.br
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