Axonal dysfunction is associated with interferon-gamma levels in childhood-onset systemic lupus erythematosus : a multivoxel magnetic resonance spectroscopy study
Autor(a) principal: | |
---|---|
Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Título da fonte: | Repositório da Produção Científica e Intelectual da Unicamp |
Texto Completo: | https://hdl.handle.net/20.500.12733/4836 |
Resumo: | Agradecimentos: S.A. received grants from Fundação Apoio À Pesquisa Estado São Paulo-Brasil (FAPESP 2019/06632-5), Conselho Nacional Pesquisa Desenvolvimento-Brasil CNPq (306723/2019-0, 401477/2016-9) and CAPES 001. F.C. received grants from Fundação Apoio À Pesquisa Estado São Paulo-Brasil (FAPESP 2013/07559–3). T.B.N. received grants from the NIH (AR060861, AR057781, AR065964, AI071651), Rheumatology Research Foundation, CureJM Foundation, the Colton Center for Autoimmunity, and the Lupus Research Alliance, and was supported in part by a Visiting Professor grant from the Conselho Nacional Pesquisa Desenvolvimento-Brasil CNPq (473328/2013-5) |
id |
CAMP_5ca1eab0ebfce803eb18eb001eee22da |
---|---|
oai_identifier_str |
oai:https://www.repositorio.unicamp.br/:1245226 |
network_acronym_str |
CAMP |
network_name_str |
Repositório da Produção Científica e Intelectual da Unicamp |
repository_id_str |
|
spelling |
Axonal dysfunction is associated with interferon-gamma levels in childhood-onset systemic lupus erythematosus : a multivoxel magnetic resonance spectroscopy studyEspectroscopia de ressonância magnéticaLupus eritematosoSubstância brancaMagnetic resonance spectroscopyLupus erythematosusWhite matterChildhood-onset systemic lupus erythematosusArtigo originalAgradecimentos: S.A. received grants from Fundação Apoio À Pesquisa Estado São Paulo-Brasil (FAPESP 2019/06632-5), Conselho Nacional Pesquisa Desenvolvimento-Brasil CNPq (306723/2019-0, 401477/2016-9) and CAPES 001. F.C. received grants from Fundação Apoio À Pesquisa Estado São Paulo-Brasil (FAPESP 2013/07559–3). T.B.N. received grants from the NIH (AR060861, AR057781, AR065964, AI071651), Rheumatology Research Foundation, CureJM Foundation, the Colton Center for Autoimmunity, and the Lupus Research Alliance, and was supported in part by a Visiting Professor grant from the Conselho Nacional Pesquisa Desenvolvimento-Brasil CNPq (473328/2013-5)Abstract: Objective Axonal/neuronal damage has been shown to be a pathological finding that precedes neuropsychiatric manifestations in SLE. The objective of this study was to determine the presence of axonal dysfunction in childhood-onset SLE patients (cSLE) and to determine clinical, immunological and treatment features associated with its occurrence. Methods We included 86 consecutive cSLE patients [median age 17 (range 5-28) years] and 71 controls [median age 18 (5-28) years]. We performed proton magnetic resonance spectroscopic imaging using point resolved spectroscopy sequence over the superior-posterior region of the corpus callosum and signals from N-acetylaspartate (NAA), choline-based (CHO), creatine-containing (Cr), myo-inositol (mI), glutamate, glutamine and lactate were measured and metabolites/Cr ratios were determined. Complete clinical, laboratory and neurological evaluations were performed in all subjects. Serum IL-4, IL-5, IL-6, IL-10, IL-12, IL-17, TNF-alpha and INF-gamma cytokine levels, antiribosomal P protein antibodies (anti-P) and S100 beta were measured by ELISA using commercial kits. Data were compared by non-parametric tests. Results NAA/Cr ratios (P = 0.035) and lactate/Cr ratios (P = 0.019) were significantly decreased in cSLE patients when compared with controls. In multivariate analysis, IFN-gamma levels [odds ratio (OR) = 4.1; 95% CI: 2.01, 7.9] and depressive symptoms (OR = 1.9; 95% CI: 1.1, 3.2) were associated with NAA/Cr ratio. Increased CHO/Cr was associated with the presence of cognitive impairment (OR = 3.4; 95% CI: 2.034, 5.078; P < 0.001). mI/Cr ratio correlated with cumulative glucocorticoids dosage (r = 0.361, P = 0.014). Conclusion NAA and CHO ratios may be useful as biomarkers in neuropsychiatric cSLE. Longitudinal studies are necessary to determine whether they predict structural damageFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESFechadoUNIVERSIDADE ESTADUAL DE CAMPINASFrittoli, Renan Bazuco, 1992-Pereira, Danilo Rodrigues, 1984-Lapa, Aline Tamires, 1989-Postal, Mariana, 1987-Martin, Nailú Angélica Sinicato, 1989-Fernandes, Paula Teixeira, 1975-Cendes, Fernando, 1962-Castellano, Gabriela, 1970-Rittner, Leticia, 1972-Marini, Roberto, 1951-Appenzeller, Simone, 1974-2022info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.12733/4836FRITTOLI, Renan Bazuco et al. Axonal dysfunction is associated with interferon-gamma levels in childhood-onset systemic lupus erythematosus: a multivoxel magnetic resonance spectroscopy study. Rheumatology. Oxford : Oxford University Press, 2022. Vol. 61, n. 4 (Apr., 2022), p. 1529-1537. Disponível em: https://hdl.handle.net/20.500.12733/4836. Acesso em: 24 mai. 2023.Inglêshttps://repositorio.unicamp.br/acervo/detalhe/1245226reponame:Repositório da Produção Científica e Intelectual da Unicampinstname:Universidade Estadual de Campinas (UNICAMP)instacron:UNICAMPinfo:eu-repo/semantics/openAccess2022-09-09T10:52:53Zoai:https://www.repositorio.unicamp.br/:1245226Repositório InstitucionalPUBhttp://repositorio.unicamp.br/oai/requestreposip@unicamp.bropendoar:2022-09-09T10:52:53Repositório da Produção Científica e Intelectual da Unicamp - Universidade Estadual de Campinas (UNICAMP)false |
dc.title.none.fl_str_mv |
Axonal dysfunction is associated with interferon-gamma levels in childhood-onset systemic lupus erythematosus : a multivoxel magnetic resonance spectroscopy study |
title |
Axonal dysfunction is associated with interferon-gamma levels in childhood-onset systemic lupus erythematosus : a multivoxel magnetic resonance spectroscopy study |
spellingShingle |
Axonal dysfunction is associated with interferon-gamma levels in childhood-onset systemic lupus erythematosus : a multivoxel magnetic resonance spectroscopy study Frittoli, Renan Bazuco, 1992- Espectroscopia de ressonância magnética Lupus eritematoso Substância branca Magnetic resonance spectroscopy Lupus erythematosus White matter Childhood-onset systemic lupus erythematosus Artigo original |
title_short |
Axonal dysfunction is associated with interferon-gamma levels in childhood-onset systemic lupus erythematosus : a multivoxel magnetic resonance spectroscopy study |
title_full |
Axonal dysfunction is associated with interferon-gamma levels in childhood-onset systemic lupus erythematosus : a multivoxel magnetic resonance spectroscopy study |
title_fullStr |
Axonal dysfunction is associated with interferon-gamma levels in childhood-onset systemic lupus erythematosus : a multivoxel magnetic resonance spectroscopy study |
title_full_unstemmed |
Axonal dysfunction is associated with interferon-gamma levels in childhood-onset systemic lupus erythematosus : a multivoxel magnetic resonance spectroscopy study |
title_sort |
Axonal dysfunction is associated with interferon-gamma levels in childhood-onset systemic lupus erythematosus : a multivoxel magnetic resonance spectroscopy study |
author |
Frittoli, Renan Bazuco, 1992- |
author_facet |
Frittoli, Renan Bazuco, 1992- Pereira, Danilo Rodrigues, 1984- Lapa, Aline Tamires, 1989- Postal, Mariana, 1987- Martin, Nailú Angélica Sinicato, 1989- Fernandes, Paula Teixeira, 1975- Cendes, Fernando, 1962- Castellano, Gabriela, 1970- Rittner, Leticia, 1972- Marini, Roberto, 1951- Appenzeller, Simone, 1974- |
author_role |
author |
author2 |
Pereira, Danilo Rodrigues, 1984- Lapa, Aline Tamires, 1989- Postal, Mariana, 1987- Martin, Nailú Angélica Sinicato, 1989- Fernandes, Paula Teixeira, 1975- Cendes, Fernando, 1962- Castellano, Gabriela, 1970- Rittner, Leticia, 1972- Marini, Roberto, 1951- Appenzeller, Simone, 1974- |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
UNIVERSIDADE ESTADUAL DE CAMPINAS |
dc.contributor.author.fl_str_mv |
Frittoli, Renan Bazuco, 1992- Pereira, Danilo Rodrigues, 1984- Lapa, Aline Tamires, 1989- Postal, Mariana, 1987- Martin, Nailú Angélica Sinicato, 1989- Fernandes, Paula Teixeira, 1975- Cendes, Fernando, 1962- Castellano, Gabriela, 1970- Rittner, Leticia, 1972- Marini, Roberto, 1951- Appenzeller, Simone, 1974- |
dc.subject.por.fl_str_mv |
Espectroscopia de ressonância magnética Lupus eritematoso Substância branca Magnetic resonance spectroscopy Lupus erythematosus White matter Childhood-onset systemic lupus erythematosus Artigo original |
topic |
Espectroscopia de ressonância magnética Lupus eritematoso Substância branca Magnetic resonance spectroscopy Lupus erythematosus White matter Childhood-onset systemic lupus erythematosus Artigo original |
description |
Agradecimentos: S.A. received grants from Fundação Apoio À Pesquisa Estado São Paulo-Brasil (FAPESP 2019/06632-5), Conselho Nacional Pesquisa Desenvolvimento-Brasil CNPq (306723/2019-0, 401477/2016-9) and CAPES 001. F.C. received grants from Fundação Apoio À Pesquisa Estado São Paulo-Brasil (FAPESP 2013/07559–3). T.B.N. received grants from the NIH (AR060861, AR057781, AR065964, AI071651), Rheumatology Research Foundation, CureJM Foundation, the Colton Center for Autoimmunity, and the Lupus Research Alliance, and was supported in part by a Visiting Professor grant from the Conselho Nacional Pesquisa Desenvolvimento-Brasil CNPq (473328/2013-5) |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/20.500.12733/4836 FRITTOLI, Renan Bazuco et al. Axonal dysfunction is associated with interferon-gamma levels in childhood-onset systemic lupus erythematosus: a multivoxel magnetic resonance spectroscopy study. Rheumatology. Oxford : Oxford University Press, 2022. Vol. 61, n. 4 (Apr., 2022), p. 1529-1537. Disponível em: https://hdl.handle.net/20.500.12733/4836. Acesso em: 24 mai. 2023. |
url |
https://hdl.handle.net/20.500.12733/4836 |
identifier_str_mv |
FRITTOLI, Renan Bazuco et al. Axonal dysfunction is associated with interferon-gamma levels in childhood-onset systemic lupus erythematosus: a multivoxel magnetic resonance spectroscopy study. Rheumatology. Oxford : Oxford University Press, 2022. Vol. 61, n. 4 (Apr., 2022), p. 1529-1537. Disponível em: https://hdl.handle.net/20.500.12733/4836. Acesso em: 24 mai. 2023. |
dc.language.iso.fl_str_mv |
Inglês |
language_invalid_str_mv |
Inglês |
dc.relation.none.fl_str_mv |
https://repositorio.unicamp.br/acervo/detalhe/1245226 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório da Produção Científica e Intelectual da Unicamp instname:Universidade Estadual de Campinas (UNICAMP) instacron:UNICAMP |
instname_str |
Universidade Estadual de Campinas (UNICAMP) |
instacron_str |
UNICAMP |
institution |
UNICAMP |
reponame_str |
Repositório da Produção Científica e Intelectual da Unicamp |
collection |
Repositório da Produção Científica e Intelectual da Unicamp |
repository.name.fl_str_mv |
Repositório da Produção Científica e Intelectual da Unicamp - Universidade Estadual de Campinas (UNICAMP) |
repository.mail.fl_str_mv |
reposip@unicamp.br |
_version_ |
1766887327517376512 |