Spleen tissue changes after restraint stress : effects of aerobic exercise training
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório da Produção Científica e Intelectual da Unicamp |
Texto Completo: | https://hdl.handle.net/20.500.12733/4051 |
Resumo: | Abstract: Inflammation has been described as a prominent mechanism involved in dysfunctions and diseases evoked by chronic stress. Notably, the spleen is an immune organ controlled by sympathetic and glucocorticoid mechanisms, but the impact of chronic stress in the spleen is not entirely understood. Besides, the impact of aerobic exercise training on the effects of chronic stress in the spleen has never been reported. Therefore, this study aimed to assess the changes caused in the spleen by repeated restraint stress and the effect of aerobic exercise training performed after a period of chronic restraint stress in rats. We identified that daily exposure to restraint stress (120 min per session, for 14 consecutive days) increased corticosterone and noradrenaline content, gene expression of glucocorticoid and beta(2)-adrenergic receptors, TNF-alpha and IL-6 levels, and increased pro-oxidant substances in the spleen. Circulating levels of corticosterone were also increased in chronically stressed animals. Exercise training (1 h a day/5 days per week, for 60 days) increased glucocorticoid receptor gene expression, interleukin (IL)-10 and antioxidant mechanisms in the spleen. Exercise also decreased splenic noradrenaline, tumoral necrosis factor (TNF)-alpha, and IL-6 contents. Lastly, the effects of repeated restraint stress in the spleen were mitigated in animals subjected to aerobic training. Taken together, the results reported in the present study indicate that aerobic exercise training is a relevant non-pharmacological therapeutic approach to dysfunctions in the spleen caused by a period of stress |
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Spleen tissue changes after restraint stress : effects of aerobic exercise trainingGlicocorticoidesEstresse oxidativoRestraint stressSympathetic activityArtigo originalAbstract: Inflammation has been described as a prominent mechanism involved in dysfunctions and diseases evoked by chronic stress. Notably, the spleen is an immune organ controlled by sympathetic and glucocorticoid mechanisms, but the impact of chronic stress in the spleen is not entirely understood. Besides, the impact of aerobic exercise training on the effects of chronic stress in the spleen has never been reported. Therefore, this study aimed to assess the changes caused in the spleen by repeated restraint stress and the effect of aerobic exercise training performed after a period of chronic restraint stress in rats. We identified that daily exposure to restraint stress (120 min per session, for 14 consecutive days) increased corticosterone and noradrenaline content, gene expression of glucocorticoid and beta(2)-adrenergic receptors, TNF-alpha and IL-6 levels, and increased pro-oxidant substances in the spleen. Circulating levels of corticosterone were also increased in chronically stressed animals. Exercise training (1 h a day/5 days per week, for 60 days) increased glucocorticoid receptor gene expression, interleukin (IL)-10 and antioxidant mechanisms in the spleen. Exercise also decreased splenic noradrenaline, tumoral necrosis factor (TNF)-alpha, and IL-6 contents. Lastly, the effects of repeated restraint stress in the spleen were mitigated in animals subjected to aerobic training. Taken together, the results reported in the present study indicate that aerobic exercise training is a relevant non-pharmacological therapeutic approach to dysfunctions in the spleen caused by a period of stressCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPFechadoUNIVERSIDADE ESTADUAL DE CAMPINASFeriani, Daniele Jardim, 1992-Sousa, Andressa Silva, 1990-Delbin, Maria Andréia, 1982-Ruberti, Olivia Moraes, 1994-Rodrigues, Bruno, 1980-2021info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.12733/4051FERIANI, Daniele Jardim et al. Spleen tissue changes after restraint stress: effects of aerobic exercise training. Stress. Abingdon : Taylor & Francis, 2021. Vol. 24, n. 5 (Apr., 2021), p. 572-583. Disponível em: https://hdl.handle.net/20.500.12733/4051. Acesso em: 7 mai. 2024.Inglêsenghttps://repositorio.unicamp.br/acervo/detalhe/1241963reponame:Repositório da Produção Científica e Intelectual da Unicampinstname:Universidade Estadual de Campinas (UNICAMP)instacron:UNICAMPinfo:eu-repo/semantics/openAccess2022-05-19T12:04:53Zoai:https://www.repositorio.unicamp.br/:1241963Repositório InstitucionalPUBhttp://repositorio.unicamp.br/oai/requestreposip@unicamp.bropendoar:2022-05-19T12:04:53Repositório da Produção Científica e Intelectual da Unicamp - Universidade Estadual de Campinas (UNICAMP)false |
dc.title.none.fl_str_mv |
Spleen tissue changes after restraint stress : effects of aerobic exercise training |
title |
Spleen tissue changes after restraint stress : effects of aerobic exercise training |
spellingShingle |
Spleen tissue changes after restraint stress : effects of aerobic exercise training Feriani, Daniele Jardim, 1992- Glicocorticoides Estresse oxidativo Restraint stress Sympathetic activity Artigo original |
title_short |
Spleen tissue changes after restraint stress : effects of aerobic exercise training |
title_full |
Spleen tissue changes after restraint stress : effects of aerobic exercise training |
title_fullStr |
Spleen tissue changes after restraint stress : effects of aerobic exercise training |
title_full_unstemmed |
Spleen tissue changes after restraint stress : effects of aerobic exercise training |
title_sort |
Spleen tissue changes after restraint stress : effects of aerobic exercise training |
author |
Feriani, Daniele Jardim, 1992- |
author_facet |
Feriani, Daniele Jardim, 1992- Sousa, Andressa Silva, 1990- Delbin, Maria Andréia, 1982- Ruberti, Olivia Moraes, 1994- Rodrigues, Bruno, 1980- |
author_role |
author |
author2 |
Sousa, Andressa Silva, 1990- Delbin, Maria Andréia, 1982- Ruberti, Olivia Moraes, 1994- Rodrigues, Bruno, 1980- |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
UNIVERSIDADE ESTADUAL DE CAMPINAS |
dc.contributor.author.fl_str_mv |
Feriani, Daniele Jardim, 1992- Sousa, Andressa Silva, 1990- Delbin, Maria Andréia, 1982- Ruberti, Olivia Moraes, 1994- Rodrigues, Bruno, 1980- |
dc.subject.por.fl_str_mv |
Glicocorticoides Estresse oxidativo Restraint stress Sympathetic activity Artigo original |
topic |
Glicocorticoides Estresse oxidativo Restraint stress Sympathetic activity Artigo original |
description |
Abstract: Inflammation has been described as a prominent mechanism involved in dysfunctions and diseases evoked by chronic stress. Notably, the spleen is an immune organ controlled by sympathetic and glucocorticoid mechanisms, but the impact of chronic stress in the spleen is not entirely understood. Besides, the impact of aerobic exercise training on the effects of chronic stress in the spleen has never been reported. Therefore, this study aimed to assess the changes caused in the spleen by repeated restraint stress and the effect of aerobic exercise training performed after a period of chronic restraint stress in rats. We identified that daily exposure to restraint stress (120 min per session, for 14 consecutive days) increased corticosterone and noradrenaline content, gene expression of glucocorticoid and beta(2)-adrenergic receptors, TNF-alpha and IL-6 levels, and increased pro-oxidant substances in the spleen. Circulating levels of corticosterone were also increased in chronically stressed animals. Exercise training (1 h a day/5 days per week, for 60 days) increased glucocorticoid receptor gene expression, interleukin (IL)-10 and antioxidant mechanisms in the spleen. Exercise also decreased splenic noradrenaline, tumoral necrosis factor (TNF)-alpha, and IL-6 contents. Lastly, the effects of repeated restraint stress in the spleen were mitigated in animals subjected to aerobic training. Taken together, the results reported in the present study indicate that aerobic exercise training is a relevant non-pharmacological therapeutic approach to dysfunctions in the spleen caused by a period of stress |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/20.500.12733/4051 FERIANI, Daniele Jardim et al. Spleen tissue changes after restraint stress: effects of aerobic exercise training. Stress. Abingdon : Taylor & Francis, 2021. Vol. 24, n. 5 (Apr., 2021), p. 572-583. Disponível em: https://hdl.handle.net/20.500.12733/4051. Acesso em: 7 mai. 2024. |
url |
https://hdl.handle.net/20.500.12733/4051 |
identifier_str_mv |
FERIANI, Daniele Jardim et al. Spleen tissue changes after restraint stress: effects of aerobic exercise training. Stress. Abingdon : Taylor & Francis, 2021. Vol. 24, n. 5 (Apr., 2021), p. 572-583. Disponível em: https://hdl.handle.net/20.500.12733/4051. Acesso em: 7 mai. 2024. |
dc.language.iso.fl_str_mv |
Inglês eng |
language_invalid_str_mv |
Inglês |
language |
eng |
dc.relation.none.fl_str_mv |
https://repositorio.unicamp.br/acervo/detalhe/1241963 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório da Produção Científica e Intelectual da Unicamp instname:Universidade Estadual de Campinas (UNICAMP) instacron:UNICAMP |
instname_str |
Universidade Estadual de Campinas (UNICAMP) |
instacron_str |
UNICAMP |
institution |
UNICAMP |
reponame_str |
Repositório da Produção Científica e Intelectual da Unicamp |
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Repositório da Produção Científica e Intelectual da Unicamp |
repository.name.fl_str_mv |
Repositório da Produção Científica e Intelectual da Unicamp - Universidade Estadual de Campinas (UNICAMP) |
repository.mail.fl_str_mv |
reposip@unicamp.br |
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