Myocardial tissue remodeling after orthotopic heart transplantation : a pilot cardiac magnetic resonance study
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Título da fonte: | Repositório da Produção Científica e Intelectual da Unicamp |
Texto Completo: | https://hdl.handle.net/20.500.12733/823 |
Resumo: | Abstract: After orthotopic heart transplantation (OHT), the allograft undergoes characteristic alterations in myocardial structure, including hypertrophy, increased ventricular stiffness, ischemia, and inflammation, all of which may decrease overall graft survival. Methods to quantify these phenotypes may clarify the pathophysiology of progressive graft dysfunction post-OHT. We performed cardiac magnetic resonance (CMR) with T1 mapping in 26 OHT recipients (mean age 47?±?7 years, 30?% female, median follow-up post-OHT 6 months) and 30 age-matched healthy volunteers (mean age 50.5?±?15 years; LVEF 63.5?±?7?%). OHT recipients had a normal left ventricular ejection fraction (LVEF 65.3?±?11?%) with higher LV mass relative to age-matched healthy volunteers (114?±?27 vs. 85.8?±?18 g; p?<?0.001). There was no late gadolinium enhancement in either group. Both myocardial extracellular volume fraction (ECV) and intracellular lifetime of water (tic), a measure of cardiomyocyte hypertrophy, were higher in patients post-OHT (ECV: 0.39?±?0.06 vs. 0.28?±?0.03, p?<?0.0001; tic: 0.12?±?0.08 vs. 0.08?±?0.03, p?<?0.001). ECV was associated with LV mass (r?=?0.74, p?<?0.001). In follow-up, OHT recipients with normal biopsies by pathology (ISHLT grade 0R) in the first year post-OHT exhibited a lower ECV relative to patients with any rejection =2R (0.35?±?0.02 for 0R vs. 0.45?±?0, p?<?0.001). Higher ECV but not LVEF was significantly associated with a reduced rejection-free survival. After OHT, markers of tissue remodeling by CMR (ECV and tic) are elevated and associated with myocardial hypertrophy. Interstitial myocardial remodeling (by ECV) is associated with cellular rejection. Further research on the impact of graft preservation and early immunosuppression on tissue-level remodeling of the allograft is necessary to delineate the clinical implications of these findings |
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Myocardial tissue remodeling after orthotopic heart transplantation : a pilot cardiac magnetic resonance studyFibroseFibrosisHypertrophyExtracellular volume fractionGadolinium-DTPAMagnetic resonance imaging and orthotopic heart transplantationArtigo originalAbstract: After orthotopic heart transplantation (OHT), the allograft undergoes characteristic alterations in myocardial structure, including hypertrophy, increased ventricular stiffness, ischemia, and inflammation, all of which may decrease overall graft survival. Methods to quantify these phenotypes may clarify the pathophysiology of progressive graft dysfunction post-OHT. We performed cardiac magnetic resonance (CMR) with T1 mapping in 26 OHT recipients (mean age 47?±?7 years, 30?% female, median follow-up post-OHT 6 months) and 30 age-matched healthy volunteers (mean age 50.5?±?15 years; LVEF 63.5?±?7?%). OHT recipients had a normal left ventricular ejection fraction (LVEF 65.3?±?11?%) with higher LV mass relative to age-matched healthy volunteers (114?±?27 vs. 85.8?±?18 g; p?<?0.001). There was no late gadolinium enhancement in either group. Both myocardial extracellular volume fraction (ECV) and intracellular lifetime of water (tic), a measure of cardiomyocyte hypertrophy, were higher in patients post-OHT (ECV: 0.39?±?0.06 vs. 0.28?±?0.03, p?<?0.0001; tic: 0.12?±?0.08 vs. 0.08?±?0.03, p?<?0.001). ECV was associated with LV mass (r?=?0.74, p?<?0.001). In follow-up, OHT recipients with normal biopsies by pathology (ISHLT grade 0R) in the first year post-OHT exhibited a lower ECV relative to patients with any rejection =2R (0.35?±?0.02 for 0R vs. 0.45?±?0, p?<?0.001). Higher ECV but not LVEF was significantly associated with a reduced rejection-free survival. After OHT, markers of tissue remodeling by CMR (ECV and tic) are elevated and associated with myocardial hypertrophy. Interstitial myocardial remodeling (by ECV) is associated with cellular rejection. Further research on the impact of graft preservation and early immunosuppression on tissue-level remodeling of the allograft is necessary to delineate the clinical implications of these findingsCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQFechadoUNIVERSIDADE ESTADUAL DE CAMPINASCoelho-Filho, Otávio Rizzi, 1977-Lavagnoli, Carlos Fernando RamosBarros, José Carlos deOliveira, Pedro Paulo Martins de, 1968-Souza, José Roberto Matos, 1967-Severino, Elaine Soraya Barbosa de Oliveira, 1976-Vilarinho, Karlos Alexandre de SouzaSilveira Filho, Lindemberg da Mota, 1972-Coelho, Otávio Rizzi, 1948-Petrucci Junior, Orlando, 1966-2016info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.12733/823COELHO-FILHO, Otávio Rizzi et al. Myocardial tissue remodeling after orthotopic heart transplantation: a pilot cardiac magnetic resonance study. International journal of cardiovascular imaging. Dordrecht : Springer, 2018. Vol. 34 (Jan., 2018), p. 15-24. Disponível em: https://hdl.handle.net/20.500.12733/823. Acesso em: 24 mai. 2023.Inglêshttps://repositorio.unicamp.br/acervo/detalhe/1232284reponame:Repositório da Produção Científica e Intelectual da Unicampinstname:Universidade Estadual de Campinas (UNICAMP)instacron:UNICAMPinfo:eu-repo/semantics/openAccess2021-11-18T14:53:03Zoai:https://www.repositorio.unicamp.br/:1232284Repositório InstitucionalPUBhttp://repositorio.unicamp.br/oai/requestreposip@unicamp.bropendoar:2021-11-18T14:53:03Repositório da Produção Científica e Intelectual da Unicamp - Universidade Estadual de Campinas (UNICAMP)false |
dc.title.none.fl_str_mv |
Myocardial tissue remodeling after orthotopic heart transplantation : a pilot cardiac magnetic resonance study |
title |
Myocardial tissue remodeling after orthotopic heart transplantation : a pilot cardiac magnetic resonance study |
spellingShingle |
Myocardial tissue remodeling after orthotopic heart transplantation : a pilot cardiac magnetic resonance study Coelho-Filho, Otávio Rizzi, 1977- Fibrose Fibrosis Hypertrophy Extracellular volume fraction Gadolinium-DTPA Magnetic resonance imaging and orthotopic heart transplantation Artigo original |
title_short |
Myocardial tissue remodeling after orthotopic heart transplantation : a pilot cardiac magnetic resonance study |
title_full |
Myocardial tissue remodeling after orthotopic heart transplantation : a pilot cardiac magnetic resonance study |
title_fullStr |
Myocardial tissue remodeling after orthotopic heart transplantation : a pilot cardiac magnetic resonance study |
title_full_unstemmed |
Myocardial tissue remodeling after orthotopic heart transplantation : a pilot cardiac magnetic resonance study |
title_sort |
Myocardial tissue remodeling after orthotopic heart transplantation : a pilot cardiac magnetic resonance study |
author |
Coelho-Filho, Otávio Rizzi, 1977- |
author_facet |
Coelho-Filho, Otávio Rizzi, 1977- Lavagnoli, Carlos Fernando Ramos Barros, José Carlos de Oliveira, Pedro Paulo Martins de, 1968- Souza, José Roberto Matos, 1967- Severino, Elaine Soraya Barbosa de Oliveira, 1976- Vilarinho, Karlos Alexandre de Souza Silveira Filho, Lindemberg da Mota, 1972- Coelho, Otávio Rizzi, 1948- Petrucci Junior, Orlando, 1966- |
author_role |
author |
author2 |
Lavagnoli, Carlos Fernando Ramos Barros, José Carlos de Oliveira, Pedro Paulo Martins de, 1968- Souza, José Roberto Matos, 1967- Severino, Elaine Soraya Barbosa de Oliveira, 1976- Vilarinho, Karlos Alexandre de Souza Silveira Filho, Lindemberg da Mota, 1972- Coelho, Otávio Rizzi, 1948- Petrucci Junior, Orlando, 1966- |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
UNIVERSIDADE ESTADUAL DE CAMPINAS |
dc.contributor.author.fl_str_mv |
Coelho-Filho, Otávio Rizzi, 1977- Lavagnoli, Carlos Fernando Ramos Barros, José Carlos de Oliveira, Pedro Paulo Martins de, 1968- Souza, José Roberto Matos, 1967- Severino, Elaine Soraya Barbosa de Oliveira, 1976- Vilarinho, Karlos Alexandre de Souza Silveira Filho, Lindemberg da Mota, 1972- Coelho, Otávio Rizzi, 1948- Petrucci Junior, Orlando, 1966- |
dc.subject.por.fl_str_mv |
Fibrose Fibrosis Hypertrophy Extracellular volume fraction Gadolinium-DTPA Magnetic resonance imaging and orthotopic heart transplantation Artigo original |
topic |
Fibrose Fibrosis Hypertrophy Extracellular volume fraction Gadolinium-DTPA Magnetic resonance imaging and orthotopic heart transplantation Artigo original |
description |
Abstract: After orthotopic heart transplantation (OHT), the allograft undergoes characteristic alterations in myocardial structure, including hypertrophy, increased ventricular stiffness, ischemia, and inflammation, all of which may decrease overall graft survival. Methods to quantify these phenotypes may clarify the pathophysiology of progressive graft dysfunction post-OHT. We performed cardiac magnetic resonance (CMR) with T1 mapping in 26 OHT recipients (mean age 47?±?7 years, 30?% female, median follow-up post-OHT 6 months) and 30 age-matched healthy volunteers (mean age 50.5?±?15 years; LVEF 63.5?±?7?%). OHT recipients had a normal left ventricular ejection fraction (LVEF 65.3?±?11?%) with higher LV mass relative to age-matched healthy volunteers (114?±?27 vs. 85.8?±?18 g; p?<?0.001). There was no late gadolinium enhancement in either group. Both myocardial extracellular volume fraction (ECV) and intracellular lifetime of water (tic), a measure of cardiomyocyte hypertrophy, were higher in patients post-OHT (ECV: 0.39?±?0.06 vs. 0.28?±?0.03, p?<?0.0001; tic: 0.12?±?0.08 vs. 0.08?±?0.03, p?<?0.001). ECV was associated with LV mass (r?=?0.74, p?<?0.001). In follow-up, OHT recipients with normal biopsies by pathology (ISHLT grade 0R) in the first year post-OHT exhibited a lower ECV relative to patients with any rejection =2R (0.35?±?0.02 for 0R vs. 0.45?±?0, p?<?0.001). Higher ECV but not LVEF was significantly associated with a reduced rejection-free survival. After OHT, markers of tissue remodeling by CMR (ECV and tic) are elevated and associated with myocardial hypertrophy. Interstitial myocardial remodeling (by ECV) is associated with cellular rejection. Further research on the impact of graft preservation and early immunosuppression on tissue-level remodeling of the allograft is necessary to delineate the clinical implications of these findings |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/20.500.12733/823 COELHO-FILHO, Otávio Rizzi et al. Myocardial tissue remodeling after orthotopic heart transplantation: a pilot cardiac magnetic resonance study. International journal of cardiovascular imaging. Dordrecht : Springer, 2018. Vol. 34 (Jan., 2018), p. 15-24. Disponível em: https://hdl.handle.net/20.500.12733/823. Acesso em: 24 mai. 2023. |
url |
https://hdl.handle.net/20.500.12733/823 |
identifier_str_mv |
COELHO-FILHO, Otávio Rizzi et al. Myocardial tissue remodeling after orthotopic heart transplantation: a pilot cardiac magnetic resonance study. International journal of cardiovascular imaging. Dordrecht : Springer, 2018. Vol. 34 (Jan., 2018), p. 15-24. Disponível em: https://hdl.handle.net/20.500.12733/823. Acesso em: 24 mai. 2023. |
dc.language.iso.fl_str_mv |
Inglês |
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Inglês |
dc.relation.none.fl_str_mv |
https://repositorio.unicamp.br/acervo/detalhe/1232284 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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reponame:Repositório da Produção Científica e Intelectual da Unicamp instname:Universidade Estadual de Campinas (UNICAMP) instacron:UNICAMP |
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Universidade Estadual de Campinas (UNICAMP) |
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UNICAMP |
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UNICAMP |
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Repositório da Produção Científica e Intelectual da Unicamp |
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Repositório da Produção Científica e Intelectual da Unicamp |
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Repositório da Produção Científica e Intelectual da Unicamp - Universidade Estadual de Campinas (UNICAMP) |
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