WNT5A in tumor development and progression : a comprehensive review

Detalhes bibliográficos
Autor(a) principal: Bueno, Maura Lima Pereira, 1997-
Data de Publicação: 2022
Outros Autores: Saad, Sara Teresinha Olalla, 1956-, Roversi, Fernanda Marconi, 1981-
Tipo de documento: Artigo
Título da fonte: Repositório da Produção Científica e Intelectual da Unicamp
Texto Completo: https://hdl.handle.net/20.500.12733/6592
Resumo: Agradecimentos: The authors received fellowship / grants from the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP Grants 2017/21801-2, 2019/25247-5 and 2021/05320-0) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq Grants 303405/2018-0. The authors would like to thank Raquel S Foglio (Hematology and Hemotherapy Center, University of Campinas, São Paulo, Brazil) for the English revision. The authors thank FAPESP (Grants 2017/21801-2, 2019/25247-5 and 2021/05320-0) and CNPq (Grants 303405/2018-0)
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spelling WNT5A in tumor development and progression : a comprehensive reviewOncogenesMicroambiente tumoralPrognósticoTerapia de alvo molecularTumor microenvironmentPrognosisMolecular targeted therapyWNT5AArtigo originalAgradecimentos: The authors received fellowship / grants from the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP Grants 2017/21801-2, 2019/25247-5 and 2021/05320-0) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq Grants 303405/2018-0. The authors would like to thank Raquel S Foglio (Hematology and Hemotherapy Center, University of Campinas, São Paulo, Brazil) for the English revision. The authors thank FAPESP (Grants 2017/21801-2, 2019/25247-5 and 2021/05320-0) and CNPq (Grants 303405/2018-0)Abstract: The investigation of tumor microenvironment (TME) is essential to better characterize the complex cellular crosstalk and to identify important immunological phenotypes and biomarkers. The niche is a crucial contributor to neoplasm initiation, maintenance and progression. Therefore, a deeper analysis of tumor surroundings could improve cancer diagnosis, prognosis and assertive treatment. Thus, the WNT family exerts a critical action in tumorigenesis of different types of neoplasms due to dysregulations in the TME. WNT5A, an evolutionary WNT member, is involved in several cellular and physiopathological processes, in addition to tissue homeostasis. The WNT5A protein exerts paradoxical effects while acting as both an oncogene or tumor suppressor by regulating several non-canonical signaling pathways, and consequently interfering in cell growth, cytoskeletal remodeling, migration and invasiveness. This review focuses on a thorough characterization of the role of WNT5A in neoplastic transformation and progression, which may help to understand the prognostic potentiality of WNT5A and its features as a therapeutic target in several cancers. Additionally, we herein summarized novel findings on the mechanisms by which WNT5A might favor tumorigenesis or suppression of cancer progression and discussed the recently developed treatment strategies using WNT5A as a protagonistFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQAbertoUNIVERSIDADE ESTADUAL DE CAMPINASBueno, Maura Lima Pereira, 1997-Saad, Sara Teresinha Olalla, 1956-Roversi, Fernanda Marconi, 1981-2022info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.12733/6592BUENO, Maura Lima Pereira; SAAD, Sara Teresinha Olalla; ROVERSI, Fernanda Marconi. WNT5A in tumor development and progression: a comprehensive review. Biomedicine and pharmacotherapy. Issy-les-Moulineaux: Elsevier, 2022. Vol. 155 (Nov., 2022), n. art. 113599. Disponível em: https://hdl.handle.net/20.500.12733/6592. Acesso em: 24 mai. 2023.Inglêshttps://repositorio.unicamp.br/acervo/detalhe/1255623reponame:Repositório da Produção Científica e Intelectual da Unicampinstname:Universidade Estadual de Campinas (UNICAMP)instacron:UNICAMPinfo:eu-repo/semantics/openAccess2022-11-29T10:14:22Zoai:https://www.repositorio.unicamp.br/:1255623Repositório InstitucionalPUBhttp://repositorio.unicamp.br/oai/requestreposip@unicamp.bropendoar:2022-11-29T10:14:22Repositório da Produção Científica e Intelectual da Unicamp - Universidade Estadual de Campinas (UNICAMP)false
dc.title.none.fl_str_mv WNT5A in tumor development and progression : a comprehensive review
title WNT5A in tumor development and progression : a comprehensive review
spellingShingle WNT5A in tumor development and progression : a comprehensive review
Bueno, Maura Lima Pereira, 1997-
Oncogenes
Microambiente tumoral
Prognóstico
Terapia de alvo molecular
Tumor microenvironment
Prognosis
Molecular targeted therapy
WNT5A
Artigo original
title_short WNT5A in tumor development and progression : a comprehensive review
title_full WNT5A in tumor development and progression : a comprehensive review
title_fullStr WNT5A in tumor development and progression : a comprehensive review
title_full_unstemmed WNT5A in tumor development and progression : a comprehensive review
title_sort WNT5A in tumor development and progression : a comprehensive review
author Bueno, Maura Lima Pereira, 1997-
author_facet Bueno, Maura Lima Pereira, 1997-
Saad, Sara Teresinha Olalla, 1956-
Roversi, Fernanda Marconi, 1981-
author_role author
author2 Saad, Sara Teresinha Olalla, 1956-
Roversi, Fernanda Marconi, 1981-
author2_role author
author
dc.contributor.none.fl_str_mv UNIVERSIDADE ESTADUAL DE CAMPINAS
dc.contributor.author.fl_str_mv Bueno, Maura Lima Pereira, 1997-
Saad, Sara Teresinha Olalla, 1956-
Roversi, Fernanda Marconi, 1981-
dc.subject.por.fl_str_mv Oncogenes
Microambiente tumoral
Prognóstico
Terapia de alvo molecular
Tumor microenvironment
Prognosis
Molecular targeted therapy
WNT5A
Artigo original
topic Oncogenes
Microambiente tumoral
Prognóstico
Terapia de alvo molecular
Tumor microenvironment
Prognosis
Molecular targeted therapy
WNT5A
Artigo original
description Agradecimentos: The authors received fellowship / grants from the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP Grants 2017/21801-2, 2019/25247-5 and 2021/05320-0) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq Grants 303405/2018-0. The authors would like to thank Raquel S Foglio (Hematology and Hemotherapy Center, University of Campinas, São Paulo, Brazil) for the English revision. The authors thank FAPESP (Grants 2017/21801-2, 2019/25247-5 and 2021/05320-0) and CNPq (Grants 303405/2018-0)
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/20.500.12733/6592
BUENO, Maura Lima Pereira; SAAD, Sara Teresinha Olalla; ROVERSI, Fernanda Marconi. WNT5A in tumor development and progression: a comprehensive review. Biomedicine and pharmacotherapy. Issy-les-Moulineaux: Elsevier, 2022. Vol. 155 (Nov., 2022), n. art. 113599. Disponível em: https://hdl.handle.net/20.500.12733/6592. Acesso em: 24 mai. 2023.
url https://hdl.handle.net/20.500.12733/6592
identifier_str_mv BUENO, Maura Lima Pereira; SAAD, Sara Teresinha Olalla; ROVERSI, Fernanda Marconi. WNT5A in tumor development and progression: a comprehensive review. Biomedicine and pharmacotherapy. Issy-les-Moulineaux: Elsevier, 2022. Vol. 155 (Nov., 2022), n. art. 113599. Disponível em: https://hdl.handle.net/20.500.12733/6592. Acesso em: 24 mai. 2023.
dc.language.iso.fl_str_mv Inglês
language_invalid_str_mv Inglês
dc.relation.none.fl_str_mv https://repositorio.unicamp.br/acervo/detalhe/1255623
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório da Produção Científica e Intelectual da Unicamp
instname:Universidade Estadual de Campinas (UNICAMP)
instacron:UNICAMP
instname_str Universidade Estadual de Campinas (UNICAMP)
instacron_str UNICAMP
institution UNICAMP
reponame_str Repositório da Produção Científica e Intelectual da Unicamp
collection Repositório da Produção Científica e Intelectual da Unicamp
repository.name.fl_str_mv Repositório da Produção Científica e Intelectual da Unicamp - Universidade Estadual de Campinas (UNICAMP)
repository.mail.fl_str_mv reposip@unicamp.br
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