New insights on the regulation of cancer cachexia by N-3 polyunsaturated fatty acids

Detalhes bibliográficos
Autor(a) principal: Sato, Fabio Takeo, 1983-
Data de Publicação: 2019
Tipo de documento: Artigo
Título da fonte: Repositório da Produção Científica e Intelectual da Unicamp
Texto Completo: https://hdl.handle.net/20.500.12733/1661329
Resumo: Agradecimentos: The authors acknowledge the support from Sao Paulo State Research Foundation (FAPESP), Brazil, Coordination for the Improvement of Higher Level of Personnel (CAPES), Brazil, National Council for Scientific and Technological Development (CNPq), Brazil and Dean's Office for Post-graduate Studies and Research of the Cruzeiro do Sul University, Brazil
id CAMP_e396faaefeeb788e109440fba7916f24
oai_identifier_str oai:https://www.repositorio.unicamp.br/:1208922
network_acronym_str CAMP
network_name_str Repositório da Produção Científica e Intelectual da Unicamp
repository_id_str
spelling New insights on the regulation of cancer cachexia by N-3 polyunsaturated fatty acidsInflamaçãoCitocinasProteólisePerda de pesoInflammationCytokinesProteolysisWeight lossN-3 PUFAsTumorProinflammatory cytokinesArtigo originalAgradecimentos: The authors acknowledge the support from Sao Paulo State Research Foundation (FAPESP), Brazil, Coordination for the Improvement of Higher Level of Personnel (CAPES), Brazil, National Council for Scientific and Technological Development (CNPq), Brazil and Dean's Office for Post-graduate Studies and Research of the Cruzeiro do Sul University, BrazilAbstract: Cancer cachexia is a multifactorial syndrome that develops during malignant tumor growth. Changes in plasma levels of several hormones and inflammatory factors result in an intense catabolic state, decreased activity of anabolic pathways, anorexia, and marked weight loss, leading to cachexia development and/or accentuation. Inflammatory mediators appear to be related to the control of a highly regulated process of muscle protein degradation that accelerates the process of cachexia. Several mediators have been postulated to participate in this process, including TNF-a, myostatin, and activated protein degradation pathways. Some interventional therapies have been proposed, including nutritional (dietary, omega-3 fatty acid supplementation), hormonal (insulin), pharmacological (clenbuterol), and nonpharmacological (physical exercise) therapies. Omega-3 (n-3) polyunsaturated fatty acids (PUFAs), especially eicosapentaenoic acid (EPA) and docosahexaenoic acid, are recognized for their anti-inflammatory properties and have been used in therapeutic approaches to treat or attenuate cancer cachexia. In this review, we discuss recent findings on cellular and molecular mechanisms involved in inflammation in the cancer cachexia syndrome and the effectiveness of n-3 PUFAs to attenuate or prevent cancer cachexiaCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESFechadoUNIVERSIDADE ESTADUAL DE CAMPINASSato, Fabio Takeo, 1983-2019info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.12733/1661329SATO, Fabio Takeo. New insights on the regulation of cancer cachexia by N-3 polyunsaturated fatty acids. Pharmacology and therapeutics. Philadelphia, PA : Elsevier, 2019.. Vol. 196 (Apr., 2019), p. 117-134. Disponível em: https://hdl.handle.net/20.500.12733/1661329. Acesso em: 24 mai. 2023.Inglêshttps://repositorio.unicamp.br/acervo/detalhe/1208922reponame:Repositório da Produção Científica e Intelectual da Unicampinstname:Universidade Estadual de Campinas (UNICAMP)instacron:UNICAMPinfo:eu-repo/semantics/openAccess2022-03-31T11:06:40Zoai:https://www.repositorio.unicamp.br/:1208922Repositório InstitucionalPUBhttp://repositorio.unicamp.br/oai/requestreposip@unicamp.bropendoar:2022-03-31T11:06:40Repositório da Produção Científica e Intelectual da Unicamp - Universidade Estadual de Campinas (UNICAMP)false
dc.title.none.fl_str_mv New insights on the regulation of cancer cachexia by N-3 polyunsaturated fatty acids
title New insights on the regulation of cancer cachexia by N-3 polyunsaturated fatty acids
spellingShingle New insights on the regulation of cancer cachexia by N-3 polyunsaturated fatty acids
Sato, Fabio Takeo, 1983-
Inflamação
Citocinas
Proteólise
Perda de peso
Inflammation
Cytokines
Proteolysis
Weight loss
N-3 PUFAs
Tumor
Proinflammatory cytokines
Artigo original
title_short New insights on the regulation of cancer cachexia by N-3 polyunsaturated fatty acids
title_full New insights on the regulation of cancer cachexia by N-3 polyunsaturated fatty acids
title_fullStr New insights on the regulation of cancer cachexia by N-3 polyunsaturated fatty acids
title_full_unstemmed New insights on the regulation of cancer cachexia by N-3 polyunsaturated fatty acids
title_sort New insights on the regulation of cancer cachexia by N-3 polyunsaturated fatty acids
author Sato, Fabio Takeo, 1983-
author_facet Sato, Fabio Takeo, 1983-
author_role author
dc.contributor.none.fl_str_mv UNIVERSIDADE ESTADUAL DE CAMPINAS
dc.contributor.author.fl_str_mv Sato, Fabio Takeo, 1983-
dc.subject.por.fl_str_mv Inflamação
Citocinas
Proteólise
Perda de peso
Inflammation
Cytokines
Proteolysis
Weight loss
N-3 PUFAs
Tumor
Proinflammatory cytokines
Artigo original
topic Inflamação
Citocinas
Proteólise
Perda de peso
Inflammation
Cytokines
Proteolysis
Weight loss
N-3 PUFAs
Tumor
Proinflammatory cytokines
Artigo original
description Agradecimentos: The authors acknowledge the support from Sao Paulo State Research Foundation (FAPESP), Brazil, Coordination for the Improvement of Higher Level of Personnel (CAPES), Brazil, National Council for Scientific and Technological Development (CNPq), Brazil and Dean's Office for Post-graduate Studies and Research of the Cruzeiro do Sul University, Brazil
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/20.500.12733/1661329
SATO, Fabio Takeo. New insights on the regulation of cancer cachexia by N-3 polyunsaturated fatty acids. Pharmacology and therapeutics. Philadelphia, PA : Elsevier, 2019.. Vol. 196 (Apr., 2019), p. 117-134. Disponível em: https://hdl.handle.net/20.500.12733/1661329. Acesso em: 24 mai. 2023.
url https://hdl.handle.net/20.500.12733/1661329
identifier_str_mv SATO, Fabio Takeo. New insights on the regulation of cancer cachexia by N-3 polyunsaturated fatty acids. Pharmacology and therapeutics. Philadelphia, PA : Elsevier, 2019.. Vol. 196 (Apr., 2019), p. 117-134. Disponível em: https://hdl.handle.net/20.500.12733/1661329. Acesso em: 24 mai. 2023.
dc.language.iso.fl_str_mv Inglês
language_invalid_str_mv Inglês
dc.relation.none.fl_str_mv https://repositorio.unicamp.br/acervo/detalhe/1208922
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório da Produção Científica e Intelectual da Unicamp
instname:Universidade Estadual de Campinas (UNICAMP)
instacron:UNICAMP
instname_str Universidade Estadual de Campinas (UNICAMP)
instacron_str UNICAMP
institution UNICAMP
reponame_str Repositório da Produção Científica e Intelectual da Unicamp
collection Repositório da Produção Científica e Intelectual da Unicamp
repository.name.fl_str_mv Repositório da Produção Científica e Intelectual da Unicamp - Universidade Estadual de Campinas (UNICAMP)
repository.mail.fl_str_mv reposip@unicamp.br
_version_ 1766887297748303872

Registros relacionados