Bleeding complications in dengue are not associated with significant changes in the modulators of the endothelial barrier
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , |
| Tipo de documento: | Artigo |
| Título da fonte: | Repositório da Produção Científica e Intelectual da Unicamp |
| Texto Completo: | https://hdl.handle.net/20.500.12733/608 |
Resumo: | Agradecimentos: The authors wish to acknowledge the Hematology and Hemotherapy Center -Hemocentro UNICAMP, which forms part of the National Institute of Science and Technology of Blood, Brazil (INCT do Sangue CNPq/MCT/FAPESP). This work received financial support from Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, Nº: 2008/11518-2).The study was conducted in the Laboratory of Hemostasis. Hematology and Hemotherapy Center, University of Campinas, Campinas, Brazil |
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Bleeding complications in dengue are not associated with significant changes in the modulators of the endothelial barrierDengueDengueBleeding tendencyVEGFComunicaçãoAgradecimentos: The authors wish to acknowledge the Hematology and Hemotherapy Center -Hemocentro UNICAMP, which forms part of the National Institute of Science and Technology of Blood, Brazil (INCT do Sangue CNPq/MCT/FAPESP). This work received financial support from Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, Nº: 2008/11518-2).The study was conducted in the Laboratory of Hemostasis. Hematology and Hemotherapy Center, University of Campinas, Campinas, BrazilAbstract: Bleeding complications in dengue may occur irrespective of the presence of plasma leakage. We compared plasma levels of modulators of the endothelial barrier among three dengue groups: bleedings without plasma leakage, dengue hemorrhagic fever, and non-complicated dengue. The aim was to evaluate whether the presence of subtle alterations in microvascular permeability could be detected in bleeding patients. Plasma levels of VEGF-A and its soluble receptors were not associated with the occurrence of bleeding in patients without plasma leakage. These results provide additional rationale for considering bleeding as a complication independent of endothelial barrier breakdown, as proposed by the 2009 WHO classificationCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPFechadoUNIVERSIDADE ESTADUAL DE CAMPINASOrsi, Fernanda Loureiro de Andrade, 1975-Angerami, Rodrigo NogueiraFonseca, Bruna de Moraes Mazetto, 1987-De Paula, Erich Vinicius, 1972-Annichino-Bizzacchi, Joyce Maria, 1957-2014info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.12733/608ORSI, Fernanda Loureiro de Andrade et al. Bleeding complications in dengue are not associated with significant changes in the modulators of the endothelial barrier. Journal of infection in developing countries. Sassari : The Journal of Infection in Developing Countries, 2014. Vol. 8, n. 6 (June, 2014), p. 799-803. Disponível em: https://hdl.handle.net/20.500.12733/608. Acesso em: 24 mai. 2023.Inglêshttps://repositorio.unicamp.br/acervo/detalhe/1231828reponame:Repositório da Produção Científica e Intelectual da Unicampinstname:Universidade Estadual de Campinas (UNICAMP)instacron:UNICAMPinfo:eu-repo/semantics/openAccess2021-11-16T10:47:36Zoai:https://www.repositorio.unicamp.br/:1231828Repositório InstitucionalPUBhttp://repositorio.unicamp.br/oai/requestreposip@unicamp.bropendoar:2021-11-16T10:47:36Repositório da Produção Científica e Intelectual da Unicamp - Universidade Estadual de Campinas (UNICAMP)false |
| dc.title.none.fl_str_mv |
Bleeding complications in dengue are not associated with significant changes in the modulators of the endothelial barrier |
| title |
Bleeding complications in dengue are not associated with significant changes in the modulators of the endothelial barrier |
| spellingShingle |
Bleeding complications in dengue are not associated with significant changes in the modulators of the endothelial barrier Orsi, Fernanda Loureiro de Andrade, 1975- Dengue Dengue Bleeding tendency VEGF Comunicação |
| title_short |
Bleeding complications in dengue are not associated with significant changes in the modulators of the endothelial barrier |
| title_full |
Bleeding complications in dengue are not associated with significant changes in the modulators of the endothelial barrier |
| title_fullStr |
Bleeding complications in dengue are not associated with significant changes in the modulators of the endothelial barrier |
| title_full_unstemmed |
Bleeding complications in dengue are not associated with significant changes in the modulators of the endothelial barrier |
| title_sort |
Bleeding complications in dengue are not associated with significant changes in the modulators of the endothelial barrier |
| author |
Orsi, Fernanda Loureiro de Andrade, 1975- |
| author_facet |
Orsi, Fernanda Loureiro de Andrade, 1975- Angerami, Rodrigo Nogueira Fonseca, Bruna de Moraes Mazetto, 1987- De Paula, Erich Vinicius, 1972- Annichino-Bizzacchi, Joyce Maria, 1957- |
| author_role |
author |
| author2 |
Angerami, Rodrigo Nogueira Fonseca, Bruna de Moraes Mazetto, 1987- De Paula, Erich Vinicius, 1972- Annichino-Bizzacchi, Joyce Maria, 1957- |
| author2_role |
author author author author |
| dc.contributor.none.fl_str_mv |
UNIVERSIDADE ESTADUAL DE CAMPINAS |
| dc.contributor.author.fl_str_mv |
Orsi, Fernanda Loureiro de Andrade, 1975- Angerami, Rodrigo Nogueira Fonseca, Bruna de Moraes Mazetto, 1987- De Paula, Erich Vinicius, 1972- Annichino-Bizzacchi, Joyce Maria, 1957- |
| dc.subject.por.fl_str_mv |
Dengue Dengue Bleeding tendency VEGF Comunicação |
| topic |
Dengue Dengue Bleeding tendency VEGF Comunicação |
| description |
Agradecimentos: The authors wish to acknowledge the Hematology and Hemotherapy Center -Hemocentro UNICAMP, which forms part of the National Institute of Science and Technology of Blood, Brazil (INCT do Sangue CNPq/MCT/FAPESP). This work received financial support from Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, Nº: 2008/11518-2).The study was conducted in the Laboratory of Hemostasis. Hematology and Hemotherapy Center, University of Campinas, Campinas, Brazil |
| publishDate |
2014 |
| dc.date.none.fl_str_mv |
2014 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/20.500.12733/608 ORSI, Fernanda Loureiro de Andrade et al. Bleeding complications in dengue are not associated with significant changes in the modulators of the endothelial barrier. Journal of infection in developing countries. Sassari : The Journal of Infection in Developing Countries, 2014. Vol. 8, n. 6 (June, 2014), p. 799-803. Disponível em: https://hdl.handle.net/20.500.12733/608. Acesso em: 24 mai. 2023. |
| url |
https://hdl.handle.net/20.500.12733/608 |
| identifier_str_mv |
ORSI, Fernanda Loureiro de Andrade et al. Bleeding complications in dengue are not associated with significant changes in the modulators of the endothelial barrier. Journal of infection in developing countries. Sassari : The Journal of Infection in Developing Countries, 2014. Vol. 8, n. 6 (June, 2014), p. 799-803. Disponível em: https://hdl.handle.net/20.500.12733/608. Acesso em: 24 mai. 2023. |
| dc.language.iso.fl_str_mv |
Inglês |
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Inglês |
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https://repositorio.unicamp.br/acervo/detalhe/1231828 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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reponame:Repositório da Produção Científica e Intelectual da Unicamp instname:Universidade Estadual de Campinas (UNICAMP) instacron:UNICAMP |
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Universidade Estadual de Campinas (UNICAMP) |
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UNICAMP |
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UNICAMP |
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Repositório da Produção Científica e Intelectual da Unicamp |
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Repositório da Produção Científica e Intelectual da Unicamp |
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Repositório da Produção Científica e Intelectual da Unicamp - Universidade Estadual de Campinas (UNICAMP) |
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reposip@unicamp.br |
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