Metabolic syndrome in HIV-infected middle-aged women on antiretroviral therapy : prevalence and associated factors
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Título da fonte: | Repositório da Produção Científica e Intelectual da Unicamp |
Texto Completo: | https://hdl.handle.net/20.500.12733/638 |
Resumo: | Abstract: To determine the prevalence of metabolic syndrome (MetS) and its associated factors in a group of HIV-infected middle-aged women. Cross-sectional study including 273 HIV-infected climacteric women of 40–60 years of age under care in two HIV outpatient reference centers in Brazil. Metabolic syndrome diagnosis was based on 2006 International Diabetes Federation criteria. Sociodemographic, clinical and behavioral factors were evaluated as well as HIV infection-related parameters. Mean age was 47.7 years; 59.1% of women were premenopausal, 91% were on antiretroviral therapy. Current CD4 count was >500 cells/mm 3 in 61.7%, current viral load undetectable in 76.9% of women, and a quarter had previous diagnosis of aids. The prevalence of metabolic syndrome in the subgroup of menopausal women was 46.9%. Univariate analysis showed an association between metabolic syndrome and age =50 years ( p = 0.002), schooling <8 years ( p = 0.003), post-menopause ( p < 0.001), body mass index (BMI) >25 kg/m 2 ( p < 0.001), and FSH =40 mIU/mL ( p = 0.002). In the multivariate analysis only increased BMI (PR = 1.09; 95% CI: 1.05–1.13; p < 0.001) and FSH levels =40 mIU/mL (PR = 1.66; 95% CI: 1.14–2.40; p = 0.008) maintained statistical significance. There was no association between PI use or any other factor related to HIV-infection and MetS in any of the analyses performed. High BMI and FSH levels compatible with menopause were the only factors associated with MetS in these middle aged HIV-infected women. In the context of well-controlled, early treated HIV infection, traditional rather than HIV-related factors were associated with MetS |
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Metabolic syndrome in HIV-infected middle-aged women on antiretroviral therapy : prevalence and associated factorsSíndrome metabólicaMetabolic syndromeMenopauseHIVProtease inhibitorsArtigo originalAbstract: To determine the prevalence of metabolic syndrome (MetS) and its associated factors in a group of HIV-infected middle-aged women. Cross-sectional study including 273 HIV-infected climacteric women of 40–60 years of age under care in two HIV outpatient reference centers in Brazil. Metabolic syndrome diagnosis was based on 2006 International Diabetes Federation criteria. Sociodemographic, clinical and behavioral factors were evaluated as well as HIV infection-related parameters. Mean age was 47.7 years; 59.1% of women were premenopausal, 91% were on antiretroviral therapy. Current CD4 count was >500 cells/mm 3 in 61.7%, current viral load undetectable in 76.9% of women, and a quarter had previous diagnosis of aids. The prevalence of metabolic syndrome in the subgroup of menopausal women was 46.9%. Univariate analysis showed an association between metabolic syndrome and age =50 years ( p = 0.002), schooling <8 years ( p = 0.003), post-menopause ( p < 0.001), body mass index (BMI) >25 kg/m 2 ( p < 0.001), and FSH =40 mIU/mL ( p = 0.002). In the multivariate analysis only increased BMI (PR = 1.09; 95% CI: 1.05–1.13; p < 0.001) and FSH levels =40 mIU/mL (PR = 1.66; 95% CI: 1.14–2.40; p = 0.008) maintained statistical significance. There was no association between PI use or any other factor related to HIV-infection and MetS in any of the analyses performed. High BMI and FSH levels compatible with menopause were the only factors associated with MetS in these middle aged HIV-infected women. In the context of well-controlled, early treated HIV infection, traditional rather than HIV-related factors were associated with MetSFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPAbertoUNIVERSIDADE ESTADUAL DE CAMPINASValadares, Ana Lúcia Ribeiro, 1954-Moraes, Monica Jacques dePinto-Neto, Aarão Mendes, 1952-2015Costa-Paiva, Lucia, 1958-2016info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.12733/638VALADARES, Ana Lúcia Ribeiro et al. Metabolic syndrome in HIV-infected middle-aged women on antiretroviral therapy: prevalence and associated factors. Brazilian journal of infectious diseases. Barcelona : Elsevier, 2016. Vol. 21, n. 3 (2016), p. 263-269. Disponível em: https://hdl.handle.net/20.500.12733/638. Acesso em: 24 mai. 2023.Inglêshttps://repositorio.unicamp.br/acervo/detalhe/1231905reponame:Repositório da Produção Científica e Intelectual da Unicampinstname:Universidade Estadual de Campinas (UNICAMP)instacron:UNICAMPinfo:eu-repo/semantics/openAccess2021-11-16T15:04:38Zoai:https://www.repositorio.unicamp.br/:1231905Repositório InstitucionalPUBhttp://repositorio.unicamp.br/oai/requestreposip@unicamp.bropendoar:2021-11-16T15:04:38Repositório da Produção Científica e Intelectual da Unicamp - Universidade Estadual de Campinas (UNICAMP)false |
dc.title.none.fl_str_mv |
Metabolic syndrome in HIV-infected middle-aged women on antiretroviral therapy : prevalence and associated factors |
title |
Metabolic syndrome in HIV-infected middle-aged women on antiretroviral therapy : prevalence and associated factors |
spellingShingle |
Metabolic syndrome in HIV-infected middle-aged women on antiretroviral therapy : prevalence and associated factors Valadares, Ana Lúcia Ribeiro, 1954- Síndrome metabólica Metabolic syndrome Menopause HIV Protease inhibitors Artigo original |
title_short |
Metabolic syndrome in HIV-infected middle-aged women on antiretroviral therapy : prevalence and associated factors |
title_full |
Metabolic syndrome in HIV-infected middle-aged women on antiretroviral therapy : prevalence and associated factors |
title_fullStr |
Metabolic syndrome in HIV-infected middle-aged women on antiretroviral therapy : prevalence and associated factors |
title_full_unstemmed |
Metabolic syndrome in HIV-infected middle-aged women on antiretroviral therapy : prevalence and associated factors |
title_sort |
Metabolic syndrome in HIV-infected middle-aged women on antiretroviral therapy : prevalence and associated factors |
author |
Valadares, Ana Lúcia Ribeiro, 1954- |
author_facet |
Valadares, Ana Lúcia Ribeiro, 1954- Moraes, Monica Jacques de Pinto-Neto, Aarão Mendes, 1952-2015 Costa-Paiva, Lucia, 1958- |
author_role |
author |
author2 |
Moraes, Monica Jacques de Pinto-Neto, Aarão Mendes, 1952-2015 Costa-Paiva, Lucia, 1958- |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
UNIVERSIDADE ESTADUAL DE CAMPINAS |
dc.contributor.author.fl_str_mv |
Valadares, Ana Lúcia Ribeiro, 1954- Moraes, Monica Jacques de Pinto-Neto, Aarão Mendes, 1952-2015 Costa-Paiva, Lucia, 1958- |
dc.subject.por.fl_str_mv |
Síndrome metabólica Metabolic syndrome Menopause HIV Protease inhibitors Artigo original |
topic |
Síndrome metabólica Metabolic syndrome Menopause HIV Protease inhibitors Artigo original |
description |
Abstract: To determine the prevalence of metabolic syndrome (MetS) and its associated factors in a group of HIV-infected middle-aged women. Cross-sectional study including 273 HIV-infected climacteric women of 40–60 years of age under care in two HIV outpatient reference centers in Brazil. Metabolic syndrome diagnosis was based on 2006 International Diabetes Federation criteria. Sociodemographic, clinical and behavioral factors were evaluated as well as HIV infection-related parameters. Mean age was 47.7 years; 59.1% of women were premenopausal, 91% were on antiretroviral therapy. Current CD4 count was >500 cells/mm 3 in 61.7%, current viral load undetectable in 76.9% of women, and a quarter had previous diagnosis of aids. The prevalence of metabolic syndrome in the subgroup of menopausal women was 46.9%. Univariate analysis showed an association between metabolic syndrome and age =50 years ( p = 0.002), schooling <8 years ( p = 0.003), post-menopause ( p < 0.001), body mass index (BMI) >25 kg/m 2 ( p < 0.001), and FSH =40 mIU/mL ( p = 0.002). In the multivariate analysis only increased BMI (PR = 1.09; 95% CI: 1.05–1.13; p < 0.001) and FSH levels =40 mIU/mL (PR = 1.66; 95% CI: 1.14–2.40; p = 0.008) maintained statistical significance. There was no association between PI use or any other factor related to HIV-infection and MetS in any of the analyses performed. High BMI and FSH levels compatible with menopause were the only factors associated with MetS in these middle aged HIV-infected women. In the context of well-controlled, early treated HIV infection, traditional rather than HIV-related factors were associated with MetS |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/20.500.12733/638 VALADARES, Ana Lúcia Ribeiro et al. Metabolic syndrome in HIV-infected middle-aged women on antiretroviral therapy: prevalence and associated factors. Brazilian journal of infectious diseases. Barcelona : Elsevier, 2016. Vol. 21, n. 3 (2016), p. 263-269. Disponível em: https://hdl.handle.net/20.500.12733/638. Acesso em: 24 mai. 2023. |
url |
https://hdl.handle.net/20.500.12733/638 |
identifier_str_mv |
VALADARES, Ana Lúcia Ribeiro et al. Metabolic syndrome in HIV-infected middle-aged women on antiretroviral therapy: prevalence and associated factors. Brazilian journal of infectious diseases. Barcelona : Elsevier, 2016. Vol. 21, n. 3 (2016), p. 263-269. Disponível em: https://hdl.handle.net/20.500.12733/638. Acesso em: 24 mai. 2023. |
dc.language.iso.fl_str_mv |
Inglês |
language_invalid_str_mv |
Inglês |
dc.relation.none.fl_str_mv |
https://repositorio.unicamp.br/acervo/detalhe/1231905 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório da Produção Científica e Intelectual da Unicamp instname:Universidade Estadual de Campinas (UNICAMP) instacron:UNICAMP |
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Universidade Estadual de Campinas (UNICAMP) |
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UNICAMP |
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UNICAMP |
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Repositório da Produção Científica e Intelectual da Unicamp |
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Repositório da Produção Científica e Intelectual da Unicamp |
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Repositório da Produção Científica e Intelectual da Unicamp - Universidade Estadual de Campinas (UNICAMP) |
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reposip@unicamp.br |
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