Curbing Inflammation in hemorrhagic trauma: a review
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Colégio Brasileiro de Cirurgiões |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912015000500273 |
Resumo: | Trauma is one of the world's leading causes of death within the first 40 years of life and thus a significant health problem. Trauma accounts for nearly a third of the lost years of productive life before 65 years of age and is associated with infection, hemorrhagic shock, reperfusion syndrome, and inflammation. The control of hemorrhage, coagulopathy, optimal use of blood products, balancing hypo and hyperperfusion, and hemostatic resuscitation improve survival in cases of trauma with massive hemorrhage. This review discusses inflammation in the context of trauma-associated hemorrhagic shock. When one considers the known immunomodulatory effects of traumatic injury, allogeneic blood transfusion, and the overlap between patient populations, it is surprising that so few studies have assessed their combined effects on immune function. We also discuss the relative benefits of curbing inflammation rather than attempting to prevent it. |
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Curbing Inflammation in hemorrhagic trauma: a reviewWounds and InjuriesTraumatologyMultiple TraumaBlood TransfusionInflammation MediatorsImmunologic FactorsTrauma is one of the world's leading causes of death within the first 40 years of life and thus a significant health problem. Trauma accounts for nearly a third of the lost years of productive life before 65 years of age and is associated with infection, hemorrhagic shock, reperfusion syndrome, and inflammation. The control of hemorrhage, coagulopathy, optimal use of blood products, balancing hypo and hyperperfusion, and hemostatic resuscitation improve survival in cases of trauma with massive hemorrhage. This review discusses inflammation in the context of trauma-associated hemorrhagic shock. When one considers the known immunomodulatory effects of traumatic injury, allogeneic blood transfusion, and the overlap between patient populations, it is surprising that so few studies have assessed their combined effects on immune function. We also discuss the relative benefits of curbing inflammation rather than attempting to prevent it.Colégio Brasileiro de Cirurgiões2015-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912015000500273Revista do Colégio Brasileiro de Cirurgiões v.42 n.4 2015reponame:Revista do Colégio Brasileiro de Cirurgiõesinstname:Colégio Brasileiro de Cirurgiões (CBC)instacron:CBC10.1590/0100-69912015004013info:eu-repo/semantics/openAccessGODINHO,MAURICIOPADIM,PEDROEVORA,PAULO ROBERTO B.SCARPELINI,SANDROeng2015-10-23T00:00:00Zoai:scielo:S0100-69912015000500273Revistahttp://www.scielo.br/rcbcONGhttps://old.scielo.br/oai/scielo-oai.php||revistacbc@cbc.org.br1809-45460100-6991opendoar:2015-10-23T00:00Revista do Colégio Brasileiro de Cirurgiões - Colégio Brasileiro de Cirurgiões (CBC)false |
dc.title.none.fl_str_mv |
Curbing Inflammation in hemorrhagic trauma: a review |
title |
Curbing Inflammation in hemorrhagic trauma: a review |
spellingShingle |
Curbing Inflammation in hemorrhagic trauma: a review GODINHO,MAURICIO Wounds and Injuries Traumatology Multiple Trauma Blood Transfusion Inflammation Mediators Immunologic Factors |
title_short |
Curbing Inflammation in hemorrhagic trauma: a review |
title_full |
Curbing Inflammation in hemorrhagic trauma: a review |
title_fullStr |
Curbing Inflammation in hemorrhagic trauma: a review |
title_full_unstemmed |
Curbing Inflammation in hemorrhagic trauma: a review |
title_sort |
Curbing Inflammation in hemorrhagic trauma: a review |
author |
GODINHO,MAURICIO |
author_facet |
GODINHO,MAURICIO PADIM,PEDRO EVORA,PAULO ROBERTO B. SCARPELINI,SANDRO |
author_role |
author |
author2 |
PADIM,PEDRO EVORA,PAULO ROBERTO B. SCARPELINI,SANDRO |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
GODINHO,MAURICIO PADIM,PEDRO EVORA,PAULO ROBERTO B. SCARPELINI,SANDRO |
dc.subject.por.fl_str_mv |
Wounds and Injuries Traumatology Multiple Trauma Blood Transfusion Inflammation Mediators Immunologic Factors |
topic |
Wounds and Injuries Traumatology Multiple Trauma Blood Transfusion Inflammation Mediators Immunologic Factors |
description |
Trauma is one of the world's leading causes of death within the first 40 years of life and thus a significant health problem. Trauma accounts for nearly a third of the lost years of productive life before 65 years of age and is associated with infection, hemorrhagic shock, reperfusion syndrome, and inflammation. The control of hemorrhage, coagulopathy, optimal use of blood products, balancing hypo and hyperperfusion, and hemostatic resuscitation improve survival in cases of trauma with massive hemorrhage. This review discusses inflammation in the context of trauma-associated hemorrhagic shock. When one considers the known immunomodulatory effects of traumatic injury, allogeneic blood transfusion, and the overlap between patient populations, it is surprising that so few studies have assessed their combined effects on immune function. We also discuss the relative benefits of curbing inflammation rather than attempting to prevent it. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912015000500273 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912015000500273 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0100-69912015004013 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Colégio Brasileiro de Cirurgiões |
publisher.none.fl_str_mv |
Colégio Brasileiro de Cirurgiões |
dc.source.none.fl_str_mv |
Revista do Colégio Brasileiro de Cirurgiões v.42 n.4 2015 reponame:Revista do Colégio Brasileiro de Cirurgiões instname:Colégio Brasileiro de Cirurgiões (CBC) instacron:CBC |
instname_str |
Colégio Brasileiro de Cirurgiões (CBC) |
instacron_str |
CBC |
institution |
CBC |
reponame_str |
Revista do Colégio Brasileiro de Cirurgiões |
collection |
Revista do Colégio Brasileiro de Cirurgiões |
repository.name.fl_str_mv |
Revista do Colégio Brasileiro de Cirurgiões - Colégio Brasileiro de Cirurgiões (CBC) |
repository.mail.fl_str_mv |
||revistacbc@cbc.org.br |
_version_ |
1754209213139124224 |