Iliac artery myointimal hyperplasia in rabbits submitted to angioplasty and treated with Moringa oleifera

• Main Author: Rolim,Jânio Cipriano
• Publication Date: 2016
• Other Authors: Nogueira,Manoel Ricardo Sena, Lima,Paulo Roberto da Silva, Bandeira,Francisco Chavier Vieira, Pordeus,Mizael Armando Abrantes, Castro,Aldemar Araújo, Pitta,Guilherme Benjamin, Diniz,Margareth de Fátima Formiga Melo, Pereira,Adamastor Humberto
• Format: Article
• Language: eng
• Source: Revista do Colégio Brasileiro de Cirurgiões
• Download full: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912016000100028
• topic: Hyperplasia; Ilíac Artery; Moringa oleifera; Angioplasty; Rabbits

Objective: to assess post-angioplasty myointimal hyperplasia in iliac artery of rabbits treated with extract of Moringa oleifera leaves. Methods : we conducted a randomized trial in laboratory animals for five weeks of follow-up, developed in the Vivarium of Pharmaceutical Technology Laboratory of the Universidade Federal da Paraíba. We used rabbits from the New Zealand breed, subjected to a hypercholesterolemic diet and angioplasty of the external iliac artery, randomized into two groups: M200 Group (n=10) - rabbits treated with 200mg/kg/day of Moringa oleifera leaves extract orally; SF group (n=10) - rabbits treated with 0.9% saline orally. After five weeks, the animals were euthanized and the iliac arteries prepared for histology. Histological sections were analyzed by digital morphometry. Statistical analysis was performed using the Student's t test. The significance level was 0.05. Results : there was no significant difference in myointimal hyperplasia between M200 and SF groups when comparing the iliac arteries submitted to angioplasty. Conclusion : there was no difference of myointimal hyperplasia between groups treated with saline and Moringa oleifera after angioplasty.