Comparative study of the different degrees of risk of gastrointestinal stromal tumor
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Colégio Brasileiro de Cirurgiões |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912015000200032 |
Resumo: | OBJECTIVE: To evaluate the applicability of the main categories of risk and morphological factors in the prognosis of gastrointestinal stromal tumors. METHODS: we retrospectively studied fifty-four cases of GIST, assessing the main prognostic factors of this neoplasis: risk levels, topography, size, mitotic index, necrosis, histological subtype and immunophenotype. We also verified their association and the reduction of overall survival. RESULTS: Univariate analysis showed that tumors with mitoses number greater than 5 per 50CGA (high-power fields), the presence of necrosis and a high risk for both the systems proposed by Fletcher and Miettinen had a significant association with reduced survival (p = 0.00001, 0.0056, 0.03 and 0.009, respectively). The remaining analyzed factors (size, histological subtype, topography and immunophenotype) had no such association. Multivariate analysis (Jacard index) showed that the Miettinen degree of risk was the one that best correlated with prognosis. CONCLUSION: the risk criteria of Fletcher and Miettinen are important in assessing the prognosis of patients with gastrointestinal stromal tumors, especially the latter, which adds to the mitotic index and the presence of tumor necrosis. |
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Comparative study of the different degrees of risk of gastrointestinal stromal tumorGastrointestinal Stromal TumorsRisk FactorsDigestive System NeoplasmsPrognosisMitotic Index OBJECTIVE: To evaluate the applicability of the main categories of risk and morphological factors in the prognosis of gastrointestinal stromal tumors. METHODS: we retrospectively studied fifty-four cases of GIST, assessing the main prognostic factors of this neoplasis: risk levels, topography, size, mitotic index, necrosis, histological subtype and immunophenotype. We also verified their association and the reduction of overall survival. RESULTS: Univariate analysis showed that tumors with mitoses number greater than 5 per 50CGA (high-power fields), the presence of necrosis and a high risk for both the systems proposed by Fletcher and Miettinen had a significant association with reduced survival (p = 0.00001, 0.0056, 0.03 and 0.009, respectively). The remaining analyzed factors (size, histological subtype, topography and immunophenotype) had no such association. Multivariate analysis (Jacard index) showed that the Miettinen degree of risk was the one that best correlated with prognosis. CONCLUSION: the risk criteria of Fletcher and Miettinen are important in assessing the prognosis of patients with gastrointestinal stromal tumors, especially the latter, which adds to the mitotic index and the presence of tumor necrosis. Colégio Brasileiro de Cirurgiões2015-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912015000200032Revista do Colégio Brasileiro de Cirurgiões v.42 n.1 2015reponame:Revista do Colégio Brasileiro de Cirurgiõesinstname:Colégio Brasileiro de Cirurgiões (CBC)instacron:CBC10.1590/0100-69912015001007info:eu-repo/semantics/openAccessOliveira,Rodrigo Panno Basilio dePortari Filho,Pedro EderIglesias,Antonio CarlosOliveira,Carlos Alberto Basilio dePannain,Vera Lucia Nuneseng2015-08-04T00:00:00Zoai:scielo:S0100-69912015000200032Revistahttp://www.scielo.br/rcbcONGhttps://old.scielo.br/oai/scielo-oai.php||revistacbc@cbc.org.br1809-45460100-6991opendoar:2015-08-04T00:00Revista do Colégio Brasileiro de Cirurgiões - Colégio Brasileiro de Cirurgiões (CBC)false |
dc.title.none.fl_str_mv |
Comparative study of the different degrees of risk of gastrointestinal stromal tumor |
title |
Comparative study of the different degrees of risk of gastrointestinal stromal tumor |
spellingShingle |
Comparative study of the different degrees of risk of gastrointestinal stromal tumor Oliveira,Rodrigo Panno Basilio de Gastrointestinal Stromal Tumors Risk Factors Digestive System Neoplasms Prognosis Mitotic Index |
title_short |
Comparative study of the different degrees of risk of gastrointestinal stromal tumor |
title_full |
Comparative study of the different degrees of risk of gastrointestinal stromal tumor |
title_fullStr |
Comparative study of the different degrees of risk of gastrointestinal stromal tumor |
title_full_unstemmed |
Comparative study of the different degrees of risk of gastrointestinal stromal tumor |
title_sort |
Comparative study of the different degrees of risk of gastrointestinal stromal tumor |
author |
Oliveira,Rodrigo Panno Basilio de |
author_facet |
Oliveira,Rodrigo Panno Basilio de Portari Filho,Pedro Eder Iglesias,Antonio Carlos Oliveira,Carlos Alberto Basilio de Pannain,Vera Lucia Nunes |
author_role |
author |
author2 |
Portari Filho,Pedro Eder Iglesias,Antonio Carlos Oliveira,Carlos Alberto Basilio de Pannain,Vera Lucia Nunes |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Oliveira,Rodrigo Panno Basilio de Portari Filho,Pedro Eder Iglesias,Antonio Carlos Oliveira,Carlos Alberto Basilio de Pannain,Vera Lucia Nunes |
dc.subject.por.fl_str_mv |
Gastrointestinal Stromal Tumors Risk Factors Digestive System Neoplasms Prognosis Mitotic Index |
topic |
Gastrointestinal Stromal Tumors Risk Factors Digestive System Neoplasms Prognosis Mitotic Index |
description |
OBJECTIVE: To evaluate the applicability of the main categories of risk and morphological factors in the prognosis of gastrointestinal stromal tumors. METHODS: we retrospectively studied fifty-four cases of GIST, assessing the main prognostic factors of this neoplasis: risk levels, topography, size, mitotic index, necrosis, histological subtype and immunophenotype. We also verified their association and the reduction of overall survival. RESULTS: Univariate analysis showed that tumors with mitoses number greater than 5 per 50CGA (high-power fields), the presence of necrosis and a high risk for both the systems proposed by Fletcher and Miettinen had a significant association with reduced survival (p = 0.00001, 0.0056, 0.03 and 0.009, respectively). The remaining analyzed factors (size, histological subtype, topography and immunophenotype) had no such association. Multivariate analysis (Jacard index) showed that the Miettinen degree of risk was the one that best correlated with prognosis. CONCLUSION: the risk criteria of Fletcher and Miettinen are important in assessing the prognosis of patients with gastrointestinal stromal tumors, especially the latter, which adds to the mitotic index and the presence of tumor necrosis. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912015000200032 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912015000200032 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0100-69912015001007 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Colégio Brasileiro de Cirurgiões |
publisher.none.fl_str_mv |
Colégio Brasileiro de Cirurgiões |
dc.source.none.fl_str_mv |
Revista do Colégio Brasileiro de Cirurgiões v.42 n.1 2015 reponame:Revista do Colégio Brasileiro de Cirurgiões instname:Colégio Brasileiro de Cirurgiões (CBC) instacron:CBC |
instname_str |
Colégio Brasileiro de Cirurgiões (CBC) |
instacron_str |
CBC |
institution |
CBC |
reponame_str |
Revista do Colégio Brasileiro de Cirurgiões |
collection |
Revista do Colégio Brasileiro de Cirurgiões |
repository.name.fl_str_mv |
Revista do Colégio Brasileiro de Cirurgiões - Colégio Brasileiro de Cirurgiões (CBC) |
repository.mail.fl_str_mv |
||revistacbc@cbc.org.br |
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1754209212770025472 |