Acetylsalicylic acid (Aspirin®) and liver regeneration: experimental study in rats
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Colégio Brasileiro de Cirurgiões |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912021000100230 |
Resumo: | ABSTRACT Objective: to evaluate the influence of acetylsalicylic acid (ASA) on cell proliferation after partial hepatectomy in rats. Methods: 40 male Wistar rats were separated into four groups of ten rats each. Groups 1 and 2 (controls): undergoing 30% partial hepatectomy and, after one day (group 1) and seven days (group 2), to euthanasia; daily administration of 0.9% saline solution (1mL per 200g of body weight). Groups 3 and 4 (experimental): undergoing 30% partial hepatectomy and, after one day (group 3) and seven days (group 4), to euthanasia; daily administration of ASA (40mg/mL, 1mL per 200g of body weight). The absolute number of cells stained with PCNA was counted in photomicrographs, in five fields, and it was calculated the mean of positive cells per animal and per group. Results: the final mean of PCNA+ cells per group was: in group 1, 17.57 ± 6.77; in group 2, 19.31 ± 5.30; in group 3, 27.46 ± 11.55; and, in group 4, 12.40 ± 5.23. There was no significant difference at the two evaluation times in the control group (p=0.491), but there was in the experimental group (p=0.020), with a lower number of PCNA+ cells on the seventh day. The comparison between the two groups, on the first day, showed more PCNA+ cells in the livers of the animals that received ASA (p=0.047), and on the seventh day the number was lower in the experimental group (p=0.007). Conclusion: ASA induced greater hepatocyte proliferation. |
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Revista do Colégio Brasileiro de Cirurgiões |
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Acetylsalicylic acid (Aspirin®) and liver regeneration: experimental study in ratsLiver RegenerationAspirinHepatectomyABSTRACT Objective: to evaluate the influence of acetylsalicylic acid (ASA) on cell proliferation after partial hepatectomy in rats. Methods: 40 male Wistar rats were separated into four groups of ten rats each. Groups 1 and 2 (controls): undergoing 30% partial hepatectomy and, after one day (group 1) and seven days (group 2), to euthanasia; daily administration of 0.9% saline solution (1mL per 200g of body weight). Groups 3 and 4 (experimental): undergoing 30% partial hepatectomy and, after one day (group 3) and seven days (group 4), to euthanasia; daily administration of ASA (40mg/mL, 1mL per 200g of body weight). The absolute number of cells stained with PCNA was counted in photomicrographs, in five fields, and it was calculated the mean of positive cells per animal and per group. Results: the final mean of PCNA+ cells per group was: in group 1, 17.57 ± 6.77; in group 2, 19.31 ± 5.30; in group 3, 27.46 ± 11.55; and, in group 4, 12.40 ± 5.23. There was no significant difference at the two evaluation times in the control group (p=0.491), but there was in the experimental group (p=0.020), with a lower number of PCNA+ cells on the seventh day. The comparison between the two groups, on the first day, showed more PCNA+ cells in the livers of the animals that received ASA (p=0.047), and on the seventh day the number was lower in the experimental group (p=0.007). Conclusion: ASA induced greater hepatocyte proliferation.Colégio Brasileiro de Cirurgiões2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912021000100230Revista do Colégio Brasileiro de Cirurgiões v.48 2021reponame:Revista do Colégio Brasileiro de Cirurgiõesinstname:Colégio Brasileiro de Cirurgiões (CBC)instacron:CBC10.1590/0100-6991e-20213164info:eu-repo/semantics/openAccessBIONDO-SIMÕES,MARIA DE LOURDES PESSOLEPESSINI,VICTOR CEZAR DE AZEVEDOICHI,CAROLINA AYUMIROBES,ROGÉRIO RIBEIROIOSHII,SÉRGIOeng2021-11-19T00:00:00Zoai:scielo:S0100-69912021000100230Revistahttp://www.scielo.br/rcbcONGhttps://old.scielo.br/oai/scielo-oai.php||revistacbc@cbc.org.br1809-45460100-6991opendoar:2021-11-19T00:00Revista do Colégio Brasileiro de Cirurgiões - Colégio Brasileiro de Cirurgiões (CBC)false |
dc.title.none.fl_str_mv |
Acetylsalicylic acid (Aspirin®) and liver regeneration: experimental study in rats |
title |
Acetylsalicylic acid (Aspirin®) and liver regeneration: experimental study in rats |
spellingShingle |
Acetylsalicylic acid (Aspirin®) and liver regeneration: experimental study in rats BIONDO-SIMÕES,MARIA DE LOURDES PESSOLE Liver Regeneration Aspirin Hepatectomy |
title_short |
Acetylsalicylic acid (Aspirin®) and liver regeneration: experimental study in rats |
title_full |
Acetylsalicylic acid (Aspirin®) and liver regeneration: experimental study in rats |
title_fullStr |
Acetylsalicylic acid (Aspirin®) and liver regeneration: experimental study in rats |
title_full_unstemmed |
Acetylsalicylic acid (Aspirin®) and liver regeneration: experimental study in rats |
title_sort |
Acetylsalicylic acid (Aspirin®) and liver regeneration: experimental study in rats |
author |
BIONDO-SIMÕES,MARIA DE LOURDES PESSOLE |
author_facet |
BIONDO-SIMÕES,MARIA DE LOURDES PESSOLE PESSINI,VICTOR CEZAR DE AZEVEDO ICHI,CAROLINA AYUMI ROBES,ROGÉRIO RIBEIRO IOSHII,SÉRGIO |
author_role |
author |
author2 |
PESSINI,VICTOR CEZAR DE AZEVEDO ICHI,CAROLINA AYUMI ROBES,ROGÉRIO RIBEIRO IOSHII,SÉRGIO |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
BIONDO-SIMÕES,MARIA DE LOURDES PESSOLE PESSINI,VICTOR CEZAR DE AZEVEDO ICHI,CAROLINA AYUMI ROBES,ROGÉRIO RIBEIRO IOSHII,SÉRGIO |
dc.subject.por.fl_str_mv |
Liver Regeneration Aspirin Hepatectomy |
topic |
Liver Regeneration Aspirin Hepatectomy |
description |
ABSTRACT Objective: to evaluate the influence of acetylsalicylic acid (ASA) on cell proliferation after partial hepatectomy in rats. Methods: 40 male Wistar rats were separated into four groups of ten rats each. Groups 1 and 2 (controls): undergoing 30% partial hepatectomy and, after one day (group 1) and seven days (group 2), to euthanasia; daily administration of 0.9% saline solution (1mL per 200g of body weight). Groups 3 and 4 (experimental): undergoing 30% partial hepatectomy and, after one day (group 3) and seven days (group 4), to euthanasia; daily administration of ASA (40mg/mL, 1mL per 200g of body weight). The absolute number of cells stained with PCNA was counted in photomicrographs, in five fields, and it was calculated the mean of positive cells per animal and per group. Results: the final mean of PCNA+ cells per group was: in group 1, 17.57 ± 6.77; in group 2, 19.31 ± 5.30; in group 3, 27.46 ± 11.55; and, in group 4, 12.40 ± 5.23. There was no significant difference at the two evaluation times in the control group (p=0.491), but there was in the experimental group (p=0.020), with a lower number of PCNA+ cells on the seventh day. The comparison between the two groups, on the first day, showed more PCNA+ cells in the livers of the animals that received ASA (p=0.047), and on the seventh day the number was lower in the experimental group (p=0.007). Conclusion: ASA induced greater hepatocyte proliferation. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912021000100230 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912021000100230 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0100-6991e-20213164 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Colégio Brasileiro de Cirurgiões |
publisher.none.fl_str_mv |
Colégio Brasileiro de Cirurgiões |
dc.source.none.fl_str_mv |
Revista do Colégio Brasileiro de Cirurgiões v.48 2021 reponame:Revista do Colégio Brasileiro de Cirurgiões instname:Colégio Brasileiro de Cirurgiões (CBC) instacron:CBC |
instname_str |
Colégio Brasileiro de Cirurgiões (CBC) |
instacron_str |
CBC |
institution |
CBC |
reponame_str |
Revista do Colégio Brasileiro de Cirurgiões |
collection |
Revista do Colégio Brasileiro de Cirurgiões |
repository.name.fl_str_mv |
Revista do Colégio Brasileiro de Cirurgiões - Colégio Brasileiro de Cirurgiões (CBC) |
repository.mail.fl_str_mv |
||revistacbc@cbc.org.br |
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1754209215104155648 |