LACTATE CAN BE A MARKER OF METABOLIC SYNDROME IN SEVERE OBESITY?

Detalhes bibliográficos
Autor(a) principal: DE-CLEVA,Roberto
Data de Publicação: 2021
Outros Autores: CARDIA,Lilian, VIEIRA-GADDUCCI,Alexandre, GREVE,Julia Maria, SANTO,Marco Aurelio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202021000100313
Resumo: ABSTRACT Background: In the last decades, numerous studies have confirmed the importance of lactate - by-product to the nutrient signal of the intracellular redox state - to regulatory functions in energy metabolism. Aim: To evaluate changes in blood lactate in patients with severe obesity and its correlation with body composition and metabolic profile. Methods: Twenty-four people with severe obesity (BMI=40 kg/m2) were evaluated in a prospective case-control study before and six months after Roux-in-Y gastric bypass. The blood lactate, total cholesterol, and fractions, C-reactive protein and HOMA-IR were analyzed after 12 h fasting. Body mass composition was evaluated by bioelectrical impedance and respiratory quotient was measured by indirect calorimetry. Results: The initial lactate level was 2.5±1.1 mmol/l and returned to normal level (1.9±3.6 mmol/l, p=0.0018) after surgery. This reduction was positively correlated with a decrease in BMI (p=0.0001), % free fat mass (p=0,001), % fat mass (p=0.001) and HOMA-IR (p=0.01). There was normalization of lactatemia in 70% of patients. There was no correlation between lactatemia and C-reactive protein. Conclusions: There was a significant improvement of metabolic parameters, normalization of blood lactate, fat mass loss, although these individuals remained with a high BMI.
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spelling LACTATE CAN BE A MARKER OF METABOLIC SYNDROME IN SEVERE OBESITY?ObesityBariatric surgeryLactic acidMetabolic syndromeBody compositionABSTRACT Background: In the last decades, numerous studies have confirmed the importance of lactate - by-product to the nutrient signal of the intracellular redox state - to regulatory functions in energy metabolism. Aim: To evaluate changes in blood lactate in patients with severe obesity and its correlation with body composition and metabolic profile. Methods: Twenty-four people with severe obesity (BMI=40 kg/m2) were evaluated in a prospective case-control study before and six months after Roux-in-Y gastric bypass. The blood lactate, total cholesterol, and fractions, C-reactive protein and HOMA-IR were analyzed after 12 h fasting. Body mass composition was evaluated by bioelectrical impedance and respiratory quotient was measured by indirect calorimetry. Results: The initial lactate level was 2.5±1.1 mmol/l and returned to normal level (1.9±3.6 mmol/l, p=0.0018) after surgery. This reduction was positively correlated with a decrease in BMI (p=0.0001), % free fat mass (p=0,001), % fat mass (p=0.001) and HOMA-IR (p=0.01). There was normalization of lactatemia in 70% of patients. There was no correlation between lactatemia and C-reactive protein. Conclusions: There was a significant improvement of metabolic parameters, normalization of blood lactate, fat mass loss, although these individuals remained with a high BMI.Colégio Brasileiro de Cirurgia Digestiva2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202021000100313ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) v.34 n.1 2021reponame:ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)instname:Colégio Brasileiro de Cirurgia Digestiva (CBCD)instacron:CBCD10.1590/0102-672020210001e1579info:eu-repo/semantics/openAccessDE-CLEVA,RobertoCARDIA,LilianVIEIRA-GADDUCCI,AlexandreGREVE,Julia MariaSANTO,Marco Aurelioeng2021-06-08T00:00:00Zoai:scielo:S0102-67202021000100313Revistahttp://abarriguda.org.br/revista/index.php/revistaabarrigudaarepb/indexONGhttps://old.scielo.br/oai/scielo-oai.php||revistaabcd@gmail.com2317-63262317-6326opendoar:2021-06-08T00:00ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) - Colégio Brasileiro de Cirurgia Digestiva (CBCD)false
dc.title.none.fl_str_mv LACTATE CAN BE A MARKER OF METABOLIC SYNDROME IN SEVERE OBESITY?
title LACTATE CAN BE A MARKER OF METABOLIC SYNDROME IN SEVERE OBESITY?
spellingShingle LACTATE CAN BE A MARKER OF METABOLIC SYNDROME IN SEVERE OBESITY?
DE-CLEVA,Roberto
Obesity
Bariatric surgery
Lactic acid
Metabolic syndrome
Body composition
title_short LACTATE CAN BE A MARKER OF METABOLIC SYNDROME IN SEVERE OBESITY?
title_full LACTATE CAN BE A MARKER OF METABOLIC SYNDROME IN SEVERE OBESITY?
title_fullStr LACTATE CAN BE A MARKER OF METABOLIC SYNDROME IN SEVERE OBESITY?
title_full_unstemmed LACTATE CAN BE A MARKER OF METABOLIC SYNDROME IN SEVERE OBESITY?
title_sort LACTATE CAN BE A MARKER OF METABOLIC SYNDROME IN SEVERE OBESITY?
author DE-CLEVA,Roberto
author_facet DE-CLEVA,Roberto
CARDIA,Lilian
VIEIRA-GADDUCCI,Alexandre
GREVE,Julia Maria
SANTO,Marco Aurelio
author_role author
author2 CARDIA,Lilian
VIEIRA-GADDUCCI,Alexandre
GREVE,Julia Maria
SANTO,Marco Aurelio
author2_role author
author
author
author
dc.contributor.author.fl_str_mv DE-CLEVA,Roberto
CARDIA,Lilian
VIEIRA-GADDUCCI,Alexandre
GREVE,Julia Maria
SANTO,Marco Aurelio
dc.subject.por.fl_str_mv Obesity
Bariatric surgery
Lactic acid
Metabolic syndrome
Body composition
topic Obesity
Bariatric surgery
Lactic acid
Metabolic syndrome
Body composition
description ABSTRACT Background: In the last decades, numerous studies have confirmed the importance of lactate - by-product to the nutrient signal of the intracellular redox state - to regulatory functions in energy metabolism. Aim: To evaluate changes in blood lactate in patients with severe obesity and its correlation with body composition and metabolic profile. Methods: Twenty-four people with severe obesity (BMI=40 kg/m2) were evaluated in a prospective case-control study before and six months after Roux-in-Y gastric bypass. The blood lactate, total cholesterol, and fractions, C-reactive protein and HOMA-IR were analyzed after 12 h fasting. Body mass composition was evaluated by bioelectrical impedance and respiratory quotient was measured by indirect calorimetry. Results: The initial lactate level was 2.5±1.1 mmol/l and returned to normal level (1.9±3.6 mmol/l, p=0.0018) after surgery. This reduction was positively correlated with a decrease in BMI (p=0.0001), % free fat mass (p=0,001), % fat mass (p=0.001) and HOMA-IR (p=0.01). There was normalization of lactatemia in 70% of patients. There was no correlation between lactatemia and C-reactive protein. Conclusions: There was a significant improvement of metabolic parameters, normalization of blood lactate, fat mass loss, although these individuals remained with a high BMI.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202021000100313
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202021000100313
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0102-672020210001e1579
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Colégio Brasileiro de Cirurgia Digestiva
publisher.none.fl_str_mv Colégio Brasileiro de Cirurgia Digestiva
dc.source.none.fl_str_mv ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) v.34 n.1 2021
reponame:ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)
instname:Colégio Brasileiro de Cirurgia Digestiva (CBCD)
instacron:CBCD
instname_str Colégio Brasileiro de Cirurgia Digestiva (CBCD)
instacron_str CBCD
institution CBCD
reponame_str ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)
collection ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)
repository.name.fl_str_mv ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) - Colégio Brasileiro de Cirurgia Digestiva (CBCD)
repository.mail.fl_str_mv ||revistaabcd@gmail.com
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