Tin speciation in the blood plasma of workers occupationally exposed in a cassiterite ore processing industry
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Saude em Debate |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-11042022000200459 |
Resumo: | ABSTRACT Mining is a high-risk activity due to its dangerous processes. Tin (Sn) is obtained from cassiterite ore and mining activities expose workers to the metal. Chronic exposure to Sn may cause pneumoconiosis, gastrointestinal and hematological effects, among others. This work aimed to assess the exposure of workers to tin in a cassiterite ore processing industry, using the speciation analysis in blood plasma. Twelve subjects donated the blood samples; six were occupationally exposed to Sn. Size exclusion chromatography separated proteins in blood plasma; a graphite furnace atomic absorption spectrometer determined total tin in the plasma and eluted fractions, while SDS-PAGE determined molecular masses of proteins. Tin levels in the workers’ plasma were four times higher than in the reference individuals. After fractionation, the metal only appeared in the total inclusion volume, not being possible to confirm the binding of tin to proteins, which certainly modifies their functions and impair workers’ health. Despite that, the work process needs to change since Sn levels in the workers’ plasma pointed to metal exposure. Further works are necessary to clarify whether the metal is free or bound to small proteins in blood plasma and understand the true impact of tin on workers’ health. |
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Tin speciation in the blood plasma of workers occupationally exposed in a cassiterite ore processing industryTinMiningBlood plasmaSpeciationProteinsABSTRACT Mining is a high-risk activity due to its dangerous processes. Tin (Sn) is obtained from cassiterite ore and mining activities expose workers to the metal. Chronic exposure to Sn may cause pneumoconiosis, gastrointestinal and hematological effects, among others. This work aimed to assess the exposure of workers to tin in a cassiterite ore processing industry, using the speciation analysis in blood plasma. Twelve subjects donated the blood samples; six were occupationally exposed to Sn. Size exclusion chromatography separated proteins in blood plasma; a graphite furnace atomic absorption spectrometer determined total tin in the plasma and eluted fractions, while SDS-PAGE determined molecular masses of proteins. Tin levels in the workers’ plasma were four times higher than in the reference individuals. After fractionation, the metal only appeared in the total inclusion volume, not being possible to confirm the binding of tin to proteins, which certainly modifies their functions and impair workers’ health. Despite that, the work process needs to change since Sn levels in the workers’ plasma pointed to metal exposure. Further works are necessary to clarify whether the metal is free or bound to small proteins in blood plasma and understand the true impact of tin on workers’ health.Centro Brasileiro de Estudos de Saúde2022-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-11042022000200459Saúde em Debate v.46 n.133 2022reponame:Saude em Debateinstname:Centro Brasileiro de Estudos de Saudeinstacron:CBES10.1590/0103-1104202213315info:eu-repo/semantics/openAccessLima,Débora Resende de SouzaSilva,Filipe Soares Quirino daborges,Renato MarçulloMarques,Rejane CorreaMoreira,Maria de Fátima Ramoseng2022-06-14T00:00:00Zoai:scielo:S0103-11042022000200459Revistahttp://www.scielo.br/scielo.php?script=sci_serial&pid=0103-1104&lng=en&nrm=isohttps://old.scielo.br/oai/scielo-oai.phprevista@saudeemdebate.org.br2358-28980103-1104opendoar:2022-06-14T00:00Saude em Debate - Centro Brasileiro de Estudos de Saudefalse |
dc.title.none.fl_str_mv |
Tin speciation in the blood plasma of workers occupationally exposed in a cassiterite ore processing industry |
title |
Tin speciation in the blood plasma of workers occupationally exposed in a cassiterite ore processing industry |
spellingShingle |
Tin speciation in the blood plasma of workers occupationally exposed in a cassiterite ore processing industry Lima,Débora Resende de Souza Tin Mining Blood plasma Speciation Proteins |
title_short |
Tin speciation in the blood plasma of workers occupationally exposed in a cassiterite ore processing industry |
title_full |
Tin speciation in the blood plasma of workers occupationally exposed in a cassiterite ore processing industry |
title_fullStr |
Tin speciation in the blood plasma of workers occupationally exposed in a cassiterite ore processing industry |
title_full_unstemmed |
Tin speciation in the blood plasma of workers occupationally exposed in a cassiterite ore processing industry |
title_sort |
Tin speciation in the blood plasma of workers occupationally exposed in a cassiterite ore processing industry |
author |
Lima,Débora Resende de Souza |
author_facet |
Lima,Débora Resende de Souza Silva,Filipe Soares Quirino da borges,Renato Marçullo Marques,Rejane Correa Moreira,Maria de Fátima Ramos |
author_role |
author |
author2 |
Silva,Filipe Soares Quirino da borges,Renato Marçullo Marques,Rejane Correa Moreira,Maria de Fátima Ramos |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Lima,Débora Resende de Souza Silva,Filipe Soares Quirino da borges,Renato Marçullo Marques,Rejane Correa Moreira,Maria de Fátima Ramos |
dc.subject.por.fl_str_mv |
Tin Mining Blood plasma Speciation Proteins |
topic |
Tin Mining Blood plasma Speciation Proteins |
description |
ABSTRACT Mining is a high-risk activity due to its dangerous processes. Tin (Sn) is obtained from cassiterite ore and mining activities expose workers to the metal. Chronic exposure to Sn may cause pneumoconiosis, gastrointestinal and hematological effects, among others. This work aimed to assess the exposure of workers to tin in a cassiterite ore processing industry, using the speciation analysis in blood plasma. Twelve subjects donated the blood samples; six were occupationally exposed to Sn. Size exclusion chromatography separated proteins in blood plasma; a graphite furnace atomic absorption spectrometer determined total tin in the plasma and eluted fractions, while SDS-PAGE determined molecular masses of proteins. Tin levels in the workers’ plasma were four times higher than in the reference individuals. After fractionation, the metal only appeared in the total inclusion volume, not being possible to confirm the binding of tin to proteins, which certainly modifies their functions and impair workers’ health. Despite that, the work process needs to change since Sn levels in the workers’ plasma pointed to metal exposure. Further works are necessary to clarify whether the metal is free or bound to small proteins in blood plasma and understand the true impact of tin on workers’ health. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-11042022000200459 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-11042022000200459 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0103-1104202213315 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Centro Brasileiro de Estudos de Saúde |
publisher.none.fl_str_mv |
Centro Brasileiro de Estudos de Saúde |
dc.source.none.fl_str_mv |
Saúde em Debate v.46 n.133 2022 reponame:Saude em Debate instname:Centro Brasileiro de Estudos de Saude instacron:CBES |
instname_str |
Centro Brasileiro de Estudos de Saude |
instacron_str |
CBES |
institution |
CBES |
reponame_str |
Saude em Debate |
collection |
Saude em Debate |
repository.name.fl_str_mv |
Saude em Debate - Centro Brasileiro de Estudos de Saude |
repository.mail.fl_str_mv |
revista@saudeemdebate.org.br |
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1754209002105864192 |