Effect of electroacupuncture to prevent selenite-induced cataract in Wistar rats
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos brasileiros de oftalmologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492006000300003 |
Resumo: | PURPOSE: To investigate whether electroacupuncture can prevent selenite-induced cataract in an experimental model. METHODS: Fifty Wistar rat pups were randomized into 5 groups of 10 animals: Group 1 (control), no procedure was performed; Group 2 (selenite), sodium selenite (30 micromoles/kg body weight) was injected subcutaneously between postpartum days 10 to 12; Group 3 (anesthesia) received the same dose of selenite and underwent ether inhalation anesthesia during 10 minutes daily for one week; Group 4 (electroacupuncture) underwent the same procedure of Group 3, but also receiving electroacupuncture (2 Hz, 50 mA) applied to the Neiguan (PC6) and Guangming (GB37) acupoints during the anesthesia period; and Group 5 (Sham) underwent the same procedures of Group 4, but needles were applied to non-acupoints. The development of cataract was assessed one week later, and its density was graded by slit lamp biomicroscopy. RESULTS: All control rats lenses (Group 1) were clear. Groups 2, 3 and 5 rats developed more severe cataract or complete opacification. In Group 4 (electroacupuncture), 45% of eyes did not develop cataract while thirty per cent developed less severe cataract than Groups 2, 3 and 5. The between-group difference was statistically significant (p<0.001). Lens opacification grade in Groups 1 and 4 was lower than in the Groups 2, 3 and 5 (p<0.001). CONCLUSION: Electroacupuncture effectively decreased selenite-induced cataract formation rate in pup rats when needles were applied at specific acupoints. |
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Effect of electroacupuncture to prevent selenite-induced cataract in Wistar ratsCataractAntioxidantsElectroacupunctureFree radicalsRats, WistarPURPOSE: To investigate whether electroacupuncture can prevent selenite-induced cataract in an experimental model. METHODS: Fifty Wistar rat pups were randomized into 5 groups of 10 animals: Group 1 (control), no procedure was performed; Group 2 (selenite), sodium selenite (30 micromoles/kg body weight) was injected subcutaneously between postpartum days 10 to 12; Group 3 (anesthesia) received the same dose of selenite and underwent ether inhalation anesthesia during 10 minutes daily for one week; Group 4 (electroacupuncture) underwent the same procedure of Group 3, but also receiving electroacupuncture (2 Hz, 50 mA) applied to the Neiguan (PC6) and Guangming (GB37) acupoints during the anesthesia period; and Group 5 (Sham) underwent the same procedures of Group 4, but needles were applied to non-acupoints. The development of cataract was assessed one week later, and its density was graded by slit lamp biomicroscopy. RESULTS: All control rats lenses (Group 1) were clear. Groups 2, 3 and 5 rats developed more severe cataract or complete opacification. In Group 4 (electroacupuncture), 45% of eyes did not develop cataract while thirty per cent developed less severe cataract than Groups 2, 3 and 5. The between-group difference was statistically significant (p<0.001). Lens opacification grade in Groups 1 and 4 was lower than in the Groups 2, 3 and 5 (p<0.001). CONCLUSION: Electroacupuncture effectively decreased selenite-induced cataract formation rate in pup rats when needles were applied at specific acupoints.Conselho Brasileiro de Oftalmologia2006-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492006000300003Arquivos Brasileiros de Oftalmologia v.69 n.3 2006reponame:Arquivos brasileiros de oftalmologia (Online)instname:Conselho Brasileiro de Oftalmologia (CBO)instacron:CBO10.1590/S0004-27492006000300003info:eu-repo/semantics/openAccessCariello,Angelino JulioCasanova,Fábio HenriqueLima Filho,Acácio Alves de SouzaJuliano,YaraTabosa,Angelaeng2006-08-21T00:00:00Zoai:scielo:S0004-27492006000300003Revistahttp://aboonline.org.br/https://old.scielo.br/oai/scielo-oai.phpaboonline@cbo.com.br||abo@cbo.com.br1678-29250004-2749opendoar:2006-08-21T00:00Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)false |
dc.title.none.fl_str_mv |
Effect of electroacupuncture to prevent selenite-induced cataract in Wistar rats |
title |
Effect of electroacupuncture to prevent selenite-induced cataract in Wistar rats |
spellingShingle |
Effect of electroacupuncture to prevent selenite-induced cataract in Wistar rats Cariello,Angelino Julio Cataract Antioxidants Electroacupuncture Free radicals Rats, Wistar |
title_short |
Effect of electroacupuncture to prevent selenite-induced cataract in Wistar rats |
title_full |
Effect of electroacupuncture to prevent selenite-induced cataract in Wistar rats |
title_fullStr |
Effect of electroacupuncture to prevent selenite-induced cataract in Wistar rats |
title_full_unstemmed |
Effect of electroacupuncture to prevent selenite-induced cataract in Wistar rats |
title_sort |
Effect of electroacupuncture to prevent selenite-induced cataract in Wistar rats |
author |
Cariello,Angelino Julio |
author_facet |
Cariello,Angelino Julio Casanova,Fábio Henrique Lima Filho,Acácio Alves de Souza Juliano,Yara Tabosa,Angela |
author_role |
author |
author2 |
Casanova,Fábio Henrique Lima Filho,Acácio Alves de Souza Juliano,Yara Tabosa,Angela |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Cariello,Angelino Julio Casanova,Fábio Henrique Lima Filho,Acácio Alves de Souza Juliano,Yara Tabosa,Angela |
dc.subject.por.fl_str_mv |
Cataract Antioxidants Electroacupuncture Free radicals Rats, Wistar |
topic |
Cataract Antioxidants Electroacupuncture Free radicals Rats, Wistar |
description |
PURPOSE: To investigate whether electroacupuncture can prevent selenite-induced cataract in an experimental model. METHODS: Fifty Wistar rat pups were randomized into 5 groups of 10 animals: Group 1 (control), no procedure was performed; Group 2 (selenite), sodium selenite (30 micromoles/kg body weight) was injected subcutaneously between postpartum days 10 to 12; Group 3 (anesthesia) received the same dose of selenite and underwent ether inhalation anesthesia during 10 minutes daily for one week; Group 4 (electroacupuncture) underwent the same procedure of Group 3, but also receiving electroacupuncture (2 Hz, 50 mA) applied to the Neiguan (PC6) and Guangming (GB37) acupoints during the anesthesia period; and Group 5 (Sham) underwent the same procedures of Group 4, but needles were applied to non-acupoints. The development of cataract was assessed one week later, and its density was graded by slit lamp biomicroscopy. RESULTS: All control rats lenses (Group 1) were clear. Groups 2, 3 and 5 rats developed more severe cataract or complete opacification. In Group 4 (electroacupuncture), 45% of eyes did not develop cataract while thirty per cent developed less severe cataract than Groups 2, 3 and 5. The between-group difference was statistically significant (p<0.001). Lens opacification grade in Groups 1 and 4 was lower than in the Groups 2, 3 and 5 (p<0.001). CONCLUSION: Electroacupuncture effectively decreased selenite-induced cataract formation rate in pup rats when needles were applied at specific acupoints. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492006000300003 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492006000300003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-27492006000300003 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Conselho Brasileiro de Oftalmologia |
publisher.none.fl_str_mv |
Conselho Brasileiro de Oftalmologia |
dc.source.none.fl_str_mv |
Arquivos Brasileiros de Oftalmologia v.69 n.3 2006 reponame:Arquivos brasileiros de oftalmologia (Online) instname:Conselho Brasileiro de Oftalmologia (CBO) instacron:CBO |
instname_str |
Conselho Brasileiro de Oftalmologia (CBO) |
instacron_str |
CBO |
institution |
CBO |
reponame_str |
Arquivos brasileiros de oftalmologia (Online) |
collection |
Arquivos brasileiros de oftalmologia (Online) |
repository.name.fl_str_mv |
Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO) |
repository.mail.fl_str_mv |
aboonline@cbo.com.br||abo@cbo.com.br |
_version_ |
1754209023402442752 |