Unusual early recurrence of granular dystrophy after deep anterior lamellar keratoplasty: case report

Detalhes bibliográficos
Autor(a) principal: Rama,Paolo
Data de Publicação: 2013
Outros Autores: Knutsson,Karl Anders, Rojo,Carmen, Carrera,Paola, Ferrari,Maurizio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos brasileiros de oftalmologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492013000200015
Resumo: We report an atypical case of granular corneal dystrophy recurrence after deep anterior lamellar keratoplasty. We describe clinical features, histopathological analysis of the lamellar graft specimen and DNA analysis results. The slit-lamp examination and histopathological findings from the graft specimen indicated the confinement of the typical deposits of granular corneal dystrophy deep in the graft interface area. This localization is atypical, since in most cases recurrences in grafts tend to be initially superficial and situated in the epithelial or subepithelial corneal layers. Molecular genetic analysis revealed an already described mutation and a new intronic variant. The unusual localization and timing of this recurrence of granular corneal dystrophy after deep anterior lamellar keratoplasty suggests that corneal stromal keratocytes may play a role in the formation of granular deposits.
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spelling Unusual early recurrence of granular dystrophy after deep anterior lamellar keratoplasty: case reportCorneal transplantationCorneal dystrophies, hereditaryCornea/pathologyCorneal stromaCorneal keratocytesEpithelium, corneal/cytologyRecurrenceWe report an atypical case of granular corneal dystrophy recurrence after deep anterior lamellar keratoplasty. We describe clinical features, histopathological analysis of the lamellar graft specimen and DNA analysis results. The slit-lamp examination and histopathological findings from the graft specimen indicated the confinement of the typical deposits of granular corneal dystrophy deep in the graft interface area. This localization is atypical, since in most cases recurrences in grafts tend to be initially superficial and situated in the epithelial or subepithelial corneal layers. Molecular genetic analysis revealed an already described mutation and a new intronic variant. The unusual localization and timing of this recurrence of granular corneal dystrophy after deep anterior lamellar keratoplasty suggests that corneal stromal keratocytes may play a role in the formation of granular deposits.Conselho Brasileiro de Oftalmologia2013-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492013000200015Arquivos Brasileiros de Oftalmologia v.76 n.2 2013reponame:Arquivos brasileiros de oftalmologia (Online)instname:Conselho Brasileiro de Oftalmologia (CBO)instacron:CBO10.1590/S0004-27492013000200015info:eu-repo/semantics/openAccessRama,PaoloKnutsson,Karl AndersRojo,CarmenCarrera,PaolaFerrari,Maurizioeng2013-07-15T00:00:00Zoai:scielo:S0004-27492013000200015Revistahttp://aboonline.org.br/https://old.scielo.br/oai/scielo-oai.phpaboonline@cbo.com.br||abo@cbo.com.br1678-29250004-2749opendoar:2013-07-15T00:00Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)false
dc.title.none.fl_str_mv Unusual early recurrence of granular dystrophy after deep anterior lamellar keratoplasty: case report
title Unusual early recurrence of granular dystrophy after deep anterior lamellar keratoplasty: case report
spellingShingle Unusual early recurrence of granular dystrophy after deep anterior lamellar keratoplasty: case report
Rama,Paolo
Corneal transplantation
Corneal dystrophies, hereditary
Cornea/pathology
Corneal stroma
Corneal keratocytes
Epithelium, corneal/cytology
Recurrence
title_short Unusual early recurrence of granular dystrophy after deep anterior lamellar keratoplasty: case report
title_full Unusual early recurrence of granular dystrophy after deep anterior lamellar keratoplasty: case report
title_fullStr Unusual early recurrence of granular dystrophy after deep anterior lamellar keratoplasty: case report
title_full_unstemmed Unusual early recurrence of granular dystrophy after deep anterior lamellar keratoplasty: case report
title_sort Unusual early recurrence of granular dystrophy after deep anterior lamellar keratoplasty: case report
author Rama,Paolo
author_facet Rama,Paolo
Knutsson,Karl Anders
Rojo,Carmen
Carrera,Paola
Ferrari,Maurizio
author_role author
author2 Knutsson,Karl Anders
Rojo,Carmen
Carrera,Paola
Ferrari,Maurizio
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Rama,Paolo
Knutsson,Karl Anders
Rojo,Carmen
Carrera,Paola
Ferrari,Maurizio
dc.subject.por.fl_str_mv Corneal transplantation
Corneal dystrophies, hereditary
Cornea/pathology
Corneal stroma
Corneal keratocytes
Epithelium, corneal/cytology
Recurrence
topic Corneal transplantation
Corneal dystrophies, hereditary
Cornea/pathology
Corneal stroma
Corneal keratocytes
Epithelium, corneal/cytology
Recurrence
description We report an atypical case of granular corneal dystrophy recurrence after deep anterior lamellar keratoplasty. We describe clinical features, histopathological analysis of the lamellar graft specimen and DNA analysis results. The slit-lamp examination and histopathological findings from the graft specimen indicated the confinement of the typical deposits of granular corneal dystrophy deep in the graft interface area. This localization is atypical, since in most cases recurrences in grafts tend to be initially superficial and situated in the epithelial or subepithelial corneal layers. Molecular genetic analysis revealed an already described mutation and a new intronic variant. The unusual localization and timing of this recurrence of granular corneal dystrophy after deep anterior lamellar keratoplasty suggests that corneal stromal keratocytes may play a role in the formation of granular deposits.
publishDate 2013
dc.date.none.fl_str_mv 2013-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492013000200015
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492013000200015
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-27492013000200015
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Oftalmologia v.76 n.2 2013
reponame:Arquivos brasileiros de oftalmologia (Online)
instname:Conselho Brasileiro de Oftalmologia (CBO)
instacron:CBO
instname_str Conselho Brasileiro de Oftalmologia (CBO)
instacron_str CBO
institution CBO
reponame_str Arquivos brasileiros de oftalmologia (Online)
collection Arquivos brasileiros de oftalmologia (Online)
repository.name.fl_str_mv Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)
repository.mail.fl_str_mv aboonline@cbo.com.br||abo@cbo.com.br
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