Evaluation of the retinal vasculature of patients with branch retinal vein occlusion using optical coherence tomography angiography

Detalhes bibliográficos
Autor(a) principal: Moura,Bárbara de Carvalho Freire Santos
Data de Publicação: 2020
Outros Autores: Lira,Rodrigo Pessoa Cavalcanti, Arantes,Tiago Eugênio Faria e, Paiva,Isabel Braga, Bravo Filho,Vasco Torres Fernandes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos brasileiros de oftalmologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492020000600517
Resumo: ABSTRACT Purpose: To evaluate vascular density in super­ficial and deep capillary plexuses of the retina, measured using optical coherence tomography angiography in patients with branch retinal vein occlusion. Affected eyes were compared with the contralateral eye of the same patient and both were compared with normal eyes. Methods: A cross-sectional study including 16 previously untreated patients with branch retinal vein occlusion. Patients with poor quality examinations, bilateral disease, high refractive error, or any other retinal or choroidal disease were excluded. A total of 31 patients without eye disease were also selected as a comparison group. All participants underwent five optical coherence tomography angiographies, and only those with at least two good quality examinations were selected. The Kruskal-Wallis, Wilcoxon signed-rank, and Mann-Whitney U tests were used for the statistical analysis. Results: Vascular density was lower in affected eyes compared with contralateral eyes: whole density (p=0.020 for capillary plexuses superficial; p=0.049 for deep capillary plexuses) and parafoveal density (p=0.020 for capillary plexuses superficial; p=0.011 for deep capillary plexuses). Vascular density was also lower in affected eyes compared with normal eyes: whole density (p<0.001 for capillary plexuses superficial and deep) and parafoveal density (p<0.001 for capillary plexuses superficial and deep). Whole density (p=0.001 for capillary plexuses superficial and deep) and parafoveal density (p=0.001 for capillary plexuses superficial; p<0.001 for deep capillary plexuses) were both lower in the contralateral eyes compared with normal eyes. Following adjustment for arterial hypertension, this difference was no longer observed. Conclusions: Vascular density in capillary plexuses and deep capillary plexuses was lower in the eyes affected by branch retinal vein occlusion. Furthermore, the lower vascular density noted in the contralateral eyes indicates that changes most likely occurred in these eyes prior to the appearance of any clinically detectable alterations, reflecting the early signs of hypertensive retinopathy.
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spelling Evaluation of the retinal vasculature of patients with branch retinal vein occlusion using optical coherence tomography angiographyRetinal vein occlusionCapillaries/pathologyRetinal vessels/physiopathology; Fovea centralisTomography, optical coherenceFluorescein angiographyABSTRACT Purpose: To evaluate vascular density in super­ficial and deep capillary plexuses of the retina, measured using optical coherence tomography angiography in patients with branch retinal vein occlusion. Affected eyes were compared with the contralateral eye of the same patient and both were compared with normal eyes. Methods: A cross-sectional study including 16 previously untreated patients with branch retinal vein occlusion. Patients with poor quality examinations, bilateral disease, high refractive error, or any other retinal or choroidal disease were excluded. A total of 31 patients without eye disease were also selected as a comparison group. All participants underwent five optical coherence tomography angiographies, and only those with at least two good quality examinations were selected. The Kruskal-Wallis, Wilcoxon signed-rank, and Mann-Whitney U tests were used for the statistical analysis. Results: Vascular density was lower in affected eyes compared with contralateral eyes: whole density (p=0.020 for capillary plexuses superficial; p=0.049 for deep capillary plexuses) and parafoveal density (p=0.020 for capillary plexuses superficial; p=0.011 for deep capillary plexuses). Vascular density was also lower in affected eyes compared with normal eyes: whole density (p<0.001 for capillary plexuses superficial and deep) and parafoveal density (p<0.001 for capillary plexuses superficial and deep). Whole density (p=0.001 for capillary plexuses superficial and deep) and parafoveal density (p=0.001 for capillary plexuses superficial; p<0.001 for deep capillary plexuses) were both lower in the contralateral eyes compared with normal eyes. Following adjustment for arterial hypertension, this difference was no longer observed. Conclusions: Vascular density in capillary plexuses and deep capillary plexuses was lower in the eyes affected by branch retinal vein occlusion. Furthermore, the lower vascular density noted in the contralateral eyes indicates that changes most likely occurred in these eyes prior to the appearance of any clinically detectable alterations, reflecting the early signs of hypertensive retinopathy.Conselho Brasileiro de Oftalmologia2020-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492020000600517Arquivos Brasileiros de Oftalmologia v.83 n.6 2020reponame:Arquivos brasileiros de oftalmologia (Online)instname:Conselho Brasileiro de Oftalmologia (CBO)instacron:CBO10.5935/0004-2749.20200091info:eu-repo/semantics/openAccessMoura,Bárbara de Carvalho Freire SantosLira,Rodrigo Pessoa CavalcantiArantes,Tiago Eugênio Faria ePaiva,Isabel BragaBravo Filho,Vasco Torres Fernandeseng2021-01-12T00:00:00Zoai:scielo:S0004-27492020000600517Revistahttp://aboonline.org.br/https://old.scielo.br/oai/scielo-oai.phpaboonline@cbo.com.br||abo@cbo.com.br1678-29250004-2749opendoar:2021-01-12T00:00Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)false
dc.title.none.fl_str_mv Evaluation of the retinal vasculature of patients with branch retinal vein occlusion using optical coherence tomography angiography
title Evaluation of the retinal vasculature of patients with branch retinal vein occlusion using optical coherence tomography angiography
spellingShingle Evaluation of the retinal vasculature of patients with branch retinal vein occlusion using optical coherence tomography angiography
Moura,Bárbara de Carvalho Freire Santos
Retinal vein occlusion
Capillaries/pathology
Retinal vessels/physiopathology; Fovea centralis
Tomography, optical coherence
Fluorescein angiography
title_short Evaluation of the retinal vasculature of patients with branch retinal vein occlusion using optical coherence tomography angiography
title_full Evaluation of the retinal vasculature of patients with branch retinal vein occlusion using optical coherence tomography angiography
title_fullStr Evaluation of the retinal vasculature of patients with branch retinal vein occlusion using optical coherence tomography angiography
title_full_unstemmed Evaluation of the retinal vasculature of patients with branch retinal vein occlusion using optical coherence tomography angiography
title_sort Evaluation of the retinal vasculature of patients with branch retinal vein occlusion using optical coherence tomography angiography
author Moura,Bárbara de Carvalho Freire Santos
author_facet Moura,Bárbara de Carvalho Freire Santos
Lira,Rodrigo Pessoa Cavalcanti
Arantes,Tiago Eugênio Faria e
Paiva,Isabel Braga
Bravo Filho,Vasco Torres Fernandes
author_role author
author2 Lira,Rodrigo Pessoa Cavalcanti
Arantes,Tiago Eugênio Faria e
Paiva,Isabel Braga
Bravo Filho,Vasco Torres Fernandes
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Moura,Bárbara de Carvalho Freire Santos
Lira,Rodrigo Pessoa Cavalcanti
Arantes,Tiago Eugênio Faria e
Paiva,Isabel Braga
Bravo Filho,Vasco Torres Fernandes
dc.subject.por.fl_str_mv Retinal vein occlusion
Capillaries/pathology
Retinal vessels/physiopathology; Fovea centralis
Tomography, optical coherence
Fluorescein angiography
topic Retinal vein occlusion
Capillaries/pathology
Retinal vessels/physiopathology; Fovea centralis
Tomography, optical coherence
Fluorescein angiography
description ABSTRACT Purpose: To evaluate vascular density in super­ficial and deep capillary plexuses of the retina, measured using optical coherence tomography angiography in patients with branch retinal vein occlusion. Affected eyes were compared with the contralateral eye of the same patient and both were compared with normal eyes. Methods: A cross-sectional study including 16 previously untreated patients with branch retinal vein occlusion. Patients with poor quality examinations, bilateral disease, high refractive error, or any other retinal or choroidal disease were excluded. A total of 31 patients without eye disease were also selected as a comparison group. All participants underwent five optical coherence tomography angiographies, and only those with at least two good quality examinations were selected. The Kruskal-Wallis, Wilcoxon signed-rank, and Mann-Whitney U tests were used for the statistical analysis. Results: Vascular density was lower in affected eyes compared with contralateral eyes: whole density (p=0.020 for capillary plexuses superficial; p=0.049 for deep capillary plexuses) and parafoveal density (p=0.020 for capillary plexuses superficial; p=0.011 for deep capillary plexuses). Vascular density was also lower in affected eyes compared with normal eyes: whole density (p<0.001 for capillary plexuses superficial and deep) and parafoveal density (p<0.001 for capillary plexuses superficial and deep). Whole density (p=0.001 for capillary plexuses superficial and deep) and parafoveal density (p=0.001 for capillary plexuses superficial; p<0.001 for deep capillary plexuses) were both lower in the contralateral eyes compared with normal eyes. Following adjustment for arterial hypertension, this difference was no longer observed. Conclusions: Vascular density in capillary plexuses and deep capillary plexuses was lower in the eyes affected by branch retinal vein occlusion. Furthermore, the lower vascular density noted in the contralateral eyes indicates that changes most likely occurred in these eyes prior to the appearance of any clinically detectable alterations, reflecting the early signs of hypertensive retinopathy.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0004-2749.20200091
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Oftalmologia v.83 n.6 2020
reponame:Arquivos brasileiros de oftalmologia (Online)
instname:Conselho Brasileiro de Oftalmologia (CBO)
instacron:CBO
instname_str Conselho Brasileiro de Oftalmologia (CBO)
instacron_str CBO
institution CBO
reponame_str Arquivos brasileiros de oftalmologia (Online)
collection Arquivos brasileiros de oftalmologia (Online)
repository.name.fl_str_mv Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)
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