Anthelmintic activity of Cymbopogon citratus against Haemonchus contortus

• Autor(a) principal: Macedo,Iara Tersia Freitas
• Data de Publicação: 2015
• Outros Autores: Oliveira,Lorena Mayana Beserra de, Ribeiro,Wesley Lyeverton Correia, Santos,Jessica Maria Leite dos, Silva,Kaline das Chagas, Araújo Filho,José Vilemar de, Camurça-Vasconcelos,Ana Lourdes Fernandes, Bevilaqua,Claudia Maria Leal
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista Brasileira de Parasitologia Veterinária (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612015000300268
• topic: Phytotherapy; anthelmintic; Meriones unguiculatus; in vitro; citral

Parasitic nematodes are of major economic importance in livestock. An alternative for the control of parasites is phytotherapy. This study evaluated the efficacy of Cymbopogon citratus decoction (CcD), C. citratus essential oil (CcEo) and citral against Haemonchus contortus using in vitro egg hatch test (EHT) and larval development test (LDT) and an in vivo test using a Meriones unguiculatus (gerbil) model. The effect of 800 mg/kg CcEo was evaluated in gerbils that had been artificially infected with 5,000 third-stage H. contortus larvae. The effective concentrations required to inhibit 50% (EC50) of egg hatching were 0.46, 0.14 and 0.13 mg/mL for CcD, CcEo and citral, respectively. The EC50 values in the LDT were 5.04, 1.92 and 1.37 mg/mL for CcD, CcEo and citral, respectively. H. contortus population in the group treated with C. citratus essential oil was reduced by 38.5% (P< 0.05) in comparison to the control group. These results suggest that it may be possible to use C. citratusessential oil to control of H. contortus parasite of small ruminant.