Experimental Ehrlichia canis infection changes acute-phase proteins
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Parasitologia Veterinária (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612012000300006 |
Resumo: | Early diagnosis of canine ehrlichiosis favors prompt institution of treatment and improves the prognosis for the animal, since this disease causes mortality among dogs. Studies have shown that determining the concentration of acute-phase proteins (APPs) may contribute towards early detection of disease and aid in predicting the prognosis. This study aimed to evaluate the APP profile in dogs experimentally infected with Ehrlichia canis, at the start of the infection and after treatment. It also investigated whether any correlation between APP levels and the clinical and laboratory alterations over the course of the disease would be possible. The results obtained showed abnormal levels of all the APPs on the third day after infection (D3), with the highest levels being reached on D18, with the exception of ceruloplasmin and acid glycoprotein, which presented their peaks on D6 and D12 respectively. We concluded that assessment of APP levels could contribute towards establishing an early diagnosis of canine ehrlichiosis, particularly regarding acid glycoprotein and ceruloplasmin, since these proteins were detected at increased levels even before the onset of clinical and laboratory findings of the disease. |
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Experimental Ehrlichia canis infection changes acute-phase proteinsEhrlichia canisexperimental infectionacute-phase proteinsdogsEarly diagnosis of canine ehrlichiosis favors prompt institution of treatment and improves the prognosis for the animal, since this disease causes mortality among dogs. Studies have shown that determining the concentration of acute-phase proteins (APPs) may contribute towards early detection of disease and aid in predicting the prognosis. This study aimed to evaluate the APP profile in dogs experimentally infected with Ehrlichia canis, at the start of the infection and after treatment. It also investigated whether any correlation between APP levels and the clinical and laboratory alterations over the course of the disease would be possible. The results obtained showed abnormal levels of all the APPs on the third day after infection (D3), with the highest levels being reached on D18, with the exception of ceruloplasmin and acid glycoprotein, which presented their peaks on D6 and D12 respectively. We concluded that assessment of APP levels could contribute towards establishing an early diagnosis of canine ehrlichiosis, particularly regarding acid glycoprotein and ceruloplasmin, since these proteins were detected at increased levels even before the onset of clinical and laboratory findings of the disease.Colégio Brasileiro de Parasitologia Veterinária2012-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612012000300006Revista Brasileira de Parasitologia Veterinária v.21 n.3 2012reponame:Revista Brasileira de Parasitologia Veterinária (Online)instname:Colégio Brasileiro de Parasitologia Veterinária (CBPV)instacron:CBPV10.1590/S1984-29612012000300006info:eu-repo/semantics/openAccessMunhoz,Thiago DemarchiFaria,Joice Lara MaiaVargas-Hérnandez,GiovanniFagliari,José JurandirSantana,Áureo EvangelistaMachado,Rosangela ZacariasTinucci-Costa,Mirelaeng2012-10-11T00:00:00Zoai:scielo:S1984-29612012000300006Revistahttp://www.scielo.br/scielo.php?script=sci_serial&lng=pt&pid=1984-2961https://old.scielo.br/oai/scielo-oai.php||zacariascbpv@fcav.unesp.br1984-29610103-846Xopendoar:2012-10-11T00:00Revista Brasileira de Parasitologia Veterinária (Online) - Colégio Brasileiro de Parasitologia Veterinária (CBPV)false |
dc.title.none.fl_str_mv |
Experimental Ehrlichia canis infection changes acute-phase proteins |
title |
Experimental Ehrlichia canis infection changes acute-phase proteins |
spellingShingle |
Experimental Ehrlichia canis infection changes acute-phase proteins Munhoz,Thiago Demarchi Ehrlichia canis experimental infection acute-phase proteins dogs |
title_short |
Experimental Ehrlichia canis infection changes acute-phase proteins |
title_full |
Experimental Ehrlichia canis infection changes acute-phase proteins |
title_fullStr |
Experimental Ehrlichia canis infection changes acute-phase proteins |
title_full_unstemmed |
Experimental Ehrlichia canis infection changes acute-phase proteins |
title_sort |
Experimental Ehrlichia canis infection changes acute-phase proteins |
author |
Munhoz,Thiago Demarchi |
author_facet |
Munhoz,Thiago Demarchi Faria,Joice Lara Maia Vargas-Hérnandez,Giovanni Fagliari,José Jurandir Santana,Áureo Evangelista Machado,Rosangela Zacarias Tinucci-Costa,Mirela |
author_role |
author |
author2 |
Faria,Joice Lara Maia Vargas-Hérnandez,Giovanni Fagliari,José Jurandir Santana,Áureo Evangelista Machado,Rosangela Zacarias Tinucci-Costa,Mirela |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Munhoz,Thiago Demarchi Faria,Joice Lara Maia Vargas-Hérnandez,Giovanni Fagliari,José Jurandir Santana,Áureo Evangelista Machado,Rosangela Zacarias Tinucci-Costa,Mirela |
dc.subject.por.fl_str_mv |
Ehrlichia canis experimental infection acute-phase proteins dogs |
topic |
Ehrlichia canis experimental infection acute-phase proteins dogs |
description |
Early diagnosis of canine ehrlichiosis favors prompt institution of treatment and improves the prognosis for the animal, since this disease causes mortality among dogs. Studies have shown that determining the concentration of acute-phase proteins (APPs) may contribute towards early detection of disease and aid in predicting the prognosis. This study aimed to evaluate the APP profile in dogs experimentally infected with Ehrlichia canis, at the start of the infection and after treatment. It also investigated whether any correlation between APP levels and the clinical and laboratory alterations over the course of the disease would be possible. The results obtained showed abnormal levels of all the APPs on the third day after infection (D3), with the highest levels being reached on D18, with the exception of ceruloplasmin and acid glycoprotein, which presented their peaks on D6 and D12 respectively. We concluded that assessment of APP levels could contribute towards establishing an early diagnosis of canine ehrlichiosis, particularly regarding acid glycoprotein and ceruloplasmin, since these proteins were detected at increased levels even before the onset of clinical and laboratory findings of the disease. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612012000300006 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612012000300006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1984-29612012000300006 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Colégio Brasileiro de Parasitologia Veterinária |
publisher.none.fl_str_mv |
Colégio Brasileiro de Parasitologia Veterinária |
dc.source.none.fl_str_mv |
Revista Brasileira de Parasitologia Veterinária v.21 n.3 2012 reponame:Revista Brasileira de Parasitologia Veterinária (Online) instname:Colégio Brasileiro de Parasitologia Veterinária (CBPV) instacron:CBPV |
instname_str |
Colégio Brasileiro de Parasitologia Veterinária (CBPV) |
instacron_str |
CBPV |
institution |
CBPV |
reponame_str |
Revista Brasileira de Parasitologia Veterinária (Online) |
collection |
Revista Brasileira de Parasitologia Veterinária (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Parasitologia Veterinária (Online) - Colégio Brasileiro de Parasitologia Veterinária (CBPV) |
repository.mail.fl_str_mv |
||zacariascbpv@fcav.unesp.br |
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1754208914376753152 |