Experimental Ehrlichia canis infection changes acute-phase proteins

Detalhes bibliográficos
Autor(a) principal: Munhoz,Thiago Demarchi
Data de Publicação: 2012
Outros Autores: Faria,Joice Lara Maia, Vargas-Hérnandez,Giovanni, Fagliari,José Jurandir, Santana,Áureo Evangelista, Machado,Rosangela Zacarias, Tinucci-Costa,Mirela
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Parasitologia Veterinária (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612012000300006
Resumo: Early diagnosis of canine ehrlichiosis favors prompt institution of treatment and improves the prognosis for the animal, since this disease causes mortality among dogs. Studies have shown that determining the concentration of acute-phase proteins (APPs) may contribute towards early detection of disease and aid in predicting the prognosis. This study aimed to evaluate the APP profile in dogs experimentally infected with Ehrlichia canis, at the start of the infection and after treatment. It also investigated whether any correlation between APP levels and the clinical and laboratory alterations over the course of the disease would be possible. The results obtained showed abnormal levels of all the APPs on the third day after infection (D3), with the highest levels being reached on D18, with the exception of ceruloplasmin and acid glycoprotein, which presented their peaks on D6 and D12 respectively. We concluded that assessment of APP levels could contribute towards establishing an early diagnosis of canine ehrlichiosis, particularly regarding acid glycoprotein and ceruloplasmin, since these proteins were detected at increased levels even before the onset of clinical and laboratory findings of the disease.
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spelling Experimental Ehrlichia canis infection changes acute-phase proteinsEhrlichia canisexperimental infectionacute-phase proteinsdogsEarly diagnosis of canine ehrlichiosis favors prompt institution of treatment and improves the prognosis for the animal, since this disease causes mortality among dogs. Studies have shown that determining the concentration of acute-phase proteins (APPs) may contribute towards early detection of disease and aid in predicting the prognosis. This study aimed to evaluate the APP profile in dogs experimentally infected with Ehrlichia canis, at the start of the infection and after treatment. It also investigated whether any correlation between APP levels and the clinical and laboratory alterations over the course of the disease would be possible. The results obtained showed abnormal levels of all the APPs on the third day after infection (D3), with the highest levels being reached on D18, with the exception of ceruloplasmin and acid glycoprotein, which presented their peaks on D6 and D12 respectively. We concluded that assessment of APP levels could contribute towards establishing an early diagnosis of canine ehrlichiosis, particularly regarding acid glycoprotein and ceruloplasmin, since these proteins were detected at increased levels even before the onset of clinical and laboratory findings of the disease.Colégio Brasileiro de Parasitologia Veterinária2012-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612012000300006Revista Brasileira de Parasitologia Veterinária v.21 n.3 2012reponame:Revista Brasileira de Parasitologia Veterinária (Online)instname:Colégio Brasileiro de Parasitologia Veterinária (CBPV)instacron:CBPV10.1590/S1984-29612012000300006info:eu-repo/semantics/openAccessMunhoz,Thiago DemarchiFaria,Joice Lara MaiaVargas-Hérnandez,GiovanniFagliari,José JurandirSantana,Áureo EvangelistaMachado,Rosangela ZacariasTinucci-Costa,Mirelaeng2012-10-11T00:00:00Zoai:scielo:S1984-29612012000300006Revistahttp://www.scielo.br/scielo.php?script=sci_serial&lng=pt&pid=1984-2961https://old.scielo.br/oai/scielo-oai.php||zacariascbpv@fcav.unesp.br1984-29610103-846Xopendoar:2012-10-11T00:00Revista Brasileira de Parasitologia Veterinária (Online) - Colégio Brasileiro de Parasitologia Veterinária (CBPV)false
dc.title.none.fl_str_mv Experimental Ehrlichia canis infection changes acute-phase proteins
title Experimental Ehrlichia canis infection changes acute-phase proteins
spellingShingle Experimental Ehrlichia canis infection changes acute-phase proteins
Munhoz,Thiago Demarchi
Ehrlichia canis
experimental infection
acute-phase proteins
dogs
title_short Experimental Ehrlichia canis infection changes acute-phase proteins
title_full Experimental Ehrlichia canis infection changes acute-phase proteins
title_fullStr Experimental Ehrlichia canis infection changes acute-phase proteins
title_full_unstemmed Experimental Ehrlichia canis infection changes acute-phase proteins
title_sort Experimental Ehrlichia canis infection changes acute-phase proteins
author Munhoz,Thiago Demarchi
author_facet Munhoz,Thiago Demarchi
Faria,Joice Lara Maia
Vargas-Hérnandez,Giovanni
Fagliari,José Jurandir
Santana,Áureo Evangelista
Machado,Rosangela Zacarias
Tinucci-Costa,Mirela
author_role author
author2 Faria,Joice Lara Maia
Vargas-Hérnandez,Giovanni
Fagliari,José Jurandir
Santana,Áureo Evangelista
Machado,Rosangela Zacarias
Tinucci-Costa,Mirela
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Munhoz,Thiago Demarchi
Faria,Joice Lara Maia
Vargas-Hérnandez,Giovanni
Fagliari,José Jurandir
Santana,Áureo Evangelista
Machado,Rosangela Zacarias
Tinucci-Costa,Mirela
dc.subject.por.fl_str_mv Ehrlichia canis
experimental infection
acute-phase proteins
dogs
topic Ehrlichia canis
experimental infection
acute-phase proteins
dogs
description Early diagnosis of canine ehrlichiosis favors prompt institution of treatment and improves the prognosis for the animal, since this disease causes mortality among dogs. Studies have shown that determining the concentration of acute-phase proteins (APPs) may contribute towards early detection of disease and aid in predicting the prognosis. This study aimed to evaluate the APP profile in dogs experimentally infected with Ehrlichia canis, at the start of the infection and after treatment. It also investigated whether any correlation between APP levels and the clinical and laboratory alterations over the course of the disease would be possible. The results obtained showed abnormal levels of all the APPs on the third day after infection (D3), with the highest levels being reached on D18, with the exception of ceruloplasmin and acid glycoprotein, which presented their peaks on D6 and D12 respectively. We concluded that assessment of APP levels could contribute towards establishing an early diagnosis of canine ehrlichiosis, particularly regarding acid glycoprotein and ceruloplasmin, since these proteins were detected at increased levels even before the onset of clinical and laboratory findings of the disease.
publishDate 2012
dc.date.none.fl_str_mv 2012-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612012000300006
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612012000300006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1984-29612012000300006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Colégio Brasileiro de Parasitologia Veterinária
publisher.none.fl_str_mv Colégio Brasileiro de Parasitologia Veterinária
dc.source.none.fl_str_mv Revista Brasileira de Parasitologia Veterinária v.21 n.3 2012
reponame:Revista Brasileira de Parasitologia Veterinária (Online)
instname:Colégio Brasileiro de Parasitologia Veterinária (CBPV)
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instname_str Colégio Brasileiro de Parasitologia Veterinária (CBPV)
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institution CBPV
reponame_str Revista Brasileira de Parasitologia Veterinária (Online)
collection Revista Brasileira de Parasitologia Veterinária (Online)
repository.name.fl_str_mv Revista Brasileira de Parasitologia Veterinária (Online) - Colégio Brasileiro de Parasitologia Veterinária (CBPV)
repository.mail.fl_str_mv ||zacariascbpv@fcav.unesp.br
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