Ethanolic Extract of the Red Algae Meristiella echinocarpa (Areschoug) Confers Neuroprotection in Mice
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of Health & Biological Sciences |
Texto Completo: | https://periodicos.unichristus.edu.br/jhbs/article/view/3572 |
Resumo: | Objectives: This study aimed to investigate the neuroprotective effects of the ethanolic extract obtained from red algae marine Meristiella echinocarpa (Areschougiaceae) – EEMe. Methods: EEMe was used in doses ranging from 10 to 40 mg/kg, administered intraperitoneally in mice. Behavioral tests were performed to assess locomotor activity (open field), anxiety (elevated plus maze), depression (tail suspension), and motor coordination (rota-rod). The anticonvulsant effect of the algae extract was evaluated in two models of seizures induced by strychnine and pentylenetetrazol. The level of oxidative stress was also evaluated in the following brain areas: the prefrontal cortex, hippocampus, and striatum. Statistical analysis was performed applying ANOVA followed by the Bonferroni test. Results: EEMe reduced significantly the number of crossing (36%) and rearing (54%) in the open field test and increased 1.3x the immobility time in the tail suspension test. In brain areas EEMe also reduced significantly malondialdehyde levels (striatum: 45%, hippocampus: 38%, prefrontal cortex: 37%) and nitrite levels (striatum: 72%, hippocampus: 79%, prefrontal cortex: 63%), and increased the reduced-glutathione levels (striatum: 72%, hippocampus: 73%, prefrontal cortex: 42%). In addition, the extract significantly prolonged the latency of seizures induced by strychnine (38%) or pentylenetetrazol (57%), and the latency of death induced by pentylenetetrazol (6.1x). Conclusion: EEMe exhibits antioxidant and anticonvulsant effects, probably involving GABAergic and glycinergic pathways. extract exhibits antioxidant and anticonvulsant effects, involving GABAergic and glycinergic pathways. |
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Ethanolic Extract of the Red Algae Meristiella echinocarpa (Areschoug) Confers Neuroprotection in MiceSaúde;Ciências BiológicasMarine alga; Meristiella echinocarpa; Brain; Anticonvulsant; Oxidative StressObjectives: This study aimed to investigate the neuroprotective effects of the ethanolic extract obtained from red algae marine Meristiella echinocarpa (Areschougiaceae) – EEMe. Methods: EEMe was used in doses ranging from 10 to 40 mg/kg, administered intraperitoneally in mice. Behavioral tests were performed to assess locomotor activity (open field), anxiety (elevated plus maze), depression (tail suspension), and motor coordination (rota-rod). The anticonvulsant effect of the algae extract was evaluated in two models of seizures induced by strychnine and pentylenetetrazol. The level of oxidative stress was also evaluated in the following brain areas: the prefrontal cortex, hippocampus, and striatum. Statistical analysis was performed applying ANOVA followed by the Bonferroni test. Results: EEMe reduced significantly the number of crossing (36%) and rearing (54%) in the open field test and increased 1.3x the immobility time in the tail suspension test. In brain areas EEMe also reduced significantly malondialdehyde levels (striatum: 45%, hippocampus: 38%, prefrontal cortex: 37%) and nitrite levels (striatum: 72%, hippocampus: 79%, prefrontal cortex: 63%), and increased the reduced-glutathione levels (striatum: 72%, hippocampus: 73%, prefrontal cortex: 42%). In addition, the extract significantly prolonged the latency of seizures induced by strychnine (38%) or pentylenetetrazol (57%), and the latency of death induced by pentylenetetrazol (6.1x). Conclusion: EEMe exhibits antioxidant and anticonvulsant effects, probably involving GABAergic and glycinergic pathways. extract exhibits antioxidant and anticonvulsant effects, involving GABAergic and glycinergic pathways. Instituto para o Desenvolvimento da EducacaoConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico (FUNCAP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)dos Santos, Mayula MirelyAssreuy, Ana Maria SampaioOliveira, Luis Gustavo FariasAlencar, Daniel Barroso deSampaio, Silvana SakerSampaio, Alexandre HolandaChaves, Edna Maria CameloSampaio, AlexandreAragão, Gislei Frota2021-11-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAvaliado por ParesPeer ReviewRevisado por paresapplication/pdfhttps://periodicos.unichristus.edu.br/jhbs/article/view/357210.12662/2317-3076jhbs.v9i1.3572.p1-7.2021Journal of Health & Biological Sciences; v. 9, n. 1 (2021): Journal of Health and Biological Sciences; 1-7Journal of Health & Biological Sciences; v. 9, n. 1 (2021): Journal of Health and Biological Sciences; 1-7Journal of Health and Biological Sciences; v. 9, n. 1 (2021): Journal of Health and Biological Sciences; 1-72317-30762317-308410.12662/2317-3076jhbs.v9i1.2021reponame:Journal of Health & Biological Sciencesinstname:Centro Universitário Christus (Unichristus)instacron:CHRISTUSenghttps://periodicos.unichristus.edu.br/jhbs/article/view/3572/1500América do SulDireitos autorais 2021 Journal of Health & Biological Scienceshttp://creativecommons.org/licenses/by-nc-sa/4.0info:eu-repo/semantics/openAccess2021-12-30T20:32:10Zoai:ojs.unichristus.emnuvens.com.br:article/3572Revistahttps://periodicos.unichristus.edu.br/jhbs/indexPRIhttps://periodicos.unichristus.edu.br/jhbs/oaisecretaria.jhbs@unichristus.edu.br || editor.jhbs@fchristus.edu.br2317-30762317-3084opendoar:2023-01-13T09:47:24.015940Journal of Health & Biological Sciences - Centro Universitário Christus (Unichristus)true |
dc.title.none.fl_str_mv |
Ethanolic Extract of the Red Algae Meristiella echinocarpa (Areschoug) Confers Neuroprotection in Mice |
title |
Ethanolic Extract of the Red Algae Meristiella echinocarpa (Areschoug) Confers Neuroprotection in Mice |
spellingShingle |
Ethanolic Extract of the Red Algae Meristiella echinocarpa (Areschoug) Confers Neuroprotection in Mice dos Santos, Mayula Mirely Saúde;Ciências Biológicas Marine alga; Meristiella echinocarpa; Brain; Anticonvulsant; Oxidative Stress |
title_short |
Ethanolic Extract of the Red Algae Meristiella echinocarpa (Areschoug) Confers Neuroprotection in Mice |
title_full |
Ethanolic Extract of the Red Algae Meristiella echinocarpa (Areschoug) Confers Neuroprotection in Mice |
title_fullStr |
Ethanolic Extract of the Red Algae Meristiella echinocarpa (Areschoug) Confers Neuroprotection in Mice |
title_full_unstemmed |
Ethanolic Extract of the Red Algae Meristiella echinocarpa (Areschoug) Confers Neuroprotection in Mice |
title_sort |
Ethanolic Extract of the Red Algae Meristiella echinocarpa (Areschoug) Confers Neuroprotection in Mice |
author |
dos Santos, Mayula Mirely |
author_facet |
dos Santos, Mayula Mirely Assreuy, Ana Maria Sampaio Oliveira, Luis Gustavo Farias Alencar, Daniel Barroso de Sampaio, Silvana Saker Sampaio, Alexandre Holanda Chaves, Edna Maria Camelo Sampaio, Alexandre Aragão, Gislei Frota |
author_role |
author |
author2 |
Assreuy, Ana Maria Sampaio Oliveira, Luis Gustavo Farias Alencar, Daniel Barroso de Sampaio, Silvana Saker Sampaio, Alexandre Holanda Chaves, Edna Maria Camelo Sampaio, Alexandre Aragão, Gislei Frota |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico (FUNCAP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) |
dc.contributor.author.fl_str_mv |
dos Santos, Mayula Mirely Assreuy, Ana Maria Sampaio Oliveira, Luis Gustavo Farias Alencar, Daniel Barroso de Sampaio, Silvana Saker Sampaio, Alexandre Holanda Chaves, Edna Maria Camelo Sampaio, Alexandre Aragão, Gislei Frota |
dc.subject.none.fl_str_mv |
|
dc.subject.por.fl_str_mv |
Saúde;Ciências Biológicas Marine alga; Meristiella echinocarpa; Brain; Anticonvulsant; Oxidative Stress |
topic |
Saúde;Ciências Biológicas Marine alga; Meristiella echinocarpa; Brain; Anticonvulsant; Oxidative Stress |
description |
Objectives: This study aimed to investigate the neuroprotective effects of the ethanolic extract obtained from red algae marine Meristiella echinocarpa (Areschougiaceae) – EEMe. Methods: EEMe was used in doses ranging from 10 to 40 mg/kg, administered intraperitoneally in mice. Behavioral tests were performed to assess locomotor activity (open field), anxiety (elevated plus maze), depression (tail suspension), and motor coordination (rota-rod). The anticonvulsant effect of the algae extract was evaluated in two models of seizures induced by strychnine and pentylenetetrazol. The level of oxidative stress was also evaluated in the following brain areas: the prefrontal cortex, hippocampus, and striatum. Statistical analysis was performed applying ANOVA followed by the Bonferroni test. Results: EEMe reduced significantly the number of crossing (36%) and rearing (54%) in the open field test and increased 1.3x the immobility time in the tail suspension test. In brain areas EEMe also reduced significantly malondialdehyde levels (striatum: 45%, hippocampus: 38%, prefrontal cortex: 37%) and nitrite levels (striatum: 72%, hippocampus: 79%, prefrontal cortex: 63%), and increased the reduced-glutathione levels (striatum: 72%, hippocampus: 73%, prefrontal cortex: 42%). In addition, the extract significantly prolonged the latency of seizures induced by strychnine (38%) or pentylenetetrazol (57%), and the latency of death induced by pentylenetetrazol (6.1x). Conclusion: EEMe exhibits antioxidant and anticonvulsant effects, probably involving GABAergic and glycinergic pathways. extract exhibits antioxidant and anticonvulsant effects, involving GABAergic and glycinergic pathways. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-11-29 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Avaliado por Pares Peer Review Revisado por pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.unichristus.edu.br/jhbs/article/view/3572 10.12662/2317-3076jhbs.v9i1.3572.p1-7.2021 |
url |
https://periodicos.unichristus.edu.br/jhbs/article/view/3572 |
identifier_str_mv |
10.12662/2317-3076jhbs.v9i1.3572.p1-7.2021 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://periodicos.unichristus.edu.br/jhbs/article/view/3572/1500 |
dc.rights.driver.fl_str_mv |
Direitos autorais 2021 Journal of Health & Biological Sciences http://creativecommons.org/licenses/by-nc-sa/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Direitos autorais 2021 Journal of Health & Biological Sciences http://creativecommons.org/licenses/by-nc-sa/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.coverage.none.fl_str_mv |
América do Sul |
dc.publisher.none.fl_str_mv |
Instituto para o Desenvolvimento da Educacao |
publisher.none.fl_str_mv |
Instituto para o Desenvolvimento da Educacao |
dc.source.none.fl_str_mv |
Journal of Health & Biological Sciences; v. 9, n. 1 (2021): Journal of Health and Biological Sciences; 1-7 Journal of Health & Biological Sciences; v. 9, n. 1 (2021): Journal of Health and Biological Sciences; 1-7 Journal of Health and Biological Sciences; v. 9, n. 1 (2021): Journal of Health and Biological Sciences; 1-7 2317-3076 2317-3084 10.12662/2317-3076jhbs.v9i1.2021 reponame:Journal of Health & Biological Sciences instname:Centro Universitário Christus (Unichristus) instacron:CHRISTUS |
instname_str |
Centro Universitário Christus (Unichristus) |
instacron_str |
CHRISTUS |
institution |
CHRISTUS |
reponame_str |
Journal of Health & Biological Sciences |
collection |
Journal of Health & Biological Sciences |
repository.name.fl_str_mv |
Journal of Health & Biological Sciences - Centro Universitário Christus (Unichristus) |
repository.mail.fl_str_mv |
secretaria.jhbs@unichristus.edu.br || editor.jhbs@fchristus.edu.br |
_version_ |
1797052856443863040 |