Anxious phenotype potentiates damage in peripheral organs of animals submitted to sepsis
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of Health & Biological Sciences |
Texto Completo: | https://periodicos.unichristus.edu.br/jhbs/article/view/1960 |
Resumo: | Introduction: Anxiety and sepsis are important public health problems that present high morbidity, mortality and significant economic repercussions. The present study investigated the presence of oxidative damage in peripheral organs in two lines of animals that are bred for high and low freezing responses to contextual cues that are previously associated with foot shock (Carioca High-conditioned Freezing [CHF] and Carioca Low-conditioned Freezing [CLF]) associated to sepsis. Methods: Animals were subject to sepsis by the cecal ligation and perforation (CLP) or sham operated. 24 hours and 10 days after sepsis animals were euthanized and removed adrenal, kidney, lung, serum, heart for the determination of carbonyl protein levels and adrenal for check weight this structure. Results: Sepsis increased oxidative damage in different systemic organs, included serum. There wasn’t a significant increase in protein carbonyls in heart and kidney. Anxious phenotype potentiates this damage. Conclusion: These findings suggest that an anxious phenotype plus sepsis may induce more pronounced organs damage, and promote more alterations in the HPA axis. These findings may help to explain, at least in part, the common point of the mechanisms involved with the pathophysiology of sepsis and anxiety. |
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Journal of Health & Biological Sciences |
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Anxious phenotype potentiates damage in peripheral organs of animals submitted to sepsissaude; ciencias da saudeAnxiety; Stress; Sepsis; Carioca high-freezing; Carioca low-freezingStress disordersIntroduction: Anxiety and sepsis are important public health problems that present high morbidity, mortality and significant economic repercussions. The present study investigated the presence of oxidative damage in peripheral organs in two lines of animals that are bred for high and low freezing responses to contextual cues that are previously associated with foot shock (Carioca High-conditioned Freezing [CHF] and Carioca Low-conditioned Freezing [CLF]) associated to sepsis. Methods: Animals were subject to sepsis by the cecal ligation and perforation (CLP) or sham operated. 24 hours and 10 days after sepsis animals were euthanized and removed adrenal, kidney, lung, serum, heart for the determination of carbonyl protein levels and adrenal for check weight this structure. Results: Sepsis increased oxidative damage in different systemic organs, included serum. There wasn’t a significant increase in protein carbonyls in heart and kidney. Anxious phenotype potentiates this damage. Conclusion: These findings suggest that an anxious phenotype plus sepsis may induce more pronounced organs damage, and promote more alterations in the HPA axis. These findings may help to explain, at least in part, the common point of the mechanisms involved with the pathophysiology of sepsis and anxiety.Instituto para o Desenvolvimento da Educacaocapes, cnpq, fapescMichels, MoniqueÁvila, PricilaMichelon, CleoniceBurger, HenriqueSonai, beatrizAbatti, MarianeBilesimo, rafaelamillioli, maria vitoriaFucilini, vanessaSteckert, amandafernandez, jesus landeiradal-pizzol, felipe2018-07-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAvaliado por ParesPeer ReviewRevisado por paresapplication/pdfhttps://periodicos.unichristus.edu.br/jhbs/article/view/196010.12662/2317-3076jhbs.v6i3.1960.p234-241.2018Journal of Health & Biological Sciences; v. 6, n. 3 (2018): Journal of Health and Biological Sciences; 234-241Journal of Health & Biological Sciences; v. 6, n. 3 (2018): Journal of Health and Biological Sciences; 234-241Journal of Health and Biological Sciences; v. 6, n. 3 (2018): Journal of Health and Biological Sciences; 234-2412317-30762317-308410.12662/2317-3076jhbs.v6i3.2018reponame:Journal of Health & Biological Sciencesinstname:Centro Universitário Christus (Unichristus)instacron:CHRISTUSenghttps://periodicos.unichristus.edu.br/jhbs/article/view/1960/706https://periodicos.unichristus.edu.br/jhbs/article/downloadSuppFile/1960/459https://periodicos.unichristus.edu.br/jhbs/article/downloadSuppFile/1960/460https://periodicos.unichristus.edu.br/jhbs/article/downloadSuppFile/1960/461america do sulDireitos autorais 2018 Journal of Health & Biological Scienceshttp://creativecommons.org/licenses/by-nc-sa/4.0info:eu-repo/semantics/openAccess2018-07-04T21:52:22Zoai:ojs.unichristus.emnuvens.com.br:article/1960Revistahttps://periodicos.unichristus.edu.br/jhbs/indexPRIhttps://periodicos.unichristus.edu.br/jhbs/oaisecretaria.jhbs@unichristus.edu.br || editor.jhbs@fchristus.edu.br2317-30762317-3084opendoar:2023-01-13T09:47:12.502456Journal of Health & Biological Sciences - Centro Universitário Christus (Unichristus)true |
dc.title.none.fl_str_mv |
Anxious phenotype potentiates damage in peripheral organs of animals submitted to sepsis |
title |
Anxious phenotype potentiates damage in peripheral organs of animals submitted to sepsis |
spellingShingle |
Anxious phenotype potentiates damage in peripheral organs of animals submitted to sepsis Michels, Monique saude; ciencias da saude Anxiety; Stress; Sepsis; Carioca high-freezing; Carioca low-freezing Stress disorders |
title_short |
Anxious phenotype potentiates damage in peripheral organs of animals submitted to sepsis |
title_full |
Anxious phenotype potentiates damage in peripheral organs of animals submitted to sepsis |
title_fullStr |
Anxious phenotype potentiates damage in peripheral organs of animals submitted to sepsis |
title_full_unstemmed |
Anxious phenotype potentiates damage in peripheral organs of animals submitted to sepsis |
title_sort |
Anxious phenotype potentiates damage in peripheral organs of animals submitted to sepsis |
author |
Michels, Monique |
author_facet |
Michels, Monique Ávila, Pricila Michelon, Cleonice Burger, Henrique Sonai, beatriz Abatti, Mariane Bilesimo, rafaela millioli, maria vitoria Fucilini, vanessa Steckert, amanda fernandez, jesus landeira dal-pizzol, felipe |
author_role |
author |
author2 |
Ávila, Pricila Michelon, Cleonice Burger, Henrique Sonai, beatriz Abatti, Mariane Bilesimo, rafaela millioli, maria vitoria Fucilini, vanessa Steckert, amanda fernandez, jesus landeira dal-pizzol, felipe |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
capes, cnpq, fapesc |
dc.contributor.author.fl_str_mv |
Michels, Monique Ávila, Pricila Michelon, Cleonice Burger, Henrique Sonai, beatriz Abatti, Mariane Bilesimo, rafaela millioli, maria vitoria Fucilini, vanessa Steckert, amanda fernandez, jesus landeira dal-pizzol, felipe |
dc.subject.por.fl_str_mv |
saude; ciencias da saude Anxiety; Stress; Sepsis; Carioca high-freezing; Carioca low-freezing Stress disorders |
topic |
saude; ciencias da saude Anxiety; Stress; Sepsis; Carioca high-freezing; Carioca low-freezing Stress disorders |
description |
Introduction: Anxiety and sepsis are important public health problems that present high morbidity, mortality and significant economic repercussions. The present study investigated the presence of oxidative damage in peripheral organs in two lines of animals that are bred for high and low freezing responses to contextual cues that are previously associated with foot shock (Carioca High-conditioned Freezing [CHF] and Carioca Low-conditioned Freezing [CLF]) associated to sepsis. Methods: Animals were subject to sepsis by the cecal ligation and perforation (CLP) or sham operated. 24 hours and 10 days after sepsis animals were euthanized and removed adrenal, kidney, lung, serum, heart for the determination of carbonyl protein levels and adrenal for check weight this structure. Results: Sepsis increased oxidative damage in different systemic organs, included serum. There wasn’t a significant increase in protein carbonyls in heart and kidney. Anxious phenotype potentiates this damage. Conclusion: These findings suggest that an anxious phenotype plus sepsis may induce more pronounced organs damage, and promote more alterations in the HPA axis. These findings may help to explain, at least in part, the common point of the mechanisms involved with the pathophysiology of sepsis and anxiety. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-07-02 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Avaliado por Pares Peer Review Revisado por pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.unichristus.edu.br/jhbs/article/view/1960 10.12662/2317-3076jhbs.v6i3.1960.p234-241.2018 |
url |
https://periodicos.unichristus.edu.br/jhbs/article/view/1960 |
identifier_str_mv |
10.12662/2317-3076jhbs.v6i3.1960.p234-241.2018 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://periodicos.unichristus.edu.br/jhbs/article/view/1960/706 https://periodicos.unichristus.edu.br/jhbs/article/downloadSuppFile/1960/459 https://periodicos.unichristus.edu.br/jhbs/article/downloadSuppFile/1960/460 https://periodicos.unichristus.edu.br/jhbs/article/downloadSuppFile/1960/461 |
dc.rights.driver.fl_str_mv |
Direitos autorais 2018 Journal of Health & Biological Sciences http://creativecommons.org/licenses/by-nc-sa/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Direitos autorais 2018 Journal of Health & Biological Sciences http://creativecommons.org/licenses/by-nc-sa/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.coverage.none.fl_str_mv |
america do sul |
dc.publisher.none.fl_str_mv |
Instituto para o Desenvolvimento da Educacao |
publisher.none.fl_str_mv |
Instituto para o Desenvolvimento da Educacao |
dc.source.none.fl_str_mv |
Journal of Health & Biological Sciences; v. 6, n. 3 (2018): Journal of Health and Biological Sciences; 234-241 Journal of Health & Biological Sciences; v. 6, n. 3 (2018): Journal of Health and Biological Sciences; 234-241 Journal of Health and Biological Sciences; v. 6, n. 3 (2018): Journal of Health and Biological Sciences; 234-241 2317-3076 2317-3084 10.12662/2317-3076jhbs.v6i3.2018 reponame:Journal of Health & Biological Sciences instname:Centro Universitário Christus (Unichristus) instacron:CHRISTUS |
instname_str |
Centro Universitário Christus (Unichristus) |
instacron_str |
CHRISTUS |
institution |
CHRISTUS |
reponame_str |
Journal of Health & Biological Sciences |
collection |
Journal of Health & Biological Sciences |
repository.name.fl_str_mv |
Journal of Health & Biological Sciences - Centro Universitário Christus (Unichristus) |
repository.mail.fl_str_mv |
secretaria.jhbs@unichristus.edu.br || editor.jhbs@fchristus.edu.br |
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1797052855299866624 |