The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: a case series
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/25269 |
Resumo: | University of Liverpool. National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections. Liverpool, United Kingdom / University of Liverpool, Institute of Infection and Global Health. Liverpool, United Kingdom. |
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Mehta, RaviSoares, Cristiane NascimentoMedialdea-Carrera, RaquelEllul, MarkSilva, Marcus Tulius Texeira daRosala-Hallas, AnnaJardim, Marcia RodriguesBurnside, GirvanPamplona, LucianaBhojak, ManeeshManohar, RadhikaSilva, Gabriel Amorelli Medeiros daAdriano, Marcus ViniciusBrasil, PatríciaNogueira, Rita Maria RibeiroSantos, Carolina Cardoso dosTurtle, LanceSequeira, Patricia Carvalho deBrown, David W.Griffiths, Michael J.Filippis, Ana Maria Bispo deSolomon, Tom2018-03-13T12:30:51Z2018-03-13T12:30:51Z2018MEHTA, Ravi et al. The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: a case series. PLoS Neglected Tropical Diseases, v. 12, n. 2, p. 1-20, Feb. 2018.1935-2727https://www.arca.fiocruz.br/handle/icict/2526910.1371/journal.pntd.00062121935-2735engPublic Library of ScienceZika virusChikungunya virusRio de JaneiroAdultosDoenças neurológicasZika virusVírus ChikungunyaRio de JaneiroAdultsNeurological diseaseThe spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: a case seriesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of Liverpool. National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections. Liverpool, United Kingdom / University of Liverpool, Institute of Infection and Global Health. Liverpool, United Kingdom.Hospital Federal dos Servidores do Estado. Departamento de Neurologia. Rio de Janeiro, RJ, BrasilUniversity of Liverpool. National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections. Liverpool, United Kingdom / University of Liverpool, Institute of Infection and Global Health. Liverpool, United Kingdom.University of Liverpool. National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections. Liverpool, United Kingdom / University of Liverpool, Institute of Infection and Global Health. Liverpool, United Kingdom / Walton Centre NHS Foundation Trust. Department of Neurology. Liverpool, United Kingdom.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa em Neuroinfecção. Rio de Janeiro, RJ. Brasil / Hospital de Clínicas de Niterói. Departamento de Neurologia. Niterói, RJ, Brasil.University of Liverpool. Institute of Translational Medicine. Department of Biostatistics. Liverpóol, United Kingdom.Universidade do Estado do Rio de Janeiro. Hospital Universitário Pedro Ernesto. Rio de Janeiro, RJ, Brasil.University of Liverpool. Institute of Translational Medicine. Department of Biostatistics. Liverpóol, United Kingdom.Hospital Geral de Bonsucesso. Departamento de Neurologia. Rio de Janeiro, RJ, BrasilWalton Centre NHS Foundation Trust. Department of Neurology. Liverpool, United Kingdom.Walton Centre NHS Foundation Trust. Department of Neurology. Liverpool, United Kingdom.Hospital Federal dos Servidores do Estado. Departamento de Neurologia. Rio de Janeiro, RJ, BrasilHospital Barra D'or. Departamento de Neurologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ. Brasil.University of Liverpool. National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections. Liverpool, United Kingdom / University of Liverpool, Institute of Infection and Global Health. Liverpool, United Kingdom / Walton Centre NHS Foundation Trust. Department of Neurology. Liverpool, United Kingdom.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e de Sarampo. Rio de Janeiro, RJ, Brasil / Public Health England. National Infection Service. Virus Reference Department. London, United Kingdom.University of Liverpool. National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections. Liverpool, United Kingdom / University of Liverpool, Institute of Infection and Global Health. Liverpool, United Kingdom / Alder Hey Children's NHS Foundation Trust. Department of Neurology. Liverpool, United Kingdom.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ. Brasil.University of Liverpool. National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections. Liverpool, United Kingdom / University of Liverpool, Institute of Infection and Global Health. Liverpool, United Kingdom / Walton Centre NHS Foundation Trust. Department of Neurology. Liverpool, United Kingdom.Background: During 2015–16 Brazil experienced the largest epidemic of Zika virus ever reported. This arthropod-borne virus (arbovirus) has been linked to Guillain-Barre´ syndrome (GBS) in adults but other neurological associations are uncertain. Chikungunya virus has caused outbreaks in Brazil since 2014 but associated neurological disease has rarely been reported here. We investigated adults with acute neurological disorders for Zika, chikungunya and dengue, another arbovirus circulating in Brazil. Methods: We studied adults who had developed a new neurological condition following suspected Zika virus infection between 1st November 2015 and 1st June 2016. Cerebrospinal fluid (CSF), serum, and urine were tested for evidence of Zika, chikungunya, and dengue viruses. Results: Of 35 patients studied, 22 had evidence of recent arboviral infection. Twelve had positive PCR or IgM for Zika, five of whom also had evidence for chikungunya, three for dengue, and one for all three viruses. Five of them presented with GBS; seven had presentations other than GBS, including meningoencephalitis, myelitis, radiculitis or combinations of these syndromes. Additionally, ten patients positive for chikungunya virus, two of whom also had evidence for dengue virus, presented with a similar range of neurological conditions. Conclusions: Zika virus is associated with a wide range of neurological manifestations, including central nervous system disease. Chikungunya virus appears to have and equally important association with neurological disease in Brazil, and any patients had dual infection. To understand fully the burden of Zika we must look beyond GBS, and also investigate for other co-circulating arboviruses, particularly chikungunya.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25269/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALdavid_brown_etal_IOC_2018.pdfdavid_brown_etal_IOC_2018.pdfapplication/pdf1279180https://www.arca.fiocruz.br/bitstream/icict/25269/2/david_brown_etal_IOC_2018.pdfcdbffc3b25e5a4cfabc4f55e9f17456cMD52TEXTdavid_brown_etal_IOC_2018.pdf.txtdavid_brown_etal_IOC_2018.pdf.txtExtracted texttext/plain64279https://www.arca.fiocruz.br/bitstream/icict/25269/3/david_brown_etal_IOC_2018.pdf.txtdbfd10fc3907c1a4da0e65281dd4f734MD53icict/252692023-08-15 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| dc.title.pt_BR.fl_str_mv |
The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: a case series |
| title |
The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: a case series |
| spellingShingle |
The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: a case series Mehta, Ravi Zika virus Chikungunya virus Rio de Janeiro Adultos Doenças neurológicas Zika virus Vírus Chikungunya Rio de Janeiro Adults Neurological disease |
| title_short |
The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: a case series |
| title_full |
The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: a case series |
| title_fullStr |
The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: a case series |
| title_full_unstemmed |
The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: a case series |
| title_sort |
The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: a case series |
| author |
Mehta, Ravi |
| author_facet |
Mehta, Ravi Soares, Cristiane Nascimento Medialdea-Carrera, Raquel Ellul, Mark Silva, Marcus Tulius Texeira da Rosala-Hallas, Anna Jardim, Marcia Rodrigues Burnside, Girvan Pamplona, Luciana Bhojak, Maneesh Manohar, Radhika Silva, Gabriel Amorelli Medeiros da Adriano, Marcus Vinicius Brasil, Patrícia Nogueira, Rita Maria Ribeiro Santos, Carolina Cardoso dos Turtle, Lance Sequeira, Patricia Carvalho de Brown, David W. Griffiths, Michael J. Filippis, Ana Maria Bispo de Solomon, Tom |
| author_role |
author |
| author2 |
Soares, Cristiane Nascimento Medialdea-Carrera, Raquel Ellul, Mark Silva, Marcus Tulius Texeira da Rosala-Hallas, Anna Jardim, Marcia Rodrigues Burnside, Girvan Pamplona, Luciana Bhojak, Maneesh Manohar, Radhika Silva, Gabriel Amorelli Medeiros da Adriano, Marcus Vinicius Brasil, Patrícia Nogueira, Rita Maria Ribeiro Santos, Carolina Cardoso dos Turtle, Lance Sequeira, Patricia Carvalho de Brown, David W. Griffiths, Michael J. Filippis, Ana Maria Bispo de Solomon, Tom |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Mehta, Ravi Soares, Cristiane Nascimento Medialdea-Carrera, Raquel Ellul, Mark Silva, Marcus Tulius Texeira da Rosala-Hallas, Anna Jardim, Marcia Rodrigues Burnside, Girvan Pamplona, Luciana Bhojak, Maneesh Manohar, Radhika Silva, Gabriel Amorelli Medeiros da Adriano, Marcus Vinicius Brasil, Patrícia Nogueira, Rita Maria Ribeiro Santos, Carolina Cardoso dos Turtle, Lance Sequeira, Patricia Carvalho de Brown, David W. Griffiths, Michael J. Filippis, Ana Maria Bispo de Solomon, Tom |
| dc.subject.other.pt_BR.fl_str_mv |
Zika virus Chikungunya virus Rio de Janeiro Adultos Doenças neurológicas |
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Zika virus Chikungunya virus Rio de Janeiro Adultos Doenças neurológicas Zika virus Vírus Chikungunya Rio de Janeiro Adults Neurological disease |
| dc.subject.en.pt_BR.fl_str_mv |
Zika virus Vírus Chikungunya Rio de Janeiro Adults Neurological disease |
| description |
University of Liverpool. National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections. Liverpool, United Kingdom / University of Liverpool, Institute of Infection and Global Health. Liverpool, United Kingdom. |
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2018 |
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2018-03-13T12:30:51Z |
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2018-03-13T12:30:51Z |
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2018 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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MEHTA, Ravi et al. The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: a case series. PLoS Neglected Tropical Diseases, v. 12, n. 2, p. 1-20, Feb. 2018. |
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https://www.arca.fiocruz.br/handle/icict/25269 |
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1935-2727 |
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10.1371/journal.pntd.0006212 |
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1935-2735 |
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MEHTA, Ravi et al. The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: a case series. PLoS Neglected Tropical Diseases, v. 12, n. 2, p. 1-20, Feb. 2018. 1935-2727 10.1371/journal.pntd.0006212 1935-2735 |
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https://www.arca.fiocruz.br/handle/icict/25269 |
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eng |
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eng |
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openAccess |
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Public Library of Science |
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Public Library of Science |
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