Coassociations between IL10 polymorphisms, IL-10 production, helminth infection, and asthma/wheeze in an urban tropical population in Brazil.
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/8222 |
Resumo: | Johns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, EUA / Instituto de Ciências da Saúde. Salvador, BA, Brasil |
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Figueiredo, Camila Alexandrina VianaBarreto, Maurício LimaNeves, Neuza Maria AlcântaraRodrigues, Laura CunhaCooper, Philip JohnCruz Filho, Alvaro Augusto Souza daPontes-de-Carvalho, Lain CarlosLemaire, Denise CarneiroCosta, Ryan dos SantosAmorim, Leila DVergara, CandelariaRafaels, NicholasGao, LiFoster, CassandraCampbell, MonicaMathias, Rasika ABarnes, Kathleen C2014-08-22T19:26:05Z2014-08-22T19:26:05Z2013FIFUEIREDO, C. A. et al. Coassociations between IL10 polymorphisms, IL-10 production, helminth infection, and asthma/wheeze in an urban tropical population in Brazil. Journal of Allergy Clinical Immunology, v. 131, n. 6, p. 1683-1690, 2013.1097-6825https://www.arca.fiocruz.br/handle/icict/8222engAmerican Academy of Allergy, Asthma & ImmunologyCoassociations between IL10 polymorphisms, IL-10 production, helminth infection, and asthma/wheeze in an urban tropical population in Brazil.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleJohns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, EUA / Instituto de Ciências da Saúde. Salvador, BA, BrasilInstituto de Sa ude Coletiva. Salvador, BA, BrasilInstituto de Ciências da Saúde. Salvador, BA, BrasilLondon School of Hygiene and Tropical Medicine. London, USAUniversidad San Francisco de Quito. Ecuador, Quito / University of London. Centre for Infection St George’s. London, USAProAR–N ucleo de Excelência em Asma. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilInstituto de Ciências da Saúde. Salvador, BA, Brasil / Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, BrasilInstituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Matem atica. Salvador, BA, BrasilJohns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, EUAJohns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, EUAJohns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, EUAJohns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, EUAJohns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, EUAJohns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, EUAJohns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, EUABACKGROUND: Helminth infections are associated with protection against allergies. It is postulated that IL-10 production after helminth infection suppresses skin hypersensitivity and increases IgG4 production, protecting against allergies. OBJECTIVE: We aimed to determine whether IL10 polymorphisms are associated with helminth infection and the risk of wheeze and allergy. METHODS: Twelve IL10 single nucleotide polymorphisms were genotyped in 1353 children aged 4 to 11 years living in a poor urban area in Salvador, Brazil. Wheezing status, Ascaris lumbricoides and Trichuris trichiura infection, IL-10 production by peripheral blood leukocytes stimulated with A lumbricoides extract, serum total IgE levels, specific IgE levels, skin prick test responses to common aeroallergens, and IgG4 and IgE anti-A lumbricoides antibody levels were measured in all children. Association tests were performed by using logistic or linear regression when appropriate, including sex, age, helminth infection, and principal components for ancestry informative markers as covariates by using PLINK. RESULTS: Allele G of marker rs3024496 was associated with the decreased production of IL-10 by peripheral blood leukocytes in response to A lumbricoides stimulation. Allele C of marker rs3024498 was negatively associated with helminth infection or its markers. Marker rs3024492 was positively associated with the risk of atopic wheeze, total IgE levels, and skin prick test responses to cockroach. CONCLUSIONS: Our findings suggest that IL10 polymorphisms might play a role in the production of IL-10, helminth infection, and allergy. We hypothesize that polymorphisms related to protection against helminths, which would offer an evolutionary advantage to subjects in the past, might be associated with increased risk of allergic diseases.IL10PolymorphismsHelminth infectionImmune modulationAllergyAsthmaSocial changes asthma and allergy in Latin AmericaAsma/epidemiologiaAsma/etiologiaHelmintíase/complicaçõesInterleucina-10/biossíntesePolimorfismo GenéticoSons Respiratórios/etiologiaAdolescenteAlelosBrasil/epidemiologiaCriançaPré-EscolarFemininoLigação GenéticaGenótipoHumanosLactenteDesequilíbrio de LigaçãoMasculinoPolimorfismo de Nucleotídeo ÚnicoPopulação Urbanainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8222/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALFigueiredo C. 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| dc.title.pt_BR.fl_str_mv |
Coassociations between IL10 polymorphisms, IL-10 production, helminth infection, and asthma/wheeze in an urban tropical population in Brazil. |
| title |
Coassociations between IL10 polymorphisms, IL-10 production, helminth infection, and asthma/wheeze in an urban tropical population in Brazil. |
| spellingShingle |
Coassociations between IL10 polymorphisms, IL-10 production, helminth infection, and asthma/wheeze in an urban tropical population in Brazil. Figueiredo, Camila Alexandrina Viana IL10 Polymorphisms Helminth infection Immune modulation Allergy Asthma Social changes asthma and allergy in Latin America Asma/epidemiologia Asma/etiologia Helmintíase/complicações Interleucina-10/biossíntese Polimorfismo Genético Sons Respiratórios/etiologia Adolescente Alelos Brasil/epidemiologia Criança Pré-Escolar Feminino Ligação Genética Genótipo Humanos Lactente Desequilíbrio de Ligação Masculino Polimorfismo de Nucleotídeo Único População Urbana |
| title_short |
Coassociations between IL10 polymorphisms, IL-10 production, helminth infection, and asthma/wheeze in an urban tropical population in Brazil. |
| title_full |
Coassociations between IL10 polymorphisms, IL-10 production, helminth infection, and asthma/wheeze in an urban tropical population in Brazil. |
| title_fullStr |
Coassociations between IL10 polymorphisms, IL-10 production, helminth infection, and asthma/wheeze in an urban tropical population in Brazil. |
| title_full_unstemmed |
Coassociations between IL10 polymorphisms, IL-10 production, helminth infection, and asthma/wheeze in an urban tropical population in Brazil. |
| title_sort |
Coassociations between IL10 polymorphisms, IL-10 production, helminth infection, and asthma/wheeze in an urban tropical population in Brazil. |
| author |
Figueiredo, Camila Alexandrina Viana |
| author_facet |
Figueiredo, Camila Alexandrina Viana Barreto, Maurício Lima Neves, Neuza Maria Alcântara Rodrigues, Laura Cunha Cooper, Philip John Cruz Filho, Alvaro Augusto Souza da Pontes-de-Carvalho, Lain Carlos Lemaire, Denise Carneiro Costa, Ryan dos Santos Amorim, Leila D Vergara, Candelaria Rafaels, Nicholas Gao, Li Foster, Cassandra Campbell, Monica Mathias, Rasika A Barnes, Kathleen C |
| author_role |
author |
| author2 |
Barreto, Maurício Lima Neves, Neuza Maria Alcântara Rodrigues, Laura Cunha Cooper, Philip John Cruz Filho, Alvaro Augusto Souza da Pontes-de-Carvalho, Lain Carlos Lemaire, Denise Carneiro Costa, Ryan dos Santos Amorim, Leila D Vergara, Candelaria Rafaels, Nicholas Gao, Li Foster, Cassandra Campbell, Monica Mathias, Rasika A Barnes, Kathleen C |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Figueiredo, Camila Alexandrina Viana Barreto, Maurício Lima Neves, Neuza Maria Alcântara Rodrigues, Laura Cunha Cooper, Philip John Cruz Filho, Alvaro Augusto Souza da Pontes-de-Carvalho, Lain Carlos Lemaire, Denise Carneiro Costa, Ryan dos Santos Amorim, Leila D Vergara, Candelaria Rafaels, Nicholas Gao, Li Foster, Cassandra Campbell, Monica Mathias, Rasika A Barnes, Kathleen C |
| dc.subject.en.pt_BR.fl_str_mv |
IL10 Polymorphisms Helminth infection Immune modulation Allergy Asthma Social changes asthma and allergy in Latin America |
| topic |
IL10 Polymorphisms Helminth infection Immune modulation Allergy Asthma Social changes asthma and allergy in Latin America Asma/epidemiologia Asma/etiologia Helmintíase/complicações Interleucina-10/biossíntese Polimorfismo Genético Sons Respiratórios/etiologia Adolescente Alelos Brasil/epidemiologia Criança Pré-Escolar Feminino Ligação Genética Genótipo Humanos Lactente Desequilíbrio de Ligação Masculino Polimorfismo de Nucleotídeo Único População Urbana |
| dc.subject.decs.pt_BR.fl_str_mv |
Asma/epidemiologia Asma/etiologia Helmintíase/complicações Interleucina-10/biossíntese Polimorfismo Genético Sons Respiratórios/etiologia Adolescente Alelos Brasil/epidemiologia Criança Pré-Escolar Feminino Ligação Genética Genótipo Humanos Lactente Desequilíbrio de Ligação Masculino Polimorfismo de Nucleotídeo Único População Urbana |
| description |
Johns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, EUA / Instituto de Ciências da Saúde. Salvador, BA, Brasil |
| publishDate |
2013 |
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2013 |
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2014-08-22T19:26:05Z |
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2014-08-22T19:26:05Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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FIFUEIREDO, C. A. et al. Coassociations between IL10 polymorphisms, IL-10 production, helminth infection, and asthma/wheeze in an urban tropical population in Brazil. Journal of Allergy Clinical Immunology, v. 131, n. 6, p. 1683-1690, 2013. |
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https://www.arca.fiocruz.br/handle/icict/8222 |
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1097-6825 |
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FIFUEIREDO, C. A. et al. Coassociations between IL10 polymorphisms, IL-10 production, helminth infection, and asthma/wheeze in an urban tropical population in Brazil. Journal of Allergy Clinical Immunology, v. 131, n. 6, p. 1683-1690, 2013. 1097-6825 |
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American Academy of Allergy, Asthma & Immunology |
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American Academy of Allergy, Asthma & Immunology |
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