The ACE inhibitors enalapril and captopril modulate cytokine responses in Balb/c and C57Bl/6 normal mice and increase CD4(+)CD103(+)CD25(negative) splenic T cell numbers.

Albuquerque, Deijanira; Nihei, Jorge Sadao; Cardillo, Fabíola; Singh, Ram

The ACE inhibitors enalapril and captopril modulate cytokine responses in Balb/c and C57Bl/6 normal mice and increase CD4(+)CD103(+)CD25(negative) splenic T cell numbers.

Bibliographic Details
Main Author:	Albuquerque, Deijanira
Publication Date:	2010
Other Authors:	Nihei, Jorge Sadao, Cardillo, Fabíola, Singh, Ram
Format:	Article
Language:	eng
Source:	Repositório Institucional da FIOCRUZ (ARCA)
Download full:	https://www.arca.fiocruz.br/handle/icict/10905
Summary:	Federal University of Mato Grosso. Faculty of Medicine. Department of Basic Health Science. Cuiabá, MG, Brasil

Item metadata

id	CRUZ_026e9e1762b1ce793c5b99115c42a2ed
oai_identifier_str	oai:www.arca.fiocruz.br:icict/10905
network_acronym_str	CRUZ
network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str	2135
spelling	Albuquerque, DeijaniraNihei, Jorge SadaoCardillo, FabíolaSingh, Ram2015-06-17T18:44:21Z2015-06-17T18:44:21Z2010ALBUQUERQUE, D. et al. The ACE inhibitors enalapril and captopril modulate cytokine responses in Balb/c and C57Bl/6 normal mice and increase CD4(+)CD103(+)CD25(negative) splenic T cell numbers. Cellular Immunology, v. 260, n. 2, p. 92-97, 2010.0008-8749https://www.arca.fiocruz.br/handle/icict/10905engElsevierThe ACE inhibitors enalapril and captopril modulate cytokine responses in Balb/c and C57Bl/6 normal mice and increase CD4(+)CD103(+)CD25(negative) splenic T cell numbers.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFederal University of Mato Grosso. Faculty of Medicine. Department of Basic Health Science. Cuiabá, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUCLA David Geffen School of Medicine. Division of Rheumatology. Los Angeles, CA, USAIncreasing evidence implies beneficial effects of angiotensin-converting enzyme (ACE) inhibitors beyond those of their original indications to control hypertension. One of the most attractive non-hemodynamic properties of ACE inhibitors is their ability to regulate cytokine production. The mechanism(s) underlying the role of ACE inhibitors on cytokine synthesis are not well understood but they have traditionally been attributed to the inhibition of angiotensin (Ang) II formation. In fact, it has been extensively demonstrated that ACE inhibitors decrease Ang II-induced production of proinflammatory cytokines and chemokines. However, it is not well described if inhibition of endogenous Ang II generation by ACE inhibitors modulates systemic cytokine production in mice. To verify that, in this work, we investigated the effects of treatment with the ACE inhibitors enalapril and captopril on cytokine synthesis in C57Bl/6 and Balb/c mice. Our results show that enalapril up regulates IL-10 produced by splenocytes from Balb/c and C57Bl/6 mice and captopril increased it only in Balb/c mice. Furthermore, CD4(+)CD103(+) presented increased IL-10 production after enalapril treatment. Enalapril as well as captopril short-term treatment enhanced IL-2 synthesis in Balb/c mice. Besides, enhanced IL-2 and IL-10 levels correlates with increased CD4(+)CD103(+)CD25(negative) T cells numbers in spleens from enalapril-treated miceACE inhibitorsCytokinesEnalaprilRegulatory T cellsCaptopril/farmacologiaEnalapril/farmacologiaCitocinas/metabolismoBaço/efeitos de drogasLinfócitos T/efeitos de drogasInibidores da Enzima Conversora de Angiotensina/farmacologiaAnimaisAntígenos CD/metabolismoCélulas CultivadasEnsaio de Imunoadsorção EnzimáticaCitometria de FluxoCadeias alfa de Integrinas/metabolismoInterleucina-10/metabolismoSubunidade alfa de Receptor de Interleucina-2/metabolismoCamundongosCamundongos Endogâmicos BALB CEspecificidade da EspécieBaço/citologiaLinfócitos T/citologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAlbuquerque D The ace inhibitors....pdfAlbuquerque D The ace inhibitors....pdfapplication/pdf598548https://www.arca.fiocruz.br/bitstream/icict/10905/2/Albuquerque%20D%20The%20ace%20inhibitors....pdf83147fecb282449cb85445c07f81bde3MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82354https://www.arca.fiocruz.br/bitstream/icict/10905/3/license.txt8b4c200b4e10021c5683c6ccaba07169MD53TEXTAlbuquerque D The ace inhibitors....pdf.txtAlbuquerque D The ace inhibitors....pdf.txtExtracted texttext/plain30950https://www.arca.fiocruz.br/bitstream/icict/10905/4/Albuquerque%20D%20The%20ace%20inhibitors....pdf.txt4cb7ef6524a6287e9d0a3434c10497f3MD54icict/109052023-03-15 14:33:09.487oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:09Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv	The ACE inhibitors enalapril and captopril modulate cytokine responses in Balb/c and C57Bl/6 normal mice and increase CD4(+)CD103(+)CD25(negative) splenic T cell numbers.
title	The ACE inhibitors enalapril and captopril modulate cytokine responses in Balb/c and C57Bl/6 normal mice and increase CD4(+)CD103(+)CD25(negative) splenic T cell numbers.
spellingShingle	The ACE inhibitors enalapril and captopril modulate cytokine responses in Balb/c and C57Bl/6 normal mice and increase CD4(+)CD103(+)CD25(negative) splenic T cell numbers. Albuquerque, Deijanira ACE inhibitors Cytokines Enalapril Regulatory T cells Captopril/farmacologia Enalapril/farmacologia Citocinas/metabolismo Baço/efeitos de drogas Linfócitos T/efeitos de drogas Inibidores da Enzima Conversora de Angiotensina/farmacologia Animais Antígenos CD/metabolismo Células Cultivadas Ensaio de Imunoadsorção Enzimática Citometria de Fluxo Cadeias alfa de Integrinas/metabolismo Interleucina-10/metabolismo Subunidade alfa de Receptor de Interleucina-2/metabolismo Camundongos Camundongos Endogâmicos BALB C Especificidade da Espécie Baço/citologia Linfócitos T/citologia
title_short	The ACE inhibitors enalapril and captopril modulate cytokine responses in Balb/c and C57Bl/6 normal mice and increase CD4(+)CD103(+)CD25(negative) splenic T cell numbers.
title_full	The ACE inhibitors enalapril and captopril modulate cytokine responses in Balb/c and C57Bl/6 normal mice and increase CD4(+)CD103(+)CD25(negative) splenic T cell numbers.
title_fullStr	The ACE inhibitors enalapril and captopril modulate cytokine responses in Balb/c and C57Bl/6 normal mice and increase CD4(+)CD103(+)CD25(negative) splenic T cell numbers.
title_full_unstemmed	The ACE inhibitors enalapril and captopril modulate cytokine responses in Balb/c and C57Bl/6 normal mice and increase CD4(+)CD103(+)CD25(negative) splenic T cell numbers.
title_sort	The ACE inhibitors enalapril and captopril modulate cytokine responses in Balb/c and C57Bl/6 normal mice and increase CD4(+)CD103(+)CD25(negative) splenic T cell numbers.
author	Albuquerque, Deijanira
author_facet	Albuquerque, Deijanira Nihei, Jorge Sadao Cardillo, Fabíola Singh, Ram
author_role	author
author2	Nihei, Jorge Sadao Cardillo, Fabíola Singh, Ram
author2_role	author author author
dc.contributor.author.fl_str_mv	Albuquerque, Deijanira Nihei, Jorge Sadao Cardillo, Fabíola Singh, Ram
dc.subject.en.pt_BR.fl_str_mv	ACE inhibitors Cytokines Enalapril Regulatory T cells
topic	ACE inhibitors Cytokines Enalapril Regulatory T cells Captopril/farmacologia Enalapril/farmacologia Citocinas/metabolismo Baço/efeitos de drogas Linfócitos T/efeitos de drogas Inibidores da Enzima Conversora de Angiotensina/farmacologia Animais Antígenos CD/metabolismo Células Cultivadas Ensaio de Imunoadsorção Enzimática Citometria de Fluxo Cadeias alfa de Integrinas/metabolismo Interleucina-10/metabolismo Subunidade alfa de Receptor de Interleucina-2/metabolismo Camundongos Camundongos Endogâmicos BALB C Especificidade da Espécie Baço/citologia Linfócitos T/citologia
dc.subject.decs.pt_BR.fl_str_mv	Captopril/farmacologia Enalapril/farmacologia Citocinas/metabolismo Baço/efeitos de drogas Linfócitos T/efeitos de drogas Inibidores da Enzima Conversora de Angiotensina/farmacologia Animais Antígenos CD/metabolismo Células Cultivadas Ensaio de Imunoadsorção Enzimática Citometria de Fluxo Cadeias alfa de Integrinas/metabolismo Interleucina-10/metabolismo Subunidade alfa de Receptor de Interleucina-2/metabolismo Camundongos Camundongos Endogâmicos BALB C Especificidade da Espécie Baço/citologia Linfócitos T/citologia
description	Federal University of Mato Grosso. Faculty of Medicine. Department of Basic Health Science. Cuiabá, MG, Brasil
publishDate	2010
dc.date.issued.fl_str_mv	2010
dc.date.accessioned.fl_str_mv	2015-06-17T18:44:21Z
dc.date.available.fl_str_mv	2015-06-17T18:44:21Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	ALBUQUERQUE, D. et al. The ACE inhibitors enalapril and captopril modulate cytokine responses in Balb/c and C57Bl/6 normal mice and increase CD4(+)CD103(+)CD25(negative) splenic T cell numbers. Cellular Immunology, v. 260, n. 2, p. 92-97, 2010.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/10905
dc.identifier.issn.none.fl_str_mv	0008-8749
identifier_str_mv	ALBUQUERQUE, D. et al. The ACE inhibitors enalapril and captopril modulate cytokine responses in Balb/c and C57Bl/6 normal mice and increase CD4(+)CD103(+)CD25(negative) splenic T cell numbers. Cellular Immunology, v. 260, n. 2, p. 92-97, 2010. 0008-8749
url	https://www.arca.fiocruz.br/handle/icict/10905
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/10905/2/Albuquerque%20D%20The%20ace%20inhibitors....pdf https://www.arca.fiocruz.br/bitstream/icict/10905/3/license.txt https://www.arca.fiocruz.br/bitstream/icict/10905/4/Albuquerque%20D%20The%20ace%20inhibitors....pdf.txt
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bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5 MD5
repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
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The ACE inhibitors enalapril and captopril modulate cytokine responses in Balb/c and C57Bl/6 normal mice and increase CD4(+)CD103(+)CD25(negative) splenic T cell numbers.

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