Preclinical validation of occupational and environmental safety of an isolation system for noninvasive ventilation in COVID-19 and other aerosol-transmitted infections
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/46269 |
Resumo: | Laboratory of Nuclear Magnetic Resonance, Department of Chemistry, São Carlos Federal University and the Center for Biotechnology and Cell Therapy, São Rafael Hospital, D’Or Institute for Research and Education. |
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Quadros, Claudio AlmeidaLeal, Maria Carolina Bezerra Di MedeirosBaptista Sobrinho, Carlos de AlmeidaNonaka, Carolina Kymie VasquesSouza, Bruno Solano De FreitasMattos, Juliana Cristina MilanCatai, Aparecida MariaLorenzo, Valéria Amorim Pires DiFerreira, Antonio Gilberto2021-03-05T12:56:27Z2021-03-05T12:56:27Z2020QUADROS, Claudio Almeida et al. Preclinical validation of occupational and environmental safety of an isolation system for noninvasive ventilation in COVID-19 and other aerosol-transmitted infections. Expert Review of Medical Devices, v. 17, n. 11, p. 1211–1220, 2020.1743-4440https://www.arca.fiocruz.br/handle/icict/4626910.1080/17434440.2020.1842190Laboratory of Nuclear Magnetic Resonance, Department of Chemistry, São Carlos Federal University and the Center for Biotechnology and Cell Therapy, São Rafael Hospital, D’Or Institute for Research and Education.Bahia State University, Medical School. Department of Life Sciences. Salvador, BA, Brazil.São Carlos Federal University. Department of Chemistry. São Carlos,SP, Brazil.University Center of Planalto Central Aparecido dos Santos. Brasília, DF, Brazil.São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.São Carlos Federal University. Department of Physiotherapy. São Carlos, SP, Brazil.São Carlos Federal University. Department of Physiotherapy. São Carlos, SP, Brazil.São Carlos Federal University. Department of Physiotherapy. São Carlos, SP, Brazil.São Carlos Federal University. Department of Chemistry. São Carlos,SP, Brazil.The current SARS-CoV-2 pandemic has provoked the collapse of some health systems due to insufficient intensive care unit capacity. The use of continuous positive airway pressure (CPAP) and high-flow nasal oxygen (HFNO) therapies has been limited in consideration of the risk of occupational infection in health-care professionals. Aims: In preclinical experimental simulations, evaluate occupational and environmental safety of the newly developed isolation system for aerosol-transmitted infections (ISATI). Method: Simulations were conducted to test ISATI’s capability to isolate aerosolized molecular (caffeine), and biological (SARS-CoV-2 synthetic RNA) markers. Caffeine deposition was analyzed on nitrocellulose sensor discs by proton nuclear magnetic resonance spectroscopy. Synthetic SARS-CoV-2 detection was performed by reverse transcription-polymerase chain reaction. Results: ISATI demonstrated efficacy in isolating molecular and biological markers within the enclosed environment in simulated conditions of CPAP, HFNO and mechanical ventilation therapy. Neither the molecular marker nor substantial amounts of synthetic SARS-CoV-2 RNA were detected in the surrounding environment, outside ISATI, indicating appropriate occupational safety for health-care professionals. Conclusion: Aerosolized markers were successfully contained within ISATI in all experimental simulations, offering occupational and environmental protection against the dissemination of aerosolized microparticles under CPAP or HFNO therapy conditions, which are indicated for patients with acute respiratory infections.engExpert ReviewsInfecções respiratóriasRespiratória artificialCOVID-19SARS-CoV-2OxigênioPressão Positiva Contínua nas Vias AéreasSegurançaOccupational respiratory infectionIsolation devices respiratory infectionCOVID-19InfluenzaHigh-flow oxygenContinuous positive airway pressurePreclinical validation of occupational and environmental safety of an isolation system for noninvasive ventilation in COVID-19 and other aerosol-transmitted infectionsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/46269/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALQuadros_Claudio_etal_IGM_2021_COVID-19 (Artigo).pdfQuadros_Claudio_etal_IGM_2021_COVID-19 (Artigo).pdfapplication/pdf5760096https://www.arca.fiocruz.br/bitstream/icict/46269/2/Quadros_Claudio_etal_IGM_2021_COVID-19%20%28Artigo%29.pdf430dab2c8fd127d6bf9e800c45fea656MD52TEXTQuadros_Claudio_etal_IGM_2021_COVID-19 (Artigo).pdf.txtQuadros_Claudio_etal_IGM_2021_COVID-19 (Artigo).pdf.txtExtracted texttext/plain48811https://www.arca.fiocruz.br/bitstream/icict/46269/3/Quadros_Claudio_etal_IGM_2021_COVID-19%20%28Artigo%29.pdf.txtb3da07891abaed59f843ad05efae5abdMD53icict/462692023-03-15 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| dc.title.pt_BR.fl_str_mv |
Preclinical validation of occupational and environmental safety of an isolation system for noninvasive ventilation in COVID-19 and other aerosol-transmitted infections |
| title |
Preclinical validation of occupational and environmental safety of an isolation system for noninvasive ventilation in COVID-19 and other aerosol-transmitted infections |
| spellingShingle |
Preclinical validation of occupational and environmental safety of an isolation system for noninvasive ventilation in COVID-19 and other aerosol-transmitted infections Quadros, Claudio Almeida Infecções respiratórias Respiratória artificial COVID-19 SARS-CoV-2 Oxigênio Pressão Positiva Contínua nas Vias Aéreas Segurança Occupational respiratory infection Isolation devices respiratory infection COVID-19 Influenza High-flow oxygen Continuous positive airway pressure |
| title_short |
Preclinical validation of occupational and environmental safety of an isolation system for noninvasive ventilation in COVID-19 and other aerosol-transmitted infections |
| title_full |
Preclinical validation of occupational and environmental safety of an isolation system for noninvasive ventilation in COVID-19 and other aerosol-transmitted infections |
| title_fullStr |
Preclinical validation of occupational and environmental safety of an isolation system for noninvasive ventilation in COVID-19 and other aerosol-transmitted infections |
| title_full_unstemmed |
Preclinical validation of occupational and environmental safety of an isolation system for noninvasive ventilation in COVID-19 and other aerosol-transmitted infections |
| title_sort |
Preclinical validation of occupational and environmental safety of an isolation system for noninvasive ventilation in COVID-19 and other aerosol-transmitted infections |
| author |
Quadros, Claudio Almeida |
| author_facet |
Quadros, Claudio Almeida Leal, Maria Carolina Bezerra Di Medeiros Baptista Sobrinho, Carlos de Almeida Nonaka, Carolina Kymie Vasques Souza, Bruno Solano De Freitas Mattos, Juliana Cristina Milan Catai, Aparecida Maria Lorenzo, Valéria Amorim Pires Di Ferreira, Antonio Gilberto |
| author_role |
author |
| author2 |
Leal, Maria Carolina Bezerra Di Medeiros Baptista Sobrinho, Carlos de Almeida Nonaka, Carolina Kymie Vasques Souza, Bruno Solano De Freitas Mattos, Juliana Cristina Milan Catai, Aparecida Maria Lorenzo, Valéria Amorim Pires Di Ferreira, Antonio Gilberto |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Quadros, Claudio Almeida Leal, Maria Carolina Bezerra Di Medeiros Baptista Sobrinho, Carlos de Almeida Nonaka, Carolina Kymie Vasques Souza, Bruno Solano De Freitas Mattos, Juliana Cristina Milan Catai, Aparecida Maria Lorenzo, Valéria Amorim Pires Di Ferreira, Antonio Gilberto |
| dc.subject.other.pt_BR.fl_str_mv |
Infecções respiratórias Respiratória artificial COVID-19 SARS-CoV-2 Oxigênio Pressão Positiva Contínua nas Vias Aéreas Segurança |
| topic |
Infecções respiratórias Respiratória artificial COVID-19 SARS-CoV-2 Oxigênio Pressão Positiva Contínua nas Vias Aéreas Segurança Occupational respiratory infection Isolation devices respiratory infection COVID-19 Influenza High-flow oxygen Continuous positive airway pressure |
| dc.subject.en.pt_BR.fl_str_mv |
Occupational respiratory infection Isolation devices respiratory infection COVID-19 Influenza High-flow oxygen Continuous positive airway pressure |
| description |
Laboratory of Nuclear Magnetic Resonance, Department of Chemistry, São Carlos Federal University and the Center for Biotechnology and Cell Therapy, São Rafael Hospital, D’Or Institute for Research and Education. |
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2020 |
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2020 |
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2021-03-05T12:56:27Z |
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2021-03-05T12:56:27Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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QUADROS, Claudio Almeida et al. Preclinical validation of occupational and environmental safety of an isolation system for noninvasive ventilation in COVID-19 and other aerosol-transmitted infections. Expert Review of Medical Devices, v. 17, n. 11, p. 1211–1220, 2020. |
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https://www.arca.fiocruz.br/handle/icict/46269 |
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1743-4440 |
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10.1080/17434440.2020.1842190 |
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QUADROS, Claudio Almeida et al. Preclinical validation of occupational and environmental safety of an isolation system for noninvasive ventilation in COVID-19 and other aerosol-transmitted infections. Expert Review of Medical Devices, v. 17, n. 11, p. 1211–1220, 2020. 1743-4440 10.1080/17434440.2020.1842190 |
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Expert Reviews |
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Expert Reviews |
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