Adult T-cell leukemia/lymphoma (ATL) presenting in the skin: clinical, histological and immunohistochemical features of 52 cases.

Detalhes bibliográficos
Autor(a) principal: Bittencourt, Achilea Candida Lisboa
Data de Publicação: 2009
Outros Autores: Barbosa, Helenemarie Schaer, Vieira, Maria das Graças, Vallve, Maria de Lourdes Farre
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/10736
Resumo: Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Patologia. Salvador, BA, Brasil
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spelling Bittencourt, Achilea Candida LisboaBarbosa, Helenemarie SchaerVieira, Maria das GraçasVallve, Maria de Lourdes Farre2015-06-08T18:26:20Z2015-06-08T18:26:20Z2009BITTENCOURT, A. C.L. et al. Adult T-cell leukemia/lymphoma (ATL) presenting in the skin: clinical, histological and immunohistochemical features of 52 cases. Acta Oncologica, v. 48, n. 4, p. 598-604, 2009.1651-226Xhttps://www.arca.fiocruz.br/handle/icict/1073610.1080/02841860802657235engInforma HealthcareAdult T-cell leukemia/lymphoma (ATL) presenting in the skin: clinical, histological and immunohistochemical features of 52 cases.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Patologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Patologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Patologia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, BrasilBackground. Adult T-cell leukemia/lymphoma (ATL) is a severe disease caused by HTLV-I. This paper describes the clinicopathological and immunohistochemical findings of 52 cases of ATL with skin involvement and investigates whether there is any relationship between median survival time (MST) and histological patterns, primary cutaneous involvement and CD8 positivity. Material and methods. All cases were HTLV-I and HIV- and were clinically classified. HTLV-I proviral integration was investigated in atypical cases. Immunohistochemistry was performed using CD3, CD4, CD5, CD7, CD8, CD20, CD25, CD30 and CD45RO markers. Ki-67 was used to evaluate the proliferative index. Results. Twentyseven cases were primary, while 25 were secondary. Monoclonal viral integration was demonstrated in all atypical cases. Patterns resembling mycosis fungoides (MF) were found in 19 cases and anaplastic large-cell lymphoma (ALCL) in two cases. Fifteen cases had an atypical immunophenotype and expressed CD8. Primary cutaneous ATL had a longer MST (48 months) than the secondary cutaneous ATL (7 months) and the difference was statistically significant, but no statistically significant difference was found between the MST of CD8-positive and negative cases. Conclusions. It is important to differentiate between primary and secondary cutaneous ATL and classify the cases histologically in order to better evaluate the prognosis. The two forms of primary cutaneous ATL, primary cutaneous smoldering and primary cutaneous tumoral (PCT), should also be identified. The smoldering type presented a longer survival (58 months) and histological aspects suggestive of better prognosis in contrast to the PCT type that had a shorter survival (20 months) and histological characteristics suggestive of worse outcome.Antígenos CD8/análiseLinfócitos T CD8-Positivos/virologiaVírus 1 Linfotrópico T Humano/isolamento & purificaçãoLeucemia-Linfoma de Células T do Adulto/diagnósticoNeoplasias Cutâneas/diagnósticoAdolescenteAdultoIdosoIdoso de 80 anos ou maisAntígenos CD/análiseLinfócitos T CD8-Positivos/imunologiaProliferação de CélulasCriançaFemininoHumanosImuno-HistoquímicaImunofenotipagemLeucemia-Linfoma de Células T do Adulto/imunologiaNeoplasias Cutâneas/imunologiaAnálise de Sobrevidainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/10736/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINALBittencourt A Adult T-cell leukemia....pdfBittencourt A Adult T-cell leukemia....pdfapplication/pdf426472https://www.arca.fiocruz.br/bitstream/icict/10736/2/Bittencourt%20A%20Adult%20T-cell%20leukemia....pdf0d2d996b35c575576e8bd8f81dc0f86cMD52TEXTBittencourt A Adult T-cell leukemia....pdf.txtBittencourt A Adult T-cell leukemia....pdf.txtExtracted texttext/plain32095https://www.arca.fiocruz.br/bitstream/icict/10736/3/Bittencourt%20A%20Adult%20T-cell%20leukemia....pdf.txt8e8fa7956c65c14243808623d80f7b2bMD53icict/107362023-03-15 14:33:07.186oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:07Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Adult T-cell leukemia/lymphoma (ATL) presenting in the skin: clinical, histological and immunohistochemical features of 52 cases.
title Adult T-cell leukemia/lymphoma (ATL) presenting in the skin: clinical, histological and immunohistochemical features of 52 cases.
spellingShingle Adult T-cell leukemia/lymphoma (ATL) presenting in the skin: clinical, histological and immunohistochemical features of 52 cases.
Bittencourt, Achilea Candida Lisboa
Antígenos CD8/análise
Linfócitos T CD8-Positivos/virologia
Vírus 1 Linfotrópico T Humano/isolamento & purificação
Leucemia-Linfoma de Células T do Adulto/diagnóstico
Neoplasias Cutâneas/diagnóstico
Adolescente
Adulto
Idoso
Idoso de 80 anos ou mais
Antígenos CD/análise
Linfócitos T CD8-Positivos/imunologia
Proliferação de Células
Criança
Feminino
Humanos
Imuno-Histoquímica
Imunofenotipagem
Leucemia-Linfoma de Células T do Adulto/imunologia
Neoplasias Cutâneas/imunologia
Análise de Sobrevida
title_short Adult T-cell leukemia/lymphoma (ATL) presenting in the skin: clinical, histological and immunohistochemical features of 52 cases.
title_full Adult T-cell leukemia/lymphoma (ATL) presenting in the skin: clinical, histological and immunohistochemical features of 52 cases.
title_fullStr Adult T-cell leukemia/lymphoma (ATL) presenting in the skin: clinical, histological and immunohistochemical features of 52 cases.
title_full_unstemmed Adult T-cell leukemia/lymphoma (ATL) presenting in the skin: clinical, histological and immunohistochemical features of 52 cases.
title_sort Adult T-cell leukemia/lymphoma (ATL) presenting in the skin: clinical, histological and immunohistochemical features of 52 cases.
author Bittencourt, Achilea Candida Lisboa
author_facet Bittencourt, Achilea Candida Lisboa
Barbosa, Helenemarie Schaer
Vieira, Maria das Graças
Vallve, Maria de Lourdes Farre
author_role author
author2 Barbosa, Helenemarie Schaer
Vieira, Maria das Graças
Vallve, Maria de Lourdes Farre
author2_role author
author
author
dc.contributor.author.fl_str_mv Bittencourt, Achilea Candida Lisboa
Barbosa, Helenemarie Schaer
Vieira, Maria das Graças
Vallve, Maria de Lourdes Farre
dc.subject.decs.pt_BR.fl_str_mv Antígenos CD8/análise
Linfócitos T CD8-Positivos/virologia
Vírus 1 Linfotrópico T Humano/isolamento & purificação
Leucemia-Linfoma de Células T do Adulto/diagnóstico
Neoplasias Cutâneas/diagnóstico
Adolescente
Adulto
Idoso
Idoso de 80 anos ou mais
Antígenos CD/análise
Linfócitos T CD8-Positivos/imunologia
Proliferação de Células
Criança
Feminino
Humanos
Imuno-Histoquímica
Imunofenotipagem
Leucemia-Linfoma de Células T do Adulto/imunologia
Neoplasias Cutâneas/imunologia
Análise de Sobrevida
topic Antígenos CD8/análise
Linfócitos T CD8-Positivos/virologia
Vírus 1 Linfotrópico T Humano/isolamento & purificação
Leucemia-Linfoma de Células T do Adulto/diagnóstico
Neoplasias Cutâneas/diagnóstico
Adolescente
Adulto
Idoso
Idoso de 80 anos ou mais
Antígenos CD/análise
Linfócitos T CD8-Positivos/imunologia
Proliferação de Células
Criança
Feminino
Humanos
Imuno-Histoquímica
Imunofenotipagem
Leucemia-Linfoma de Células T do Adulto/imunologia
Neoplasias Cutâneas/imunologia
Análise de Sobrevida
description Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Patologia. Salvador, BA, Brasil
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2015-06-08T18:26:20Z
dc.date.available.fl_str_mv 2015-06-08T18:26:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BITTENCOURT, A. C.L. et al. Adult T-cell leukemia/lymphoma (ATL) presenting in the skin: clinical, histological and immunohistochemical features of 52 cases. Acta Oncologica, v. 48, n. 4, p. 598-604, 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/10736
dc.identifier.issn.none.fl_str_mv 1651-226X
dc.identifier.doi.none.fl_str_mv 10.1080/02841860802657235
identifier_str_mv BITTENCOURT, A. C.L. et al. Adult T-cell leukemia/lymphoma (ATL) presenting in the skin: clinical, histological and immunohistochemical features of 52 cases. Acta Oncologica, v. 48, n. 4, p. 598-604, 2009.
1651-226X
10.1080/02841860802657235
url https://www.arca.fiocruz.br/handle/icict/10736
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Informa Healthcare
publisher.none.fl_str_mv Informa Healthcare
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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