Pharmacological interaction of lopinavir/ritonavir 800/200 mg BID and rifampicin in subjects presenting tuberculosis with contraindication for an efavirenz containing antiretroviral regimen

Detalhes bibliográficos
Autor(a) principal: Schmaltz, Carolina Arana Stanis
Data de Publicação: 2014
Outros Autores: Costa, Marli Jane Martins, Cattani, Vitória Berg, Pinto, Douglas Pereira, Liporage, José, Benjamin, Aline, Boulanger, Catherine, Morgado, Mariza, Rolla, Valeria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33381
Resumo: Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.
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spelling Schmaltz, Carolina Arana StanisCosta, Marli Jane MartinsCattani, Vitória BergPinto, Douglas PereiraLiporage, JoséBenjamin, AlineBoulanger, CatherineMorgado, MarizaRolla, Valeria2019-06-05T12:59:05Z2019-06-05T12:59:05Z2014SCHMALTZ, Carolina Arana Stanis et al. Pharmacological interaction of lopinavir/ritonavir 800/200 mg bid and rifampicin in subjects presenting tuberculosis with contraindication for an efavirenz containing antiretroviral regimen. Journal of AIDS and Clinical Research, v. 5, n. 10, p. 1-7, 2014.2155-6113https://www.arca.fiocruz.br/handle/icict/3338110.4172/2155-6113.10003582155-6113engOMICS InternationalPharmacological interaction of lopinavir/ritonavir 800/200 mg BID and rifampicin in subjects presenting tuberculosis with contraindication for an efavirenz containing antiretroviral regimeninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.University of Miami. School of Medicine. Division of Infectious Disease. Miami, FL, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Rifampicin reduces plasma concentration of most HIV protease inhibitors. Lopinavir boosted with ritonavir (LPV/r) could be an option to treat TB-HIV patients. Our aim was to evaluate lopinavir interaction with rifampicin during TB-HIV therapy. TB-HIV patients who could not use efavirenz and with no genotypic resistance to lopinavir were included. Rifampicin 600 mg, isoniazid 400 mg and pyrazinamide 2000 mg were started at day one for 6 months and LPV/r plus two nucleoside/nucleotide reverse transcriptase inhibitors were introduced at day 30. LPV/r dose was started at 400/100 mg BID and escalated over 7 days to 800/200 mg BID. Pharmacokinetic sampling was performed at day 15 (rifampicin), 45, 90, 180 (rifampicin, lopinavir, ritonavir) and 210 (lopinavir, ritonavir). Viral load (VL) and CD4 counts were performed at baseline and days 30, 60, 120, and 180. Genotypic testing was done in baseline and in the last visit. Fifteen patients were enrolled. Five were excluded during exclusively TB therapy. After LPV/r introduction five patients were excluded, three due to adverse events, and two due to low adherence. Five patients finished the study, two of them with VL<50 copies/mL. LPV/r genotypic resistance was detected in one patient. Lopinavir concentrations were below 1µg/mL in 4/10 patients (in one study point), and one in two study points. Lopinavir concentrations were above 4 µg/mL in 6/10 patients, at least in one pharmacokinetic sample. Although target drug concentrations of lopinavir were achieved for most patients, adverse events were frequent and low adherence was observed for both TB and HIV therapies, showing how difficult it is to treat both diseases simultaneously. Hepatic and pancreatic enzymes should be routinely monitored.AIDSTuberculosisPharmacokineticsLopinavirRifampicininfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/33381/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Schmaltz_Carolina_etal_INI_2014.pdfve_Schmaltz_Carolina_etal_INI_2014.pdfapplication/pdf635867https://www.arca.fiocruz.br/bitstream/icict/33381/2/ve_Schmaltz_Carolina_etal_INI_2014.pdf532cc429ee64ce1457a9edae50f2b77aMD52TEXTve_Schmaltz_Carolina_etal_INI_2014.pdf.txtve_Schmaltz_Carolina_etal_INI_2014.pdf.txtExtracted texttext/plain37249https://www.arca.fiocruz.br/bitstream/icict/33381/3/ve_Schmaltz_Carolina_etal_INI_2014.pdf.txtf26813855603ea2b59c8da9e950c4d30MD53icict/333812019-06-06 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dc.title.pt_BR.fl_str_mv Pharmacological interaction of lopinavir/ritonavir 800/200 mg BID and rifampicin in subjects presenting tuberculosis with contraindication for an efavirenz containing antiretroviral regimen
title Pharmacological interaction of lopinavir/ritonavir 800/200 mg BID and rifampicin in subjects presenting tuberculosis with contraindication for an efavirenz containing antiretroviral regimen
spellingShingle Pharmacological interaction of lopinavir/ritonavir 800/200 mg BID and rifampicin in subjects presenting tuberculosis with contraindication for an efavirenz containing antiretroviral regimen
Schmaltz, Carolina Arana Stanis
AIDS
Tuberculosis
Pharmacokinetics
Lopinavir
Rifampicin
title_short Pharmacological interaction of lopinavir/ritonavir 800/200 mg BID and rifampicin in subjects presenting tuberculosis with contraindication for an efavirenz containing antiretroviral regimen
title_full Pharmacological interaction of lopinavir/ritonavir 800/200 mg BID and rifampicin in subjects presenting tuberculosis with contraindication for an efavirenz containing antiretroviral regimen
title_fullStr Pharmacological interaction of lopinavir/ritonavir 800/200 mg BID and rifampicin in subjects presenting tuberculosis with contraindication for an efavirenz containing antiretroviral regimen
title_full_unstemmed Pharmacological interaction of lopinavir/ritonavir 800/200 mg BID and rifampicin in subjects presenting tuberculosis with contraindication for an efavirenz containing antiretroviral regimen
title_sort Pharmacological interaction of lopinavir/ritonavir 800/200 mg BID and rifampicin in subjects presenting tuberculosis with contraindication for an efavirenz containing antiretroviral regimen
author Schmaltz, Carolina Arana Stanis
author_facet Schmaltz, Carolina Arana Stanis
Costa, Marli Jane Martins
Cattani, Vitória Berg
Pinto, Douglas Pereira
Liporage, José
Benjamin, Aline
Boulanger, Catherine
Morgado, Mariza
Rolla, Valeria
author_role author
author2 Costa, Marli Jane Martins
Cattani, Vitória Berg
Pinto, Douglas Pereira
Liporage, José
Benjamin, Aline
Boulanger, Catherine
Morgado, Mariza
Rolla, Valeria
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Schmaltz, Carolina Arana Stanis
Costa, Marli Jane Martins
Cattani, Vitória Berg
Pinto, Douglas Pereira
Liporage, José
Benjamin, Aline
Boulanger, Catherine
Morgado, Mariza
Rolla, Valeria
dc.subject.en.pt_BR.fl_str_mv AIDS
Tuberculosis
Pharmacokinetics
Lopinavir
Rifampicin
topic AIDS
Tuberculosis
Pharmacokinetics
Lopinavir
Rifampicin
description Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2019-06-05T12:59:05Z
dc.date.available.fl_str_mv 2019-06-05T12:59:05Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SCHMALTZ, Carolina Arana Stanis et al. Pharmacological interaction of lopinavir/ritonavir 800/200 mg bid and rifampicin in subjects presenting tuberculosis with contraindication for an efavirenz containing antiretroviral regimen. Journal of AIDS and Clinical Research, v. 5, n. 10, p. 1-7, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33381
dc.identifier.issn.pt_BR.fl_str_mv 2155-6113
dc.identifier.doi.none.fl_str_mv 10.4172/2155-6113.1000358
dc.identifier.eissn.none.fl_str_mv 2155-6113
identifier_str_mv SCHMALTZ, Carolina Arana Stanis et al. Pharmacological interaction of lopinavir/ritonavir 800/200 mg bid and rifampicin in subjects presenting tuberculosis with contraindication for an efavirenz containing antiretroviral regimen. Journal of AIDS and Clinical Research, v. 5, n. 10, p. 1-7, 2014.
2155-6113
10.4172/2155-6113.1000358
url https://www.arca.fiocruz.br/handle/icict/33381
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv OMICS International
publisher.none.fl_str_mv OMICS International
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/33381/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/33381/2/ve_Schmaltz_Carolina_etal_INI_2014.pdf
https://www.arca.fiocruz.br/bitstream/icict/33381/3/ve_Schmaltz_Carolina_etal_INI_2014.pdf.txt
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