Primary muscle disease: definition of a 25-kDa polypeptide myopathic specific chagas antigen

Detalhes bibliográficos
Autor(a) principal: Buch, Charles A. Santos
Data de Publicação: 1985
Outros Autores: Acosta, A. M., Zweerink, H. J., Sadigursky, Moysés, Andersen, O. F., Von Kreuter, Betsy F., Brodskyn, Claudia Ida, Sadigursky, Clésia Andrade, Cody, R. J
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/8405
Resumo: Cornell University Medical College. Departments of Pathology and Medicine. New York, NY
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spelling Buch, Charles A. SantosAcosta, A. M.Zweerink, H. J.Sadigursky, MoysésAndersen, O. F.Von Kreuter, Betsy F.Brodskyn, Claudia IdaSadigursky, Clésia AndradeCody, R. J2014-09-19T17:03:37Z2014-09-19T17:03:37Z1985BUCH, C. S. et al. Primary muscle disease: definition of a 25-kDa polypeptide myopathic specific chagas antigen. Clinical Immunology and Immunopathology, v. 37, n. 3, p. 334-350, 1985.0090-1229https://www.arca.fiocruz.br/handle/icict/8405engAcademic Press Inc.Primary muscle disease: definition of a 25-kDa polypeptide myopathic specific chagas antigeninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCornell University Medical College. Departments of Pathology and Medicine. New York, NYCornell University Medical College. Departments of Pathology and Medicine. New York, NYCornell University Medical College. Departments of Pathology and Medicine. New York, NYFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilCornell University Medical College. Departments of Pathology and Medicine. New York, NYCornell University Medical College. Departments of Pathology and Medicine. New York, NYFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilMerck Sharp and Dohme Research Laboratories. Department of Immunology and Inflammation Research. Rahxaay. New JerseyThe sera from patients with primary heart and skeletal muscle diseases, hospitalized patients without intrinsic muscle disease from an area endemic for Trypanosoma cruzi infections, and normal subjects (N = 693) were studied for the presence of immunoglobulin G (IgG) antisarcolemma activity using serologic methods. The prevalence of elevated serum IgG antisarcolemma activity from patients with chronic Chagas' cardiomyopathy, idiopathic cardiomyopathy, polymyositis, and Duchenne muscular dystrophy was 58.9 +/- 10.4% (N = 101) (P less than 0.001 when compared to normal subjects). Two of twelve (16.7%) patients with acute T. cruzi infection and parasitemia developed elevated antisarcolemma titers, and 9/46 (19.6%) patients with chronic T. cruzi infection without evidence of cardiomyopathy yielded high antisarcolemma titers. On the other hand, patients with chronic T. cruzi infection with advanced cardiomyopathy yielded high antisarcolemma titers in 35/74 (47.3%) (P less than 0.001 when compared to normal subjects). Radioimmunoprecipitation showed a circulating antibody to a 25-kDa T. cruzi polypeptide (P25) in 16/17 (94.1%) patients with advanced cardiomyopathy and T. cruzi infection. No such antibody was shown in 12 asymptomatic subjects with chronic T. cruzi infection.Anticorpos/análiseCardiomiopatia Chagásica/imunologiaEnsaio de Imunoadsorção EnzimáticaEpitoposReações Falso-PositivasHumanosImunoglobulina G/análiseMicrossomos/imunologiaMiocárdio/citologiaSarcolema/imunologiaRetículo Sarcoplasmático/imunologiaTrypanosoma cruzi/imunologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8405/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALBuch CS Primary muscle disease.......pdfBuch CS Primary muscle disease.......pdfapplication/pdf1943825https://www.arca.fiocruz.br/bitstream/icict/8405/2/Buch%20CS%20Primary%20muscle%20disease.......pdf7ed5a321223b0accc6b0d232bb9f9264MD52TEXTBuch CS Primary muscle disease.......pdf.txtBuch CS Primary muscle disease.......pdf.txtExtracted texttext/plain47869https://www.arca.fiocruz.br/bitstream/icict/8405/3/Buch%20CS%20Primary%20muscle%20disease.......pdf.txtbab5daf4d48a169f42f776d89ee0849aMD53icict/84052023-03-15 14:33:05.606oai:www.arca.fiocruz.br:icict/8405TElDRU7Dh0EgREUgRElTVFJJQlVJw4fDg08gTsODTy1FWENMVVNJVkEKCkFvIGNvbmNvcmRhciBlIGFjZWl0YXIgZXN0YSBsaWNlbsOnYSB2b2PDqiAoYXV0b3Igb3UgZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzKToKCmEpIERlY2xhcmEgcXVlIGNvbmhlY2UgYSBwb2zDrXRpY2EgZGUgY29weXJpZ2h0IGRhIGVkaXRvcmEgZG8gc2V1IGRvY3VtZW50by4KCmIpIERlY2xhcmEgcXVlIGNvbmhlY2UgZSBhY2VpdGEgYXMgRGlyZXRyaXplcyBwYXJhIG8gUmVwb3NpdMOzcmlvIEluc3RpdHVjaW9uYWwgZGEgRnVuZGHDp8OjbyBPc3dhbGRvIENydXogKEZJT0NSVVopLgoKYykgQ29uY2VkZSDDoCBGSU9DUlVaIG8gZGlyZWl0byBuw6NvLWV4Y2x1c2l2byBkZSBhcnF1aXZhciwgcmVwcm9kdXppciwgY29udmVydGVyIChjb21vIGRlZmluaWRvIGEgc2VndWlyKSwgY29tdW5pY2FyCiAKZS9vdSBkaXN0cmlidWlyIG5vIFJlcG9zaXTDs3JpbyBkYSBGSU9DUlVaLCBvIGRvY3VtZW50byBlbnRyZWd1ZSAoaW5jbHVpbmRvIG8gcmVzdW1vL2Fic3RyYWN0KSBlbSBmb3JtYXRvIGRpZ2l0YWwgb3UgCgpwb3IgcXVhbHF1ZXIgb3V0cm8gbWVpby4KCmQpIERlY2xhcmEgcXVlIGF1dG9yaXphIGEgRklPQ1JVWiBhIGFycXVpdmFyIG1haXMgZGUgdW1hIGPDs3BpYSBkZXN0ZSBkb2N1bWVudG8gZSBjb252ZXJ0w6otbG8sIHNlbSBhbHRlcmFyIG8gc2V1IGNvbnRlw7pkbywgCgpwYXJhIHF1YWxxdWVyIGZvcm1hdG8gZGUgYXJxdWl2bywgbWVpbyBvdSBzdXBvcnRlLCBwYXJhIGVmZWl0b3MgZGUgc2VndXJhbsOnYSwgcHJlc2VydmHDp8OjbyAoYmFja3VwKSBlIGFjZXNzby4KCmUpIERlY2xhcmEgcXVlIG8gZG9jdW1lbnRvIHN1Ym1ldGlkbyDDqSBvIHNldSB0cmFiYWxobyBvcmlnaW5hbCwgZSBxdWUgZGV0w6ltIG8gZGlyZWl0byBkZSBjb25jZWRlciBhIHRlcmNlaXJvcyBvcyBkaXJlaXRvcyAKCmNvbnRpZG9zIG5lc3RhIGxpY2Vuw6dhLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGEgZW50cmVnYSBkbyBkb2N1bWVudG8gbsOjbyBpbmZyaW5nZSBvcyBkaXJlaXRvcyBkZSBxdWFscXVlciBvdXRyYSBwZXNzb2Egb3UgZW50aWRhZGUuCgpmKSBEZWNsYXJhIHF1ZSwgbm8gY2FzbyBkbyBkb2N1bWVudG8gc3VibWV0aWRvIGNvbnRlciBtYXRlcmlhbCBkbyBxdWFsIG7Do28gZGV0w6ltIG9zIGRpcmVpdG9zIGRlIGF1dG9yLCBvYnRldmUgYSBhdXRvcml6YcOnw6NvIAoKaXJyZXN0cml0YSBkbyByZXNwZWN0aXZvIGRldGVudG9yIGRlc3NlcyBkaXJlaXRvcywgcGFyYSBjZWRlciBhIEZJT0NSVVogb3MgZGlyZWl0b3MgcmVxdWVyaWRvcyBwb3IgZXN0YSBMaWNlbsOnYSBlIGF1dG9yaXphciBhIAoKdXRpbGl6w6EtbG9zIGxlZ2FsbWVudGUuIERlY2xhcmEgdGFtYsOpbSBxdWUgZXNzZSBtYXRlcmlhbCBjdWpvcyBkaXJlaXRvcyBzw6NvIGRlIHRlcmNlaXJvcyBlc3TDoSBjbGFyYW1lbnRlIGlkZW50aWZpY2FkbyBlIHJlY29uaGVjaWRvIAoKbm8gdGV4dG8gb3UgY29udGXDumRvIGRvIGRvY3VtZW50byBlbnRyZWd1ZS4KCmcpIFNFIE8gRE9DVU1FTlRPIEVOVFJFR1VFIMOJIEJBU0VBRE8gRU0gVFJBQkFMSE8gRklOQU5DSUFETyBPVSBBUE9JQURPIFBPUiBPVVRSQSBJTlNUSVRVScOHw4NPIFFVRSBOw4NPIEEgRklPQ1JVWiwgREVDTEFSQSBRVUUgQ1VNUFJJVSAKClFVQUlTUVVFUiBPQlJJR0HDh8OVRVMgRVhJR0lEQVMgUEVMTyBSRVNQRUNUSVZPIENPTlRSQVRPIE9VIEFDT1JETy4gQSBGSU9DUlVaIGlkZW50aWZpY2Fyw6EgY2xhcmFtZW50ZSBvKHMpIG5vbWUocykgZG8ocykgYXV0b3IoZXMpIGRvcyAKCmRpcmVpdG9zIGRvIGRvY3VtZW50byBlbnRyZWd1ZSBlIG7Do28gZmFyw6EgcXVhbHF1ZXIgYWx0ZXJhw6fDo28sIHBhcmEgYWzDqW0gZG8gcHJldmlzdG8gbmEgYWzDrW5lYSBjKS4KRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:05Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Primary muscle disease: definition of a 25-kDa polypeptide myopathic specific chagas antigen
title Primary muscle disease: definition of a 25-kDa polypeptide myopathic specific chagas antigen
spellingShingle Primary muscle disease: definition of a 25-kDa polypeptide myopathic specific chagas antigen
Buch, Charles A. Santos
Anticorpos/análise
Cardiomiopatia Chagásica/imunologia
Ensaio de Imunoadsorção Enzimática
Epitopos
Reações Falso-Positivas
Humanos
Imunoglobulina G/análise
Microssomos/imunologia
Miocárdio/citologia
Sarcolema/imunologia
Retículo Sarcoplasmático/imunologia
Trypanosoma cruzi/imunologia
title_short Primary muscle disease: definition of a 25-kDa polypeptide myopathic specific chagas antigen
title_full Primary muscle disease: definition of a 25-kDa polypeptide myopathic specific chagas antigen
title_fullStr Primary muscle disease: definition of a 25-kDa polypeptide myopathic specific chagas antigen
title_full_unstemmed Primary muscle disease: definition of a 25-kDa polypeptide myopathic specific chagas antigen
title_sort Primary muscle disease: definition of a 25-kDa polypeptide myopathic specific chagas antigen
author Buch, Charles A. Santos
author_facet Buch, Charles A. Santos
Acosta, A. M.
Zweerink, H. J.
Sadigursky, Moysés
Andersen, O. F.
Von Kreuter, Betsy F.
Brodskyn, Claudia Ida
Sadigursky, Clésia Andrade
Cody, R. J
author_role author
author2 Acosta, A. M.
Zweerink, H. J.
Sadigursky, Moysés
Andersen, O. F.
Von Kreuter, Betsy F.
Brodskyn, Claudia Ida
Sadigursky, Clésia Andrade
Cody, R. J
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Buch, Charles A. Santos
Acosta, A. M.
Zweerink, H. J.
Sadigursky, Moysés
Andersen, O. F.
Von Kreuter, Betsy F.
Brodskyn, Claudia Ida
Sadigursky, Clésia Andrade
Cody, R. J
dc.subject.decs.pt_BR.fl_str_mv Anticorpos/análise
Cardiomiopatia Chagásica/imunologia
Ensaio de Imunoadsorção Enzimática
Epitopos
Reações Falso-Positivas
Humanos
Imunoglobulina G/análise
Microssomos/imunologia
Miocárdio/citologia
Sarcolema/imunologia
Retículo Sarcoplasmático/imunologia
Trypanosoma cruzi/imunologia
topic Anticorpos/análise
Cardiomiopatia Chagásica/imunologia
Ensaio de Imunoadsorção Enzimática
Epitopos
Reações Falso-Positivas
Humanos
Imunoglobulina G/análise
Microssomos/imunologia
Miocárdio/citologia
Sarcolema/imunologia
Retículo Sarcoplasmático/imunologia
Trypanosoma cruzi/imunologia
description Cornell University Medical College. Departments of Pathology and Medicine. New York, NY
publishDate 1985
dc.date.issued.fl_str_mv 1985
dc.date.accessioned.fl_str_mv 2014-09-19T17:03:37Z
dc.date.available.fl_str_mv 2014-09-19T17:03:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv BUCH, C. S. et al. Primary muscle disease: definition of a 25-kDa polypeptide myopathic specific chagas antigen. Clinical Immunology and Immunopathology, v. 37, n. 3, p. 334-350, 1985.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/8405
dc.identifier.issn.none.fl_str_mv 0090-1229
identifier_str_mv BUCH, C. S. et al. Primary muscle disease: definition of a 25-kDa polypeptide myopathic specific chagas antigen. Clinical Immunology and Immunopathology, v. 37, n. 3, p. 334-350, 1985.
0090-1229
url https://www.arca.fiocruz.br/handle/icict/8405
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Academic Press Inc.
publisher.none.fl_str_mv Academic Press Inc.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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