Immunological studies and in vitro schistosomicide action of new imidazolidine derivatives
| Main Author: | |
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| Publication Date: | 2011 |
| Other Authors: | , , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositório Institucional da FIOCRUZ (ARCA) |
| Download full: | https://www.arca.fiocruz.br/handle/icict/28721 |
Summary: | Fundação Federal de Pesquisa e Desenvolvimento (FINEP), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) e Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) |
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Neves, Juliana Kelle de Andrade LemoineSarinho, S.Melo, C. M. L. dePereira, V. R. A.Lima, M. C. A. dePitta, I. R.Albuquerque, M. C. P. A.Galdino, S. L.2018-09-13T12:27:26Z2018-09-13T12:27:26Z2011JKAL, N. et al. Immunological studies and in vitro schistosomicide action of new imidazolidine derivatives. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 17, n. 3, p. 277–286, 2011.1678-9199https://www.arca.fiocruz.br/handle/icict/2872110.1590/S1678-91992011000300007Fundação Federal de Pesquisa e Desenvolvimento (FINEP), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) e Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Federal de Pernambuco (UFPE). Departamento de Antibióticos. Laboratório de Desenho e Síntese de Fármacos. Recife, PE, Brasil.Universidade Federal de Pernambuco (UFPE). Departamento de Antibióticos. Laboratório de Desenho e Síntese de Fármacos. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil.Universidade Federal de Pernambuco (UFPE). Departamento de Antibióticos. Laboratório de Desenho e Síntese de Fármacos. Recife, PE, Brasil.Universidade Federal de Pernambuco (UFPE). Departamento de Antibióticos. Laboratório de Desenho e Síntese de Fármacos. Recife, PE, Brasil.Universidade Federal de Pernambuco (UFPE). Laboratório de Imunopatologia Keizo Asami. Recife, PE, Brasil / Universidade Federal de Pernambuco (UFPE). Departamento de Medicina Tropical. Recife, PE, Brasil.Universidade Federal de Pernambuco (UFPE). Departamento de Antibióticos. Laboratório de Desenho e Síntese de Fármacos. Recife, PE, Brasil.Schistosomiasis is a major public health problem with 207 million people infected and more than 779 million at risk. The drug of choice for treating schistosomiasis is praziquantel (PZQ); however, it is inefficient against immature forms of schistosomes. The aim of this study was to test new imidazolidine derivatives LPSF/PT09 and LPSF/PT10 against adult Schistosoma mansoni worms. IC50, cytotoxicity, immune response and cell viability assays were also available for these imidazolidines. Different concentrations of imidazolidine, from 32 to 320 ¼M, promoted motor abnormalities in breeding and unpaired worms, and death in 24 hours at higher concentrations. Although LPSF/PT09 and LPSF/PT10 did not affect IFN-³ and IL-10 production, they induced nitric oxide production and showed a similar behavior to praziquantel on cell death test. Thus, these new imidazolidine derivatives should undergo further study to develop schistosomiasis drugs.engSchistosoma mansoniIn vitroImidazolidinaSchistosoma mansoniIn vitroImidazolidinesSchistosoma mansoni / imunologiaSchistosoma mansoni / epidemiologiaBrasil / epidemiologiaHumanosSchistosoma mansoni / efeitos dos fármacosCitotoxicidade ImunológicaTestes Imunológicos de CitotoxicidadeTécnicas In VitroImmunological studies and in vitro schistosomicide action of new imidazolidine derivativesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83092https://www.arca.fiocruz.br/bitstream/icict/28721/1/license.txt447f2497af1ef5cf99b5c07f6fa18dceMD51ORIGINALImmunological studies and in vitro schistosomicide action of new.pdfImmunological studies and in vitro schistosomicide action of 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| dc.title.pt_BR.fl_str_mv |
Immunological studies and in vitro schistosomicide action of new imidazolidine derivatives |
| title |
Immunological studies and in vitro schistosomicide action of new imidazolidine derivatives |
| spellingShingle |
Immunological studies and in vitro schistosomicide action of new imidazolidine derivatives Neves, Juliana Kelle de Andrade Lemoine Schistosoma mansoni In vitro Imidazolidina Schistosoma mansoni In vitro Imidazolidines Schistosoma mansoni / imunologia Schistosoma mansoni / epidemiologia Brasil / epidemiologia Humanos Schistosoma mansoni / efeitos dos fármacos Citotoxicidade Imunológica Testes Imunológicos de Citotoxicidade Técnicas In Vitro |
| title_short |
Immunological studies and in vitro schistosomicide action of new imidazolidine derivatives |
| title_full |
Immunological studies and in vitro schistosomicide action of new imidazolidine derivatives |
| title_fullStr |
Immunological studies and in vitro schistosomicide action of new imidazolidine derivatives |
| title_full_unstemmed |
Immunological studies and in vitro schistosomicide action of new imidazolidine derivatives |
| title_sort |
Immunological studies and in vitro schistosomicide action of new imidazolidine derivatives |
| author |
Neves, Juliana Kelle de Andrade Lemoine |
| author_facet |
Neves, Juliana Kelle de Andrade Lemoine Sarinho, S. Melo, C. M. L. de Pereira, V. R. A. Lima, M. C. A. de Pitta, I. R. Albuquerque, M. C. P. A. Galdino, S. L. |
| author_role |
author |
| author2 |
Sarinho, S. Melo, C. M. L. de Pereira, V. R. A. Lima, M. C. A. de Pitta, I. R. Albuquerque, M. C. P. A. Galdino, S. L. |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Neves, Juliana Kelle de Andrade Lemoine Sarinho, S. Melo, C. M. L. de Pereira, V. R. A. Lima, M. C. A. de Pitta, I. R. Albuquerque, M. C. P. A. Galdino, S. L. |
| dc.subject.other.pt_BR.fl_str_mv |
Schistosoma mansoni In vitro Imidazolidina |
| topic |
Schistosoma mansoni In vitro Imidazolidina Schistosoma mansoni In vitro Imidazolidines Schistosoma mansoni / imunologia Schistosoma mansoni / epidemiologia Brasil / epidemiologia Humanos Schistosoma mansoni / efeitos dos fármacos Citotoxicidade Imunológica Testes Imunológicos de Citotoxicidade Técnicas In Vitro |
| dc.subject.en.pt_BR.fl_str_mv |
Schistosoma mansoni In vitro Imidazolidines |
| dc.subject.decs.pt_BR.fl_str_mv |
Schistosoma mansoni / imunologia Schistosoma mansoni / epidemiologia Brasil / epidemiologia Humanos Schistosoma mansoni / efeitos dos fármacos Citotoxicidade Imunológica Testes Imunológicos de Citotoxicidade Técnicas In Vitro |
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Fundação Federal de Pesquisa e Desenvolvimento (FINEP), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) e Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) |
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2011 |
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2011 |
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2018-09-13T12:27:26Z |
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2018-09-13T12:27:26Z |
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JKAL, N. et al. Immunological studies and in vitro schistosomicide action of new imidazolidine derivatives. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 17, n. 3, p. 277–286, 2011. |
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https://www.arca.fiocruz.br/handle/icict/28721 |
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1678-9199 |
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10.1590/S1678-91992011000300007 |
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JKAL, N. et al. Immunological studies and in vitro schistosomicide action of new imidazolidine derivatives. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 17, n. 3, p. 277–286, 2011. 1678-9199 10.1590/S1678-91992011000300007 |
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