Sex-related differences in inflammatory and immune activation markers before and after combined antiretroviral therapy initiation
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/17845 |
Resumo: | The authors thank the Prospective Evaluation of Antiretrovirals in Resource-Limited Setting study participants for volunteering their time and efforts. |
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Mathad, Jyoti SGupte, NikhilBalagopal, AshwinAsmuth, David MHakim, JamesSantos, BrenoRiviere, CynthiaHosseinipour, MinaSugandhavesa, PatcharaphanInfante, RosaPillay, SandyCardoso, Sandra WagnerMwelase, NoluthandoPawar, JyotiBerendes, SimaKumarasamy, NagalingeswaranAndrade, Bruno de BezerrilCampbell, Thomas BCurrier, Judith SCohn, Susan EGupta, Amita2017-02-16T16:52:16Z2017-02-16T16:52:16Z2016MATHAD, Jyoti S. et al. Sex-related differences in inflammatory and immune activation markers before and after combined antiretroviral therapy initiation. Journal Acquir. Immune Defic. Syndr., v. 73, p. 123–129, 2016.1077-9450https://www.arca.fiocruz.br/handle/icict/1784510.1097/QAI.0000000000001095The authors thank the Prospective Evaluation of Antiretrovirals in Resource-Limited Setting study participants for volunteering their time and efforts.US National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH). NIH/NIAID Johns Hopkins Baltimore Washington India HIV Clinical Trials Unit. NIH/National Center for Advancing Translational Sciences. Ujala Foundation. Johns Hopkins Center for AIDS Research and the Gilead Foundation.2017-10-02Weill Cornell Medical College. Center for Global Health. Division of Infectious Diseases. New York, NY, USA.Byramjee Jeejeebhoy Government Medical College. Johns Hopkins Clinical Trials Unit. Pune, India / Johns Hopkins University School of Medicine. Division of Infectious Diseases. Baltimore, USA.Byramjee Jeejeebhoy Government Medical College. Johns Hopkins Clinical Trials Unit. Pune, IndiaUniversity of California Davis Medical Center. Department of Internal Medicine. Division of Infectious Diseases. Sacramento, CA, USA.University of California Davis Medical Center. Department of Internal Medicine. Division of Infectious Diseases. Sacramento, CA, USA.Hospital Nossa Senhora de Conceição. Divisão de Doenças Infecciosas. Porto Alegre, RS, Brasil.Les Centres GHESKIO. Port-Au-Prince, Haiti.University of North Carolina-Lilongwe. Department of Medicine. Lilongwe, Malawi.Research Institute for Health Sciences. Chiang Mai, Thailand.Impacta Peru. San Miguel, Peru.Durban University of Technology. Durban International Clinical Research Site. Durban, South Africa.Fundação Oswaldo Cruz. Instituto de Pesquisa Clinica Evandro Chagas. STD/AIDS Clinical Research Laboratory. Rio de Janeiro, RJ, Brasil.University of Witwatersrand. Department of Medicine. Johannesburg, South Africa.National AIDS Research Institute (ICMR). Pune, India.Johns Hopkins University Research Project. Malawi College of Medicine. Blantyre, Malawi.Johns Hopkins University Research Project. Malawi College of Medicine. Blantyre, Malawi.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Departamento de Medicina de Investigações. Laboratório Integrado de Microbiologia e Imunorregulação. Salvador, BA, Brasil.University of Colorado-Denver. Division of Infectious Diseases, Aurora, CO, USA.University of California Los Angeles. Division of Infectious Diseases. Department of Medicine. Los Angeles, CA, USA.Northwestern University Feinberg School of Medicine. Division of Infectious Diseases. Chicago, USA.Background: Women progress to death at the same rate as men despite lower plasma HIV RNA (viral load). We investigated sex-specific differences in immune activation and inflammation as a potential explanation. Methods: Inflammatory and immune activation markers [interferon g, tumor necrosis factor (TNF) a, IL-6, IL-18, IFN-g–induced protein 10, C-reactive protein (CRP), lipopolysaccharide, and sCD14] were measured at weeks 0, 24, and 48 after combination antiretroviral therapy (cART) in a random subcohort (n = 215) who achieved virologic suppression in ACTG A5175 (Prospective Evaluation of Antiretrovirals in Resource-Limited Settings). Association between sex and changes in markers postcART was examined using random effects models. Average marker differences and 95% confidence intervals were estimated using multivariable models. Results: At baseline, women had lower median log10 viral load (4.93 vs 5.18 copies per milliliter, P = 0.01), CRP (2.32 vs 4.62 mg/L, P =0.01), detectable lipopolysaccharide (39% vs 55%, P = 0.04), and sCD14 (1.9 vs 2.3 mg/mL, P = 0.06) vs men. By week 48, women had higher interferon g (22.4 vs 14.9 pg/mL, P = 0.05), TNF-a (11.5 vs 9.5pg/mL, P = 0.02), and CD4 (373 vs 323 cells per cubic millimeter, P =0.02). In multivariate analysis, women had greater increases in CD4 and TNF-a but less of a decrease in CRP and sCD14 compared with men. Conclusions: With cART-induced viral suppression, women have less reduction in key markers of inflammation and immune activation compared with men. Future studies should investigate the impact of these sex-specific differences on morbidity and mortality.engLippincott, Williams & WilkinsHIVInflamaçãoAtivação imunológicaSexoMulheresTratamento antiretroviralHIVInflammationImmune activationSexWomenAntiretroviral treatmentHIVComportamento SexualSex-related differences in inflammatory and immune activation markers before and after combined antiretroviral therapy initiationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
Sex-related differences in inflammatory and immune activation markers before and after combined antiretroviral therapy initiation |
| title |
Sex-related differences in inflammatory and immune activation markers before and after combined antiretroviral therapy initiation |
| spellingShingle |
Sex-related differences in inflammatory and immune activation markers before and after combined antiretroviral therapy initiation Mathad, Jyoti S HIV Inflamação Ativação imunológica Sexo Mulheres Tratamento antiretroviral HIV Inflammation Immune activation Sex Women Antiretroviral treatment HIV Comportamento Sexual |
| title_short |
Sex-related differences in inflammatory and immune activation markers before and after combined antiretroviral therapy initiation |
| title_full |
Sex-related differences in inflammatory and immune activation markers before and after combined antiretroviral therapy initiation |
| title_fullStr |
Sex-related differences in inflammatory and immune activation markers before and after combined antiretroviral therapy initiation |
| title_full_unstemmed |
Sex-related differences in inflammatory and immune activation markers before and after combined antiretroviral therapy initiation |
| title_sort |
Sex-related differences in inflammatory and immune activation markers before and after combined antiretroviral therapy initiation |
| author |
Mathad, Jyoti S |
| author_facet |
Mathad, Jyoti S Gupte, Nikhil Balagopal, Ashwin Asmuth, David M Hakim, James Santos, Breno Riviere, Cynthia Hosseinipour, Mina Sugandhavesa, Patcharaphan Infante, Rosa Pillay, Sandy Cardoso, Sandra Wagner Mwelase, Noluthando Pawar, Jyoti Berendes, Sima Kumarasamy, Nagalingeswaran Andrade, Bruno de Bezerril Campbell, Thomas B Currier, Judith S Cohn, Susan E Gupta, Amita |
| author_role |
author |
| author2 |
Gupte, Nikhil Balagopal, Ashwin Asmuth, David M Hakim, James Santos, Breno Riviere, Cynthia Hosseinipour, Mina Sugandhavesa, Patcharaphan Infante, Rosa Pillay, Sandy Cardoso, Sandra Wagner Mwelase, Noluthando Pawar, Jyoti Berendes, Sima Kumarasamy, Nagalingeswaran Andrade, Bruno de Bezerril Campbell, Thomas B Currier, Judith S Cohn, Susan E Gupta, Amita |
| author2_role |
author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Mathad, Jyoti S Gupte, Nikhil Balagopal, Ashwin Asmuth, David M Hakim, James Santos, Breno Riviere, Cynthia Hosseinipour, Mina Sugandhavesa, Patcharaphan Infante, Rosa Pillay, Sandy Cardoso, Sandra Wagner Mwelase, Noluthando Pawar, Jyoti Berendes, Sima Kumarasamy, Nagalingeswaran Andrade, Bruno de Bezerril Campbell, Thomas B Currier, Judith S Cohn, Susan E Gupta, Amita |
| dc.subject.other.pt_BR.fl_str_mv |
HIV Inflamação Ativação imunológica Sexo Mulheres Tratamento antiretroviral |
| topic |
HIV Inflamação Ativação imunológica Sexo Mulheres Tratamento antiretroviral HIV Inflammation Immune activation Sex Women Antiretroviral treatment HIV Comportamento Sexual |
| dc.subject.en.pt_BR.fl_str_mv |
HIV Inflammation Immune activation Sex Women Antiretroviral treatment |
| dc.subject.decs.pt_BR.fl_str_mv |
HIV Comportamento Sexual |
| description |
The authors thank the Prospective Evaluation of Antiretrovirals in Resource-Limited Setting study participants for volunteering their time and efforts. |
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2016 |
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2016 |
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2017-02-16T16:52:16Z |
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2017-02-16T16:52:16Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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MATHAD, Jyoti S. et al. Sex-related differences in inflammatory and immune activation markers before and after combined antiretroviral therapy initiation. Journal Acquir. Immune Defic. Syndr., v. 73, p. 123–129, 2016. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/17845 |
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1077-9450 |
| dc.identifier.doi.none.fl_str_mv |
10.1097/QAI.0000000000001095 |
| identifier_str_mv |
MATHAD, Jyoti S. et al. Sex-related differences in inflammatory and immune activation markers before and after combined antiretroviral therapy initiation. Journal Acquir. Immune Defic. Syndr., v. 73, p. 123–129, 2016. 1077-9450 10.1097/QAI.0000000000001095 |
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https://www.arca.fiocruz.br/handle/icict/17845 |
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Lippincott, Williams & Wilkins |
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Lippincott, Williams & Wilkins |
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