The Interleukin-17 (IL-17) Puzzle in Chagas’ Disease

Detalhes bibliográficos
Autor(a) principal: Mengel, Jose
Data de Publicação: 2017
Outros Autores: Cardillo, Fabíola
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/25414
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil / Faculty of Medicine of Petrópolis. Petrópolis, RJ, Brazil
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spelling Mengel, JoseCardillo, Fabíola2018-03-20T13:11:33Z2018-03-20T13:11:33Z2017MENGEL, J.; CARDILLO, F. The Interleukin-17 (IL-17) Puzzle in Chagas’ Disease. Cellular Immunology and Serum Biology, v. 3, n. 2, p. 120-121, 2017.2471-5891https://www.arca.fiocruz.br/handle/icict/25414engOmmega PublishersDoença de ChagasTrypanosoma cruziInsuficiência cardíacaHumanosInfecçãoChagas diseaseTrypanosoma cruziCardiac insufficiencyHumansInfectionThe Interleukin-17 (IL-17) Puzzle in Chagas’ Diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil / Faculty of Medicine of Petrópolis. Petrópolis, RJ, BrazilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilIn this article, we discuss an alternative explanation for the fact that the production and plasma levels of IL-17 are diminished in patients chronically infected with Trypanosoma cruzi, suffering from congestive heart failure. This alternate hypothesis considers the inhibitory pharmacological action of digoxin, a drug commonly used to treat heart failure. We believe this is a significant point to be further studied as IL-17 was initially considered to be heart-protective. Therefore, our argument has profound therapeutic implicationsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25414/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMengel J The Interleukin-17 (IL-17) puzzle ....pdfMengel J The Interleukin-17 (IL-17) puzzle ....pdfapplication/pdf416819https://www.arca.fiocruz.br/bitstream/icict/25414/2/Mengel%20J%20The%20Interleukin-17%20%28IL-17%29%20puzzle%20....pdf341236ff108c0829c4429bb88a1cddcfMD52TEXTMengel J The Interleukin-17 (IL-17) puzzle ....pdf.txtMengel J The Interleukin-17 (IL-17) puzzle ....pdf.txtExtracted texttext/plain11318https://www.arca.fiocruz.br/bitstream/icict/25414/3/Mengel%20J%20The%20Interleukin-17%20%28IL-17%29%20puzzle%20....pdf.txt807436e6ed7a12eff2ea3d5bd2fe72daMD53icict/254142023-03-15 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dc.title.pt_BR.fl_str_mv The Interleukin-17 (IL-17) Puzzle in Chagas’ Disease
title The Interleukin-17 (IL-17) Puzzle in Chagas’ Disease
spellingShingle The Interleukin-17 (IL-17) Puzzle in Chagas’ Disease
Mengel, Jose
Doença de Chagas
Trypanosoma cruzi
Insuficiência cardíaca
Humanos
Infecção
Chagas disease
Trypanosoma cruzi
Cardiac insufficiency
Humans
Infection
title_short The Interleukin-17 (IL-17) Puzzle in Chagas’ Disease
title_full The Interleukin-17 (IL-17) Puzzle in Chagas’ Disease
title_fullStr The Interleukin-17 (IL-17) Puzzle in Chagas’ Disease
title_full_unstemmed The Interleukin-17 (IL-17) Puzzle in Chagas’ Disease
title_sort The Interleukin-17 (IL-17) Puzzle in Chagas’ Disease
author Mengel, Jose
author_facet Mengel, Jose
Cardillo, Fabíola
author_role author
author2 Cardillo, Fabíola
author2_role author
dc.contributor.author.fl_str_mv Mengel, Jose
Cardillo, Fabíola
dc.subject.other.pt_BR.fl_str_mv Doença de Chagas
Trypanosoma cruzi
Insuficiência cardíaca
Humanos
Infecção
topic Doença de Chagas
Trypanosoma cruzi
Insuficiência cardíaca
Humanos
Infecção
Chagas disease
Trypanosoma cruzi
Cardiac insufficiency
Humans
Infection
dc.subject.en.pt_BR.fl_str_mv Chagas disease
Trypanosoma cruzi
Cardiac insufficiency
Humans
Infection
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil / Faculty of Medicine of Petrópolis. Petrópolis, RJ, Brazil
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2018-03-20T13:11:33Z
dc.date.available.fl_str_mv 2018-03-20T13:11:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MENGEL, J.; CARDILLO, F. The Interleukin-17 (IL-17) Puzzle in Chagas’ Disease. Cellular Immunology and Serum Biology, v. 3, n. 2, p. 120-121, 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/25414
dc.identifier.issn.pt_BR.fl_str_mv 2471-5891
identifier_str_mv MENGEL, J.; CARDILLO, F. The Interleukin-17 (IL-17) Puzzle in Chagas’ Disease. Cellular Immunology and Serum Biology, v. 3, n. 2, p. 120-121, 2017.
2471-5891
url https://www.arca.fiocruz.br/handle/icict/25414
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Ommega Publishers
publisher.none.fl_str_mv Ommega Publishers
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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