Zika virus infection at different pregnancy stages: anatomopathological findings, target cells and viral persistence in placental tissues
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/31674 |
Resumo: | Pontifícia Universidade Católica do Paraná. Laboratório de Patologia Experimental. Curitiba, PR, Brasil. |
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Noronha, Lucia deZanluca, CamilaBurger, MarionSuzukawa, Andréia AkemiAzevedo, MarinaRebutini, Patricia Z.Novadzki, Iolanda MariaTanabe, Laurina SetsukoPresibella, Mayra MarinhoSantos, Claudia Nunes Duarte dos2019-02-15T13:26:36Z2019-02-15T13:26:36Z2018NORONHA, Lúcia de et al. Zika virus infection at different pregnancy stages: anatomopathological findings, target cells and viral persistence in placental tissues. Frontiers in Microbiology, v. 9, n. p. 1-11, 2018.1664-302Xhttps://www.arca.fiocruz.br/handle/icict/3167410.3389/fmicb.2018.02266porFrontiers MediaAnálise anatomopatológicaAnálise morfométricaCélulas de HofbauerInfectious Disease Transmission VerticalAnatomopathological AnalysisMorphometric AnalysisHofbauer cellsZika VirusTransmissão Vertical de Doença InfecciosaPlacentaZika virus infection at different pregnancy stages: anatomopathological findings, target cells and viral persistence in placental tissuesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePontifícia Universidade Católica do Paraná. Laboratório de Patologia Experimental. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Secretaria da Saúde do Estado do Paraná. Curitiba, PR, Brazil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Pontifícia Universidade Católica do Paraná. Laboratório de Patologia Experimental. Curitiba, PR, Brasil.Pontifícia Universidade Católica do Paraná. Laboratório de Patologia Experimental. Curitiba, PR, Brasil.Secretaria da Saúde do Estado do Paraná. Curitiba, PR, Brazil.Secretaria da Saúde do Estado do Paraná. Curitiba, PR, Brazil.Laboratório Central do Estado do Paraná. Curitiba, PR, Brazil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Zika virus (ZIKV) infection in humans has been associated with congenital malformations and other neurological disorders, such as Guillain-Barré syndrome. The mechanism(s) of ZIKV intrauterine transmission, the cell types involved, the most vulnerable period of pregnancy for severe outcomes from infection and other physiopathological aspects are not completely elucidated. In this study, we analyzed placental samples obtained at the time of delivery from a group of 24 women diagnosed with ZIKV infection during the first, second or third trimesters of pregnancy. Villous immaturity was the main histological finding in the placental tissues, although placentas without alterations were also frequently observed. Significant enhancement of the number of syncytial sprouts was observed in the placentas of women infected during the third trimester, indicating the development of placental abnormalities after ZIKV infection. Hyperplasia of Hofbauer cells (HCs) was also observed in these third-trimester placental tissues, and remarkably, HCs were the only ZIKV-positive fetal cells found in the placentas studied that persisted until birth, as revealed by immunohistochemical (IHC) analysis. Thirty-three percent of women infected during pregnancy delivered infants with congenital abnormalities, although no pattern correlating the gestational stage at infection, the IHC positivity of HCs in placental tissues and the presence of congenital malformations at birth was observed. Placental tissue analysis enabled us to confirm maternal ZIKV infection in cases where serum from the acute infection phase was not available, which reinforces the importance of this technique in identifying possible causal factors of birth defects. The results we observed in the samples from naturally infected pregnant women may contribute to the understanding of some aspects of the pathophysiology of ZIKV.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/31674/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALfmicb-09-022.pdffmicb-09-022.pdfapplication/pdf3153468https://www.arca.fiocruz.br/bitstream/icict/31674/2/fmicb-09-022.pdfb2bf60a08f3e7d2f27337b6b8dc5c53eMD52TEXTfmicb-09-022.pdf.txtfmicb-09-022.pdf.txtExtracted texttext/plain51985https://www.arca.fiocruz.br/bitstream/icict/31674/3/fmicb-09-022.pdf.txt2947fa1ccd6e08786997ae991dd9e14eMD53icict/316742019-12-15 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| dc.title.pt_BR.fl_str_mv |
Zika virus infection at different pregnancy stages: anatomopathological findings, target cells and viral persistence in placental tissues |
| title |
Zika virus infection at different pregnancy stages: anatomopathological findings, target cells and viral persistence in placental tissues |
| spellingShingle |
Zika virus infection at different pregnancy stages: anatomopathological findings, target cells and viral persistence in placental tissues Noronha, Lucia de Análise anatomopatológica Análise morfométrica Células de Hofbauer Infectious Disease Transmission Vertical Anatomopathological Analysis Morphometric Analysis Hofbauer cells Zika Virus Transmissão Vertical de Doença Infecciosa Placenta |
| title_short |
Zika virus infection at different pregnancy stages: anatomopathological findings, target cells and viral persistence in placental tissues |
| title_full |
Zika virus infection at different pregnancy stages: anatomopathological findings, target cells and viral persistence in placental tissues |
| title_fullStr |
Zika virus infection at different pregnancy stages: anatomopathological findings, target cells and viral persistence in placental tissues |
| title_full_unstemmed |
Zika virus infection at different pregnancy stages: anatomopathological findings, target cells and viral persistence in placental tissues |
| title_sort |
Zika virus infection at different pregnancy stages: anatomopathological findings, target cells and viral persistence in placental tissues |
| author |
Noronha, Lucia de |
| author_facet |
Noronha, Lucia de Zanluca, Camila Burger, Marion Suzukawa, Andréia Akemi Azevedo, Marina Rebutini, Patricia Z. Novadzki, Iolanda Maria Tanabe, Laurina Setsuko Presibella, Mayra Marinho Santos, Claudia Nunes Duarte dos |
| author_role |
author |
| author2 |
Zanluca, Camila Burger, Marion Suzukawa, Andréia Akemi Azevedo, Marina Rebutini, Patricia Z. Novadzki, Iolanda Maria Tanabe, Laurina Setsuko Presibella, Mayra Marinho Santos, Claudia Nunes Duarte dos |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Noronha, Lucia de Zanluca, Camila Burger, Marion Suzukawa, Andréia Akemi Azevedo, Marina Rebutini, Patricia Z. Novadzki, Iolanda Maria Tanabe, Laurina Setsuko Presibella, Mayra Marinho Santos, Claudia Nunes Duarte dos |
| dc.subject.other.pt_BR.fl_str_mv |
Análise anatomopatológica Análise morfométrica Células de Hofbauer |
| topic |
Análise anatomopatológica Análise morfométrica Células de Hofbauer Infectious Disease Transmission Vertical Anatomopathological Analysis Morphometric Analysis Hofbauer cells Zika Virus Transmissão Vertical de Doença Infecciosa Placenta |
| dc.subject.en.pt_BR.fl_str_mv |
Infectious Disease Transmission Vertical Anatomopathological Analysis Morphometric Analysis Hofbauer cells |
| dc.subject.decs.pt_BR.fl_str_mv |
Zika Virus Transmissão Vertical de Doença Infecciosa Placenta |
| description |
Pontifícia Universidade Católica do Paraná. Laboratório de Patologia Experimental. Curitiba, PR, Brasil. |
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2018 |
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2018 |
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2019-02-15T13:26:36Z |
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2019-02-15T13:26:36Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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NORONHA, Lúcia de et al. Zika virus infection at different pregnancy stages: anatomopathological findings, target cells and viral persistence in placental tissues. Frontiers in Microbiology, v. 9, n. p. 1-11, 2018. |
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https://www.arca.fiocruz.br/handle/icict/31674 |
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1664-302X |
| dc.identifier.doi.none.fl_str_mv |
10.3389/fmicb.2018.02266 |
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NORONHA, Lúcia de et al. Zika virus infection at different pregnancy stages: anatomopathological findings, target cells and viral persistence in placental tissues. Frontiers in Microbiology, v. 9, n. p. 1-11, 2018. 1664-302X 10.3389/fmicb.2018.02266 |
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