In silico epitope mapping and experimental evaluation of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) as a malaria vaccine candidate
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/38872 |
Resumo: | Universidade Nova de Lisboa. Instituto de Higiene e Medicina Tropical. Centro de Medicina Tropical e Saúde Global. Lisboa, Portugal / Universidade Federal de Goiás. Instituto de Patologia Tropícal e Saúde Pública. GenoBio. Goiânia, GO, Brasil / Centro Universitário de Anápolis. PPG-SOMA. Anápolis, GO, Brasil. |
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Cravo, PedroMachado, Renato B.Leite, Juliana A.Leda, TaizySuwanarusk, RossarinBittencourt, Najara CarneiroAlbrecht, LetusaJudice, CarlaLopes, Stefanie C. P.Lacerda, Marcus V. G.Ferreira, Marcelo U.Soares, Irene S.Goh, Yun ShanBargieri, Daniel Y.Nosten, FrançoisRussell, BruceRénia, LaurentCosta, Fabio T. M.2019-12-26T18:47:27Z2019-12-26T18:47:27Z2018CRAVO, Pedro et al. In silico epitope mapping and experimental evaluation of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) as a malaria vaccine candidate. Malaria Journal, v. 17, n. 20, p. 1-9, 2018.1475-2875https://www.arca.fiocruz.br/handle/icict/3887210.1186/s12936-017-2144-xporBMCPlasmodium vivaxPlasmodium yoeliiMalaria VivaxCarrier ProteinsMerozoitesErythrocytesAntigensMalaria VivaxProteínas PortadorasEritrocitosMalária VivaxProteínas de TransporteMerozoítosEritrócitosAntígenosIn silico epitope mapping and experimental evaluation of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) as a malaria vaccine candidateinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Nova de Lisboa. Instituto de Higiene e Medicina Tropical. Centro de Medicina Tropical e Saúde Global. Lisboa, Portugal / Universidade Federal de Goiás. Instituto de Patologia Tropícal e Saúde Pública. GenoBio. Goiânia, GO, Brasil / Centro Universitário de Anápolis. PPG-SOMA. Anápolis, GO, Brasil.Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. GenoBio. Goiânia, GO, Brasil.Universidade Estadual de Campinas. Departamento de Genética, Evolução, Microbiologia e Imunologia. Laboratório de Doenças Tropicais Prof. Dr. Jacintho da Silva. Campinas, SP, Brasil.Universidade Federal de Goiás. Instituto de Patologia Tropícal e Saúde Pública. GenoBio. Goiânia, GO, Brasil.Singapore Immunology Network. Agency for Science, Technology and Research. Singapore, Singapore.Universidade Estadual de Campinas. Departamento de Genética, Evolução, Microbiologia e Imunologia. Laboratório de Doenças Tropicais Prof. Dr. Jacintho da Silva. Campinas, SP, Brasil.Universidade Estadual de Campinas. Departamento de Genética, Evolução, Microbiologia e Imunologia. Laboratório de Doenças Tropicais Prof. Dr. Jacintho da Silva. Campinas, SP, Brasil / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Universidade Estadual de Campinas. Departamento de Genética, Evolução, Microbiologia e Imunologia. Laboratório de Doenças Tropicais Prof. Dr. Jacintho da Silva. Campinas, SP, Brasil.Universidade Estadual de Campinas. Departamento de Genética, Evolução, Microbiologia e Imunologia. Laboratório de Doenças Tropicais Prof. Dr. Jacintho da Silva. Campinas, SP, Brasil. / Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brasil / Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Gerência de Malária. Manaus, AM, Brasil.Universidade de São Paulo. Departamento de Parasitologia. São Paulo, SP, Brasil.Universidade de São Paulo. Faculdade de Ciências Farmaceuticas. Departamento de Análises Clínicas e Toxicológicas. São Paulo, SP, Brasil.Singapore Immunology Network. Agency for Science, Technology and Research. Singapore, Singapore.Universidade de São Paulo. Departamento de Parasitologia. São Paulo, SP, Brasil.Shoklo Malaria Research Unit. Mahidol Oxford Tropical Medicine Research Unit. Faculty of Tropical Medicine. Mahidol University. Mae Sot, Thailand.Department of Microbiology and Immunology. University of Otago. Dunedin, New Zealand.Singapore Immunology Network. Agency for Science, Technology and Research. Singapore, Singapore.Universidade Estadual de Campinas. Departamento de Genética, Evolução, Microbiologia e Imunologia. Laboratório de Doenças Tropicais Prof. Dr. Jacintho da Silva. Campinas, SP, Brasil.Technical limitations for culturing the human malaria parasite Plasmodium vivax have impaired the discovery of vaccine candidates, challenging the malaria eradication agenda. The immunogenicity of the M2 domain of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) antigen cloned from the Plasmodium yoelii murine parasite, has been previously demonstrated. Detailed epitope mapping of MAEBL through immunoinformatics identifed several MHCI, MHCII and B cell epitopes throughout the peptide, with several of these lying in the M2 domain and being conserved between P. vivax, P. yoelii and Plasmodium falciparum, hinting that the M2-MAEBL is pan-reactive. This hypothesis was tested through functional assays, showing that P. yoelii M2-MAEBL antisera are able to recognize and inhibit erythrocyte invasion from both P. falciparum and P. vivax parasites isolated from Thai patients, in ex vivo assays. Moreover, the sequence of the M2-MAEBL is shown to be highly conserved between P. vivax isolates from the Amazon and Thailand, indicating that the MAEBL antigen may constitute a vaccine candidate outwitting strain-specifc immunity. Therefore, can concluded that the MAEBL antigen is promising candidate towards the development of a malaria vaccine.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/38872/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALs12936-017-2144-ok.pdfs12936-017-2144-ok.pdfapplication/pdf1645911https://www.arca.fiocruz.br/bitstream/icict/38872/2/s12936-017-2144-ok.pdf0ed5b598ff7fef498aef8fc5b929105cMD52TEXTs12936-017-2144-ok.pdf.txts12936-017-2144-ok.pdf.txtExtracted texttext/plain43443https://www.arca.fiocruz.br/bitstream/icict/38872/3/s12936-017-2144-ok.pdf.txtcfc3a735b0fc3abb8a0ddfbc47c973f8MD53icict/388722021-12-23 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| dc.title.pt_BR.fl_str_mv |
In silico epitope mapping and experimental evaluation of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) as a malaria vaccine candidate |
| title |
In silico epitope mapping and experimental evaluation of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) as a malaria vaccine candidate |
| spellingShingle |
In silico epitope mapping and experimental evaluation of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) as a malaria vaccine candidate Cravo, Pedro Plasmodium vivax Plasmodium yoelii Malaria Vivax Carrier Proteins Merozoites Erythrocytes Antigens Malaria Vivax Proteínas Portadoras Eritrocitos Malária Vivax Proteínas de Transporte Merozoítos Eritrócitos Antígenos |
| title_short |
In silico epitope mapping and experimental evaluation of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) as a malaria vaccine candidate |
| title_full |
In silico epitope mapping and experimental evaluation of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) as a malaria vaccine candidate |
| title_fullStr |
In silico epitope mapping and experimental evaluation of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) as a malaria vaccine candidate |
| title_full_unstemmed |
In silico epitope mapping and experimental evaluation of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) as a malaria vaccine candidate |
| title_sort |
In silico epitope mapping and experimental evaluation of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) as a malaria vaccine candidate |
| author |
Cravo, Pedro |
| author_facet |
Cravo, Pedro Machado, Renato B. Leite, Juliana A. Leda, Taizy Suwanarusk, Rossarin Bittencourt, Najara Carneiro Albrecht, Letusa Judice, Carla Lopes, Stefanie C. P. Lacerda, Marcus V. G. Ferreira, Marcelo U. Soares, Irene S. Goh, Yun Shan Bargieri, Daniel Y. Nosten, François Russell, Bruce Rénia, Laurent Costa, Fabio T. M. |
| author_role |
author |
| author2 |
Machado, Renato B. Leite, Juliana A. Leda, Taizy Suwanarusk, Rossarin Bittencourt, Najara Carneiro Albrecht, Letusa Judice, Carla Lopes, Stefanie C. P. Lacerda, Marcus V. G. Ferreira, Marcelo U. Soares, Irene S. Goh, Yun Shan Bargieri, Daniel Y. Nosten, François Russell, Bruce Rénia, Laurent Costa, Fabio T. M. |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Cravo, Pedro Machado, Renato B. Leite, Juliana A. Leda, Taizy Suwanarusk, Rossarin Bittencourt, Najara Carneiro Albrecht, Letusa Judice, Carla Lopes, Stefanie C. P. Lacerda, Marcus V. G. Ferreira, Marcelo U. Soares, Irene S. Goh, Yun Shan Bargieri, Daniel Y. Nosten, François Russell, Bruce Rénia, Laurent Costa, Fabio T. M. |
| dc.subject.other.pt_BR.fl_str_mv |
Plasmodium vivax Plasmodium yoelii |
| topic |
Plasmodium vivax Plasmodium yoelii Malaria Vivax Carrier Proteins Merozoites Erythrocytes Antigens Malaria Vivax Proteínas Portadoras Eritrocitos Malária Vivax Proteínas de Transporte Merozoítos Eritrócitos Antígenos |
| dc.subject.en.pt_BR.fl_str_mv |
Malaria Vivax Carrier Proteins Merozoites Erythrocytes Antigens |
| dc.subject.es.pt_BR.fl_str_mv |
Malaria Vivax Proteínas Portadoras Eritrocitos |
| dc.subject.decs.pt_BR.fl_str_mv |
Malária Vivax Proteínas de Transporte Merozoítos Eritrócitos Antígenos |
| description |
Universidade Nova de Lisboa. Instituto de Higiene e Medicina Tropical. Centro de Medicina Tropical e Saúde Global. Lisboa, Portugal / Universidade Federal de Goiás. Instituto de Patologia Tropícal e Saúde Pública. GenoBio. Goiânia, GO, Brasil / Centro Universitário de Anápolis. PPG-SOMA. Anápolis, GO, Brasil. |
| publishDate |
2018 |
| dc.date.issued.fl_str_mv |
2018 |
| dc.date.accessioned.fl_str_mv |
2019-12-26T18:47:27Z |
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2019-12-26T18:47:27Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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| dc.identifier.citation.fl_str_mv |
CRAVO, Pedro et al. In silico epitope mapping and experimental evaluation of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) as a malaria vaccine candidate. Malaria Journal, v. 17, n. 20, p. 1-9, 2018. |
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https://www.arca.fiocruz.br/handle/icict/38872 |
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1475-2875 |
| dc.identifier.doi.none.fl_str_mv |
10.1186/s12936-017-2144-x |
| identifier_str_mv |
CRAVO, Pedro et al. In silico epitope mapping and experimental evaluation of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) as a malaria vaccine candidate. Malaria Journal, v. 17, n. 20, p. 1-9, 2018. 1475-2875 10.1186/s12936-017-2144-x |
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BMC |
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BMC |
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