HIV-1 subtype C dissemination in southern Brazil

Detalhes bibliográficos
Autor(a) principal: Soares, Esmeralda A. J. M.
Data de Publicação: 2005
Outros Autores: Martínez, Ana M. B., Souza, Thatiana M., Santos, André F. A., Hora, Vanusa da, Silveira, Jussara, Bastos, Francisco Inácio Pinkusfeld Monteiro, Tanuri, Amilcar, Soares, Marcelo A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/530
Resumo: Universidade Federal do Rio de Janeiro. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
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spelling Soares, Esmeralda A. J. M.Martínez, Ana M. B.Souza, Thatiana M.Santos, André F. A.Hora, Vanusa daSilveira, JussaraBastos, Francisco Inácio Pinkusfeld MonteiroTanuri, AmilcarSoares, Marcelo A.2010-08-23T16:48:28Z2010-11-04T14:19:42Z2010-08-23T16:48:28Z2010-11-04T14:19:42Z2005SOARES, E. A. J. M. et al. HIV-1 subtype C dissemination in southern Brazil. AIDS, London, v. 19, p. S81–S86, 2005. Suppl. 4.0269-9370https://www.arca.fiocruz.br/handle/icict/53010.1097/01.aids.0000191497.00928.e4engLippincott Williams & WilkinsHIV-1 subtype C dissemination in southern Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Universidade Federal do Rio Grande. Departamento de Patologia. Rio Grande, RS, Brasil.Universidade Federal do Rio de Janeiro. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Universidade Federal do Rio Grande. Departamento de Patologia. Rio Grande, RS, Brasil.Fundação Universidade Federal do Rio Grande. Departamento de Patologia. Rio Grande, RS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Objectives: To describe the molecular and epidemiological profile of HIV-1 in patients followed at the University Hospital of Rio Grande, Brazil. Design and methods: A cross-sectional study was conducted from September to December 2002. Plasma viral RNA of 85 patients was extracted and protease and reverse transcriptase genes were polymerase chain reaction-amplified and sequenced. Sequences were subtyped and examined to antiretroviral resistance mutations. Laboratory data and past history of antiretroviral treatment were also collected. Results: Most viruses were either subtype B (42%) or subtype C (45%). No risk behaviour, sexual orientation or laboratory parameter was associated with any specific subtype, but subtype C tended to be more frequently found in women (P ¼ 0.06). The prevalence of subtype C has increased over the HIV/AIDS epidemic, accounting for almost 60% of cases diagnosed in 2002. Intra-subtype genetic distances were smaller in subtype C than in subtype B, suggesting a more recent introduction of the former in the epidemic. Of patients under treatment, 60% had at least one antiretroviral drug resistance mutation, but no mutation was specifically associated with any HIV-1 subtype. Only one resistance mutation each was found in drug-naive patients with subtypes B and C. Conclusion: Despite the fact that subtype C appeared in southern Brazil more recently than subtype B, it is now the predominant strain in Rio Grande. The epidemic spread of subtype C could be taking place in Brazil, and possibly in south America, a phenomenon similar to that seen in other countries where this subtype is now totally dominant.Molecular epidemiologyHIV-1Southern BrazilSubtype Cinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZTEXTBastos_HIV_1 subtype C dissemination _2005.pdf.txtBastos_HIV_1 subtype C dissemination _2005.pdf.txtExtracted texttext/plain30153https://www.arca.fiocruz.br/bitstream/icict/530/6/Bastos_HIV_1%20subtype%20C%20dissemination%20_2005.pdf.txtba55d8adf031ca00f207c10623bbd78fMD56LICENSElicense.txttext/plain1842https://www.arca.fiocruz.br/bitstream/icict/530/2/license.txt21aa59b700ef524eed2673cf8ee461a7MD52ORIGINALBastos_HIV_1 subtype C dissemination _2005.pdfapplication/pdf140965https://www.arca.fiocruz.br/bitstream/icict/530/3/Bastos_HIV_1%20subtype%20C%20dissemination%20_2005.pdf982f1d266214b90e2e960a16b1ab41b3MD53THUMBNAILBastos_HIV_1 subtype C dissemination _2005.pdf.jpgBastos_HIV_1 subtype C dissemination _2005.pdf.jpgGenerated Thumbnailimage/jpeg1991https://www.arca.fiocruz.br/bitstream/icict/530/5/Bastos_HIV_1%20subtype%20C%20dissemination%20_2005.pdf.jpge21fed7cc6406c5657cf252d1c042909MD55icict/5302023-08-01 16:54:59.842oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-08-01T19:54:59Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv HIV-1 subtype C dissemination in southern Brazil
title HIV-1 subtype C dissemination in southern Brazil
spellingShingle HIV-1 subtype C dissemination in southern Brazil
Soares, Esmeralda A. J. M.
Molecular epidemiology
HIV-1
Southern Brazil
Subtype C
title_short HIV-1 subtype C dissemination in southern Brazil
title_full HIV-1 subtype C dissemination in southern Brazil
title_fullStr HIV-1 subtype C dissemination in southern Brazil
title_full_unstemmed HIV-1 subtype C dissemination in southern Brazil
title_sort HIV-1 subtype C dissemination in southern Brazil
author Soares, Esmeralda A. J. M.
author_facet Soares, Esmeralda A. J. M.
Martínez, Ana M. B.
Souza, Thatiana M.
Santos, André F. A.
Hora, Vanusa da
Silveira, Jussara
Bastos, Francisco Inácio Pinkusfeld Monteiro
Tanuri, Amilcar
Soares, Marcelo A.
author_role author
author2 Martínez, Ana M. B.
Souza, Thatiana M.
Santos, André F. A.
Hora, Vanusa da
Silveira, Jussara
Bastos, Francisco Inácio Pinkusfeld Monteiro
Tanuri, Amilcar
Soares, Marcelo A.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Soares, Esmeralda A. J. M.
Martínez, Ana M. B.
Souza, Thatiana M.
Santos, André F. A.
Hora, Vanusa da
Silveira, Jussara
Bastos, Francisco Inácio Pinkusfeld Monteiro
Tanuri, Amilcar
Soares, Marcelo A.
dc.subject.en.pt_BR.fl_str_mv Molecular epidemiology
HIV-1
Southern Brazil
Subtype C
topic Molecular epidemiology
HIV-1
Southern Brazil
Subtype C
description Universidade Federal do Rio de Janeiro. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
publishDate 2005
dc.date.issued.fl_str_mv 2005
dc.date.accessioned.fl_str_mv 2010-08-23T16:48:28Z
2010-11-04T14:19:42Z
dc.date.available.fl_str_mv 2010-08-23T16:48:28Z
2010-11-04T14:19:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SOARES, E. A. J. M. et al. HIV-1 subtype C dissemination in southern Brazil. AIDS, London, v. 19, p. S81–S86, 2005. Suppl. 4.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/530
dc.identifier.issn.pt_BR.fl_str_mv 0269-9370
dc.identifier.doi.pt_BR.fl_str_mv 10.1097/01.aids.0000191497.00928.e4
identifier_str_mv SOARES, E. A. J. M. et al. HIV-1 subtype C dissemination in southern Brazil. AIDS, London, v. 19, p. S81–S86, 2005. Suppl. 4.
0269-9370
10.1097/01.aids.0000191497.00928.e4
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dc.language.iso.fl_str_mv eng
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dc.publisher.none.fl_str_mv Lippincott Williams & Wilkins
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