Trypanosoma cruzi infection induces a global host cell response in cardiomyocytes
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/25434 |
Resumo: | Virginia Commonwealth University. Center for the Study of Biological Complexity. Department of Microbiology and Immunology. Richmond, Virginia, USA. |
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Manque, Patricio A.Probst, Christian M.Probst, ChristianPereira, Mirian C. S.Rampazzo, Rita C. P.Ozaki, Luiz ShozoOzaki, L. ShozoPavoni, Daniela P.Silva Neto, Dayse T.Carvalho, M. RuthXu, PingSerrano, Myrna G.Alves, João M. P.Meirelles, Maria de Nazareth S. L.Goldenberg, SamuelKrieger, Marco A.Buck, Gregory A.2018-03-20T16:39:43Z2018-03-20T16:39:43Z2011MANQUE, Patricio A. et al. Trypanosoma cruzi Infection Induces a Global Host Cell Response in Cardiomyocytes. Infection and Immunity, v.79, n.5, p.1855-1862, 2011.0019-9567https://www.arca.fiocruz.br/handle/icict/2543410.1128/IAI.00643-101098-5522engAmerican Society for MicrobiologyDoença de ChagasTrypanosoma cruziMiócitos CardíacosChagas DiseaseTrypanosoma cruziCardiomyocytesTrypanosoma cruzi infection induces a global host cell response in cardiomyocytesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleVirginia Commonwealth University. Center for the Study of Biological Complexity. Department of Microbiology and Immunology. Richmond, Virginia, USA.Instituto Carlos Chagas. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil / Instituto Carlos Chagas. Curitiba, PR, Brasil.Virginia Commonwealth University. Center for the Study of Biological Complexity. Department of Microbiology and Immunology. Richmond, Virginia, USA.Instituto Carlos Chagas. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.Virginia Commonwealth University. Center for the Study of Biological Complexity. Department of Microbiology and Immunology. Richmond, Virginia, USA.Virginia Commonwealth University. Center for the Study of Biological Complexity. Department of Microbiology and Immunology. Richmond, Virginia, USA.Virginia Commonwealth University. Center for the Study of Biological Complexity. Department of Microbiology and Immunology. Richmond, Virginia, USA.Virginia Commonwealth University. Center for the Study of Biological Complexity. Department of Microbiology and Immunology. Richmond, Virginia, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.Instituto Carlos Chagas. Curitiba, PR, Brasil.Instituto Carlos Chagas. Curitiba, PR, Brasil.Virginia Commonwealth University. Center for the Study of Biological Complexity. Department of Microbiology and Immunology. Richmond, Virginia, USA.Chagas' disease, caused by the hemoflagellate protozoan Trypanosoma cruzi, affects millions of people in South and Central America. Chronic chagasic cardiomyopathy, the most devastating manifestation of this disease, occurs in approximately one-third of infected individuals. Events associated with the parasite's tropism for and invasion of cardiomyocytes have been the focus of intense investigation in recent years. In the present study, we use murine microarrays to investigate the cellular response caused by invasion of primary murine cardiomyocytes by T. cruzi trypomastigotes. These studies identified 353 murine genes that were differentially expressed during the early stages of invasion and infection of these cells. Genes associated with the immune response, inflammation, cytoskeleton organization, cell-cell and cell-matrix interactions, apoptosis, cell cycle, and oxidative stress are among those affected during the infection. Our data indicate that T. cruzi induces broad modulations of the host cell machinery in ways that provide insight into how the parasite survives, replicates, and persists in the infected host and ultimately defines the clinical outcome of the infection.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25434/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALrita_rampazzo_etal_IOC_2011.pdfrita_rampazzo_etal_IOC_2011.pdfapplication/pdf1192608https://www.arca.fiocruz.br/bitstream/icict/25434/2/rita_rampazzo_etal_IOC_2011.pdf9a02e8cf0f958662a09d9498e9d5df25MD52TEXTrita_rampazzo_etal_IOC_2011.pdf.txtrita_rampazzo_etal_IOC_2011.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Trypanosoma cruzi infection induces a global host cell response in cardiomyocytes |
| title |
Trypanosoma cruzi infection induces a global host cell response in cardiomyocytes |
| spellingShingle |
Trypanosoma cruzi infection induces a global host cell response in cardiomyocytes Manque, Patricio A. Doença de Chagas Trypanosoma cruzi Miócitos Cardíacos Chagas Disease Trypanosoma cruzi Cardiomyocytes |
| title_short |
Trypanosoma cruzi infection induces a global host cell response in cardiomyocytes |
| title_full |
Trypanosoma cruzi infection induces a global host cell response in cardiomyocytes |
| title_fullStr |
Trypanosoma cruzi infection induces a global host cell response in cardiomyocytes |
| title_full_unstemmed |
Trypanosoma cruzi infection induces a global host cell response in cardiomyocytes |
| title_sort |
Trypanosoma cruzi infection induces a global host cell response in cardiomyocytes |
| author |
Manque, Patricio A. |
| author_facet |
Manque, Patricio A. Probst, Christian M. Probst, Christian Pereira, Mirian C. S. Rampazzo, Rita C. P. Ozaki, Luiz Shozo Ozaki, L. Shozo Pavoni, Daniela P. Silva Neto, Dayse T. Carvalho, M. Ruth Xu, Ping Serrano, Myrna G. Alves, João M. P. Meirelles, Maria de Nazareth S. L. Goldenberg, Samuel Krieger, Marco A. Buck, Gregory A. |
| author_role |
author |
| author2 |
Probst, Christian M. Probst, Christian Pereira, Mirian C. S. Rampazzo, Rita C. P. Ozaki, Luiz Shozo Ozaki, L. Shozo Pavoni, Daniela P. Silva Neto, Dayse T. Carvalho, M. Ruth Xu, Ping Serrano, Myrna G. Alves, João M. P. Meirelles, Maria de Nazareth S. L. Goldenberg, Samuel Krieger, Marco A. Buck, Gregory A. |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Manque, Patricio A. Probst, Christian M. Probst, Christian Pereira, Mirian C. S. Rampazzo, Rita C. P. Ozaki, Luiz Shozo Ozaki, L. Shozo Pavoni, Daniela P. Silva Neto, Dayse T. Carvalho, M. Ruth Xu, Ping Serrano, Myrna G. Alves, João M. P. Meirelles, Maria de Nazareth S. L. Goldenberg, Samuel Krieger, Marco A. Buck, Gregory A. |
| dc.subject.other.pt_BR.fl_str_mv |
Doença de Chagas Trypanosoma cruzi Miócitos Cardíacos |
| topic |
Doença de Chagas Trypanosoma cruzi Miócitos Cardíacos Chagas Disease Trypanosoma cruzi Cardiomyocytes |
| dc.subject.en.pt_BR.fl_str_mv |
Chagas Disease Trypanosoma cruzi Cardiomyocytes |
| description |
Virginia Commonwealth University. Center for the Study of Biological Complexity. Department of Microbiology and Immunology. Richmond, Virginia, USA. |
| publishDate |
2011 |
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2011 |
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2018-03-20T16:39:43Z |
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2018-03-20T16:39:43Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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| dc.identifier.citation.fl_str_mv |
MANQUE, Patricio A. et al. Trypanosoma cruzi Infection Induces a Global Host Cell Response in Cardiomyocytes. Infection and Immunity, v.79, n.5, p.1855-1862, 2011. |
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https://www.arca.fiocruz.br/handle/icict/25434 |
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0019-9567 |
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10.1128/IAI.00643-10 |
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1098-5522 |
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MANQUE, Patricio A. et al. Trypanosoma cruzi Infection Induces a Global Host Cell Response in Cardiomyocytes. Infection and Immunity, v.79, n.5, p.1855-1862, 2011. 0019-9567 10.1128/IAI.00643-10 1098-5522 |
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American Society for Microbiology |
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American Society for Microbiology |
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