Ancestral Genomes, Sex, and the Population Structure of Trypanosoma cruzi
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/31869 |
Resumo: | Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil. |
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Freitas, Jorge M. dePinto, Luiz AugustoPimenta, Juliana R.Rodrigues, Luciana BastosGonçalves, Vanessa F.Teixeira, Santuza M. R.Chiari, EglerJunqueira, Ângela C. V.Fernandes, OctavioMacedo, Andréa M.Machado, Carlos RenatoPena, Sergio D. J.2019-02-26T12:52:38Z2019-02-26T12:52:38Z2006FREITAS, Jorge M. et al. Ancestral Genomes, Sex, and the Population Structure of Trypanosoma cruzi. Plos Pathogens, v.2, n.3, e24, 10p, Mar. 2006.1553-7366https://www.arca.fiocruz.br/handle/icict/318691553-7374engPublic Library of ScienceTrypanosoma cruziGenomas AncestraisSexoEstrutura de populaçãoTrypanosoma cruziAncestral GenomesSexPopulation StructureAncestral Genomes, Sex, and the Population Structure of Trypanosoma cruziinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Departamento de Medicina Tropical. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Departamento de Medicina Tropical. Rio de Janeiro, RJ. Brasil.Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil.Acquisition of detailed knowledge of the structure and evolution of Trypanosoma cruzi populations is essential for control of Chagas disease. We profiled 75 strains of the parasite with five nuclear microsatellite loci, 24Sa RNA genes, and sequence polymorphisms in the mitochondrial cytochrome oxidase subunit II gene. We also used sequences available in GenBank for the mitochondrial genes cytochrome B and NADH dehydrogenase subunit 1. A multidimensional scaling plot (MDS) based in microsatellite data divided the parasites into four clusters corresponding to T. cruzi I (MDS-cluster A), T. cruzi II (MDS-cluster C), a third group of T. cruzi strains (MDS-cluster B), and hybrid strains (MDS-cluster BH). The first two clusters matched respectively mitochondrial clades A and C, while the other two belonged to mitochondrial clade B. The 24Sa rDNA and microsatellite profiling data were combined into multilocus genotypes that were analyzed by the haplotype reconstruction program PHASE. We identified 141 haplotypes that were clearly distributed into three haplogroups (X, Y, and Z). All strains belonging to T. cruzi I (MDS-cluster A) were Z/Z, the T. cruzi II strains (MDS-cluster C) were Y/Y, and those belonging to MDS-cluster B (unclassified T. cruzi) had X/X haplogroup genotypes. The strains grouped in the MDS-cluster BH were X/Y, confirming their hybrid character. Based on these results we propose the following minimal scenario for T. cruzi evolution. In a distant past there were at a minimum three ancestral lineages that we may call, respectively, T. cruzi I, T. cruzi II, and T. cruzi III. At least two hybridization events involving T. cruzi II and T. cruzi III produced evolutionarily viable progeny. In both events, the mitochondrial recipient (as identified by the mitochondrial clade of the hybrid strains) was T. cruzi II and the mitochondrial donor was T. cruzi III.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31869/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALangela_junqueira_etal_IOC_2006.pdfangela_junqueira_etal_IOC_2006.pdfapplication/pdf380241https://www.arca.fiocruz.br/bitstream/icict/31869/2/angela_junqueira_etal_IOC_2006.pdf7714c689ac7b0d41dc67ed30e218b05fMD52TEXTangela_junqueira_etal_IOC_2006.pdf.txtangela_junqueira_etal_IOC_2006.pdf.txtExtracted texttext/plain48105https://www.arca.fiocruz.br/bitstream/icict/31869/3/angela_junqueira_etal_IOC_2006.pdf.txt688df69866b4c0664f84c445e4d72513MD53icict/318692019-02-27 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dc.title.pt_BR.fl_str_mv |
Ancestral Genomes, Sex, and the Population Structure of Trypanosoma cruzi |
title |
Ancestral Genomes, Sex, and the Population Structure of Trypanosoma cruzi |
spellingShingle |
Ancestral Genomes, Sex, and the Population Structure of Trypanosoma cruzi Freitas, Jorge M. de Trypanosoma cruzi Genomas Ancestrais Sexo Estrutura de população Trypanosoma cruzi Ancestral Genomes Sex Population Structure |
title_short |
Ancestral Genomes, Sex, and the Population Structure of Trypanosoma cruzi |
title_full |
Ancestral Genomes, Sex, and the Population Structure of Trypanosoma cruzi |
title_fullStr |
Ancestral Genomes, Sex, and the Population Structure of Trypanosoma cruzi |
title_full_unstemmed |
Ancestral Genomes, Sex, and the Population Structure of Trypanosoma cruzi |
title_sort |
Ancestral Genomes, Sex, and the Population Structure of Trypanosoma cruzi |
author |
Freitas, Jorge M. de |
author_facet |
Freitas, Jorge M. de Pinto, Luiz Augusto Pimenta, Juliana R. Rodrigues, Luciana Bastos Gonçalves, Vanessa F. Teixeira, Santuza M. R. Chiari, Egler Junqueira, Ângela C. V. Fernandes, Octavio Macedo, Andréa M. Machado, Carlos Renato Pena, Sergio D. J. |
author_role |
author |
author2 |
Pinto, Luiz Augusto Pimenta, Juliana R. Rodrigues, Luciana Bastos Gonçalves, Vanessa F. Teixeira, Santuza M. R. Chiari, Egler Junqueira, Ângela C. V. Fernandes, Octavio Macedo, Andréa M. Machado, Carlos Renato Pena, Sergio D. J. |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Freitas, Jorge M. de Pinto, Luiz Augusto Pimenta, Juliana R. Rodrigues, Luciana Bastos Gonçalves, Vanessa F. Teixeira, Santuza M. R. Chiari, Egler Junqueira, Ângela C. V. Fernandes, Octavio Macedo, Andréa M. Machado, Carlos Renato Pena, Sergio D. J. |
dc.subject.other.pt_BR.fl_str_mv |
Trypanosoma cruzi Genomas Ancestrais Sexo Estrutura de população |
topic |
Trypanosoma cruzi Genomas Ancestrais Sexo Estrutura de população Trypanosoma cruzi Ancestral Genomes Sex Population Structure |
dc.subject.en.pt_BR.fl_str_mv |
Trypanosoma cruzi Ancestral Genomes Sex Population Structure |
description |
Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil. |
publishDate |
2006 |
dc.date.issued.fl_str_mv |
2006 |
dc.date.accessioned.fl_str_mv |
2019-02-26T12:52:38Z |
dc.date.available.fl_str_mv |
2019-02-26T12:52:38Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
FREITAS, Jorge M. et al. Ancestral Genomes, Sex, and the Population Structure of Trypanosoma cruzi. Plos Pathogens, v.2, n.3, e24, 10p, Mar. 2006. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/31869 |
dc.identifier.issn.pt_BR.fl_str_mv |
1553-7366 |
dc.identifier.eissn.none.fl_str_mv |
1553-7374 |
identifier_str_mv |
FREITAS, Jorge M. et al. Ancestral Genomes, Sex, and the Population Structure of Trypanosoma cruzi. Plos Pathogens, v.2, n.3, e24, 10p, Mar. 2006. 1553-7366 1553-7374 |
url |
https://www.arca.fiocruz.br/handle/icict/31869 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Public Library of Science |
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Public Library of Science |
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