Distribution of superantigens in group A streptococcal isolates from Salvador, Brazil

Bibliographic Details
Main Author: Berman, Hillary F
Publication Date: 2014
Other Authors: Tartof, Sara Yee, Reis, Joice N, Reis, Mitermayer Galvão dos, Riley, Lee W
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
Download full: https://www.arca.fiocruz.br/handle/icict/24980
Summary: Fogarty International Center, NIH, Grant number TW006563.
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spelling Berman, Hillary FTartof, Sara YeeReis, Joice NReis, Mitermayer Galvão dosRiley, Lee W2018-02-27T16:37:14Z2018-02-27T16:37:14Z2014BERMAN, H. F. et al. Distribution of superantigens in group A streptococcal isolates from Salvador, Brazil. BMC Infectious Diseases, v. 14, p. 294, 2014.1471-2334https://www.arca.fiocruz.br/handle/icict/2498010.1186/1471-2334-14-294Fogarty International Center, NIH, Grant number TW006563.University of California. School of Public Health. Division of Infectious Disease and Vaccinology. Berkeley, CA, USAUniversity of California. School of Public Health. Division of Infectious Disease and Vaccinology. Berkeley, CA, USA / Kaiser Permanente Southern California Research and Evaluation. Pasadena, CA, USAFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilUniversity of California. School of Public Health. Division of Infectious Disease and Vaccinology. Berkeley, CA, USAGroup A streptococcus (GAS) causes invasive disease, superficial disease, and can asymptomatically colonize humans. Superantigens are one virulence factor found in GAS. Previous studies found associations between the genes that encode superantigens and emm type of GAS. It is unknown if these associations are due to underlying biological factors that limit the distribution of superantigens or, alternatively, if these associations are due to the expansion of local GAS linages where these studies took place. To further address this question we screened GAS isolates collected from Salvador, Brazil for 11 known superantigen genes. Methods: Seventy-seven GAS isolates were screened by PCR for superantigen genes. These superantigen genes were speA, speC, speG, speH, speI, speJ, speK, speL, speM, ssa, and smeZ. We used Fisher’s two-sided exact test to identify associations between superantigens and GAS emm type. We then compared our results to previous reports of superantigen prevalence and superantigen association with emm type. Results: In our collection we found several emm type and superantigen genotype combinations that have previously been reported in isolates from Europe and Australia. We also found that speA was significantly associated with emm type 1, and that speC was significantly associated with emm type 12. Conclusions: Our study reports superantigen genotypes of GAS from a region of the world that is lacking this information. We found evidence of common GAS superantigen genotypes that are spread worldwide as well as novel superantigen genotypes that, so far, are unique to Brazil.engBioMed CentralStreptococcus pyogenesFagos estreptocócicosEstreptococosStreptococcus pyogenesStreptococcal superantigensGroup A streptococcusEmm typesDistribution of superantigens in group A streptococcal isolates from Salvador, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/24980/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALBerman HF Distribution of superantigens....pdfBerman HF Distribution of 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dc.title.pt_BR.fl_str_mv Distribution of superantigens in group A streptococcal isolates from Salvador, Brazil
title Distribution of superantigens in group A streptococcal isolates from Salvador, Brazil
spellingShingle Distribution of superantigens in group A streptococcal isolates from Salvador, Brazil
Berman, Hillary F
Streptococcus pyogenes
Fagos estreptocócicos
Estreptococos
Streptococcus pyogenes
Streptococcal superantigens
Group A streptococcus
Emm types
title_short Distribution of superantigens in group A streptococcal isolates from Salvador, Brazil
title_full Distribution of superantigens in group A streptococcal isolates from Salvador, Brazil
title_fullStr Distribution of superantigens in group A streptococcal isolates from Salvador, Brazil
title_full_unstemmed Distribution of superantigens in group A streptococcal isolates from Salvador, Brazil
title_sort Distribution of superantigens in group A streptococcal isolates from Salvador, Brazil
author Berman, Hillary F
author_facet Berman, Hillary F
Tartof, Sara Yee
Reis, Joice N
Reis, Mitermayer Galvão dos
Riley, Lee W
author_role author
author2 Tartof, Sara Yee
Reis, Joice N
Reis, Mitermayer Galvão dos
Riley, Lee W
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Berman, Hillary F
Tartof, Sara Yee
Reis, Joice N
Reis, Mitermayer Galvão dos
Riley, Lee W
dc.subject.other.pt_BR.fl_str_mv Streptococcus pyogenes
Fagos estreptocócicos
Estreptococos
topic Streptococcus pyogenes
Fagos estreptocócicos
Estreptococos
Streptococcus pyogenes
Streptococcal superantigens
Group A streptococcus
Emm types
dc.subject.en.pt_BR.fl_str_mv Streptococcus pyogenes
Streptococcal superantigens
Group A streptococcus
Emm types
description Fogarty International Center, NIH, Grant number TW006563.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2018-02-27T16:37:14Z
dc.date.available.fl_str_mv 2018-02-27T16:37:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BERMAN, H. F. et al. Distribution of superantigens in group A streptococcal isolates from Salvador, Brazil. BMC Infectious Diseases, v. 14, p. 294, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/24980
dc.identifier.issn.pt_BR.fl_str_mv 1471-2334
dc.identifier.doi.none.fl_str_mv 10.1186/1471-2334-14-294
identifier_str_mv BERMAN, H. F. et al. Distribution of superantigens in group A streptococcal isolates from Salvador, Brazil. BMC Infectious Diseases, v. 14, p. 294, 2014.
1471-2334
10.1186/1471-2334-14-294
url https://www.arca.fiocruz.br/handle/icict/24980
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/24980/1/license.txt
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https://www.arca.fiocruz.br/bitstream/icict/24980/3/Berman%20HF%20Distribution%20of%20superantigens....pdf.txt
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